Stat4 (signal transducer and activator of transcription 4) - Rat Genome Database

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Gene: Stat4 (signal transducer and activator of transcription 4) Mus musculus
Analyze
Symbol: Stat4
Name: signal transducer and activator of transcription 4
RGD ID: 1313965
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; positive regulation of macromolecule biosynthetic process; and protein phosphorylation. Located in nucleus. Is expressed in several structures, including axial skeleton; cranium; early conceptus; genitourinary system; and thymus primordium. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); genital herpes; and scleroderma (multiple). Orthologous to human STAT4 (signal transducer and activator of transcription 4).
Type: protein-coding
RefSeq Status: REVIEWED
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,026,265 - 52,146,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,026,307 - 52,146,348 (+)EnsemblGRCm39 Ensembl
GRCm38151,987,106 - 52,107,189 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl151,987,148 - 52,107,189 (+)EnsemblGRCm38mm10GRCm38
MGSCv37152,065,088 - 52,164,028 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36151,952,789 - 52,051,729 (+)NCBIMGSCv36mm8
Celera152,546,764 - 52,645,629 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
aconitine  (ISO)
acrylamide  (ISO)
ammonium chloride  (ISO)
antigen  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
chlorophyllin  (EXP)
choline  (EXP)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
eugenol  (ISO)
folic acid  (EXP)
genistein  (EXP)
gentamycin  (ISO)
L-methionine  (EXP)
leptomycin B  (ISO)
lipopolysaccharide  (EXP,ISO)
maneb  (EXP)
melatonin  (EXP)
methotrexate  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenytoin  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
propanal  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Disease susceptibility genes shared by primary biliary cirrhosis and Crohn's disease in the Japanese population. Aiba Y, etal., J Hum Genet. 2015 Sep;60(9):525-31. doi: 10.1038/jhg.2015.59. Epub 2015 Jun 18.
2. Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study. Alonso-Perez E, etal., PLoS One. 2012;7(9):e45356. doi: 10.1371/journal.pone.0045356. Epub 2012 Sep 26.
3. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. Aprahamian T, etal., J Immunol. 2006 Sep 1;177(5):3028-34.
4. Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis. Avouac J, etal., Arthritis Rheum. 2011 Mar;63(3):800-9. doi: 10.1002/art.30171.
5. Role of Stat4-mediated signal transduction events in the generation of aggressor CD4+ T cells in herpetic stromal keratitis pathogenesis. Banerjee K, etal., J Interferon Cytokine Res. 2007 Jan;27(1):65-75.
6. Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort. Bowes J, etal., Ann Rheum Dis. 2012 Aug;71(8):1350-4. doi: 10.1136/annrheumdis-2011-200802. Epub 2012 Feb 10.
7. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Chakrabarti SK, etal., Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E175-87. Epub 2010 Oct 26.
8. Chronic exposure to staphylococcal superantigen elicits a systemic inflammatory disease mimicking lupus. Chowdhary VR, etal., J Immunol. 2012 Aug 15;189(4):2054-62. doi: 10.4049/jimmunol.1201097. Epub 2012 Jul 13.
9. STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis. Dieude P, etal., Arthritis Rheum. 2009 Aug;60(8):2472-9. doi: 10.1002/art.24688.
10. Jak-Stat signaling pathway may play a role in the pathogenesis of cholesteatoma. Eskiizmir G, etal., Am J Otolaryngol. 2014 Mar-Apr;35(2):130-6. doi: 10.1016/j.amjoto.2013.10.005. Epub 2013 Oct 30.
11. STAT4 is a confirmed genetic risk factor for Sjogren's syndrome and could be involved in type 1 interferon pathway signaling. Gestermann N, etal., Genes Immun. 2010 Jul;11(5):432-8. doi: 10.1038/gene.2010.29. Epub 2010 Jun 10.
12. Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines. Gourh P, etal., Arthritis Rheum. 2009 Dec;60(12):3794-806. doi: 10.1002/art.24958.
