MKNK2 (MAPK interacting serine/threonine kinase 2) - Rat Genome Database

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Gene: MKNK2 (MAPK interacting serine/threonine kinase 2) Homo sapiens
Analyze
Symbol: MKNK2
Name: MAPK interacting serine/threonine kinase 2
RGD ID: 1313930
HGNC Page HGNC:7111
Description: Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including cellular response to arsenic-containing substance; intracellular signal transduction; and protein phosphorylation. Located in nuclear body.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: G protein-coupled receptor kinase 7; GPRK7; MAP kinase interacting serine/threonine kinase 2; MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MAPK signal-integrating kinase 2; MNK2; Putative map kinase interacting kinase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: MKNK2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,037,471 - 2,051,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,037,465 - 2,051,244 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,037,470 - 2,051,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,988,470 - 2,002,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,988,469 - 2,002,233NCBI
Celera191,972,223 - 1,985,996 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,809,368 - 1,822,963 (-)NCBIHuRef
CHM1_1192,037,373 - 2,051,145 (-)NCBICHM1_1
T2T-CHM13v2.0192,010,542 - 2,024,317 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
amitrole  (ISO)
amosite asbestos  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (EXP)
beta-lapachone  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
cadmium dichloride  (ISO)
camptothecin  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
diclofenac  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP)
Enterolactone  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
FR900359  (EXP)
furan  (ISO)
genistein  (EXP,ISO)
glyphosate  (EXP)
isoprenaline  (ISO)
lead diacetate  (ISO)
methapyrilene  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
niclosamide  (EXP)
Nor-9-carboxy-delta9-THC  (EXP)
orphenadrine  (ISO)
oxytocin  (ISO)
ozone  (EXP)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
progesterone  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
serpentine asbestos  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
streptozocin  (ISO)
sunitinib  (EXP)
T-2 toxin  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (EXP)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
nuclear body  (IDA)
nucleoplasm  (IDA)
nucleus  (IBA,IEA)
PML body  (IEA)

References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8415712   PMID:8889548   PMID:9155017   PMID:10922375   PMID:11013076   PMID:11154262   PMID:11463832   PMID:12477932   PMID:12897141   PMID:14702039   PMID:15057824   PMID:15489334  
PMID:16103188   PMID:16216586   PMID:16344560   PMID:16856496   PMID:18299328   PMID:18508592   PMID:19322201   PMID:20936779   PMID:21149447   PMID:21873635   PMID:21988832   PMID:22797067  
PMID:23602568   PMID:23814052   PMID:23831578   PMID:25193863   PMID:25241761   PMID:25403230   PMID:25527453   PMID:26147685   PMID:26186194   PMID:26496610   PMID:26668315   PMID:27618366  
PMID:28514442   PMID:28878291   PMID:29117863   PMID:30329087   PMID:30945288   PMID:32170339   PMID:32296183   PMID:32513696   PMID:32707033   PMID:32814053   PMID:33564073   PMID:33602301  
PMID:33836345   PMID:33961781   PMID:35271311   PMID:36764601  


Genomics

Comparative Map Data
MKNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,037,471 - 2,051,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,037,465 - 2,051,244 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,037,470 - 2,051,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,988,470 - 2,002,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,988,469 - 2,002,233NCBI
Celera191,972,223 - 1,985,996 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,809,368 - 1,822,963 (-)NCBIHuRef
CHM1_1192,037,373 - 2,051,145 (-)NCBICHM1_1
T2T-CHM13v2.0192,010,542 - 2,024,317 (-)NCBIT2T-CHM13v2.0
Mknk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,501,152 - 80,512,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,501,161 - 80,513,946 (-)EnsemblGRCm39 Ensembl
GRCm381080,665,318 - 80,676,293 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,665,327 - 80,678,112 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,128,072 - 80,134,721 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,068,456 - 80,075,105 (-)NCBIMGSCv36mm8
