Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | CCT8 | Human | (+)-schisandrin B | multiple interactions | ISO | Cct8 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CCT8 mRNA] | CTD | PMID:31150632 | CCT8 | Human | (-)-epigallocatechin 3-gallate | decreases expression | EXP | | 6480464 | epigallocatechin gallate results in decreased expression of CCT8 protein | CTD | PMID:31195006 | CCT8 | Human | 1,2-dimethylhydrazine | multiple interactions | ISO | Cct8 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CCT8 mRNA | CTD | PMID:22206623 | CCT8 | Human | 17alpha-ethynylestradiol | increases expression | ISO | Cct8 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of CCT8 mRNA | CTD | PMID:17942748 | CCT8 | Human | 17alpha-ethynylestradiol | multiple interactions | ISO | Cct8 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCT8 mRNA | CTD | PMID:17942748 | CCT8 | Human | 17beta-estradiol | affects expression | ISO | Cct8 (Mus musculus) | 6480464 | Estradiol affects the expression of CCT8 mRNA | CTD | PMID:15598610 | CCT8 | Human | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Cct8 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | CCT8 | Human | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Cct8 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCT8 mRNA | CTD | PMID:17942748 | CCT8 | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Cct8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CCT8 mRNA | CTD | PMID:21570461 and PMID:24680724 | CCT8 | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CCT8 mRNA | CTD | PMID:22574217 | CCT8 | Human | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Cct8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CCT8 mRNA | CTD | PMID:19770486 | CCT8 | Human | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CCT8 mRNA | CTD | PMID:15056799 | CCT8 | Human | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | decreases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:19954255 | CCT8 | Human | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:19954255 | CCT8 | Human | 2,4-dinitrotoluene | affects expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of CCT8 mRNA | CTD | PMID:21346803 | CCT8 | Human | 2,6-dimethoxyphenol | multiple interactions | EXP | | 6480464 | [Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in decreased expression of and affects the localization of CCT8 protein | CTD | PMID:38598786 | CCT8 | Human | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of CCT8 protein | CTD | PMID:34186270 | CCT8 | Human | 6-propyl-2-thiouracil | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of CCT8 mRNA | CTD | PMID:30047161 | CCT8 | Human | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of CCT8 mRNA | CTD | PMID:32763439 | CCT8 | Human | amitrole | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of CCT8 mRNA | CTD | PMID:30047161 | CCT8 | Human | aniline | multiple interactions | ISO | Cct8 (Rattus norvegicus) | 6480464 | aniline results in increased nitrosation of and results in increased expression of CCT8 protein | CTD | PMID:21708182 | CCT8 | Human | antirheumatic drug | decreases expression | EXP | | 6480464 | Antirheumatic Agents results in decreased expression of CCT8 mRNA | CTD | PMID:24449571 | CCT8 | Human | Aroclor 1254 | decreases expression | ISO | Cct8 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of CCT8 mRNA | CTD | PMID:23650126 | CCT8 | Human | arsenite(3-) | multiple interactions | EXP | | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to CCT8 mRNA] and arsenite promotes the reaction [G3BP1 protein binds to CCT8 protein] | CTD | PMID:32406909 | CCT8 | Human | arsenous acid | increases expression | EXP | | 6480464 | Arsenic Trioxide results in increased expression of CCT8 mRNA | CTD | PMID:20458559 | CCT8 | Human | arsenous acid | multiple interactions | EXP | | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CCT8 protein] | CTD | PMID:26598702 | CCT8 | Human | benzatropine | multiple interactions | EXP | | 6480464 | [Cuprizone co-treated with Benztropine] results in decreased expression of CCT8 protein | CTD | PMID:34122009 | CCT8 | Human | benzo[a]pyrene | increases expression | ISO | Cct8 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of CCT8 mRNA | CTD | PMID:22228805 | CCT8 | Human | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Cct8 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of CCT8 mRNA | CTD | PMID:33754040 | CCT8 | Human | bisphenol A | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of CCT8 mRNA | CTD | PMID:25181051 | CCT8 | Human | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CCT8 protein | CTD | PMID:34186270 | CCT8 | Human | bisphenol AF | increases expression | EXP | | 6480464 | bisphenol AF results in increased expression of CCT8 protein | CTD | PMID:34186270 | CCT8 | Human | Bisphenol B | increases expression | EXP | | 6480464 | bisphenol B results in increased expression of CCT8 protein | CTD | PMID:34186270 | CCT8 | Human | bisphenol F | increases expression | EXP | | 6480464 | bisphenol F results in increased expression of CCT8 protein | CTD | PMID:34186270 | CCT8 | Human | bleomycin A2 | multiple interactions | ISO | Cct8 (Mus musculus) | 6480464 | [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of CCT8 protein | CTD | PMID:29733421 | CCT8 | Human | Brodifacoum | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | bromfenacoum