13. Polymorphisms of signal transducers and activators of transcription 1 and 4 (STAT1 and STAT4) contribute to progression of childhood IgA nephropathy. Hahn WH, etal., Cytokine. 2010 Apr;50(1):69-74. doi: 10.1016/j.cyto.2009.12.004. Epub 2010 Jan 4.
14. Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. Holz A, etal., J Immunol. 1999 Nov 15;163(10):5374-82.
15. Identification of a susceptibility locus in STAT4 for Behcet's disease in Han Chinese in a genome-wide association study. Hou S, etal., Arthritis Rheum. 2012 Dec;64(12):4104-13. doi: 10.1002/art.37708.
16. STAT4 polymorphism in a Chinese Han population with Vogt-Koyanagi-Harada syndrome and Behcet's disease. Hu K, etal., Hum Immunol. 2010 Jul;71(7):723-6. doi: 10.1016/j.humimm.2010.04.007. Epub 2010 May 14.
17. STAT expression and localization in the central nervous system during autoimmune encephalomyelitis in Lewis rats. Jee Y, etal., J Neuroimmunol. 2001 Mar 1;114(1-2):40-7.
18. STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis. Joshita S, etal., Dis Markers. 2014;2014:727393. doi: 10.1155/2014/727393. Epub 2014 Feb 4.
19. Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region. Kawasaki A, etal., Arthritis Res Ther. 2008;10(5):R113. doi: 10.1186/ar2516. Epub 2008 Sep 19.
20. Variant form of STAT4 is associated with primary Sjogren's syndrome. Korman BD, etal., Genes Immun. 2008 Apr;9(3):267-70. doi: 10.1038/gene.2008.1. Epub 2008 Feb 14.
21. Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis. Kremer M, etal., Hepatology. 2006 Jul;44(1):216-27. doi: 10.1002/hep.21221.
22. Differential requirement of signal transducer and activator of transcription-4 (Stat4) and Stat6 in a thyrotropin receptor-289-adenovirus-induced model of Graves' hyperthyroidism. Land KJ, etal., Endocrinology. 2006 Jan;147(1):111-9. Epub 2005 Sep 29.
23. [Effect of Radix Astragali on signal transducer and activator of transcription activator-4 and its mRNA expression in a rat model of asthma] Li CC, etal., Zhonghua Er Ke Za Zhi. 2007 Oct;45(10):727-31.
24. Association of STAT4 and PTPN22 polymorphisms and their interactions with type-1 autoimmune hepatitis susceptibility in Chinese Han children. Li X, etal., Oncotarget. 2017 Apr 27;8(37):60933-60940. doi: 10.18632/oncotarget.17458. eCollection 2017 Sep 22.
25. STAT4 genetic polymorphisms association with spontaneous clearance of hepatitis B virus infection. Lu Y, etal., Immunol Res. 2015 Jun;62(2):146-52. doi: 10.1007/s12026-015-8645-1.
26. Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. Matsukawa A, etal., J Exp Med. 2001 Mar 19;193(6):679-88.
27. Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice. Menke J, etal., Kidney Int. 2011 Feb;79(4):452-63. Epub 2010 Oct 27.
28. MGDs mouse GO annotations MGD data from the GO Consortium
29. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
30. Quantitative PCR on 5 genes reliably identifies CTCL patients with 5% to 99% circulating tumor cells with 90% accuracy. Nebozhyn M, etal., Blood. 2006 Apr 15;107(8):3189-96. Epub 2006 Jan 10.
31. STAT4 is critical for immunity but not for antileishmanial activity of antimonials in experimental visceral leishmaniasis. Oghumu S, etal., Eur J Immunol. 2014 Feb;44(2):450-9. doi: 10.1002/eji.201343477. Epub 2013 Nov 15.
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. Influence of STAT4 polymorphism in primary Sjogren's syndrome. Palomino-Morales RJ, etal., J Rheumatol. 2010 May;37(5):1016-9. doi: 10.3899/jrheum.091007. Epub 2010 Apr 1.
34. Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome. Pei H, etal., Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E92-E102. Epub 2005 Aug 23.
