Lrp1b (low density lipoprotein-related protein 1B) - Rat Genome Database

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Gene: Lrp1b (low density lipoprotein-related protein 1B) Mus musculus
Analyze
Symbol: Lrp1b
Name: low density lipoprotein-related protein 1B
RGD ID: 1314618
MGI Page MGI
Description: Enables low-density lipoprotein particle receptor activity. Acts upstream of or within in utero embryonic development. Located in membrane. Is expressed in several structures, including adrenal medulla; central nervous system; and eye. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung disease (multiple); and melanoma. Orthologous to human LRP1B (LDL receptor related protein 1B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9630004P12Rik; low density lipoprotein-related protein 1B (deleted in tumors); low-density lipoprotein receptor-related protein 1B; low-density lipoprotein receptor-related protein-deleted in tumor; LRP-1B; LRP-DIT
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39240,485,302 - 42,543,747 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl240,485,258 - 42,543,636 (-)EnsemblGRCm39 Ensembl
GRCm38240,595,290 - 42,653,598 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl240,595,246 - 42,653,624 (-)EnsemblGRCm38mm10GRCm38
MGSCv37240,452,293 - 42,509,118 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36240,418,782 - 42,475,607 (-)NCBIMGSCv36mm8
Celera242,315,294 - 44,349,825 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity. Benoit ME, etal., J Biol Chem. 2013 Jan 4;288(1):654-65. doi: 10.1074/jbc.M112.400168. Epub 2012 Nov 13.
2. Association of LRP1B Mutation With Tumor Mutation Burden and Outcomes in Melanoma and Non-small Cell Lung Cancer Patients Treated With Immune Check-Point Blockades. Chen H, etal., Front Immunol. 2019 May 21;10:1113. doi: 10.3389/fimmu.2019.01113. eCollection 2019.
3. Somatic mutations affect key pathways in lung adenocarcinoma. Ding L, etal., Nature. 2008 Oct 23;455(7216):1069-75. doi: 10.1038/nature07423.
4. High-risk Stage III colon cancer patients identified by a novel five-gene mutational signature are characterized by upregulation of IL-23A and gut bacterial translocation of the tumor microenvironment. Ge W, etal., Int J Cancer. 2020 Apr 1;146(7):2027-2035. doi: 10.1002/ijc.32775. Epub 2019 Nov 27.
5. Hypolipidemic effect of novel 2,5-bis(4-hydroxybenzylidenamino)-1,3,4-thiadiazole as potential peroxisome proliferation-activated receptor-α agonist in acute hyperlipidemic rat model. Hamadneh LA, etal., Mol Cell Biochem. 2019 Aug;458(1-2):39-47. doi: 10.1007/s11010-019-03528-5. Epub 2019 Mar 23.
6. RNF213 gene mutation in circulating tumor DNA detected by targeted next-generation sequencing in the assisted discrimination of early-stage lung cancer from pulmonary nodules. Jiang N, etal., Thorac Cancer. 2021 Jan;12(2):181-193. doi: 10.1111/1759-7714.13741. Epub 2020 Nov 16.
7. Integrative clinical and molecular analysis of advanced biliary tract cancers on immune checkpoint blockade reveals potential markers of response. Li J, etal., Clin Transl Med. 2020 Aug;10(4):e118. doi: 10.1002/ctm2.118.
8. Effects of LRP1B Regulated by HSF1 on Lipid Metabolism in Hepatocellular Carcinoma. Li M, etal., J Hepatocell Carcinoma. 2020 Dec 8;7:361-376. doi: 10.2147/JHC.S279123. eCollection 2020.
9. Aberrant methylation impairs low density lipoprotein receptor-related protein 1B tumor suppressor function in gastric cancer. Lu YJ, etal., Genes Chromosomes Cancer. 2010 May;49(5):412-24. doi: 10.1002/gcc.20752.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib/gefitinib. Shang Y, etal., Sci Rep. 2020 Nov 20;10(1):20243. doi: 10.1038/s41598-020-76791-y.
17. LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma. Wang L, etal., J Cancer. 2021 Jan 1;12(1):217-223. doi: 10.7150/jca.48983. eCollection 2021.
18. Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells. Wang Z, etal., Exp Cell Res. 2017 Aug 1;357(1):1-8. doi: 10.1016/j.yexcr.2017.04.010. Epub 2017 Apr 11.
19. Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD. Xiao D, etal., Sci Rep. 2017 May 18;7(1):2121. doi: 10.1038/s41598-017-02405-9.