Celera1081,683,709 - 81,690,357 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Mknk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,690,385 - 9,701,527 (+)NCBIGRCr8
mRatBN7.279,039,771 - 9,050,832 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,039,728 - 9,050,827 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,918,241 - 11,929,263 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,793,754 - 13,804,776 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,659,834 - 11,670,885 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,908,107 - 11,919,161 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,908,107 - 11,919,156 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,075,381 - 12,086,471 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,550,040 - 10,561,100 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,550,039 - 10,561,095 (+)NCBI
Celera77,222,443 - 7,233,496 (+)NCBICelera
Cytogenetic Map7q11NCBI
Mknk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,048,128 - 6,062,913 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,048,346 - 6,061,579 (+)NCBIChiLan1.0ChiLan1.0
MKNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,417,727 - 6,431,445 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,648,480 - 5,662,190 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,045,316 - 1,059,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,018,822 - 2,032,429 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,018,822 - 2,032,429 (-)Ensemblpanpan1.1panPan2
MKNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,966,656 - 56,978,414 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,965,800 - 56,974,073 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,761,516 - 56,773,096 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,699,409 - 57,711,005 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,698,709 - 57,709,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,756,543 - 56,768,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,236,165 - 57,247,743 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,436,941 - 57,448,534 (+)NCBIUU_Cfam_GSD_1.0
Mknk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,645,852 - 216,657,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,178,890 - 1,188,896 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,176,861 - 1,188,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MKNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,510,303 - 76,522,883 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,510,302 - 76,522,885 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,245,674 - 77,254,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MKNK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,836,009 - 1,851,325 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,835,993 - 1,851,039 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,889,976 - 6,905,278 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mknk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248286,788,069 - 6,801,370 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MKNK2
24 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.3(chr19:259395-2555149)x3 copy number gain See cases [RCV000051044] Chr19:259395..2555149 [GRCh38]
Chr19:259395..2555147 [GRCh37]
Chr19:210395..2506147 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:1565575-4108128)x3 copy number gain See cases [RCV000052878] Chr19:1565575..4108128 [GRCh38]
Chr19:1565574..4108126 [GRCh37]
Chr19:1516574..4059126 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:1972245-9648879)x3 copy number gain See cases [RCV000052879] Chr19:1972245..9648879 [GRCh38]
Chr19:1972244..9759555 [GRCh37]
Chr19:1923244..9620555 [NCBI36]
Chr19:19p13.3-13.2		 pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:265917-8564134)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|See cases [RCV000052876] Chr19:265917..8564134 [GRCh38]
Chr19:265917..8629018 [GRCh37]
Chr19:216917..8535018 [NCBI36]
Chr19:19p13.3-13.2		 pathogenic
GRCh38/hg38 19p13.3(chr19:233565-4699472)x3 copy number gain See cases [RCV000052575] Chr19:233565..4699472 [GRCh38]
Chr19:233565..4699484 [GRCh37]
Chr19:184565..4650484 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:1727562-2306496)x1 copy number loss See cases [RCV000053941] Chr19:1727562..2306496 [GRCh38]
Chr19:1727561..2306495 [GRCh37]
Chr19:1678561..2257495 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:1549144-4288720)x1 copy number loss See cases [RCV000134795] Chr19:1549144..4288720 [GRCh38]
Chr19:1549143..4288717 [GRCh37]