35. Contribution of STAT4 gene single-nucleotide polymorphism to systemic lupus erythematosus in the Polish population. Piotrowski P, etal., Mol Biol Rep. 2012 Sep;39(9):8861-6. doi: 10.1007/s11033-012-1752-3. Epub 2012 Jun 24.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. Mouse MP Annotation Import Pipeline RGD automated import pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Cytokine and chemokine expression associated with steatohepatitis and hepatocyte proliferation in rats fed ethanol via total enteral nutrition. Ronis MJ, etal., Exp Biol Med (Maywood). 2008 Mar;233(3):344-55. doi: 10.3181/0707-RM-203.
42. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype. Rueda B, etal., Hum Mol Genet. 2009 Jun 1;18(11):2071-7. doi: 10.1093/hmg/ddp119. Epub 2009 Mar 13.
43. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Sanchez E, etal., Ann Rheum Dis. 2011 Jun 30.
44. Association of variants in innate immune genes with asthma and eczema. Sharma S, etal., Pediatr Allergy Immunol. 2012 Jun;23(4):315-23. doi: 10.1111/j.1399-3038.2011.01243.x. Epub 2011 Dec 23.
45. JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. Slattery ML, etal., Mol Carcinog. 2013 Feb;52(2):155-66. doi: 10.1002/mc.21841. Epub 2011 Nov 28.
46. STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis. Stamm LM, etal., Eur J Immunol. 1999 Aug;29(8):2524-9.
47. Positive association between STAT4 polymorphisms and polymyositis/dermatomyositis in a Japanese population. Sugiura T, etal., Ann Rheum Dis. 2012 Oct;71(10):1646-50. doi: 10.1136/annrheumdis-2011-200839. Epub 2012 Mar 8.
48. Association between a C8orf13-BLK polymorphism and polymyositis/dermatomyositis in the Japanese population: an additive effect with STAT4 on disease susceptibility. Sugiura T, etal., PLoS One. 2014 Mar 14;9(3):e90019. doi: 10.1371/journal.pone.0090019. eCollection 2014.
49. STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection. Svensson A, etal., J Virol. 2012 Sep;86(17):9409-15. doi: 10.1128/JVI.00947-12. Epub 2012 Jun 20.
50. Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. Taylor KE, etal., PLoS Genet. 2008 May 30;4(5):e1000084. doi: 10.1371/journal.pgen.1000084.
51. Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap. Vuong MT, etal., PLoS One. 2010 May 10;5(5):e10559. doi: 10.1371/journal.pone.0010559.
52. [Relationship of reduced lung function with Th1/Th2 polarization, STAT4/6 expression in rats of chronic obstructive pulmonary disease]. Wang C and Li Z, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Dec;29(12):1233-6.
53. STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis. Wang Y, etal., Am J Pathol. 2014 Jun;184(6):1785-94. doi: 10.1016/j.ajpath.2014.02.023. Epub 2014 Apr 13.
54. Polymorphisms in STAT4 increase the risk of acute renal allograft rejection in the Chinese population. Yang H, etal., Transpl Immunol. 2011 May;24(4):216-9. doi: 10.1016/j.trim.2011.01.001. Epub 2011 Jan 13.
55. STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population. Yi L, etal., Int J Immunopathol Pharmacol. 2013 Apr-Jun;26(2):473-8.
56. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. You Q, etal., Biochem Pharmacol. 2013 Sep 15;86(6):836-43. doi: 10.1016/j.bcp.2013.07.006. Epub 2013 Jul 19.
57. STAT4 gene polymorphism is associated with psoriasis in the genetically homogeneous population of Crete, Greece. Zervou MI, etal., Hum Immunol. 2009 Sep;70(9):738-41. doi: 10.1016/j.humimm.2009.05.008. Epub 2009 Jun 17.
58. [Single nucleotide polymorphism of STAT4 rs7574865 is associated with the susceptibility of primary biliary cirrhosis in Han population of partial regions of Jiangsu province]. Zheng L and Zhou H, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Apr;33(4):521-525.