20. Somatic Mutation Profiling of Intrahepatic Cholangiocarcinoma: Comparison between Primary and Metastasis Tumor Tissues. Xu SF, etal., J Oncol. 2020 Sep 17;2020:5675020. doi: 10.1155/2020/5675020. eCollection 2020.
21. Multi gene mutation signatures in colorectal cancer patients: predict for the diagnosis, pathological classification, staging and prognosis. Zhuang Y, etal., BMC Cancer. 2021 Apr 9;21(1):380. doi: 10.1186/s12885-021-08108-9.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:15082773   PMID:15235602   PMID:15963947   PMID:16141072   PMID:16141073   PMID:17658514  
PMID:18287559   PMID:19000842   PMID:19071120   PMID:20383322   PMID:21267068   PMID:21337463   PMID:21873635   PMID:23382219   PMID:24639464   PMID:27626682   PMID:29799838   PMID:32325033  
PMID:32554809   PMID:36237181   PMID:36417873   PMID:38355793  


Genomics

Comparative Map Data
Lrp1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39240,485,302 - 42,543,747 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl240,485,258 - 42,543,636 (-)EnsemblGRCm39 Ensembl
GRCm38240,595,290 - 42,653,598 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl240,595,246 - 42,653,624 (-)EnsemblGRCm38mm10GRCm38
MGSCv37240,452,293 - 42,509,118 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36240,418,782 - 42,475,607 (-)NCBIMGSCv36mm8
Celera242,315,294 - 44,349,825 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.51NCBI
LRP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382140,231,423 - 142,131,016 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2140,231,423 - 142,131,016 (-)EnsemblGRCh38hg38GRCh38
GRCh372140,988,992 - 142,888,585 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362140,705,466 - 142,605,740 (-)NCBINCBI36Build 36hg18NCBI36
Build 342140,822,727 - 142,723,002NCBI
Celera2134,700,555 - 136,601,626 (-)NCBICelera
Cytogenetic Map2q22.1-q22.2NCBI
HuRef2132,979,804 - 134,880,174 (-)NCBIHuRef
CHM1_12140,994,306 - 142,894,408 (-)NCBICHM1_1
T2T-CHM13v2.02140,677,183 - 142,576,386 (-)NCBIT2T-CHM13v2.0
Lrp1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8345,004,001 - 47,125,147 (-)NCBIGRCr8
mRatBN7.2324,594,302 - 26,715,037 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl324,594,991 - 26,715,505 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0325,201,194 - 27,348,126 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl325,921,427 - 26,056,818 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0330,416,590 - 32,551,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4320,761,304 - 22,918,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1320,657,918 - 22,334,356 (-)NCBI
Celera322,989,759 - 25,068,930 (-)NCBICelera
Cytogenetic Map3q12NCBI
Lrp1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554407,050,135 - 8,475,122 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554407,048,527 - 8,475,566 (-)NCBIChiLan1.0ChiLan1.0
LRP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21332,770,481 - 34,680,683 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B32,785,945 - 34,695,648 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B17,702,178 - 19,611,567 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B144,316,387 - 146,222,214 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B144,382,759 - 146,221,243 (-)Ensemblpanpan1.1panPan2
LRP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11942,608,167 - 44,427,492 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1942,609,684 - 44,427,262 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1942,862,037 - 44,679,502 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01944,045,875 - 45,876,524 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1944,045,827 - 45,876,493 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11942,706,549 - 44,535,337 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01942,860,287 - 44,675,163 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01944,109,034 - 46,068,924 (-)NCBIUU_Cfam_GSD_1.0
Lrp1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303105,453,907 - 107,220,269 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646935,203,594 - 36,159,283 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646935,000,773 - 36,160,216 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl159,613,238 - 11,499,530 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1159,612,805 - 11,499,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21510,898,196 - 11,701,298 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11025,611,400 - 27,511,903 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1025,616,590 - 26,609,111 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040172,851,084 - 173,703,822 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473239,993,907 - 41,902,824 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473239,993,972 - 41,903,552 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrp1b