Chr19:1500143..4239717 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:421537-2897921)x3 copy number gain See cases [RCV000134894] Chr19:421537..2897921 [GRCh38]
Chr19:421537..2897919 [GRCh37]
Chr19:372537..2848919 [NCBI36]
Chr19:19p13.3		 likely pathogenic
GRCh38/hg38 19p13.3(chr19:259395-2068507)x3 copy number gain See cases [RCV000135433] Chr19:259395..2068507 [GRCh38]
Chr19:259395..2068506 [GRCh37]
Chr19:210395..2019506 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:1351163-2555149)x3 copy number gain See cases [RCV000136880] Chr19:1351163..2555149 [GRCh38]
Chr19:1351162..2555147 [GRCh37]
Chr19:1302162..2506147 [NCBI36]
Chr19:19p13.3		 uncertain significance
GRCh38/hg38 19p13.3(chr19:259395-6795611)x3 copy number gain See cases [RCV000142627] Chr19:259395..6795611 [GRCh38]
Chr19:259395..6795622 [GRCh37]
Chr19:210395..6746622 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:1997403-2076912)x3 copy number gain Breast ductal adenocarcinoma [RCV000207144] Chr19:1997403..2076912 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:1952590-2698712)x3 copy number gain See cases [RCV000239912] Chr19:1952590..2698712 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:277373-2555164)x3 copy number gain See cases [RCV000240507] Chr19:277373..2555164 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:259395-3152419) copy number gain Global developmental delay [RCV000626520] Chr19:259395..3152419 [GRCh37]
Chr19:19p13.3		 likely pathogenic
GRCh37/hg19 19p13.3(chr19:1952590-2050814)x1 copy number loss See cases [RCV000449216] Chr19:1952590..2050814 [GRCh37]
Chr19:19p13.3		 benign
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3(chr19:260911-3200875)x3 copy number gain not provided [RCV000684094] Chr19:260911..3200875 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3(chr19:2039746-2059585)x3 copy number gain not provided [RCV000739979] Chr19:2039746..2059585 [GRCh37]
Chr19:19p13.3		 benign
NM_199054.3(MKNK2):c.1132C>G (p.Pro378Ala) single nucleotide variant not specified [RCV004319785] Chr19:2040156 [GRCh38]
Chr19:2040155 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.751-7C>T single nucleotide variant not provided [RCV000949415] Chr19:2042041 [GRCh38]
Chr19:2042040 [GRCh37]
Chr19:19p13.3		 benign
NM_199054.3(MKNK2):c.76T>G (p.Phe26Val) single nucleotide variant not specified [RCV004312955] Chr19:2046667 [GRCh38]
Chr19:2046666 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.77T>C (p.Phe26Ser) single nucleotide variant not specified [RCV004312956] Chr19:2046666 [GRCh38]
Chr19:2046665 [GRCh37]
Chr19:19p13.3		 uncertain significance
NC_000019.9:g.1406030_3597207dup duplication Neurodevelopmental disorder [RCV000787423] Chr19:1406030..3597207 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:1816218-2152190)x3 copy number gain not provided [RCV000849885] Chr19:1816218..2152190 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:260911-4788357)x3 copy number gain not provided [RCV000846988] Chr19:260911..4788357 [GRCh37]
Chr19:19p13.3		 pathogenic
NC_000019.9:g.(?_589946)_(4818389_?)dup duplication not provided [RCV003105391] Chr19:589946..4818389 [GRCh37]
Chr19:19p13.3		 uncertain significance
NC_000019.9:g.(?_589946)_(2151333_?)dup duplication Cyclical neutropenia [RCV003107569] Chr19:589946..2151333 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:260912-4384674)x3 copy number gain See cases [RCV001007443] Chr19:260912..4384674 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:1075192-2256387)x3 copy number gain not provided [RCV001007026] Chr19:1075192..2256387 [GRCh37]
Chr19:19p13.3		 likely pathogenic
GRCh37/hg19 19p13.3(chr19:260911-3501271)x3 copy number gain not provided [RCV001007025] Chr19:260911..3501271 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:260911-2256387)x3 copy number gain See cases [RCV002285065] Chr19:260911..2256387 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:1973753-2380699)x3 copy number gain not provided [RCV001834492] Chr19:1973753..2380699 [GRCh37]
Chr19:19p13.3		 uncertain significance
NC_000019.9:g.(?_589946)_(5696788_?)dup duplication not provided [RCV003113597] Chr19:589946..5696788 [GRCh37]
Chr19:19p13.3		 uncertain significance
NC_000019.9:g.(?_1456055)_(2456931_?)dup duplication Progressive myoclonic epilepsy type 9 [RCV003122897] Chr19:1456055..2456931 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.25C>A (p.Leu9Ile) single nucleotide variant not specified [RCV004233305] Chr19:2050827 [GRCh38]
Chr19:2050826 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.514C>G (p.His172Asp) single nucleotide variant not specified [RCV004131055] Chr19:2042850 [GRCh38]
