Otx2 (orthodenticle homeobox 2) - Rat Genome Database

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Gene: Otx2 (orthodenticle homeobox 2) Mus musculus
Analyze
Symbol: Otx2
Name: orthodenticle homeobox 2
RGD ID: 1313893
MGI Page MGI
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription and positive regulation of gastrulation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; nervous system development; and regionalization. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; early conceptus; ectoderm; and sensory organ. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Orthologous to human OTX2 (orthodenticle homeobox 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: E130306E05Rik; homeobox protein OTX2; orthodenticle homolog 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391448,894,238 - 48,905,101 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1448,895,134 - 48,911,276 (-)EnsemblGRCm39 Ensembl
GRCm381448,656,781 - 48,667,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1448,657,677 - 48,673,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv371449,277,846 - 49,282,547 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361447,579,630 - 47,587,057 (-)NCBIMGSCv36mm8
Celera1444,858,278 - 44,862,991 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1425.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
1,2-dichloroethane  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
captan  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (EXP)
CHIR 99021  (ISO)
CHIR-98014  (ISO)
choline  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
diazinon  (ISO)
dieldrin  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fluoxetine  (EXP)
flusilazole  (EXP)
folic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
glycidol  (ISO)
hexachlorophene  (ISO)
kainic acid  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lipoic acid  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
panobinostat  (ISO)
phenylmercury acetate  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
Theaflavin 3,3'-digallate  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adenohypophysis morphology  (IAGP)
abnormal alisphenoid bone morphology  (IAGP)
abnormal allantois morphology  (IAGP)
abnormal Ammon gyrus morphology  (IAGP)
abnormal amnion morphology  (IAGP)
abnormal anterior commissure morphology  (IAGP)
abnormal anterior eye segment morphology  (IAGP)
abnormal anterior head development  (IAGP)
abnormal axial mesoderm morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cephalic neural fold morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal ciliary ganglion morphology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal dopaminergic neuron morphology  (IAGP)
abnormal ectoderm development  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal extraocular muscle morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal eye distance/ position  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal gonadotroph morphology  (IAGP)
abnormal head development  (IAGP)
abnormal head morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hindbrain development  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal hippocampal fornix morphology  (IAGP)
abnormal hippocampus region morphology  (IAGP)
abnormal hypothalamus morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal inferior colliculus morphology  (IAGP)
abnormal iris morphology  (IAGP)
abnormal lateral ganglionic eminence morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal mammillary body morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal maxillary prominence morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal medial ganglionic eminence morphology  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal metencephalon morphology  (IAGP)
abnormal midbrain development  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal midbrain-hindbrain boundary development  (IAGP)
abnormal midbrain-hindbrain boundary morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal nasal capsule morphology  (IAGP)
abnormal nasal cavity morphology  (IAGP)
abnormal nasal septum morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neural plate morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal oculomotor nerve morphology  (IAGP)
abnormal oculomotor nucleus morphology  (IAGP)
abnormal olfactory bulb mitral cell layer morphology  (IAGP)
abnormal olfactory epithelium morphology  (IAGP)
abnormal olfactory sensory neuron morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal orbitosphenoid bone morphology  (IAGP)
abnormal palate morphology  (IAGP)
abnormal posterior commissure morphology  (IAGP)
abnormal presphenoid bone morphology  (IAGP)
abnormal pretectal region morphology  (IAGP)
abnormal primitive node morphology  (IAGP)
abnormal primitive streak elongation  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal pterygoid bone morphology  (IAGP)
abnormal red nucleus morphology  (IAGP)
abnormal retina bipolar cell morphology  (IAGP)
abnormal retina horizontal cell morphology  (IAGP)