120224 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1226
Count of miRNA genes:485
Interacting mature miRNAs:606
Transcripts:ENSMUST00000052550, ENSMUST00000129974, ENSMUST00000133104, ENSMUST00000134032, ENSMUST00000138700, ENSMUST00000142546, ENSMUST00000142688, ENSMUST00000167270
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)23997166573971811Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
12904008Cfq6_mconditioned fear QTL 6 (mouse)23120303544508204Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
10449151Hdl8_mhigh density lipoprotein (HDL) level 8 (mouse)23812972567072607Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
10449150Pvldlc1_mplasma VLDL-cholesterol 1 (mouse)23812972567072607Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
10449145Lanq1_mlanosterol level QTL 1 (mouse)23812972567072607Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
13464253Ifvrq1_minfluenza virus resistance QTL 1 (mouse)23303449252034492Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24182071975820843Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse

Markers in Region
Lrp1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2BUniSTS
cM Map2 UniSTS
24.MHAa81T_M13Rev.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38241,110,582 - 41,110,732UniSTSGRCm38
MGSCv37240,966,102 - 40,966,252UniSTSGRCm37
Celera242,825,698 - 42,825,848UniSTS
Cytogenetic Map2BUniSTS
Whitehead_YAC2 UniSTS
D2Mit237  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38240,995,481 - 40,995,603UniSTSGRCm38
MGSCv37240,851,001 - 40,851,123UniSTSGRCm37
Celera242,716,090 - 42,716,198UniSTS
Cytogenetic Map2BUniSTS
cM Map228.0UniSTS
Whitehead Genetic227.3UniSTS
Whitehead_YAC2 UniSTS
D2Mit369  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38240,799,133 - 40,799,257UniSTSGRCm38
MGSCv37240,654,653 - 40,654,777UniSTSGRCm37
Celera242,526,194 - 42,526,300UniSTS
Cytogenetic Map2BUniSTS
cM Map227.3UniSTS
Whitehead Genetic227.3UniSTS
Whitehead_YAC2 UniSTS
D2Mit371  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38241,495,188 - 41,495,306UniSTSGRCm38
MGSCv37241,350,708 - 41,350,826UniSTSGRCm37
Celera243,216,064 - 43,216,182UniSTS
Cytogenetic Map2BUniSTS
cM Map227.3UniSTS
Whitehead Genetic227.3UniSTS
D2Mit370  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38240,799,139 - 40,799,257UniSTSGRCm38
MGSCv37240,654,659 - 40,654,777UniSTSGRCm37
Celera242,526,200 - 42,526,300UniSTS
Cytogenetic Map2BUniSTS
cM Map227.3UniSTS
Whitehead Genetic227.3UniSTS
Whitehead/MRC_RH2630.0UniSTS
Whitehead_YAC2 UniSTS
D2Mit466  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38241,225,066 - 41,225,178UniSTSGRCm38
MGSCv37241,080,586 - 41,080,698UniSTSGRCm37
Celera242,940,722 - 42,940,832UniSTS
Cytogenetic Map2BUniSTS
cM Map227.3UniSTS
Whitehead Genetic227.3UniSTS
Whitehead_YAC2 UniSTS
D2Mit468  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38241,551,079 - 41,551,203UniSTSGRCm38
MGSCv37241,406,599 - 41,406,723UniSTSGRCm37
Celera243,271,764 - 43,271,882UniSTS
Cytogenetic Map2BUniSTS
cM Map227.3UniSTS
Whitehead Genetic227.3UniSTS
D2Dcr49  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38240,799,136 - 40,799,271UniSTSGRCm38
MGSCv37240,654,656 - 40,654,791UniSTSGRCm37
Celera242,526,197 - 42,526,314UniSTS
Cytogenetic Map2BUniSTS
cM Map2 UniSTS
D2Mit297  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38242,605,486 - 42,605,626UniSTSGRCm38
MGSCv37242,461,006 - 42,461,146UniSTSGRCm37
Celera244,301,578 - 44,301,720UniSTS
Cytogenetic Map2BUniSTS
cM Map229.0UniSTS
Whitehead Genetic228.4UniSTS
UniSTS:224757  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38241,472,821 - 41,473,004UniSTSGRCm38
MGSCv37241,328,341 - 41,328,524UniSTSGRCm37
Celera243,193,740 - 43,193,923UniSTS
Cytogenetic Map2BUniSTS
D9Mco7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38240,785,338 - 40,785,547UniSTSGRCm38
MGSCv37240,640,858 - 40,641,067UniSTSGRCm37
Celera242,512,656 - 42,512,859UniSTS
Cytogenetic Map2BUniSTS
D2Ucl4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38241,369,511 - 41,369,723UniSTSGRCm38
MGSCv37241,225,031 - 41,225,243UniSTSGRCm37
Celera243,089,979 - 43,090,195UniSTS