Additional References at PubMed
PMID:7545930   PMID:8007943   PMID:8140422   PMID:8530075   PMID:8700208   PMID:8700209   PMID:9126479   PMID:9247188   PMID:9287210   PMID:9342212   PMID:9379007   PMID:9421796  
PMID:9461439   PMID:9469446   PMID:9638363   PMID:9695817   PMID:9743537   PMID:9846495   PMID:9881967   PMID:10097133   PMID:10200816   PMID:10227985   PMID:10349636   PMID:10526573  
PMID:10675904   PMID:10781830   PMID:10792004   PMID:10851056   PMID:10880049   PMID:10881177   PMID:10903759   PMID:10946290   PMID:11042159   PMID:11067913   PMID:11076861   PMID:11086031  
PMID:11207258   PMID:11217851   PMID:11290331   PMID:11313414   PMID:11382732   PMID:11418001   PMID:11441063   PMID:11466347   PMID:11485921   PMID:11488977   PMID:11489994   PMID:11544280  
PMID:11687437   PMID:11739505   PMID:11801649   PMID:11894097   PMID:12006974   PMID:12097373   PMID:12121663   PMID:12165484   PMID:12213961   PMID:12218156   PMID:12221108   PMID:12242445  
PMID:12244168   PMID:12370340   PMID:12370359   PMID:12370372   PMID:12372421   PMID:12396623   PMID:12426389   PMID:12458040   PMID:12466851   PMID:12477932   PMID:12488562   PMID:12540779  
PMID:12555666   PMID:12574364   PMID:12618521   PMID:12634107   PMID:12646654   PMID:12648458   PMID:12707364   PMID:12709397   PMID:12805384   PMID:12874250   PMID:12912921   PMID:12965077  
PMID:14500670   PMID:14523041   PMID:14610273   PMID:14660657   PMID:14688314   PMID:14704793   PMID:15034039   PMID:15041039   PMID:15044949   PMID:15153495   PMID:15226272   PMID:15271915  
PMID:15307169   PMID:15356157   PMID:15458778   PMID:15459017   PMID:15539158   PMID:15611248   PMID:15618518   PMID:15661871   PMID:15721841   PMID:15728489   PMID:15804285   PMID:15814665  
PMID:15905519   PMID:15963787   PMID:15967629   PMID:16027138   PMID:16081786   PMID:16099875   PMID:16141072   PMID:16141073   PMID:16200068   PMID:16200070   PMID:16251181   PMID:16352646  
PMID:16365403   PMID:16365415   PMID:16413227   PMID:16462603   PMID:16493033   PMID:16602821   PMID:16621996   PMID:16670015   PMID:16688680   PMID:16713741   PMID:16717115   PMID:16751369  
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PMID:17404323   PMID:17517868   PMID:17548589   PMID:17548600   PMID:17575072   PMID:17846149   PMID:17950290   PMID:18071585   PMID:18172549   PMID:18211965   PMID:18234692   PMID:18250420  
PMID:18287559   PMID:18375937   PMID:18424713   PMID:18453585   PMID:18505813   PMID:18514749   PMID:18521064   PMID:18599325   PMID:18625883   PMID:18663125   PMID:18714006   PMID:18725520  
PMID:18768863   PMID:18799693   PMID:18802110   PMID:18832727   PMID:18981084   PMID:18988675   PMID:18993086   PMID:19020307   PMID:19050254   PMID:19119024   PMID:19224632   PMID:19246642  
PMID:19324016   PMID:19338001   PMID:19380776   PMID:19567879   PMID:19604309   PMID:19646904   PMID:19666510   PMID:19710469   PMID:19805095   PMID:20049876   PMID:20059953   PMID:20104254  
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PMID:21205293   PMID:21206087   PMID:21219110   PMID:21267068   PMID:21364747   PMID:21525389   PMID:21646799   PMID:21677750   PMID:21731673   PMID:21821779   PMID:21873635   PMID:21949024  
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PMID:38875504   PMID:39447575  


Genomics

Comparative Map Data
Stat4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,026,265 - 52,146,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,026,307 - 52,146,348 (+)EnsemblGRCm39 Ensembl
GRCm38151,987,106 - 52,107,189 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl151,987,148 - 52,107,189 (+)EnsemblGRCm38mm10GRCm38
MGSCv37152,065,088 - 52,164,028 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36151,952,789 - 52,051,729 (+)NCBIMGSCv36mm8
Celera152,546,764 - 52,645,629 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.67NCBI
STAT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382191,029,576 - 191,151,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2191,029,576 - 191,178,435 (-)EnsemblGRCh38hg38GRCh38
GRCh372191,894,302 - 192,016,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,602,551 - 191,724,170 (-)NCBINCBI36Build 36hg18NCBI36
Build 342191,719,811 - 191,841,431NCBI
Celera2185,488,908 - 185,610,548 (-)NCBICelera
Cytogenetic Map2q32.2-q32.3NCBI
HuRef2183,753,956 - 183,875,743 (-)NCBIHuRef
CHM1_12191,900,128 - 192,022,113 (-)NCBICHM1_1
T2T-CHM13v2.02191,518,699 - 191,663,236 (-)NCBIT2T-CHM13v2.0
Stat4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,964,617 - 57,080,523 (-)NCBIGRCr8
