Itgb2 (integrin beta 2) - Rat Genome Database

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Gene: Itgb2 (integrin beta 2) Mus musculus
Analyze
Symbol: Itgb2
Name: integrin beta 2
RGD ID: 1313695
MGI Page MGI
Description: Enables amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; endocytosis; and positive regulation of leukocyte adhesion to vascular endothelial cell. Acts upstream of or within several processes, including activated T cell proliferation; integrin-mediated signaling pathway; and neutrophil chemotaxis. Located in external side of plasma membrane and membrane raft. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2E6; AI528527; Cd18; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement receptor C3 subunit beta; integrin beta-2; LAD; LCAMB; Lfa1; lymphocyte function associated antigen 1; Mac-1 beta; macrophage antigen-1 beta; MF17
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,366,164 - 77,401,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,366,086 - 77,401,542 (+)EnsemblGRCm39 Ensembl
GRCm381077,530,329 - 77,565,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1077,530,252 - 77,565,708 (+)EnsemblGRCm38mm10GRCm38
MGSCv371076,993,093 - 77,028,419 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361076,985,685 - 77,009,099 (+)NCBIMGSCv36mm8
Celera1078,572,639 - 78,608,564 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-Arctigenin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(20S)-ginsenoside Rh1  (ISO)
(S)-ropivacaine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-nitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bromochloroacetic acid  (ISO)
buspirone  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
carnosic acid  (EXP)
cerivastatin  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diuron  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
Formylmethionyl-leucyl-phenylalanine methyl ester  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
ginsenoside C-K  (ISO)
ginsenoside Rb1  (ISO)
graphene oxide  (EXP)
griseofulvin  (EXP)
Heliotrine  (ISO)
hydroquinone  (EXP,ISO)
indirubin  (ISO)
indometacin  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
josamycin  (ISO)
L-methionine  (EXP)
leukotriene B4  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (ISO)
mycotoxin  (EXP)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
neoechinulin A  (EXP)
nickel atom  (ISO)
nitric oxide  (ISO)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
oxycodone  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
plaunotol  (ISO)
probucol  (EXP)
progesterone  (EXP,ISO)
quercetin  (ISO)
resveratrol  (ISO)
Senkirkine  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
SU6656  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
TMC-120A  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin D  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone structure  (IAGP)
abnormal cellular extravasation  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytotoxic T cell cytolysis  (IEA)
abnormal dendritic cell physiology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal eye physiology  (IAGP)
abnormal hair follicle dermal papilla morphology  (IAGP)
abnormal immune system cell morphology  (IAGP)
abnormal leukocyte adhesion  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal lymph organ size  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal NK cell differentiation  (IEA)
abnormal retina morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IEA)
abnormal T cell physiology  (IAGP)
abnormal T cell proliferation  (IAGP)
acanthosis  (IAGP)
alopecia  (IAGP)
conjunctivitis  (IAGP)
decreased acute inflammation  (IAGP)
decreased B cell number  (IEA)
decreased bone mineral density of femur  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone ossification  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased dendritic cell number  (IEA)
decreased double-positive T cell number  (IAGP)
decreased IgG level  (IEA)
decreased inflammatory response  (IAGP)
decreased interferon-gamma secretion  (IEA)
decreased macrophage cell number  (IEA)
decreased neutrophil cell number  (IEA)
decreased retina photoreceptor cell number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to induced choroidal neovascularization  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased T cell proliferation  (IAGP)
decreased trabecular bone mass  (IAGP)
dermatitis  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
hyperkeratosis  (IAGP)
impaired humoral immune response  (IEA)
impaired natural killer cell mediated cytotoxicity  (IEA)
impaired neutrophil recruitment  (IAGP)
increased B cell number  (IAGP)
increased B-1b cell number  (IEA)
increased basophil cell number  (IAGP)
increased bone marrow cell number  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating interleukin-3 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased dendritic cell number  (IAGP)
increased double-negative T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased eosinophil cell number  (IAGP)
increased granulocyte number  (IAGP)
increased IgA level  (IAGP)
increased IgE level  (IEA)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased immunoglobulin level  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-beta secretion  (IEA)
increased interferon-gamma secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased lymphocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased NK T cell number  (IEA)
increased susceptibility to bacterial infection  (IAGP)
increased T cell number  (IAGP)
increased T-helper 1 cell number  (IAGP)
lymph node hypoplasia  (IAGP)
mixed cellular infiltration to dermis  (IAGP)
myeloid hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
orthokeratosis  (IAGP)
osteoporosis  (IAGP)
parakeratosis  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
psoriasis  (IAGP)
reddish skin  (IAGP)
retina photoreceptor degeneration  (IAGP)
rheumatoid arthritis  (IAGP)
scaly skin  (IAGP)
spontaneous skin ulceration  (IAGP)
thrombocytosis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency. Arnaout MA, etal., J Clin Invest. 1990 Mar;85(3):977-81.
3. Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins. Choi EY, etal., Blood. 2008 Apr 1;111(7):3607-14. doi: 10.1182/blood-2007-07-103077. Epub 2008 Jan 31.
4. Increased expression of intercellular adhesion molecule-1 (ICAM-1) in a murine model of pulmonary eosinophilia and high IgE level. Chu HW, etal., Clin Exp Immunol. 1995 May;100(2):319-24.
5. Low-density array PCR analysis of reperfusion biopsies: an adjunct to histological analysis. Cravedi P, etal., Nephrol Dial Transplant. 2010 Dec;25(12):4077-86. Epub 2010 May 26.
6. Inhibitory effect of olopatadine on antigen-induced eosinophil infiltration and the LFA-1 and Mac-1 expression in eosinophils. Fukuishi N, etal., Jpn J Pharmacol. 2002 Apr;88(4):463-6.
7. Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury. Hirahashi J, etal., Circulation. 2009 Sep 29;120(13):1255-65. Epub 2009 Sep 14.
8. Unique CD18 mutations involving a deletion in the extracellular stalk region and a major truncation of the cytoplasmic domain in a patient with leukocyte adhesion deficiency type 1. Hixson P, etal., Blood. 2004 Feb 1;103(3):1105-13. Epub 2003 Sep 25.
9. Effects of monoclonal antibodies to adhesion molecules on eosinophilic myocarditis in Toxocara canis-infected CBA/J mice. Hokibara S, etal., Clin Exp Immunol. 1998 Nov;114(2):236-44.
10. Treatment of established adjuvant arthritis in rats with monoclonal antibody to CD18 and very late activation antigen-4 integrins suppresses neutrophil and T-lymphocyte migration to the joints and improves clinical disease. Issekutz AC, etal., Immunology. 1996 Aug;88(4):569-76.
11. Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease. Kevil CG, etal., Am J Pathol. 2004 Aug;165(2):609-16.
12. [Circulating adhesion molecules (cICAM-1, lcVCAM-1) in patients with suspected inflammatory heart muscle disease]. Klein RM, etal., Z Kardiol. 1998 Feb;87(2):84-93.
13. Association of a CD18 gene polymorphism with a reduced risk of restenosis after coronary stenting. Koch W, etal., Am J Cardiol. 2001 Nov 15;88(10):1120-4.
14. Differential requirement for CD18 in T-helper effector homing. Lee SH, etal., Nat Med. 2003 Oct;9(10):1281-6. doi: 10.1038/nm932. Epub 2003 Sep 14.
15. Fine structure physical mapping of the region of mouse chromosome 10 homologous to human chromosome 21. MacDonald G, etal., Genomics 1991 Oct;11(2):317-23.
16. Label-free proteomics reveals decreased expression of CD18 and AKNA in peripheral CD4+ T cells from patients with Vogt-Koyanagi-Harada syndrome. Mao L, etal., PLoS One. 2011 Jan 28;6(1):e14616.