Cytogenetic Map2BUniSTS
cM Map228.0UniSTS
BB284142  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38241,670,113 - 41,670,223UniSTSGRCm38
MGSCv37241,525,633 - 41,525,743UniSTSGRCm37
Celera243,390,487 - 43,390,597UniSTS
Cytogenetic Map2BUniSTS
Whitehead/MRC_RH2703.43UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011239217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_374143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_374144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF270884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL805948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL806522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL840626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL935161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX000439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX649304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LXEJ02010006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000052550   ⟹   ENSMUSP00000054275
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl240,485,260 - 42,543,636 (-)Ensembl
GRCm38.p6 Ensembl240,595,248 - 42,653,624 (-)Ensembl
Ensembl Acc Id: ENSMUST00000129974
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl240,485,258 - 40,505,263 (-)Ensembl
GRCm38.p6 Ensembl240,595,246 - 40,615,251 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133104
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl242,211,694 - 42,543,268 (-)Ensembl
GRCm38.p6 Ensembl242,321,682 - 42,653,256 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134032
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl240,567,528 - 40,589,788 (-)Ensembl
GRCm38.p6 Ensembl240,677,516 - 40,699,776 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138700
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl241,386,160 - 42,543,085 (-)Ensembl
GRCm38.p6 Ensembl241,496,148 - 42,653,073 (-)Ensembl
Ensembl Acc Id: ENSMUST00000142546   ⟹   ENSMUSP00000117212
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl240,485,546 - 40,592,812 (-)Ensembl
GRCm38.p6 Ensembl240,595,534 - 40,702,800 (-)Ensembl
Ensembl Acc Id: ENSMUST00000142688   ⟹   ENSMUSP00000144957
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl242,539,890 - 42,543,027 (-)Ensembl
GRCm38.p6 Ensembl242,649,878 - 42,653,015 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167270   ⟹   ENSMUSP00000129192
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl240,691,405 - 41,679,090 (-)Ensembl
GRCm38.p6 Ensembl240,801,393 - 41,789,078 (-)Ensembl
Ensembl Acc Id: ENSMUST00000185258   ⟹   ENSMUSP00000139874
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl240,485,546 - 40,517,348 (-)Ensembl
GRCm38.p6 Ensembl240,595,534 - 40,627,336 (-)Ensembl
Ensembl Acc Id: ENSMUST00000203015   ⟹   ENSMUSP00000145066
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl240,490,296 - 40,547,400 (-)Ensembl
GRCm38.p6 Ensembl240,600,284 - 40,657,388 (-)Ensembl
Ensembl Acc Id: ENSMUST00000203080   ⟹   ENSMUSP00000145278
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl241,172,078 - 42,543,069 (-)Ensembl
GRCm38.p6 Ensembl241,282,066 - 42,653,057 (-)Ensembl
Ensembl Acc Id: ENSMUST00000204204   ⟹   ENSMUSP00000145045
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl241,944,131 - 42,542,938 (-)Ensembl
GRCm38.p6 Ensembl242,054,119 - 42,652,926 (-)Ensembl
RefSeq Acc Id: NM_053011   ⟹   NP_443737
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39240,486,785 - 42,543,610 (-)NCBI
GRCm38240,596,773 - 42,653,598 (-)NCBI
MGSCv37240,452,293 - 42,509,118 (-)RGD
Celera242,315,294 - 44,349,825 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498459   ⟹   XP_006498522
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39240,485,302 - 42,543,747 (-)NCBI
GRCm38240,595,290 - 42,653,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006498460   ⟹   XP_006498523
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39240,485,302 - 42,543,747 (-)NCBI
GRCm38240,595,290 - 42,653,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006498462   ⟹   XP_006498525
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39240,485,302 - 42,543,747 (-)NCBI
GRCm38240,595,290 - 42,653,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006498463   ⟹   XP_006498526
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39240,485,302 - 42,543,747 (-)NCBI
GRCm38240,595,290 - 42,653,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011239217   ⟹   XP_011237519
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39240,870,483 - 42,543,747 (-)NCBI