results in increased expression of CCT8 protein | CTD | PMID:28903499 | CCT8 | Human | cadmium atom | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCT8 mRNA | CTD | PMID:35301059 | CCT8 | Human | cadmium dichloride | increases methylation | ISO | Cct8 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased methylation of CCT8 promoter | CTD | PMID:22457795 | CCT8 | Human | cadmium dichloride | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCT8 mRNA | CTD | PMID:35301059 | CCT8 | Human | cadmium dichloride | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of CCT8 mRNA | CTD | PMID:33453195 | CCT8 | Human | caffeine | decreases expression | EXP | | 6480464 | Caffeine results in decreased expression of CCT8 protein | CTD | PMID:31195006 | CCT8 | Human | cannabidiol | multiple interactions | EXP | | 6480464 | [Cuprizone co-treated with Cannabidiol] results in decreased expression of CCT8 protein | CTD | PMID:34122009 | CCT8 | Human | carbon nanotube | increases expression | ISO | Cct8 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CCT8 | Human | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CCT8 gene] | CTD | PMID:28238834 | CCT8 | Human | chloropicrin | affects expression | EXP | | 6480464 | chloropicrin affects the expression of CCT8 mRNA | CTD | PMID:26352163 | CCT8 | Human | chromium(6+) | affects expression | ISO | Cct8 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of CCT8 mRNA | CTD | PMID:28472532 | CCT8 | Human | cisplatin | multiple interactions | ISO | Cct8 (Mus musculus) | 6480464 | [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of CCT8 protein | CTD | PMID:29733421 | CCT8 | Human | CU-O LINKAGE | increases expression | EXP | | 6480464 | cupric oxide results in increased expression of CCT8 protein | CTD | PMID:25470785 | CCT8 | Human | Cuprizon | multiple interactions | EXP | | 6480464 | [Cuprizone co-treated with Benztropine] results in decreased expression of CCT8 protein more ... | CTD | PMID:34122009 | CCT8 | Human | DDE | increases expression | EXP | | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of CCT8 mRNA | CTD | PMID:38568856 | CCT8 | Human | dexamethasone | decreases expression | ISO | Cct8 (Mus musculus) | 6480464 | Dexamethasone results in decreased expression of CCT8 mRNA | CTD | PMID:21041162 | CCT8 | Human | diarsenic trioxide | multiple interactions | EXP | | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CCT8 protein] | CTD | PMID:26598702 | CCT8 | Human | diarsenic trioxide | increases expression | EXP | | 6480464 | Arsenic Trioxide results in increased expression of CCT8 mRNA | CTD | PMID:20458559 | CCT8 | Human | dicrotophos | decreases expression | EXP | | 6480464 | dicrotophos results in decreased expression of CCT8 mRNA | CTD | PMID:28302478 | CCT8 | Human | diethylstilbestrol | decreases expression | ISO | Cct8 (Mus musculus) | 6480464 | Diethylstilbestrol results in decreased expression of CCT8 mRNA | CTD | PMID:21041162 | CCT8 | Human | dioxygen | multiple interactions | ISO | Cct8 (Mus musculus) | 6480464 | [sulforaphane affects the susceptibility to Oxygen] which affects the expression of CCT8 mRNA | CTD | PMID:30529165 | CCT8 | Human | doxorubicin | increases expression | EXP | | 6480464 | Doxorubicin results in increased expression of CCT8 mRNA | CTD | PMID:29803840 | CCT8 | Human | enzyme inhibitor | multiple interactions | EXP | | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CCT8 protein | CTD | PMID:23301498 | CCT8 | Human | epoxiconazole | increases expression | ISO | Cct8 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of CCT8 mRNA | CTD | PMID:35436446 | CCT8 | Human | ethanol | affects splicing | ISO | Cct8 (Mus musculus) | 6480464 | Ethanol affects the splicing of CCT8 mRNA | CTD | PMID:30319688 | CCT8 | Human | etoposide | multiple interactions | ISO | Cct8 (Mus musculus) | 6480464 | [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of CCT8 protein | CTD | PMID:29733421 | CCT8 | Human | fenvalerate | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of CCT8 protein | CTD | PMID:33656234 | CCT8 | Human | finasteride | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Finasteride results in increased expression of CCT8 mRNA | CTD | PMID:24136188 | CCT8 | Human | flutamide | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of CCT8 mRNA | CTD | PMID:24136188 | CCT8 | Human | folic acid | multiple interactions | ISO | Cct8 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CCT8 mRNA | CTD | PMID:22206623 | CCT8 | Human | FR900359 | increases phosphorylation | EXP | | 6480464 | FR900359 results in increased phosphorylation of CCT8 protein | CTD | PMID:37730182 | CCT8 | Human | furfural | multiple interactions | EXP | | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of CCT8 protein | CTD | PMID:38598786 | CCT8 | Human | glyphosate | decreases expression | ISO | Cct8 (Mus musculus) | 6480464 | Glyphosate results in decreased expression of CCT8 protein | CTD | PMID:37208198 | CCT8 | Human | haloperidol | multiple interactions | EXP | | 6480464 | [Cuprizone co-treated with Haloperidol] results in decreased expression of CCT8 protein | CTD | PMID:34122009 | CCT8 | Human | hydroquinone O-beta-D-glucopyranoside | increases expression | EXP | | 6480464 | Arbutin results in increased expression of CCT8 mRNA | CTD | PMID:17103032 | CCT8 | Human | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of CCT8 protein | CTD | PMID:32959892 | CCT8 | Human | lipopolysaccharide | multiple interactions | EXP | | 6480464 | [NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of CCT8 mRNA | CTD | PMID:35877022 | CCT8 | Human | lovastatin | decreases expression | ISO | Cct8 (Mus musculus) | 6480464 | Lovastatin results in decreased expression of CCT8 mRNA | CTD | PMID:20493250 | CCT8 | Human | methimazole | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of CCT8 mRNA | CTD | PMID:30047161 | CCT8 | Human | miconazole | increases expression | ISO | Cct8 (Mus musculus) | 6480464 | Miconazole results in increased expression of CCT8 mRNA | CTD | PMID:27462272 | CCT8 | Human | microcystin RR | increases expression | EXP | | 6480464 | microcystin RR results in increased expression of CCT8 protein | CTD | PMID:19111056 | CCT8 | Human | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | Cct8 (Mus musculus) | 6480464 | Ethylnitrosourea results in increased mutagenesis of CCT8 mRNA | CTD | PMID:27776689 | CCT8 | Human | N-nitrosomorpholine | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | N-nitrosomorpholine results in increased expression of CCT8 protein | CTD | PMID:19716841 | CCT8 | Human | nefazodone | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | nefazodone results in increased expression of CCT8 mRNA | CTD | PMID:24136188 | CCT8 | Human | nimesulide | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | nimesulide results in increased expression of CCT8 mRNA | CTD | PMID:24136188 | CCT8 | Human | nitrates | multiple interactions | ISO | Cct8 (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of CCT8 mRNA | CTD | PMID:35964746 | CCT8 | Human | ochratoxin A | affects expression | EXP | | 6480464 | ochratoxin A affects the expression of CCT8 protein | CTD | PMID:26861962 | CCT8 | Human | oxaliplatin | multiple interactions | ISO | Cct8 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CCT8 mRNA | CTD | PMID:25729387 | CCT8 | Human | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of CCT8 mRNA | CTD | PMID:35430440 | CCT8 | Human | perfluorohexanesulfonic acid | increases expression | ISO | Cct8 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of CCT8 mRNA | CTD | PMID:37995155 | CCT8 | Human | phenobarbital | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Phenobarbital results in increased expression of CCT8 mRNA | CTD | PMID:30047161 | CCT8 | Human | PhIP | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of CCT8 mRNA | CTD | PMID:15215175 | CCT8 | Human | resveratrol | multiple interactions | EXP | | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of CCT8 mRNA | CTD | PMID:23557933 | CCT8 | Human | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of CCT8 protein | CTD | PMID:20050688 and PMID:30528433 | CCT8 | Human | sodium chloride | multiple interactions | EXP | | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of CCT8 protein more ... | CTD | PMID:38598786 | CCT8 | Human | sodium dichromate | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | sodium bichromate results in increased expression of CCT8 mRNA | CTD | PMID:25993096 | CCT8 | Human | Soman | decreases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Soman results in decreased expression of CCT8 mRNA | CTD | PMID:19281266 | CCT8 | Human | sulfadimethoxine | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of CCT8 mRNA | CTD | PMID:30047161 | CCT8 | Human | sulforaphane | multiple interactions | ISO | Cct8 (Mus musculus) | 6480464 | [sulforaphane affects the susceptibility to Oxygen] which affects the expression of CCT8 mRNA | CTD | PMID:30529165 | CCT8 | Human | tanespimycin | multiple interactions | EXP | | 6480464 | [tanespimycin co-treated with VER 155008] results in decreased expression of CCT8 protein | CTD | PMID:31370342 | CCT8 | Human | tetrachloromethane | multiple interactions | ISO | Cct8 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CCT8 mRNA] | CTD | PMID:31150632 | CCT8 | Human | tetrachloromethane | increases expression | ISO | Cct8 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of CCT8 mRNA | CTD | PMID:31919559 | CCT8 | Human | tetrachloromethane | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of CCT8 mRNA | CTD | PMID:31150632 | CCT8 | Human | thioacetamide | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of CCT8 mRNA | CTD | PMID:34492290 | CCT8 | Human | titanium dioxide | decreases methylation | ISO | Cct8 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of CCT8 gene | CTD | PMID:35295148 | CCT8 | Human | topotecan | multiple interactions | ISO | Cct8 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CCT8 mRNA | CTD | PMID:25729387 | CCT8 | Human | triptonide | affects expression | ISO | Cct8 (Mus musculus) | 6480464 | triptonide affects the expression of CCT8 mRNA | CTD | PMID:33045310 | CCT8 | Human | valdecoxib | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | valdecoxib results in increased expression of CCT8 mRNA | CTD | PMID:24136188 | CCT8 | Human | vinclozolin | increases expression | ISO | Cct8 (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of CCT8 mRNA | CTD | PMID:23034163 | CCT8 | Human | warfarin | decreases expression | ISO | Cct8 (Mus musculus) | 6480464 | Warfarin results in decreased expression of CCT8 mRNA | CTD | PMID:20493250 | |
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