Chr19:2042849 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.74C>T (p.Ala25Val) single nucleotide variant not specified [RCV004137047] Chr19:2046669 [GRCh38]
Chr19:2046668 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.66C>G (p.Phe22Leu) single nucleotide variant not specified [RCV004082429] Chr19:2046677 [GRCh38]
Chr19:2046676 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.706A>C (p.Asn236His) single nucleotide variant not specified [RCV004169662] Chr19:2042471 [GRCh38]
Chr19:2042470 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.379T>C (p.Phe127Leu) single nucleotide variant not specified [RCV004134404] Chr19:2043543 [GRCh38]
Chr19:2043542 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.48C>G (p.Phe16Leu) single nucleotide variant not specified [RCV004119537] Chr19:2050804 [GRCh38]
Chr19:2050803 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.215C>T (p.Thr72Ile) single nucleotide variant not specified [RCV004110165] Chr19:2046393 [GRCh38]
Chr19:2046392 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.1388A>T (p.Asp463Val) single nucleotide variant not specified [RCV004147587] Chr19:2039623 [GRCh38]
Chr19:2039622 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.130G>A (p.Ala44Thr) single nucleotide variant not specified [RCV004231655] Chr19:2046613 [GRCh38]
Chr19:2046612 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.1334C>T (p.Ala445Val) single nucleotide variant not specified [RCV004233053] Chr19:2039677 [GRCh38]
Chr19:2039676 [GRCh37]
Chr19:19p13.3		 uncertain significance
NC_000019.9:g.(?_1206913)_(3771740_?)dup duplication not provided [RCV003154903] Chr19:1206913..3771740 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.202C>T (p.Arg68Cys) single nucleotide variant not specified [RCV004263136] Chr19:2046406 [GRCh38]
Chr19:2046405 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.503T>C (p.Leu168Pro) single nucleotide variant not specified [RCV004268678] Chr19:2042861 [GRCh38]
Chr19:2042860 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.385G>A (p.Glu129Lys) single nucleotide variant not specified [RCV004357036] Chr19:2043537 [GRCh38]
Chr19:2043536 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.1256C>T (p.Ala419Val) single nucleotide variant not specified [RCV004349726] Chr19:2039755 [GRCh38]
Chr19:2039754 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.148G>A (p.Ala50Thr) single nucleotide variant not specified [RCV004344281] Chr19:2046460 [GRCh38]
Chr19:2046459 [GRCh37]
Chr19:19p13.3		 likely benign
GRCh37/hg19 19p13.3-13.2(chr19:260912-7246777)x3 copy number gain not provided [RCV003485190] Chr19:260912..7246777 [GRCh37]
Chr19:19p13.3-13.2		 pathogenic
NM_199054.3(MKNK2):c.761C>T (p.Ala254Val) single nucleotide variant not specified [RCV004510163] Chr19:2042024 [GRCh38]
Chr19:2042023 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:1773489-2186237)x3 copy number gain not specified [RCV003986105] Chr19:1773489..2186237 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:1648089-2302433)x3 copy number gain not specified [RCV003986124] Chr19:1648089..2302433 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.523C>T (p.Arg175Trp) single nucleotide variant not specified [RCV004514544] Chr19:2042841 [GRCh38]
Chr19:2042840 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.26T>C (p.Leu9Pro) single nucleotide variant not specified [RCV004506401] Chr19:2050826 [GRCh38]
Chr19:2050825 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.1145T>C (p.Val382Ala) single nucleotide variant not specified [RCV004503567] Chr19:2040143 [GRCh38]
Chr19:2040142 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.302G>A (p.Cys101Tyr) single nucleotide variant not specified [RCV004640869] Chr19:2046223 [GRCh38]
Chr19:2046222 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.100G>A (p.Gly34Arg) single nucleotide variant not specified [RCV004640870] Chr19:2046643 [GRCh38]
Chr19:2046642 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_199054.3(MKNK2):c.170C>T (p.Pro57Leu) single nucleotide variant not specified [RCV004628937] Chr19:2046438 [GRCh38]
Chr19:2046437 [GRCh37]
Chr19:19p13.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7869
Count of miRNA genes:1163
Interacting mature miRNAs:1477
Transcripts:ENST00000250896, ENST00000309340, ENST00000541165, ENST00000585667, ENST00000586620, ENST00000586828, ENST00000587416, ENST00000588014, ENST00000588346, ENST00000589441, ENST00000589509, ENST00000589534, ENST00000591142, ENST00000591588, ENST00000591601