GRCm38240,980,336 - 42,653,535 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319348   ⟹   XP_017174837
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39240,485,302 - 42,543,747 (-)NCBI
GRCm38240,595,290 - 42,653,532 (-)NCBI
Sequence:
RefSeq Acc Id: XR_374143
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39240,485,385 - 42,543,747 (-)NCBI
GRCm38240,677,522 - 42,653,535 (-)NCBI
Sequence:
RefSeq Acc Id: XR_374144
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39240,760,329 - 42,543,747 (-)NCBI
GRCm38240,870,317 - 42,653,535 (-)NCBI
Sequence:
RefSeq Acc Id: NP_443737   ⟸   NM_053011
- Peptide Label: precursor
- UniProtKB: Q9JI18 (UniProtKB/Swiss-Prot),   Q8BZM7 (UniProtKB/Swiss-Prot),   Q8BZD3 (UniProtKB/Swiss-Prot),   A2API5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006498526   ⟸   XM_006498463
- Peptide Label: isoform X5
- UniProtKB: Q9JI18 (UniProtKB/Swiss-Prot),   Q8BZM7 (UniProtKB/Swiss-Prot),   Q8BZD3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006498523   ⟸   XM_006498460
- Peptide Label: isoform X2
- UniProtKB: Q9JI18 (UniProtKB/Swiss-Prot),   Q8BZM7 (UniProtKB/Swiss-Prot),   Q8BZD3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006498522   ⟸   XM_006498459
- Peptide Label: isoform X1
- UniProtKB: Q9JI18 (UniProtKB/Swiss-Prot),   Q8BZM7 (UniProtKB/Swiss-Prot),   Q8BZD3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006498525   ⟸   XM_006498462
- Peptide Label: isoform X4
- UniProtKB: Q9JI18 (UniProtKB/Swiss-Prot),   Q8BZM7 (UniProtKB/Swiss-Prot),   Q8BZD3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011237519   ⟸   XM_011239217
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017174837   ⟸   XM_017319348
- Peptide Label: isoform X3
- UniProtKB: Q9JI18 (UniProtKB/Swiss-Prot),   Q8BZM7 (UniProtKB/Swiss-Prot),   Q8BZD3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000145045   ⟸   ENSMUST00000204204
Ensembl Acc Id: ENSMUSP00000054275   ⟸   ENSMUST00000052550
Ensembl Acc Id: ENSMUSP00000145066   ⟸   ENSMUST00000203015
Ensembl Acc Id: ENSMUSP00000145278   ⟸   ENSMUST00000203080
Ensembl Acc Id: ENSMUSP00000139874   ⟸   ENSMUST00000185258
Ensembl Acc Id: ENSMUSP00000129192   ⟸   ENSMUST00000167270
Ensembl Acc Id: ENSMUSP00000117212   ⟸   ENSMUST00000142546
Ensembl Acc Id: ENSMUSP00000144957   ⟸   ENSMUST00000142688
Protein Domains
EGF-like   LDL-receptor class A

Promoters
RGD ID:6831729
Promoter ID:MM_KWN:29079
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000052550,   UC008JOO.1,   UC008JOP.1,   UC008JOQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36242,508,201 - 42,508,701 (-)MPROMDB
RGD ID:6877234
Promoter ID:EPDNEW_M2068
Type:initiation region
Name:Lrp1b_1
Description:Mus musculus low density lipoprotein-related protein 1B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38242,653,043 - 42,653,103EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2151136 AgrOrtholog
Ensembl Genes ENSMUSG00000049252 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000052550 ENTREZGENE
  ENSMUST00000052550.13 UniProtKB/TrEMBL
  ENSMUST00000142546.8 UniProtKB/TrEMBL
  ENSMUST00000142688.2 UniProtKB/TrEMBL
  ENSMUST00000167270.5 UniProtKB/TrEMBL
  ENSMUST00000185258.4 UniProtKB/TrEMBL
  ENSMUST00000203015.2 UniProtKB/TrEMBL
  ENSMUST00000203080.3 UniProtKB/TrEMBL
  ENSMUST00000204204.2 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5050 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH_homolog UniProtKB/TrEMBL
KEGG Report mmu:94217 UniProtKB/TrEMBL
MGD MGI:2151136 ENTREZGENE
NCBI Gene 94217 ENTREZGENE
PANTHER EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5050 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrp1b PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YWTD domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WPQ4_MOUSE UniProtKB/TrEMBL
  A0A0N4SV53_MOUSE UniProtKB/TrEMBL
  A0A0N4SVC8_MOUSE UniProtKB/TrEMBL
  A0A0N4SVE4_MOUSE UniProtKB/TrEMBL
  A0A0N4SVX0_MOUSE UniProtKB/TrEMBL
  A2API5 ENTREZGENE, UniProtKB/TrEMBL
  E9Q202_MOUSE UniProtKB/TrEMBL
  F6YDG9_MOUSE UniProtKB/TrEMBL
  LRP1B_MOUSE UniProtKB/Swiss-Prot
  Q3UWT4_MOUSE UniProtKB/TrEMBL
  Q6P220_MOUSE UniProtKB/TrEMBL
  Q8BZD3 ENTREZGENE
  Q8BZM7 ENTREZGENE
  Q9JI18 ENTREZGENE
UniProt Secondary Q8BZD3 UniProtKB/Swiss-Prot
  Q8BZM7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-12 Lrp1b  low density lipoprotein-related protein 1B    low density lipoprotein-related protein 1B (deleted in tumors)  Symbol and/or name change 5135510 APPROVED