abnormal retina layer morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal rhombic lip morphology  (IAGP)
abnormal rod electrophysiology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal sclera morphology  (IAGP)
abnormal serotonergic neuron morphology  (IAGP)
abnormal snout morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal somite shape  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal superior colliculus morphology  (IAGP)
abnormal tegmentum morphology  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal temporal bone tympanic part morphology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal third ventricle morphology  (IAGP)
abnormal trigeminal nerve morphology  (IAGP)
abnormal trigeminal V mesencephalic nucleus morphology  (IAGP)
abnormal trochlear nerve morphology  (IAGP)
abnormal visceral yolk sac endoderm morphology  (IAGP)
abnormal visceral yolk sac mesenchyme morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vomeronasal organ morphology  (IAGP)
absent choroid plexus  (IAGP)
absent cornea  (IAGP)
absent dentate gyrus  (IAGP)
absent diencephalon  (IAGP)
absent embryonic telencephalon  (IAGP)
absent forebrain  (IAGP)
absent foregut  (IAGP)
absent heart  (IAGP)
absent hippocampal fimbria  (IAGP)
absent hippocampus  (IAGP)
absent mandible  (IAGP)
absent mandibular coronoid process  (IAGP)
absent maxilla  (IAGP)
absent metencephalon  (IAGP)
absent midbrain  (IAGP)
absent midbrain-hindbrain boundary  (IAGP)
absent nasal capsule  (IAGP)
absent nasal placodes  (IAGP)
absent nasal septum  (IAGP)
absent nasopharynx  (IAGP)
absent olfactory bulb  (IAGP)
absent optic placodes  (IAGP)
absent optic vesicle  (IAGP)
absent orbitosphenoid bone  (IAGP)
absent pharyngeal arches  (IAGP)
absent pituitary gland  (IAGP)
absent prechordal mesoderm  (IAGP)
absent tectum  (IAGP)
absent tegmentum  (IAGP)
absent tongue  (IAGP)
absent vomeronasal organ  (IAGP)
acephaly  (IAGP)
anencephaly  (IAGP)
aniridia  (IAGP)
anophthalmia  (IAGP)
aphakia  (IAGP)
basisphenoid bone foramen  (IAGP)
decreased body size  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased embryo size  (IAGP)
decreased embryonic neuroepithelium thickness  (IAGP)
decreased forebrain size  (IAGP)
decreased gonadotroph cell number  (IAGP)
decreased inferior colliculus size  (IAGP)
decreased litter size  (IAGP)
decreased midbrain size  (IAGP)
decreased retina cone cell number  (IAGP)
decreased retina ganglion cell number  (IAGP)
decreased retina photoreceptor cell number  (IAGP)
decreased substantia nigra size  (IAGP)
decreased testis weight  (IAGP)
decreased visual acuity  (IAGP)
dilated heart  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic-extraembryonic boundary constriction  (IAGP)
enlarged cerebellum  (IAGP)
enlarged cerebral aqueduct  (IAGP)
enlarged tectum  (IAGP)
ethmocephaly  (IAGP)
exencephaly  (IAGP)
forebrain hypoplasia  (IAGP)
fused somites  (IAGP)
impaired somite development  (IAGP)
increased pons size  (IAGP)
increased rhombomere 1 size  (IAGP)
increased susceptibility to dopaminergic neuron neurotoxicity  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
loss of dopaminergic neurons  (IAGP)
microcephaly  (IAGP)
micrognathia  (IAGP)
microphthalmia  (IAGP)
midbrain hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
otocephaly  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
presphenoid bone hypoplasia  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
reduced fertility  (IAGP)
reduced male fertility  (IAGP)
retina hyperplasia  (IAGP)
retina pigment epithelium hyperplasia  (IAGP)
rostral body truncation  (IAGP)
short snout  (IAGP)
small cranium  (IAGP)
small heart  (IAGP)
small hippocampus  (IAGP)
small mandible  (IAGP)
small olfactory bulb  (IAGP)
small tectum  (IAGP)
small thalamus  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. Frantz GD, etal., J Neurosci 1994 Oct;14(10):5725-40.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1353865   PMID:1363228   PMID:7588062   PMID:7590242   PMID:7607086   PMID:7665171   PMID:7669695   PMID:7700351   PMID:7720587   PMID:7760812   PMID:7779685   PMID:7901323  
PMID:7913821   PMID:7915635   PMID:7959790   PMID:7974744   PMID:8069909   PMID:8101484   PMID:8555108   PMID:8565836   PMID:8575305   PMID:8582267   PMID:8626038   PMID:8743751  
PMID:8786143   PMID:8805699   PMID:8837770   PMID:8861101   PMID:8887325   PMID:8951061   PMID:9022063   PMID:9053316   PMID:9077465   PMID:9096102   PMID:9096118   PMID:9096350  
PMID:9136933   PMID:9226455   PMID:9247335   PMID:9342056   PMID:9367425   PMID:9367432   PMID:9374391   PMID:9382924   PMID:9398463   PMID:9405645   PMID:9435295   PMID:9449667  
PMID:9463349   PMID:9466889   PMID:9486536   PMID:9486824   PMID:9494100   PMID:9500550   PMID:9501024   PMID:9502734   PMID:9521907   PMID:9529255   PMID:9580990   PMID:9635399  
PMID:9671576   PMID:9753681   PMID:9790191   PMID:9811585   PMID:9811592   PMID:9831645   PMID:9832509   PMID:9843484   PMID:9851841   PMID:9851982   PMID:9872327   PMID:9895322  
PMID:9988215   PMID:10049527   PMID:10068635   PMID:10078553   PMID:10079220   PMID:10079223   PMID:10191046   PMID:10192400   PMID:10199636   PMID:10225993   PMID:10349636   PMID:10354469  