mRatBN7.2949,472,660 - 49,588,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,419,340 - 49,588,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx958,021,896 - 58,130,745 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,144,732 - 63,253,572 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,440,716 - 61,549,562 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,340,649 - 54,457,753 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0954,051,154 - 54,167,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,510,251 - 46,650,076 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,511,665 - 46,651,490 (-)NCBI
Celera947,135,713 - 47,243,684 (-)NCBICelera
Cytogenetic Map9q22NCBI
Stat4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,061,471 - 8,144,276 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,061,471 - 8,144,252 (+)NCBIChiLan1.0ChiLan1.0
STAT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,711,969 - 93,930,627 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,727,052 - 93,945,611 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,331,402 - 78,549,231 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,247,617 - 196,394,154 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,247,881 - 196,366,011 (-)Ensemblpanpan1.1panPan2
STAT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,566,563 - 1,685,378 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,566,585 - 1,829,894 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,514,598 - 2,633,404 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,453,968 - 1,572,676 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,453,990 - 1,550,821 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,463,313 - 1,581,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,431,241 - 1,549,848 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,459,885 - 1,578,875 (-)NCBIUU_Cfam_GSD_1.0
Stat4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,652,139 - 149,767,224 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,095,009 - 7,184,689 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,091,982 - 7,185,938 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,656,077 - 95,763,472 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11595,656,206 - 95,764,099 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215106,914,582 - 106,960,243 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.215107,069,138 - 107,073,997 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STAT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,553,626 - 76,708,540 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,553,606 - 76,674,928 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040122,773,405 - 122,923,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stat4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248544,976,507 - 5,057,391 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248544,975,724 - 5,056,940 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stat4
7100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:65
Interacting mature miRNAs:77
Transcripts:ENSMUST00000027277, ENSMUST00000168302
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11906535153065454Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11933908153339081Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5196402570406589Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
12879917Shm3_msperm head morphology 3 (mouse)14418690462946882Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11906535153065454Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11906535153065454Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14086800867270256Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse

Markers in Region
U09351  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38152,106,960 - 52,107,082UniSTSGRCm38
MGSCv37152,163,804 - 52,163,926UniSTSGRCm37
Celera152,645,405 - 52,645,527UniSTS
Cytogenetic Map1C1.1UniSTS
U06923  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38152,107,003 - 52,107,157UniSTSGRCm38
MGSCv37152,163,847 - 52,164,001UniSTSGRCm37
Celera152,645,448 - 52,645,602UniSTS
Cytogenetic Map1C1.1UniSTS
Whitehead_YAC1 UniSTS
PMC154013P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38152,078,500 - 52,078,642UniSTSGRCm38
MGSCv37152,135,344 - 52,135,486UniSTSGRCm37
Celera152,616,951 - 52,617,093UniSTS
Cytogenetic Map1C1.1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001308266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC108840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC123752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF020635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY097735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY750146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U09351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000027277   ⟹   ENSMUSP00000027277