17. A novel point mutation in CD18 causing the expression of dysfunctional CD11/CD18 leucocyte integrins in a patient with leucocyte adhesion deficiency (LAD). Mathew EC, etal., Clin Exp Immunol. 2000 Jul;121(1):133-8.
18. MGDs mouse GO annotations MGD data from the GO Consortium
19. MGD IEA MGD IEA
20. The ITGB2 immunomodulatory gene (CD18), enterocolitis, and Hirschsprung's disease. Moore SW, etal., J Pediatr Surg. 2008 Aug;43(8):1439-44.
21. Epstein-Barr virus infection induces an increase of T regulatory type 1 cells in Hodgkin lymphoma patients. Morales O, etal., Br J Haematol. 2014 Sep;166(6):875-90. doi: 10.1111/bjh.12980. Epub 2014 Jul 9.
22. Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine. Mulligan MS, etal., J Immunol. 1992 May 15;148(10):3086-92.
23. Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds. Oksala N, etal., Atherosclerosis. 2015 Sep;242(1):145-54. doi: 10.1016/j.atherosclerosis.2015.06.058. Epub 2015 Jul 13.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene. Parvaneh N, etal., J Clin Immunol. 2010 Sep;30(5):756-60. Epub 2010 Jun 12.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae. Prince JE, etal., J Immunol. 2001 Jun 15;166(12):7362-9. doi: 10.4049/jimmunol.166.12.7362.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Reduction in inflammation following blockade of CD18 or CD29 adhesive pathways during the acute phase of a spirochetal-induced colitis in mice. Sacco RE, etal., Microb Pathog. 2000 Nov;29(5):289-99.
33. The role of alpha4 (CD49d) and beta2 (CD18) integrins in eosinophil and neutrophil migration to allergic lung inflammation in the Brown Norway rat. Schneider T, etal., Am J Respir Cell Mol Biol. 1999 Mar;20(3):448-57.
34. Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin. Seki N, etal., J Immunol. 2002 Apr 1;168(7):3484-92.
35. Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Sendler M, etal., Gut. 2012 Apr 5.
36. The effect of gentamicin-induced readthrough on a novel premature termination codon of CD18 leukocyte adhesion deficiency patients. Simon AJ, etal., PLoS One. 2010 Nov 16;5(11):e13659.
37. Antibody-induced modulation of the leukocyte CD11b integrin prevents mild but not major renal ischaemic injury. Tajra LC, etal., Nephrol Dial Transplant. 2000 Oct;15(10):1556-61.
38. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
39. Reduced brain injury in CD18-deficient mice after experimental intracerebral hemorrhage. Titova E, etal., J Neurosci Res. 2008 Nov 1;86(14):3240-5.
40. Gene expression in macrophage-rich inflammatory cell infiltrates in human atherosclerotic lesions as studied by laser microdissection and DNA array: overexpression of HMG-CoA reductase, colony stimulating factor receptors, CD11A/CD18 integrins, and interleukin receptors. Tuomisto TT, etal., Arterioscler Thromb Vasc Biol. 2003 Dec;23(12):2235-40. Epub 2003 Oct 23.
41. The critical role of intercellular adhesion molecule-1 in Masugi nephritis in rats. Wada J, etal., Nephron. 1996;73(2):264-72.
42. Extracellular adherence protein of Staphylococcus aureus suppresses disease by inhibiting T-cell recruitment in a mouse model of psoriasis. Wang H, etal., J Invest Dermatol. 2010 Mar;130(3):743-54. Epub 2009 Oct 8.
43. A prospective evaluation of the CD14 and CD18 gene polymorphisms and risk of stroke. Zee RY, etal., Stroke. 2002 Apr;33(4):892-5.
44. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
Additional References at PubMed
PMID:1431091   PMID:1671669   PMID:1783381   PMID:1969385   PMID:2051027   PMID:2185332   PMID:2569711   PMID:6193226   PMID:6749860   PMID:7539004   PMID:7916323   PMID:8101543  
PMID:8564091   PMID:8675299   PMID:8700894   PMID:8777716   PMID:8808681   PMID:8933279   PMID:8955185   PMID:8971031   PMID:8986723   PMID:9045883   PMID:9077544   PMID:9334375  
PMID:9341771   PMID:9362259   PMID:9421166   PMID:9545490   PMID:9653089   PMID:9746442   PMID:9788965   PMID:9843832   PMID:9862668   PMID:9878246   PMID:10048443   PMID:10051316  
PMID:10213866   PMID:10228023   PMID:10330002   PMID:10349636   PMID:10358184   PMID:10395697   PMID:10512685   PMID:10528208   PMID:10601245   PMID:10613844   PMID:10679084   PMID:10706723  
PMID:10816450   PMID:10942760   PMID:11042159   PMID:11045953   PMID:11076861   PMID:11120753   PMID:11169416   PMID:11217851   PMID:11222371   PMID:11283158   PMID:11302522   PMID:11420040  
PMID:11588037   PMID:11592085   PMID:11756189   PMID:11805130   PMID:11889125   PMID:11909820   PMID:12068957   PMID:12070044   PMID:12121438   PMID:12121661   PMID:12130787   PMID:12165530  
PMID:12244179   PMID:12370391   PMID:12374771   PMID:12393639   PMID:12442326   PMID:12466851   PMID:12466854   PMID:12466855   PMID:12477932   PMID:12480703   PMID:12488493   PMID:12516546  
PMID:12623847   PMID:12637320   PMID:12652296   PMID:12675270   PMID:12734371   PMID:12766082   PMID:12818890   PMID:12819024   PMID:12819125   PMID:12871376   PMID:12883479   PMID:12958152  
PMID:14530315   PMID:14625477   PMID:14634077   PMID:14681479   PMID:14734620   PMID:15059933   PMID:15210787   PMID:15231732   PMID:15249579   PMID:15308480   PMID:15370361   PMID:15383575  
PMID:15458967   PMID:15544853   PMID:15579429   PMID:15585877   PMID:15597146   PMID:15623573   PMID:15624701   PMID:15632147   PMID:15657295   PMID:15706402   PMID:15749905   PMID:15751084  
PMID:15760467   PMID:15761851   PMID:15780986   PMID:15908348   PMID:15944247   PMID:16093349   PMID:16116224   PMID:16141072   PMID:16141073   PMID:16148944   PMID:16172402   PMID:16293653  
PMID:16339524   PMID:16418399   PMID:16505059   PMID:16567504   PMID:16585587   PMID:16614373   PMID:16639002   PMID:16825578   PMID:16844762   PMID:16882714   PMID:16886058   PMID:16886059  
PMID:16980616   PMID:16981228   PMID:16982899   PMID:17008881   PMID:17023661   PMID:17065490   PMID:17071583   PMID:17086186   PMID:17119112   PMID:17237371   PMID:17258081   PMID:17277114  
PMID:17284607   PMID:17332469   PMID:17379071   PMID:17380558   PMID:17429444   PMID:17525267   PMID:17553614   PMID:17670897   PMID:17721537   PMID:17827392   PMID:17928460   PMID:17928532  
PMID:17932565   PMID:17962453   PMID:18056371   PMID:18197144   PMID:18216298   PMID:18250426   PMID:18283105   PMID:18390736   PMID:18451854   PMID:18464936   PMID:18521187   PMID:18549652  
PMID:18583316   PMID:18606690   PMID:18622091   PMID:18641276   PMID:18701460   PMID:18753316   PMID:18755982   PMID:18775427   PMID:18799670   PMID:18802011   PMID:18832583   PMID:18844982  
PMID:18981818   PMID:19010554   PMID:19050286   PMID:19064723   PMID:19066088   PMID:19116209   PMID:19147786   PMID:19201847   PMID:19223596   PMID:19234461   PMID:19273622   PMID:19299700  
PMID:19299737   PMID:19342649   PMID:19346499   PMID:19418202   PMID:19428111   PMID:19454683   PMID:19454691   PMID:19483086   PMID:19531489   PMID:19542227   PMID:19596999   PMID:19617540  
PMID:19620298   PMID:19638624   PMID:19729481   PMID:19740384   PMID:19752240   PMID:19797524   PMID:19809160   PMID:19843511   PMID:19843951   PMID:19946016   PMID:19949107   PMID:20069263  
PMID:20072134   PMID:20142805   PMID:20167705   PMID:20199584   PMID:20299514   PMID:20347150   PMID:20362473   PMID:20388733   PMID:20404138   PMID:20413728   PMID:20445173   PMID:20471289  