PMID:10354604   PMID:10375352   PMID:10409502   PMID:10421635   PMID:10430909   PMID:10431240   PMID:10433909   PMID:10440864   PMID:10452853   PMID:10452857   PMID:10477297   PMID:10490024  
PMID:10490025   PMID:10498271   PMID:10498685   PMID:10512182   PMID:10518210   PMID:10518499   PMID:10529411   PMID:10529425   PMID:10642791   PMID:10662781   PMID:10711712   PMID:10716450  
PMID:10751172   PMID:10767524   PMID:10841580   PMID:10887078   PMID:10891582   PMID:10903182   PMID:10922068   PMID:10964938   PMID:10985852   PMID:11013212   PMID:11042159   PMID:11076861  
PMID:11105055   PMID:11114168   PMID:11124114   PMID:11134352   PMID:11171400   PMID:11180952   PMID:11217851   PMID:11290295   PMID:11291865   PMID:11291866   PMID:11298452   PMID:11311163  
PMID:11356033   PMID:11358868   PMID:11412024   PMID:11418863   PMID:11471063   PMID:11493524   PMID:11493561   PMID:11500373   PMID:11504847   PMID:11532921   PMID:11566865   PMID:11641222  
PMID:11689706   PMID:11702953   PMID:11704761   PMID:11731459   PMID:11731460   PMID:11744391   PMID:11748135   PMID:11753388   PMID:11820816   PMID:11884616   PMID:11922976   PMID:11956759  
PMID:11960706   PMID:12015300   PMID:12040030   PMID:12055180   PMID:12086465   PMID:12091315   PMID:12117810   PMID:12118260   PMID:12175515   PMID:12183386   PMID:12231626   PMID:12367504  
PMID:12381664   PMID:12431380   PMID:12447384   PMID:12466851   PMID:12477932   PMID:12490556   PMID:12520002   PMID:12544841   PMID:12569128   PMID:12581525   PMID:12588852   PMID:12642482  
PMID:12642494   PMID:12645927   PMID:12652306   PMID:12676095   PMID:12682014   PMID:12736208   PMID:12756174   PMID:12764040   PMID:12764108   PMID:12799077   PMID:12842913   PMID:12874124  
PMID:12913075   PMID:12915315   PMID:12915318   PMID:12925582   PMID:13129926   PMID:14502223   PMID:14502576   PMID:14585979   PMID:14610273   PMID:14623228   PMID:14623818   PMID:14625556  
PMID:14633973   PMID:14645121   PMID:14648878   PMID:14651936   PMID:14681479   PMID:14695375   PMID:14745958   PMID:15053978   PMID:15084457   PMID:15105370   PMID:15110720   PMID:15121182  
PMID:15123655   PMID:15147765   PMID:15183723   PMID:15201223   PMID:15201224   PMID:15207855   PMID:15226823   PMID:15242798   PMID:15302604   PMID:15459106   PMID:15525667   PMID:15533813  
PMID:15576400   PMID:15580630   PMID:15618518   PMID:15678491   PMID:15680361   PMID:15703187   PMID:15759271   PMID:15790971   PMID:15829518   PMID:15829521   PMID:15857913   PMID:15858069  
PMID:15870281   PMID:15888661   PMID:15890343   PMID:15917450   PMID:15937931   PMID:15961523   PMID:15976303   PMID:16076961   PMID:16109169   PMID:16141072   PMID:16141073   PMID:16203745  
PMID:16236767   PMID:16256364   PMID:16256739   PMID:16284942   PMID:16325169   PMID:16325481   PMID:16339193   PMID:16368929   PMID:16397896   PMID:16423343   PMID:16452096   PMID:16481355  
PMID:16530751   PMID:16539743   PMID:16540515   PMID:16571633   PMID:16602821   PMID:16611693   PMID:16613831   PMID:16651541   PMID:16728477   PMID:16728479   PMID:16738237   PMID:16782087  
PMID:16790550   PMID:16815997   PMID:16845372   PMID:16854970   PMID:16887818   PMID:16943282   PMID:17060451   PMID:17067568   PMID:17074316   PMID:17075876   PMID:17107664   PMID:17126317  
PMID:17150206   PMID:17166916   PMID:17174942   PMID:17241623   PMID:17325035   PMID:17389379   PMID:17395647   PMID:17481602   PMID:17481897   PMID:17490632   PMID:17499211   PMID:17507393  
PMID:17537797   PMID:17609112   PMID:17634284   PMID:17661397   PMID:17670789   PMID:17676634   PMID:17683524   PMID:17687036   PMID:17688467   PMID:17698011   PMID:17855431   PMID:17908793  
PMID:17922007   PMID:17936261   PMID:17980036   PMID:18028899   PMID:18061570   PMID:18094027   PMID:18171685   PMID:18196597   PMID:18216176   PMID:18224709   PMID:18241853   PMID:18268105  
PMID:18287559   PMID:18330926   PMID:18331719   PMID:18332127   PMID:18367606   PMID:18429041   PMID:18448090   PMID:18462697   PMID:18480159   PMID:18539113   PMID:18617531   PMID:18667607  
PMID:18678597   PMID:18692473   PMID:18697938   PMID:18728160   PMID:18781635   PMID:18784307   PMID:18794329   PMID:18799693   PMID:18820178   PMID:18929642   PMID:18930042   PMID:18974875  
PMID:18987029   PMID:19004851   PMID:19004853   PMID:19030180   PMID:19048639   PMID:19056886   PMID:19097048   PMID:19121383   PMID:19122665   PMID:19297409   PMID:19298856   PMID:19339600  
PMID:19386638   PMID:19401468   PMID:19416500   PMID:19474320   PMID:19553286   PMID:19592574   PMID:19596317   PMID:19607821   PMID:19615442   PMID:19741146   PMID:19786569   PMID:19793884  
PMID:19795519   PMID:19796621   PMID:19796622   PMID:19805139   PMID:19828801   PMID:19841259   PMID:19877283   PMID:19906857   PMID:19913004   PMID:19924631   PMID:19936203   PMID:19951692  
PMID:20017954   PMID:20026326   PMID:20040491   PMID:20059953   PMID:20089898   PMID:20107170   PMID:20110327   PMID:20123094   PMID:20147377   PMID:20150232   PMID:20181585   PMID:20206242  