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,047,402 - 52,146,343 (+)Ensembl
GRCm38.p6 Ensembl152,008,243 - 52,107,184 (+)Ensembl
Ensembl Acc Id: ENSMUST00000168302   ⟹   ENSMUSP00000130713
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,026,307 - 52,146,348 (+)Ensembl
GRCm38.p6 Ensembl151,987,148 - 52,107,189 (+)Ensembl
Ensembl Acc Id: ENSMUST00000187053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,047,785 - 52,111,603 (+)Ensembl
GRCm38.p6 Ensembl152,008,626 - 52,072,444 (+)Ensembl
Ensembl Acc Id: ENSMUST00000187554
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,144,608 - 52,146,347 (+)Ensembl
GRCm38.p6 Ensembl152,105,449 - 52,107,188 (+)Ensembl
RefSeq Acc Id: NM_001308266   ⟹   NP_001295195
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,026,307 - 52,146,348 (+)NCBI
GRCm38151,987,148 - 52,107,189 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011487   ⟹   NP_035617
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,047,399 - 52,146,348 (+)NCBI
GRCm38152,008,240 - 52,107,189 (+)NCBI
MGSCv37152,065,088 - 52,164,028 (+)RGD
Celera152,546,764 - 52,645,629 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006495815   ⟹   XP_006495878
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,026,265 - 52,146,348 (+)NCBI
GRCm38151,987,106 - 52,107,189 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495816   ⟹   XP_006495879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,047,384 - 52,146,348 (+)NCBI
GRCm38152,008,225 - 52,107,189 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035617   ⟸   NM_011487
- UniProtKB: P42228 (UniProtKB/Swiss-Prot),   Q3V157 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006495878   ⟸   XM_006495815
- Peptide Label: isoform X1
- UniProtKB: P42228 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006495879   ⟸   XM_006495816
- Peptide Label: isoform X2
- UniProtKB: P42228 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001295195   ⟸   NM_001308266
- UniProtKB: P42228 (UniProtKB/Swiss-Prot),   Q3V157 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027277   ⟸   ENSMUST00000027277
Ensembl Acc Id: ENSMUSP00000130713   ⟸   ENSMUST00000168302
Protein Domains
SH2   STAT transcription factor protein interaction

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42228-F1-model_v2 AlphaFold P42228 1-749 view protein structure

Promoters
RGD ID:6873664
Promoter ID:EPDNEW_M283
Type:multiple initiation site
Name:Stat4_2
Description:Mus musculus signal transducer and activator of transcription4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M284  EPDNEW_M285  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38151,987,127 - 51,987,187EPDNEW
RGD ID:6873666
Promoter ID:EPDNEW_M284
Type:initiation region
Name:Stat4_3
Description:Mus musculus signal transducer and activator of transcription4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M283  EPDNEW_M285  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38152,008,228 - 52,008,288EPDNEW
RGD ID:6873668
Promoter ID:EPDNEW_M285
Type:initiation region
Name:Stat4_1
Description:Mus musculus signal transducer and activator of transcription4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M283  EPDNEW_M284  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38152,008,672 - 52,008,732EPDNEW
RGD ID:6818549
Promoter ID:MM_KWN:692
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   ES_Cell,   Spleen
Transcripts:ENSMUST00000027277,   UC007AXW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36152,065,204 - 52,065,704 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103062 AgrOrtholog
Ensembl Genes ENSMUSG00000062939 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027277 ENTREZGENE
  ENSMUST00000027277.7 UniProtKB/TrEMBL
  ENSMUST00000168302 ENTREZGENE
  ENSMUST00000168302.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT4_CCD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT4_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_linker UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20849 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:103062 ENTREZGENE
NCBI Gene 20849 ENTREZGENE
PANTHER PTHR11801 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11801:SF19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_linker UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stat4 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48092 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P42228 ENTREZGENE
  Q3U098_MOUSE UniProtKB/TrEMBL
  Q3V157 ENTREZGENE, UniProtKB/TrEMBL
  Q4G0C1_MOUSE UniProtKB/TrEMBL
  Q8C2A4_MOUSE UniProtKB/TrEMBL
  STAT4_MOUSE UniProtKB/Swiss-Prot