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298499UAE1_HUrinary albumin excretion QTL 1 (human)2.730.0009Urinary albumin excretionurine albumin:creatinine ratio (ACR)19116075902Human
406914625GWAS563601_Hskin hydration measurement QTL GWAS563601 (human)0.000007skin hydration measurementskin water level (CMO:0002766)1920485992048600Human
407241591GWAS890567_Hbody height QTL GWAS890567 (human)4e-12body height (VT:0001253)body height (CMO:0000106)1920441762044177Human
407002675GWAS651651_HCleft palate, cleft lip QTL GWAS651651 (human)2e-08Cleft palate, cleft lip1920508242050825Human
1643451SLIPL6_HSerum lipid level QTL 6 (human)2.190.0008Lipid level19116075902Human
407193095GWAS842071_Hcarpal tunnel syndrome QTL GWAS842071 (human)2e-09carpal tunnel syndrome1920388202038821Human
406951811GWAS600787_Hwellbeing measurement QTL GWAS600787 (human)0.000003wellbeing measurement1920482822048283Human
407104032GWAS753008_Hmathematical ability QTL GWAS753008 (human)9e-09mathematical ability1920388202038821Human
1581534BP76_HBlood pressure QTL 76 (human)20.001Blood pressurepulse pressure19116075902Human
1581535BP65_HBlood pressure QTL 65 (human)3.10.001Blood pressurepulse pressure19116075902Human
2314591INSUL4_HInsulin level QTL 4 (human)3.80.000038Insulin levelfasting19116075902Human
1298476BP3_HBlood pressure QTL 3 (human)2.4Blood pressuresystolic19116075902Human

Markers in Region
D19S642E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37192,038,464 - 2,038,549UniSTSGRCh37
Build 36191,989,464 - 1,989,549RGDNCBI36
Celera191,973,217 - 1,973,302RGD
Cytogenetic Map19p13.3UniSTS
HuRef191,810,194 - 1,810,279UniSTS
RH78432  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37192,037,759 - 2,037,901UniSTSGRCh37
Build 36191,988,759 - 1,988,901RGDNCBI36
Celera191,972,512 - 1,972,654RGD
Cytogenetic Map19p13.3UniSTS
HuRef191,809,489 - 1,809,631UniSTS
GeneMap99-GB4 RH Map192.29UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_199054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024451471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF125532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF237775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF237776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL137565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL137615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL513974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM977403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU192307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA950743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB775508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB775510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI202980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI202982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000250896   ⟹   ENSP00000250896
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,037,471 - 2,051,244 (-)Ensembl
Ensembl Acc Id: ENST00000309340   ⟹   ENSP00000309485
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,037,465 - 2,051,224 (-)Ensembl
Ensembl Acc Id: ENST00000585667
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,040,132 - 2,043,532 (-)Ensembl
Ensembl Acc Id: ENST00000586620
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,040,309 - 2,042,078 (-)Ensembl
Ensembl Acc Id: ENST00000586828   ⟹   ENSP00000465425
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,039,412 - 2,050,853 (-)Ensembl
Ensembl Acc Id: ENST00000587416
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,037,473 - 2,042,676 (-)Ensembl
Ensembl Acc Id: ENST00000588014   ⟹   ENSP00000465079
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,038,248 - 2,042,633 (-)Ensembl
Ensembl Acc Id: ENST00000589441   ⟹   ENSP00000466594
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,037,465 - 2,041,842 (-)Ensembl
Ensembl Acc Id: ENST00000589509   ⟹   ENSP00000466147
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,046,461 - 2,051,244 (-)Ensembl
Ensembl Acc Id: ENST00000589534   ⟹   ENSP00000466064
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,046,522 - 2,051,232 (-)Ensembl
Ensembl Acc Id: ENST00000591142   ⟹   ENSP00000465645
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,037,465 - 2,042,140 (-)Ensembl
Ensembl Acc Id: ENST00000591588   ⟹   ENSP00000464828
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,039,955 - 2,042,082 (-)Ensembl
Ensembl Acc Id: ENST00000591601   ⟹   ENSP00000467811
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl192,037,465 - 2,050,887 (-)Ensembl
RefSeq Acc Id: NM_017572   ⟹   NP_060042