PMID:20211142   PMID:20211162   PMID:20237275   PMID:20237281   PMID:20346939   PMID:20353765   PMID:20412781   PMID:20436479   PMID:20439489   PMID:20450902   PMID:20457670   PMID:20460368  
PMID:20463215   PMID:20478998   PMID:20493948   PMID:20511190   PMID:20530484   PMID:20532162   PMID:20573704   PMID:20596238   PMID:20610763   PMID:20630950   PMID:20657788   PMID:20667915  
PMID:20702562   PMID:20736290   PMID:20816794   PMID:20826531   PMID:20875817   PMID:20876643   PMID:20932939   PMID:20941375   PMID:21057506   PMID:21149574   PMID:21246653   PMID:21246658  
PMID:21267068   PMID:21289193   PMID:21436260   PMID:21440680   PMID:21445260   PMID:21478884   PMID:21497760   PMID:21542136   PMID:21554866   PMID:21596839   PMID:21602925   PMID:21606375  
PMID:21677750   PMID:21693512   PMID:21713770   PMID:21731673   PMID:21743013   PMID:21761482   PMID:21766338   PMID:21771810   PMID:21798254   PMID:21828248   PMID:21831920   PMID:21857657  
PMID:21873635   PMID:21886788   PMID:21896628   PMID:21925604   PMID:21963459   PMID:22075149   PMID:22083510   PMID:22090505   PMID:22186731   PMID:22190459   PMID:22278924   PMID:22323600  
PMID:22411557   PMID:22492355   PMID:22553019   PMID:22558385   PMID:22566684   PMID:22586439   PMID:22627278   PMID:22627282   PMID:22669107   PMID:22718343   PMID:22745311   PMID:22761896  
PMID:22764251   PMID:22792072   PMID:22889265   PMID:22986744   PMID:22988430   PMID:22992956   PMID:22993445   PMID:23028343   PMID:23041116   PMID:23056351   PMID:23117062   PMID:23154415  
PMID:23171847   PMID:23201023   PMID:23213481   PMID:23217170   PMID:23223288   PMID:23288605   PMID:23364326   PMID:23420609   PMID:23426374   PMID:23444360   PMID:23487311   PMID:23494735  
PMID:23521771   PMID:23536097   PMID:23592779   PMID:23595746   PMID:23637192   PMID:23637629   PMID:23651855   PMID:23674600   PMID:23690951   PMID:23724000   PMID:23747598   PMID:23760955  
PMID:23761884   PMID:23765158   PMID:23770240   PMID:23811236   PMID:23824574   PMID:23843306   PMID:23867227   PMID:24125957   PMID:24146773   PMID:24148613   PMID:24167708   PMID:24234651  
PMID:24319691   PMID:24324671   PMID:24335253   PMID:24346699   PMID:24348261   PMID:24368733   PMID:24382353   PMID:24384227   PMID:24421398   PMID:24453340   PMID:24457099   PMID:24523460  
PMID:24558479   PMID:24607228   PMID:24633704   PMID:24727668   PMID:24875170   PMID:24891386   PMID:24905168   PMID:24931607   PMID:24952961   PMID:25127144   PMID:25155555   PMID:25179941  
PMID:25231759   PMID:25313862   PMID:25315894   PMID:25451153   PMID:25480914   PMID:25501893   PMID:25511461   PMID:25605784   PMID:25654255   PMID:25664857   PMID:25689933   PMID:25715397  
PMID:25775517   PMID:25804738   PMID:25867707   PMID:25907274   PMID:25910836   PMID:25915474   PMID:25927996   PMID:25977363   PMID:25990804   PMID:26013465   PMID:26062936   PMID:26160903  
PMID:26166575   PMID:26253404   PMID:26297811   PMID:26311466   PMID:26426291   PMID:26444681   PMID:26494787   PMID:26534985   PMID:26565912   PMID:26621269   PMID:26644564   PMID:26779998  
PMID:26879466   PMID:26949938   PMID:26975355   PMID:26985665   PMID:27026076   PMID:27036552   PMID:27064252   PMID:27097562   PMID:27171438   PMID:27184910   PMID:27217206   PMID:27224017  
PMID:27292645   PMID:27301906   PMID:27466203   PMID:27521049   PMID:27578777   PMID:27586544   PMID:27600842   PMID:27611684   PMID:27616714   PMID:27701636   PMID:27760115   PMID:27918583  
PMID:27929058   PMID:28130357   PMID:28165338   PMID:28174238   PMID:28194008   PMID:28199486   PMID:28288836   PMID:28334846   PMID:28340616   PMID:28402857   PMID:28424350   PMID:28560839  
PMID:28619944   PMID:28620275   PMID:28694260   PMID:28712875   PMID:28746879   PMID:28778798   PMID:28779972   PMID:28800615   PMID:28807898   PMID:28839193   PMID:28875501   PMID:28910203  
PMID:28974755   PMID:29018333   PMID:29038581   PMID:29107558   PMID:29166577   PMID:29168693   PMID:29249622   PMID:29258872   PMID:29337233   PMID:29339161   PMID:29361558   PMID:29394901  
PMID:29412136   PMID:29467473   PMID:29665410   PMID:29732603   PMID:29771284   PMID:29915126   PMID:29950673   PMID:30048641   PMID:30134160   PMID:30261489   PMID:30283136   PMID:30352686  
PMID:30485816   PMID:30593496   PMID:30635555   PMID:30659230   PMID:30684382   PMID:30689541   PMID:30739114   PMID:30783126   PMID:30885981   PMID:30953627   PMID:30959515   PMID:30991053  
PMID:31064838   PMID:31068677   PMID:31163126   PMID:31189761   PMID:31260032   PMID:31273213   PMID:31308417   PMID:31315026   PMID:31399471   PMID:31488567   PMID:31633482   PMID:31658410  
PMID:31665922   PMID:31750563   PMID:31850343   PMID:31949107   PMID:31950080   PMID:31968244   PMID:32012381   PMID:32071204   PMID:32106289   PMID:32169553   PMID:32170006   PMID:32290105  
PMID:32367046   PMID:32439762   PMID:32521258   PMID:32523119   PMID:32553121   PMID:32561725   PMID:32562661   PMID:32631829   PMID:32692983   PMID:32703236   PMID:32737182   PMID:32741376  
PMID:33046507   PMID:33075808   PMID:33143303   PMID:33195246   PMID:33195252   PMID:33230114   PMID:33382037   PMID:33469032   PMID:33472064   PMID:33500475   PMID:33526661   PMID:33674582  