PMID:20479866   PMID:20530790   PMID:20569988   PMID:20675588   PMID:20864093   PMID:21037096   PMID:21078912   PMID:21108463   PMID:21239699   PMID:21245270   PMID:21257963   PMID:21267068  
PMID:21308776   PMID:21357746   PMID:21516086   PMID:21551232   PMID:21624939   PMID:21632714   PMID:21647874   PMID:21659539   PMID:21676865   PMID:21677750   PMID:21795599   PMID:21795685  
PMID:21840991   PMID:21868579   PMID:21873635   PMID:22046385   PMID:22090317   PMID:22170060   PMID:22276210   PMID:22381526   PMID:22387552   PMID:22396536   PMID:22431571   PMID:22661700  
PMID:22711877   PMID:22865639   PMID:22875786   PMID:22893614   PMID:22933624   PMID:23093821   PMID:23144497   PMID:23178534   PMID:23184931   PMID:23200858   PMID:23209705   PMID:23297409  
PMID:23310953   PMID:23315163   PMID:23343834   PMID:23376466   PMID:23382219   PMID:23395392   PMID:23418628   PMID:23443048   PMID:23505517   PMID:23532856   PMID:23552075   PMID:23558016  
PMID:23585567   PMID:23620790   PMID:23671277   PMID:23684988   PMID:23708002   PMID:23708969   PMID:23823319   PMID:24175614   PMID:24190659   PMID:24259506   PMID:24335230   PMID:24362892  
PMID:24458438   PMID:24493668   PMID:24558493   PMID:24576991   PMID:24889201   PMID:24895121   PMID:24906078   PMID:25074980   PMID:25180062   PMID:25348463   PMID:25546260   PMID:25613092  
PMID:25775402   PMID:25801431   PMID:25892652   PMID:25918984   PMID:25987740   PMID:25998681   PMID:26098520   PMID:26169939   PMID:26169941   PMID:26214837   PMID:26337492   PMID:26405763  
PMID:26453377   PMID:26468229   PMID:26483383   PMID:26582948   PMID:26740009   PMID:26823454   PMID:26881904   PMID:26921287   PMID:27022143   PMID:27235139   PMID:27274010   PMID:27412481  
PMID:27566832   PMID:27573813   PMID:27650319   PMID:27853810   PMID:27965383   PMID:27977747   PMID:28137909   PMID:28157452   PMID:28378742   PMID:28467903   PMID:28615221   PMID:28637901  
PMID:28854362   PMID:28873429   PMID:28904019   PMID:28954823   PMID:29100055   PMID:29141155   PMID:29176738   PMID:29207960   PMID:29282280   PMID:29724896   PMID:29777221   PMID:29896200  
PMID:30024857   PMID:30048492   PMID:30068506   PMID:30233576   PMID:30333137   PMID:30498196   PMID:30537419   PMID:30538176   PMID:30696624   PMID:30726742   PMID:30910815   PMID:30949178  
PMID:30967528   PMID:31002125   PMID:31042146   PMID:31191527   PMID:31291578   PMID:31366620   PMID:31471459   PMID:31594856   PMID:31681316   PMID:32325033   PMID:32326657   PMID:32386455  
PMID:32421906   PMID:32554809   PMID:32576838   PMID:32692932   PMID:32693110   PMID:32848068   PMID:32854115   PMID:32907931   PMID:33153107   PMID:33239388   PMID:33251934   PMID:33407124  
PMID:33438263   PMID:33839682   PMID:33981306   PMID:34298979   PMID:34910922   PMID:35343899   PMID:35649374   PMID:35734179   PMID:35881547   PMID:35883631   PMID:36206304   PMID:36210579  
PMID:36263057   PMID:36346673   PMID:36527283   PMID:36922518   PMID:37047302   PMID:37179332   PMID:37267105   PMID:37279540   PMID:37283516   PMID:37627259   PMID:37723552   PMID:38355793  


Genomics

Comparative Map Data
Itgb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,366,164 - 77,401,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,366,086 - 77,401,542 (+)EnsemblGRCm39 Ensembl
GRCm381077,530,329 - 77,565,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1077,530,252 - 77,565,708 (+)EnsemblGRCm38mm10GRCm38
MGSCv371076,993,093 - 77,028,419 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361076,985,685 - 77,009,099 (+)NCBIMGSCv36mm8
Celera1078,572,639 - 78,608,564 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
ITGB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,885,953 - 44,928,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,885,953 - 44,931,989 (-)EnsemblGRCh38hg38GRCh38
GRCh372146,305,868 - 46,348,730 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362145,130,296 - 45,165,303 (-)NCBINCBI36Build 36hg18NCBI36
Build 342145,130,313 - 45,165,232NCBI
Celera2131,412,498 - 31,455,256 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,679,225 - 31,721,357 (-)NCBIHuRef