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38192,037,471 - 2,051,244 (-)NCBI
GRCh37192,037,470 - 2,051,243 (-)NCBI
Build 36191,988,470 - 2,002,243 (-)NCBI Archive
Celera191,972,223 - 1,985,996 (-)RGD
HuRef191,809,368 - 1,822,963 (-)RGD
CHM1_1192,037,373 - 2,051,145 (-)NCBI
T2T-CHM13v2.0192,010,542 - 2,024,317 (-)NCBI
Sequence:
RefSeq Acc Id: NM_199054   ⟹   NP_951009
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38192,037,471 - 2,051,244 (-)NCBI
GRCh37192,037,470 - 2,051,243 (-)NCBI
Build 36191,988,470 - 2,002,243 (-)NCBI Archive
Celera191,972,223 - 1,985,996 (-)RGD
HuRef191,809,368 - 1,822,963 (-)RGD
CHM1_1192,037,373 - 2,051,145 (-)NCBI
T2T-CHM13v2.0192,010,542 - 2,024,317 (-)NCBI
Sequence:
RefSeq Acc Id: NP_951009   ⟸   NM_199054
- Peptide Label: isoform 2
- UniProtKB: Q9UHR0 (UniProtKB/Swiss-Prot),   Q9HBH8 (UniProtKB/Swiss-Prot),   Q6GPI3 (UniProtKB/Swiss-Prot),   Q9Y2N6 (UniProtKB/Swiss-Prot),   Q9HBH9 (UniProtKB/Swiss-Prot),   A4CYL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_060042   ⟸   NM_017572
- Peptide Label: isoform 1
- UniProtKB: A4CYL7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000309485   ⟸   ENST00000309340
Ensembl Acc Id: ENSP00000465425   ⟸   ENST00000586828
Ensembl Acc Id: ENSP00000465079   ⟸   ENST00000588014
Ensembl Acc Id: ENSP00000466064   ⟸   ENST00000589534
Ensembl Acc Id: ENSP00000466147   ⟸   ENST00000589509
Ensembl Acc Id: ENSP00000466594   ⟸   ENST00000589441
Ensembl Acc Id: ENSP00000467811   ⟸   ENST00000591601
Ensembl Acc Id: ENSP00000464828   ⟸   ENST00000591588
Ensembl Acc Id: ENSP00000465645   ⟸   ENST00000591142
Ensembl Acc Id: ENSP00000250896   ⟸   ENST00000250896
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HBH9-F1-model_v2 AlphaFold Q9HBH9 1-465 view protein structure

Promoters
RGD ID:6815248
Promoter ID:HG_MRA:7628
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:AK023442,   AK024347,   AK097012,   AL137615
Position:
Human AssemblyChrPosition (strand)Source
Build 36191,989,616 - 1,991,317 (-)MPROMDB
RGD ID:6815278
Promoter ID:HG_MRA:7629
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:BC021235
Position:
Human AssemblyChrPosition (strand)Source
Build 36191,992,191 - 1,992,691 (-)MPROMDB
RGD ID:6795809
Promoter ID:HG_KWN:28436
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid
Transcripts:UC002LUQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36191,992,936 - 1,993,917 (-)MPROMDB
RGD ID:6795807
Promoter ID:HG_KWN:28438
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_017572,   NM_199054
Position:
Human AssemblyChrPosition (strand)Source
Build 36192,002,151 - 2,002,952 (-)MPROMDB
RGD ID:7237897
Promoter ID:EPDNEW_H24694
Type:initiation region
Name:MKNK2_1
Description:MAP kinase interacting serine/threonine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38192,051,243 - 2,051,303EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7111 AgrOrtholog
COSMIC MKNK2 COSMIC
Ensembl Genes ENSG00000099875 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000250896 ENTREZGENE
  ENST00000250896.9 UniProtKB/Swiss-Prot
  ENST00000309340 ENTREZGENE
  ENST00000309340.11 UniProtKB/Swiss-Prot
  ENST00000586828.5 UniProtKB/TrEMBL
  ENST00000588014.5 UniProtKB/TrEMBL
  ENST00000589441.5 UniProtKB/TrEMBL
  ENST00000589509.5 UniProtKB/TrEMBL
  ENST00000589534.2 UniProtKB/TrEMBL
  ENST00000591142.5 UniProtKB/TrEMBL
  ENST00000591588.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000099875 GTEx
HGNC ID HGNC:7111 ENTREZGENE
Human Proteome Map MKNK2 Human Proteome Map
InterPro CDPK_Ser/Thr_kinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2872 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2872 ENTREZGENE
OMIM 605069 OMIM
PANTHER MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30830 PharmGKB
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4CYL7 ENTREZGENE, UniProtKB/TrEMBL
  B3KS07_HUMAN UniProtKB/TrEMBL
  K7EIN7_HUMAN UniProtKB/TrEMBL
  K7EJ98_HUMAN UniProtKB/TrEMBL
  K7EK27_HUMAN UniProtKB/TrEMBL
  K7ELG3_HUMAN UniProtKB/TrEMBL
  K7ELN0_HUMAN UniProtKB/TrEMBL
  K7EMP5_HUMAN UniProtKB/TrEMBL
  MKNK2_HUMAN UniProtKB/Swiss-Prot
  Q6GPI3 ENTREZGENE
  Q9HBH8 ENTREZGENE
  Q9HBH9 ENTREZGENE
  Q9NV89_HUMAN UniProtKB/TrEMBL
  Q9UHR0 ENTREZGENE
  Q9Y2N6 ENTREZGENE
UniProt Secondary Q6GPI3 UniProtKB/Swiss-Prot
  Q9HBH8 UniProtKB/Swiss-Prot
  Q9UHR0 UniProtKB/Swiss-Prot
  Q9Y2N6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 MKNK2  MAPK interacting serine/threonine kinase 2  MKNK2  MAP kinase interacting serine/threonine kinase 2  Symbol and/or name change 5135510 APPROVED