PMID:33711282   PMID:33795231   PMID:33795534   PMID:33896883   PMID:33951080   PMID:33963285   PMID:33999993   PMID:34143204   PMID:34321999   PMID:34475267   PMID:34677125   PMID:34757798  
PMID:34758317   PMID:34769078   PMID:34815315   PMID:34884468   PMID:35110543   PMID:35264162   PMID:35320729   PMID:35322202   PMID:35377797   PMID:35644505   PMID:35660973   PMID:35700056  
PMID:35729116   PMID:35853870   PMID:35876795   PMID:35951005   PMID:35981753   PMID:35988542   PMID:35998584   PMID:36007540   PMID:36181537   PMID:36197846   PMID:36260151   PMID:36263009  
PMID:36318802   PMID:36326727   PMID:36351424   PMID:36434388   PMID:36517595   PMID:36521641   PMID:36537580   PMID:36649236   PMID:36849521   PMID:36924502   PMID:37017267   PMID:37048108  
PMID:37073980   PMID:37269288   PMID:37298722   PMID:37522516   PMID:37524711   PMID:37553330   PMID:37751417   PMID:37871215   PMID:37890489   PMID:38183987   PMID:38344749   PMID:38402586  
PMID:38602877   PMID:38861275   PMID:38871742  


Genomics

Comparative Map Data
Otx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391448,894,238 - 48,905,101 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1448,895,134 - 48,911,276 (-)EnsemblGRCm39 Ensembl
GRCm381448,656,781 - 48,667,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1448,657,677 - 48,673,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv371449,277,846 - 49,282,547 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361447,579,630 - 47,587,057 (-)NCBIMGSCv36mm8
Celera1444,858,278 - 44,862,991 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1425.36NCBI
OTX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381456,799,905 - 56,810,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1456,799,905 - 56,816,693 (-)EnsemblGRCh38hg38GRCh38
GRCh371457,266,623 - 57,277,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361456,337,178 - 56,346,937 (-)NCBINCBI36Build 36hg18NCBI36
Build 341456,337,179 - 56,342,098NCBI
Celera1437,316,938 - 37,326,697 (-)NCBICelera
Cytogenetic Map14q22.3NCBI
HuRef1437,431,939 - 37,441,708 (-)NCBIHuRef
CHM1_11457,206,163 - 57,215,915 (-)NCBICHM1_1
T2T-CHM13v2.01451,005,697 - 51,016,270 (-)NCBIT2T-CHM13v2.0
Otx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81524,422,876 - 24,432,709 (-)NCBIGRCr8
mRatBN7.21521,942,233 - 21,953,034 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1521,943,191 - 21,953,416 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1524,723,960 - 24,733,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01525,681,846 - 25,691,428 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01523,932,468 - 23,942,055 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01525,500,037 - 25,511,619 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1525,502,019 - 25,505,691 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1525,517,721 - 25,521,393 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01529,425,136 - 29,435,678 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41524,622,851 - 24,632,435 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11524,638,550 - 24,643,418 (-)NCBI
Celera1522,321,144 - 22,330,728 (-)NCBICelera
Cytogenetic Map15p14NCBI
Otx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546610,755,012 - 10,765,095 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546610,755,143 - 10,764,957 (-)NCBIChiLan1.0ChiLan1.0
OTX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21557,906,663 - 57,917,326 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11457,123,178 - 57,133,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01437,370,926 - 37,381,610 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11455,641,349 - 55,651,012 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1455,641,349 - 55,651,012 (-)Ensemblpanpan1.1panPan2
OTX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1832,435,169 - 32,445,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl832,435,863 - 32,445,446 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha832,203,297 - 32,213,040 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0832,685,680 - 32,695,437 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl832,686,362 - 32,695,873 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1832,288,616 - 32,298,366 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0832,364,566 - 32,374,316 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0832,740,360 - 32,750,115 (-)NCBIUU_Cfam_GSD_1.0
Otx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864072,742,666 - 72,758,575 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364951,432,598 - 1,442,918 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364951,433,124 - 1,449,409 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1186,028,579 - 186,038,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11186,028,575 - 186,039,026 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21206,642,523 - 206,650,665 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OTX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12433,975,043 - 33,984,816 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605322,189,742 - 22,199,522 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248841,830,645 - 1,840,213 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Otx2