CHM1_12145,866,651 - 45,909,349 (-)NCBICHM1_1
T2T-CHM13v2.02143,246,634 - 43,289,593 (-)NCBIT2T-CHM13v2.0
Itgb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82011,061,009 - 11,097,242 (-)NCBIGRCr8
mRatBN7.22011,061,394 - 11,097,656 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2011,061,430 - 11,097,600 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2011,760,914 - 11,797,085 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02011,121,883 - 11,158,052 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,593,622 - 11,629,796 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,777,773 - 11,815,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,777,783 - 11,815,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,944,190 - 13,981,048 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,446,521 - 11,485,009 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12011,446,936 - 11,485,236 (-)NCBI
Celera2012,564,941 - 12,601,097 (-)NCBICelera
Cytogenetic Map20p12NCBI
Itgb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,777,777 - 41,800,201 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,779,849 - 41,805,637 (-)NCBIChiLan1.0ChiLan1.0
ITGB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,933,241 - 40,976,107 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,804,383 - 35,839,245 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02131,181,228 - 31,216,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12144,470,999 - 44,505,963 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2144,470,999 - 44,505,963 (-)Ensemblpanpan1.1panPan2
ITGB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,520,733 - 38,547,003 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3138,521,103 - 38,547,018 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3137,718,851 - 37,741,911 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03138,125,566 - 38,152,274 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3138,125,550 - 38,148,633 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,988,075 - 38,014,617 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,949,217 - 37,972,818 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03138,463,168 - 38,490,402 (-)NCBIUU_Cfam_GSD_1.0
Itgb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497137,819,024 - 37,843,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367781,286,341 - 1,311,194 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367781,286,475 - 1,311,184 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13207,512,950 - 207,544,107 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113207,514,281 - 207,544,108 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213217,446,055 - 217,475,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,597,554 - 88,644,890 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,597,556 - 88,624,025 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605416,774,420 - 16,821,705 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474530,452,576 - 30,470,611 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474530,452,576 - 30,479,036 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itgb2
914 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1465
Count of miRNA genes:599
Interacting mature miRNAs:700
Transcripts:ENSMUST00000000299, ENSMUST00000130059, ENSMUST00000131023, ENSMUST00000153541, ENSMUST00000156644
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse

Markers in Region
AI528527  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381077,565,441 - 77,565,528UniSTSGRCm38
GRCm38X68,781,875 - 68,781,962UniSTSGRCm38
MGSCv37X66,035,050 - 66,035,137UniSTSGRCm37
MGSCv371077,028,186 - 77,028,273UniSTSGRCm37
Celera1078,608,331 - 78,608,418UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic MapXA7.1UniSTS
cM Map1041.5UniSTS
D10Mit92  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381077,544,096 - 77,544,280UniSTSGRCm38
MGSCv371077,006,841 - 77,007,025UniSTSGRCm37
Celera1078,586,986 - 78,587,166UniSTS
Cytogenetic Map10C1UniSTS
cM Map1041.5UniSTS
Whitehead Genetic1036.1UniSTS
X14951  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381077,565,348 - 77,565,527UniSTSGRCm38
MGSCv371077,028,093 - 77,028,272UniSTSGRCm37
Celera1078,608,238 - 78,608,417UniSTS
Cytogenetic Map10C1UniSTS
cM Map1041.5UniSTS
Whitehead/MRC_RH10877.41UniSTS
Itgb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381077,565,421 - 77,565,527UniSTSGRCm38
GRCm38X68,781,876 - 68,782,456UniSTSGRCm38
MGSCv371077,028,166 - 77,028,272UniSTSGRCm37
MGSCv37X66,035,051 - 66,035,631UniSTSGRCm37
Celera1078,608,311 - 78,608,417UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic MapXA7.1UniSTS
cM Map1041.5UniSTS
Itgb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS
Itgb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381077,546,109 - 77,547,288UniSTSGRCm38
MGSCv371077,008,854 - 77,010,033UniSTSGRCm37
Celera1078,588,993 - 78,590,171UniSTS
Cytogenetic Map10C1UniSTS
Itgb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_157228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_157229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY787094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OL792761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000000299   ⟹   ENSMUSP00000000299
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,366,086 - 77,401,520 (+)Ensembl
GRCm38.p6 Ensembl1077,530,252 - 77,565,686 (+)Ensembl
Ensembl Acc Id: ENSMUST00000130059   ⟹   ENSMUSP00000118191
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,366,204 - 77,384,506 (+)Ensembl
GRCm38.p6 Ensembl1077,530,370 - 77,548,672 (+)Ensembl
Ensembl Acc Id: ENSMUST00000131023   ⟹   ENSMUSP00000119657
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,366,181 - 77,383,029 (+)Ensembl
GRCm38.p6 Ensembl1077,530,347 - 77,547,195 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153541   ⟹   ENSMUSP00000137734
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,366,214 - 77,401,542 (+)Ensembl
GRCm38.p6 Ensembl1077,530,380 - 77,565,708 (+)Ensembl
Ensembl Acc Id: ENSMUST00000156644   ⟹   ENSMUSP00000137865
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,366,208 - 77,401,456 (+)Ensembl
GRCm38.p6 Ensembl1077,530,374 - 77,565,622 (+)Ensembl
RefSeq Acc Id: NM_008404   ⟹   NP_032430
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,366,204 - 77,401,542 (+)NCBI
GRCm381077,530,370 - 77,565,708 (+)NCBI
MGSCv371076,993,093 - 77,028,419 (+)RGD
Celera1078,572,639 - 78,608,564 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_157228
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,366,204 - 77,401,542 (+)NCBI
GRCm381077,530,370 - 77,565,708 (+)NCBI
Sequence:
RefSeq Acc Id: NR_157229
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,366,204 - 77,401,542 (+)NCBI
GRCm381077,530,370 - 77,565,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006513271   ⟹   XP_006513334
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,366,164 - 77,401,515 (+)NCBI
GRCm381077,530,329 - 77,565,681 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006513272   ⟹   XP_006513335
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,366,164 - 77,401,515 (+)NCBI
GRCm381077,530,329 - 77,565,681 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017313814   ⟹   XP_017169303
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,366,164 - 77,401,515 (+)NCBI
GRCm381077,530,329 - 77,565,681 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032430   ⟸   NM_008404
- Peptide Label: isoform 1 precursor
- UniProtKB: Q64482 (UniProtKB/Swiss-Prot),   P11835 (UniProtKB/Swiss-Prot),   Q542I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006513335   ⟸   XM_006513272
- Peptide Label: isoform X1
- UniProtKB: Q64482 (UniProtKB/Swiss-Prot),   P11835 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006513334   ⟸   XM_006513271
- Peptide Label: isoform X1
- UniProtKB: Q64482 (UniProtKB/Swiss-Prot),   P11835 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017169303   ⟸   XM_017313814
- Peptide Label: isoform X1
- UniProtKB: Q64482 (UniProtKB/Swiss-Prot),   P11835 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000118191   ⟸   ENSMUST00000130059
Ensembl Acc Id: ENSMUSP00000000299   ⟸   ENSMUST00000000299
Ensembl Acc Id: ENSMUSP00000119657   ⟸   ENSMUST00000131023
Ensembl Acc Id: ENSMUSP00000137734   ⟸   ENSMUST00000153541
Ensembl Acc Id: ENSMUSP00000137865   ⟸   ENSMUST00000156644
Protein Domains
EGF-like   Integrin beta N-terminal   Integrin beta subunit cytoplasmic   Integrin beta subunit tail   Integrin beta subunit VWA   PSI   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11835-F1-model_v2 AlphaFold P11835 1-771 view protein structure

Promoters
RGD ID:6819474
Promoter ID:MM_KWN:4664
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:OTTMUST00000047620,   OTTMUST00000047652,   OTTMUST00000047653,   OTTMUST00000047654,   OTTMUST00000047655
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361076,992,904 - 76,993,404 (+)MPROMDB
RGD ID:6819475
Promoter ID:MM_KWN:4665
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:UC007FVW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361077,004,599 - 77,005,099 (+)MPROMDB
RGD ID:6848958
Promoter ID:MM_XEF:721
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:NM_001086548,   NM_205251
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361077,008,524 - 77,009,024 (+)MPROMDB
RGD ID:8672416
Promoter ID:EPDNEW_M14239
Type:initiation region
Name:Itgb2_1
Description:Mus musculus integrin beta 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14240  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381077,530,370 - 77,530,430EPDNEW
RGD ID:8672418
Promoter ID:EPDNEW_M14240
Type:multiple initiation site
Name:Itgb2_2
Description:Mus musculus integrin beta 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14239  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381077,535,550 - 77,535,610EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96611 AgrOrtholog
Ensembl Genes ENSMUSG00000000290 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000000299 ENTREZGENE
  ENSMUST00000000299.14 UniProtKB/TrEMBL
  ENSMUST00000130059.8 UniProtKB/TrEMBL
  ENSMUST00000131023.8 UniProtKB/TrEMBL
  ENSMUST00000153541 ENTREZGENE
  ENSMUST00000153541.2 UniProtKB/TrEMBL
  ENSMUST00000156644 ENTREZGENE
  ENSMUST00000156644.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome c1, transmembrane anchor, C-terminal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ligand-binding face of the semaphorins, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Integrin_beta_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu_cyt_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu_tail_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu_VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16414 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96611 ENTREZGENE
NCBI Gene 16414 ENTREZGENE
PANTHER PTHR10082 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10082:SF15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Integrin_b_cyt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PSI_integrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itgb2 PhenoGen
PIRSF Integrin_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTEGRINB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  INTEGRIN_BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART INB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plexin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69687 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YYP8_MOUSE UniProtKB/TrEMBL
  D3Z1S4_MOUSE UniProtKB/TrEMBL
  ITB2_MOUSE UniProtKB/Swiss-Prot
  M0QWA7_MOUSE UniProtKB/TrEMBL
  M0QWJ6_MOUSE UniProtKB/TrEMBL
  P11835 ENTREZGENE
  Q542I8 ENTREZGENE, UniProtKB/TrEMBL
  Q64482 ENTREZGENE
UniProt Secondary Q64482 UniProtKB/Swiss-Prot