356 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1372
Count of miRNA genes:530
Interacting mature miRNAs:666
Transcripts:ENSMUST00000118578, ENSMUST00000119070, ENSMUST00000119739, ENSMUST00000122009, ENSMUST00000133479, ENSMUST00000135279, ENSMUST00000144465, ENSMUST00000152018
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse

Markers in Region
BB256399  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,657,715 - 48,657,817UniSTSGRCm38
MGSCv371449,277,390 - 49,277,492UniSTSGRCm37
Celera1444,857,819 - 44,857,921UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.0UniSTS
Whitehead/MRC_RH14550.48UniSTS
Otx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371449,278,234 - 49,278,335UniSTSGRCm37
MGSCv371449,278,234 - 49,278,679UniSTSGRCm37
MGSCv371449,283,623 - 49,283,795UniSTSGRCm37
MGSCv371449,280,800 - 49,280,996UniSTSGRCm37
MGSCv371449,282,505 - 49,282,710UniSTSGRCm37
MGSCv371449,280,976 - 49,282,209UniSTSGRCm37
Celera1444,861,244 - 44,861,440UniSTS
Celera1444,858,666 - 44,859,111UniSTS
Celera1444,858,666 - 44,858,767UniSTS
Celera1444,862,949 - 44,863,158UniSTS
Celera1444,864,072 - 44,864,222UniSTS
Celera1444,861,420 - 44,862,653UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.0UniSTS
RH136748  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,657,716 - 48,657,912UniSTSGRCm38
MGSCv371449,277,391 - 49,277,587UniSTSGRCm37
Celera1444,857,820 - 44,858,018UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.0UniSTS
OTX2_1019  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,658,119 - 48,659,031UniSTSGRCm38
MGSCv371449,277,794 - 49,278,706UniSTSGRCm37
Celera1444,858,225 - 44,859,138UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.0UniSTS
PMC263842P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,658,841 - 48,659,049UniSTSGRCm38
MGSCv371449,278,516 - 49,278,724UniSTSGRCm37
Celera1444,858,948 - 44,859,156UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.0UniSTS
PMC304098P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,658,839 - 48,659,049UniSTSGRCm38
MGSCv371449,278,514 - 49,278,724UniSTSGRCm37
Celera1444,858,946 - 44,859,156UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.0UniSTS
Otx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS
Otx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS
Otx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,663,948 - 48,664,120UniSTSGRCm38
MGSCv371449,283,623 - 49,283,795UniSTSGRCm37
Celera1444,864,072 - 44,864,222UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.0UniSTS
Otx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS
cM Map1419.0UniSTS
Otx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,662,830 - 48,663,035UniSTSGRCm38
MGSCv371449,282,505 - 49,282,710UniSTSGRCm37
Celera1444,862,949 - 44,863,158UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.0UniSTS
Otx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,661,301 - 48,662,534UniSTSGRCm38
MGSCv371449,280,976 - 49,282,209UniSTSGRCm37
Celera1444,861,420 - 44,862,653UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.0UniSTS
Otx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,658,559 - 48,659,004UniSTSGRCm38
MGSCv371449,278,234 - 49,278,679UniSTSGRCm37
Celera1444,858,666 - 44,859,111UniSTS
Cytogenetic Map14C1UniSTS
Otx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,658,559 - 48,658,660UniSTSGRCm38
MGSCv371449,278,234 - 49,278,335UniSTSGRCm37
Celera1444,858,666 - 44,858,767UniSTS
Cytogenetic Map14C1UniSTS
Otx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381448,661,125 - 48,661,321UniSTSGRCm38
MGSCv371449,280,800 - 49,280,996UniSTSGRCm37
Celera1444,861,244 - 44,861,440UniSTS
Cytogenetic Map14C1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001286481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_144841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017315914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017315917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC166574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV513527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ959742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF725076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK621536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO424557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U96488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000118578   ⟹   ENSMUSP00000113690
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,895,136 - 48,902,563 (-)Ensembl
GRCm38.p6 Ensembl1448,657,679 - 48,665,106 (-)Ensembl
Ensembl Acc Id: ENSMUST00000119070   ⟹   ENSMUSP00000112532
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,895,628 - 48,904,970 (-)Ensembl
GRCm38.p6 Ensembl1448,658,171 - 48,667,513 (-)Ensembl
Ensembl Acc Id: ENSMUST00000119739   ⟹   ENSMUSP00000113586
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,898,865 - 48,902,978 (-)Ensembl
GRCm38.p6 Ensembl1448,661,408 - 48,665,521 (-)Ensembl
Ensembl Acc Id: ENSMUST00000122009   ⟹   ENSMUSP00000113930
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,895,628 - 48,900,329 (-)Ensembl
GRCm38.p6 Ensembl1448,658,171 - 48,662,872 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133479   ⟹   ENSMUSP00000122200
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,898,815 - 48,904,965 (-)Ensembl
GRCm38.p6 Ensembl1448,661,358 - 48,667,508 (-)Ensembl
Ensembl Acc Id: ENSMUST00000135279
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,896,373 - 48,899,389 (-)Ensembl
GRCm38.p6 Ensembl1448,658,916 - 48,661,932 (-)Ensembl
Ensembl Acc Id: ENSMUST00000144465   ⟹   ENSMUSP00000116630
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,896,762 - 48,904,965 (-)Ensembl
GRCm38.p6 Ensembl1448,659,305 - 48,667,508 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152018   ⟹   ENSMUSP00000123454
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,896,410 - 48,905,101 (-)Ensembl
GRCm38.p6 Ensembl1448,658,953 - 48,667,644 (-)Ensembl
Ensembl Acc Id: ENSMUST00000226501   ⟹   ENSMUSP00000154264
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,895,134 - 48,904,972 (-)Ensembl
GRCm38.p6 Ensembl1448,657,677 - 48,667,515 (-)Ensembl
Ensembl Acc Id: ENSMUST00000227404   ⟹   ENSMUSP00000154066
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,895,308 - 48,911,276 (-)Ensembl
GRCm38.p6 Ensembl1448,657,851 - 48,673,819 (-)Ensembl
Ensembl Acc Id: ENSMUST00000228512
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1448,904,021 - 48,904,975 (-)Ensembl
GRCm38.p6 Ensembl1448,666,564 - 48,667,518 (-)Ensembl
RefSeq Acc Id: NM_001286481   ⟹   NP_001273410
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,895,134 - 48,905,101 (-)NCBI
GRCm381448,657,677 - 48,667,644 (-)NCBI
Celera1444,857,781 - 44,867,792 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286482   ⟹   NP_001273411
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,895,134 - 48,905,101 (-)NCBI
GRCm381448,657,677 - 48,667,644 (-)NCBI
Celera1444,857,781 - 44,867,792 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286483   ⟹   NP_001273412
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,895,134 - 48,902,566 (-)NCBI
GRCm381448,657,677 - 48,665,109 (-)NCBI
Celera1444,857,781 - 44,867,792 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360225   ⟹   NP_001347154
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,895,134 - 48,904,965 (-)NCBI
GRCm381448,657,677 - 48,667,508 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360226   ⟹   NP_001347155
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,895,134 - 48,900,191 (-)NCBI
GRCm381448,657,677 - 48,662,734 (-)NCBI
Sequence:
RefSeq Acc Id: NM_144841   ⟹   NP_659090
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,895,134 - 48,900,191 (-)NCBI
GRCm381448,657,677 - 48,662,734 (-)NCBI
MGSCv371449,277,846 - 49,282,547 (-)RGD
Celera1444,857,781 - 44,867,792 (-)NCBI
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011244988   ⟹   XP_011243290
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,894,238 - 48,905,055 (-)NCBI
GRCm381448,656,781 - 48,667,598 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011244989   ⟹   XP_011243291
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,894,238 - 48,905,053 (-)NCBI
GRCm381448,656,781 - 48,667,596 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017315914   ⟹   XP_017171403
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,894,238 - 48,905,055 (-)NCBI
GRCm381448,656,781 - 48,667,598 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017315917   ⟹   XP_017171406
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,894,238 - 48,904,650 (-)NCBI
GRCm381448,656,781 - 48,667,193 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030247685   ⟹   XP_030103545
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391448,894,238 - 48,905,049 (-)NCBI
GRCm381448,656,781 - 48,667,592 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001273410 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273411 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273412 (Get FASTA)   NCBI Sequence Viewer  
  NP_001347154 (Get FASTA)   NCBI Sequence Viewer  
  NP_001347155 (Get FASTA)   NCBI Sequence Viewer  
  NP_659090 (Get FASTA)   NCBI Sequence Viewer  
  XP_011243290 (Get FASTA)   NCBI Sequence Viewer  
  XP_011243291 (Get FASTA)   NCBI Sequence Viewer  
  XP_017171403 (Get FASTA)   NCBI Sequence Viewer  
  XP_017171406 (Get FASTA)   NCBI Sequence Viewer  
  XP_030103545 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB57690 (Get FASTA)   NCBI Sequence Viewer  
  AAH17609 (Get FASTA)   NCBI Sequence Viewer  
  AAH27104 (Get FASTA)   NCBI Sequence Viewer  
  AAH29667 (Get FASTA)   NCBI Sequence Viewer  
  BAC35500 (Get FASTA)   NCBI Sequence Viewer  
  BAC38249 (Get FASTA)   NCBI Sequence Viewer  
  BAC39913 (Get FASTA)   NCBI Sequence Viewer  
  CAA48755 (Get FASTA)   NCBI Sequence Viewer  
  EDL20772 (Get FASTA)   NCBI Sequence Viewer  
  EDL20773 (Get FASTA)   NCBI Sequence Viewer  
  EDL20774 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000112532
  ENSMUSP00000112532.2
  ENSMUSP00000113586.2
  ENSMUSP00000113690
  ENSMUSP00000113690.2
  ENSMUSP00000113930
  ENSMUSP00000113930.2
  ENSMUSP00000116630.2
  ENSMUSP00000122200.2
  ENSMUSP00000123454.2
  ENSMUSP00000154066
  ENSMUSP00000154066.2
  ENSMUSP00000154264
  ENSMUSP00000154264.2
GenBank Protein P80206 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_659090   ⟸   NM_144841
- Peptide Label: isoform b
- UniProtKB: Q8VD35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273411   ⟸   NM_001286482
- Peptide Label: isoform b
- UniProtKB: Q8VD35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273410   ⟸   NM_001286481
- Peptide Label: isoform a
- UniProtKB: Q8R0B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273412   ⟸   NM_001286483
- Peptide Label: isoform b
- UniProtKB: Q8VD35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011243290   ⟸   XM_011244988
- Peptide Label: isoform X1
- UniProtKB: Q8R0B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011243291   ⟸   XM_011244989
- Peptide Label: isoform X2
- UniProtKB: Q8VD35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017171403   ⟸   XM_017315914
- Peptide Label: isoform X1
- UniProtKB: Q8R0B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017171406   ⟸   XM_017315917
- Peptide Label: isoform X2
- UniProtKB: Q8VD35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030103545   ⟸   XM_030247685
- Peptide Label: isoform X2
- UniProtKB: Q8VD35 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001347154   ⟸   NM_001360225
- Peptide Label: isoform a
- UniProtKB: Q8R0B5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001347155   ⟸   NM_001360226
- Peptide Label: isoform a
- UniProtKB: Q8R0B5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000113586   ⟸   ENSMUST00000119739
Ensembl Acc Id: ENSMUSP00000116630   ⟸   ENSMUST00000144465
Ensembl Acc Id: ENSMUSP00000112532   ⟸   ENSMUST00000119070
Ensembl Acc Id: ENSMUSP00000113690   ⟸   ENSMUST00000118578
Ensembl Acc Id: ENSMUSP00000122200   ⟸   ENSMUST00000133479
Ensembl Acc Id: ENSMUSP00000123454   ⟸   ENSMUST00000152018
Ensembl Acc Id: ENSMUSP00000154066   ⟸   ENSMUST00000227404
Ensembl Acc Id: ENSMUSP00000154264   ⟸   ENSMUST00000226501
Ensembl Acc Id: ENSMUSP00000113930   ⟸   ENSMUST00000122009
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80206-F1-model_v2 AlphaFold P80206 1-289 view protein structure

Promoters
RGD ID:8682094
Promoter ID:EPDNEW_M19077
Type:multiple initiation site
Name:Otx2_1
Description:Mus musculus orthodenticle homeobox 2 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19078  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381448,662,748 - 48,662,808EPDNEW
RGD ID:8682096
Promoter ID:EPDNEW_M19078
Type:single initiation site
Name:Otx2_2
Description:Mus musculus orthodenticle homeobox 2 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19077  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381448,665,109 - 48,665,169EPDNEW
RGD ID:6825241
Promoter ID:MM_KWN:16500
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000080965
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361449,281,841 - 49,282,341 (-)MPROMDB
RGD ID:6825239
Promoter ID:MM_KWN:16502
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Lung
Transcripts:ENSMUST00000058010,   ENSMUST00000118578,   ENSMUST00000119739
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361449,284,696 - 49,285,922 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97451 AgrOrtholog
Ensembl Genes ENSMUSG00000021848 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000118578 ENTREZGENE
  ENSMUST00000118578.9 UniProtKB/TrEMBL
  ENSMUST00000119070 ENTREZGENE
  ENSMUST00000119070.8 UniProtKB/TrEMBL
  ENSMUST00000119739.2 UniProtKB/TrEMBL
  ENSMUST00000122009 ENTREZGENE
  ENSMUST00000122009.8 UniProtKB/TrEMBL
  ENSMUST00000133479.8 UniProtKB/TrEMBL
  ENSMUST00000144465.8 UniProtKB/TrEMBL
  ENSMUST00000152018.8 UniProtKB/TrEMBL
  ENSMUST00000226501 ENTREZGENE
  ENSMUST00000226501.2 UniProtKB/TrEMBL
  ENSMUST00000227404 ENTREZGENE
  ENSMUST00000227404.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Otx2_TF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Otx_TF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Otx_TF_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18424 UniProtKB/TrEMBL
MGD MGI:97451 ENTREZGENE
NCBI Gene 18424 ENTREZGENE
PANTHER HOMEOBOX PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX PROTEIN OTX2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_Otx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Otx2 PhenoGen
PRINTS OTX2HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OTXHOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YZ94_MOUSE UniProtKB/TrEMBL
  D3Z4G2_MOUSE UniProtKB/TrEMBL
  D3Z581_MOUSE UniProtKB/TrEMBL
  D3Z7L5_MOUSE UniProtKB/TrEMBL
  OTX2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8R0B5 ENTREZGENE, UniProtKB/TrEMBL
  Q8VD35 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Otx2  orthodenticle homeobox 2    orthodenticle homolog 2  Symbol and/or name change 5135510 APPROVED
2013-11-26 Otx2  orthodenticle homolog 2    orthodenticle homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED