Rbl1 (RB transcriptional corepressor like 1) - Rat Genome Database

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Gene: Rbl1 (RB transcriptional corepressor like 1) Mus musculus
Analyze
Symbol: Rbl1
Name: RB transcriptional corepressor like 1
RGD ID: 1313375
MGI Page MGI
Description: Enables promoter-specific chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study retinoblastoma and urinary bladder cancer. Orthologous to human RBL1 (RB transcriptional corepressor like 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 107 kDa retinoblastoma-associated protein; AW547426; p10; p107; PRB1; retinoblastoma-like 1 (p107); retinoblastoma-like protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392156,987,813 - 157,046,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2156,987,813 - 157,046,454 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382157,145,893 - 157,204,534 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,145,893 - 157,204,534 (-)Ensemblmm10GRCm38
MGSCv372156,971,629 - 157,030,270 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362156,837,339 - 156,895,960 (-)NCBIMGSCv36mm8
Celera2163,079,752 - 163,138,173 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.05NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (EXP)
4-nitrophenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alvocidib  (ISO)
amphetamine  (ISO)
antimycin A  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calyculin A  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
D-mannitol  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
GW 3965  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
lamivudine  (ISO)
Lasiocarpine  (ISO)
lidocaine  (EXP,ISO)
lipopolysaccharide  (EXP)
LY294002  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (EXP)
palbociclib  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
riddelliine  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IDA,IEA)
transcription regulator complex  (IBA,IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amacrine cell morphology  (IAGP)
abnormal awl hair morphology  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal cerebellar cortex morphology  (IAGP)
abnormal cerebellum vermis morphology  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal eye anterior chamber morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal eye posterior chamber morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal guard hair morphology  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal humerus morphology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal kidney morphology  (IEA)
abnormal limb bone morphology  (IAGP)
abnormal long bone epiphyseal ossification zone morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal perineum morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal retina apoptosis  (IAGP)
abnormal retina bipolar cell morphology  (IAGP)
abnormal retina inner nuclear layer morphology  (IAGP)
abnormal retina inner plexiform layer morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina photoreceptor morphology  (IAGP)
abnormal rib development  (IAGP)
abnormal rod electrophysiology  (IAGP)
abnormal scapular spine morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal supraoccipital bone morphology  (IAGP)
abnormal tooth development  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
abnormal white adipose tissue morphology  (IAGP)
abnormal zigzag hair morphology  (IAGP)
absent incisors  (IAGP)
apnea  (IAGP)
ataxia  (IAGP)
cerebellum hypoplasia  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased hair follicle number  (IAGP)
decreased inguinal fat pad weight  (IAGP)
decreased interscapular fat pad weight  (IAGP)
decreased length of long bones  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased retina ganglion cell number  (IAGP)
decreased retina photoreceptor cell number  (IAGP)
decreased retina rod cell number  (IAGP)
decreased total fat pad weight  (IAGP)
decreased tumor-free survival time  (IAGP)
decreased white adipose tissue amount  (IAGP)
decreased white fat cell size  (IAGP)
delayed emergence of vibrissae  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed fertility  (IAGP)
distended abdomen  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged sebaceous gland  (IAGP)
epidermal hyperplasia  (IAGP)
extramedullary hematopoiesis  (IAGP)
hematuria  (IAGP)
hepatic steatosis  (IAGP)
improved glucose tolerance  (IEA)
increased apoptosis  (IAGP)
increased bone marrow cell number  (IAGP)
increased cell proliferation  (IAGP)
increased diameter of humerus  (IAGP)
increased diameter of long bones  (IAGP)
increased diameter of radius  (IAGP)
increased diameter of ulna  (IAGP)
increased fibroblast proliferation  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuronal precursor cell number  (IAGP)
increased oxygen consumption  (IAGP)
increased pituitary gland tumor incidence  (IAGP)
increased retinoblastoma incidence  (IAGP)
increased urinary bladder carcinoma incidence  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
interparietal bone hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
pale yolk sac  (IAGP)
parakeratosis  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
reduced female fertility  (IAGP)
short femur  (IAGP)
short fibula  (IAGP)
short forelimb  (IAGP)
short humerus  (IAGP)
short limbs  (IAGP)
short radius  (IAGP)
short snout  (IAGP)
short tibia  (IAGP)
short ulna  (IAGP)
shortened QRS complex duration  (IEA)
small incisors  (IAGP)
small supraoccipital bone  (IAGP)
small thoracic cage  (IAGP)
spontaneous skin ulceration  (IAGP)
thin cerebellar molecular layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
underdeveloped hair follicles  (IAGP)
vagina atresia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7490090   PMID:7797074   PMID:8077211   PMID:8197461   PMID:8413252   PMID:8661722   PMID:8682293   PMID:8682294   PMID:8862413   PMID:8945939   PMID:9110405   PMID:9150384  
PMID:9192872   PMID:9418868   PMID:9464541   PMID:9508781   PMID:9620848   PMID:9751770   PMID:9819431   PMID:9878593   PMID:10082561   PMID:10349636   PMID:10508527   PMID:10630640  
PMID:10788617   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11114892   PMID:11114893   PMID:11571651   PMID:12086466   PMID:12096340   PMID:12177046   PMID:12242027   PMID:12379853  
PMID:12477932   PMID:12520002   PMID:12627794   PMID:12702649   PMID:12810584   PMID:12853964   PMID:12860570   PMID:14555653   PMID:14610273   PMID:14688262   PMID:14716294   PMID:14732703  
PMID:15070741   PMID:15124025   PMID:15148303   PMID:15188427   PMID:15190215   PMID:15193257   PMID:15210943   PMID:15231717   PMID:15353549   PMID:15574596   PMID:15631990   PMID:15664192  
PMID:15701640   PMID:15750587   PMID:15782199   PMID:15827088   PMID:15843406   PMID:15939381   PMID:16141072   PMID:16141073   PMID:16258171   PMID:16271529   PMID:16338659   PMID:16465443  
PMID:16602821   PMID:16672052   PMID:16884701   PMID:17080083   PMID:17235288   PMID:17257418   PMID:17363591   PMID:17502351   PMID:17563750   PMID:17591923   PMID:17608565   PMID:17923680  
PMID:17932945   PMID:17936268   PMID:17956737   PMID:18287559   PMID:18300254   PMID:18655203   PMID:18799693   PMID:18818403   PMID:18940733   PMID:18981186   PMID:19341623   PMID:19509021  
PMID:19564414   PMID:19649275   PMID:19706423   PMID:19786571   PMID:19864318   PMID:19887370   PMID:19887614   PMID:20019750   PMID:20059953   PMID:20100864   PMID:20211142   PMID:20585628  
PMID:20679727   PMID:20713602   PMID:21059851   PMID:21172336   PMID:21194568   PMID:21423694   PMID:21515735   PMID:21677750   PMID:21779340   PMID:21816922   PMID:21840489   PMID:21873635  
PMID:21875955   PMID:21993628   PMID:22237625   PMID:22286767   PMID:22484813   PMID:22560297   PMID:22714890   PMID:22864477   PMID:22942253   PMID:23145321   PMID:23146901   PMID:23558950  
PMID:23615279   PMID:23669396   PMID:23765217   PMID:23803733   PMID:24013229   PMID:24056077   PMID:24086435   PMID:24143284   PMID:24227978   PMID:24238961   PMID:24449206   PMID:24662053  
PMID:24710275   PMID:25017070   PMID:25069779   PMID:25100735   PMID:25142465   PMID:25182511   PMID:25249236   PMID:25252918   PMID:25533675   PMID:26238783   PMID:26317218   PMID:26365184  
PMID:26628093   PMID:26639898   PMID:26935419   PMID:27001308   PMID:27966456   PMID:28107452   PMID:28165337   PMID:28192409   PMID:28233396   PMID:28402854   PMID:28550162   PMID:28920576  
PMID:28928282   PMID:30383332   PMID:31239386   PMID:31270502   PMID:31611390   PMID:31613797   PMID:32071286   PMID:32325033   PMID:33444292   PMID:34270926   PMID:34430805   PMID:34645816  
PMID:34746147   PMID:35954335   PMID:37612308   PMID:37880249   PMID:38355793  


Genomics

Comparative Map Data
Rbl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392156,987,813 - 157,046,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2156,987,813 - 157,046,454 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382157,145,893 - 157,204,534 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,145,893 - 157,204,534 (-)Ensemblmm10GRCm38
MGSCv372156,971,629 - 157,030,270 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362156,837,339 - 156,895,960 (-)NCBIMGSCv36mm8
Celera2163,079,752 - 163,138,173 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.05NCBI
RBL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382036,996,349 - 37,095,997 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2036,996,349 - 37,095,997 (-)Ensemblhg38GRCh38
GRCh372035,624,752 - 35,724,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362035,059,592 - 35,157,824 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342035,065,390 - 35,157,824NCBI
Celera2032,333,780 - 32,432,015 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,360,436 - 32,458,763 (-)NCBIHuRef
CHM1_12035,527,068 - 35,627,333 (-)NCBICHM1_1
T2T-CHM13v2.02038,720,692 - 38,820,363 (-)NCBIT2T-CHM13v2.0
Rbl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,226,187 - 166,289,862 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3166,226,198 - 166,289,376 (-)EnsemblGRCr8
mRatBN7.23145,806,160 - 145,869,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,807,095 - 145,869,330 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3149,633,152 - 149,694,671 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,130,942 - 158,195,584 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,871,986 - 155,936,707 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,263,692 - 153,321,351 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,263,692 - 153,321,352 (-)Ensemblrn6Rnor6.0
Rnor_5.03158,398,177 - 158,452,482 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43147,734,622 - 147,796,630 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3144,513,506 - 144,575,032 (-)NCBICelera
Cytogenetic Map3q42NCBI
Rbl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542224,620,078 - 24,695,229 (+)Ensembl
ChiLan1.0NW_00495542224,620,068 - 24,695,203 (+)NCBIChiLan1.0ChiLan1.0
RBL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,730,094 - 42,825,356 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,722,411 - 42,818,447 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,324,663 - 33,419,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,442,865 - 34,535,248 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,443,203 - 34,534,109 (-)EnsemblpanPan2panpan1.1
RBL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,698,313 - 25,757,358 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,699,638 - 25,757,229 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2425,346,666 - 25,405,658 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02426,395,755 - 26,454,244 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,395,763 - 26,454,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,673,462 - 25,732,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,777,693 - 25,836,916 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,267,110 - 26,325,939 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rbl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,589,725 - 174,641,443 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365614,107,861 - 4,157,647 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365614,108,393 - 4,157,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,194,950 - 40,279,156 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11740,201,214 - 40,279,318 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,641,172 - 45,716,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103246453
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,593,657 - 26,601,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666054222,711 - 309,667 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,494,911 - 2,563,421 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248422,495,015 - 2,565,220 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Rbl1
3054 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:593
Count of miRNA genes:439
Interacting mature miRNAs:490
Transcripts:ENSMUST00000029170, ENSMUST00000124518, ENSMUST00000141296, ENSMUST00000154721
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
13825247Agoc2_magouti coat color QTL 2 (mouse)2151841920159841920Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
1558842Tailq2_mtail length QTL 2 (mouse)Not determined2151640941162737074Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1357862Epfq1_mepididymal fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301588Hrec_mhemotopoietic response to early cytokines (mouse)Not determined2154553217159428450Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1558852Gnf2_mgrowth and fatness 2 (mouse)Not determined2152699221162197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
1357772Scfq1_msubcutaneous fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse

Markers in Region
Tfam  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382157,187,082 - 157,187,251UniSTSGRCm38
MGSCv372157,012,818 - 157,012,987UniSTSGRCm37
Celera2163,120,877 - 163,121,046UniSTS
Cytogenetic Map10B5UniSTS
Cytogenetic Map2H1UniSTS
cM Map1038.0UniSTS
U27177  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382157,146,279 - 157,146,478UniSTSGRCm38
MGSCv372156,972,015 - 156,972,214UniSTSGRCm37
Celera2163,080,138 - 163,080,337UniSTS
Cytogenetic Map2H1UniSTS
cM Map292.0UniSTS
Whitehead_YAC2 UniSTS
U27178  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382157,175,253 - 157,175,416UniSTSGRCm38
MGSCv372157,000,989 - 157,001,152UniSTSGRCm37
Celera2163,109,034 - 163,109,197UniSTS
Cytogenetic Map2H1UniSTS
cM Map292.0UniSTS
Whitehead_YAC2 UniSTS
AW547426  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382157,146,420 - 157,146,503UniSTSGRCm38
MGSCv372156,972,156 - 156,972,239UniSTSGRCm37
Celera2163,080,279 - 163,080,362UniSTS
Cytogenetic Map2H1UniSTS
cM Map292.0UniSTS
Whitehead/MRC_RH21823.33UniSTS
Whitehead/MRC_RH21823.38UniSTS
RH125446  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382157,168,801 - 157,168,925UniSTSGRCm38
MGSCv372156,994,537 - 156,994,661UniSTSGRCm37
Celera2163,102,583 - 163,102,707UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map2H1UniSTS
cM Map292.0UniSTS
PMC152357P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382157,204,438 - 157,204,683UniSTSGRCm38
MGSCv372157,030,174 - 157,030,419UniSTSGRCm37
Celera2163,138,077 - 163,138,322UniSTS
Cytogenetic Map2H1UniSTS
cM Map292.0UniSTS
RH124565  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382157,169,015 - 157,169,195UniSTSGRCm38
GRCm381810,626,930 - 10,627,886UniSTSGRCm38
MGSCv371810,626,928 - 10,627,884UniSTSGRCm37
MGSCv372156,994,751 - 156,994,931UniSTSGRCm37
Celera2163,102,797 - 163,102,977UniSTS
Celera1810,656,925 - 10,657,881UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map2H1UniSTS
cM Map292.0UniSTS
Rbl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382157,175,121 - 157,175,548UniSTSGRCm38
MGSCv372157,000,857 - 157,001,284UniSTSGRCm37
Celera2163,108,902 - 163,109,329UniSTS
Cytogenetic Map2H1UniSTS
cM Map292.0UniSTS
Rbl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382157,146,091 - 157,146,732UniSTSGRCm38
MGSCv372156,971,827 - 156,972,468UniSTSGRCm37
Celera2163,079,950 - 163,080,591UniSTS
Cytogenetic Map2H1UniSTS
cM Map292.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001139516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006499018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF177028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL669828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U27177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U27178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U33320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000029170   ⟹   ENSMUSP00000029170
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2156,987,813 - 157,046,432 (-)Ensembl
GRCm38.p6 Ensembl2157,145,893 - 157,204,512 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124518
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2157,016,906 - 157,046,446 (-)Ensembl
GRCm38.p6 Ensembl2157,174,986 - 157,204,526 (-)Ensembl
Ensembl Acc Id: ENSMUST00000141296
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2157,030,183 - 157,034,303 (-)Ensembl
GRCm38.p6 Ensembl2157,188,263 - 157,192,383 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154721
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2157,008,898 - 157,046,454 (-)Ensembl
GRCm38.p6 Ensembl2157,166,978 - 157,204,534 (-)Ensembl
RefSeq Acc Id: NM_001139516   ⟹   NP_001132988
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392157,016,916 - 157,046,454 (-)NCBI
GRCm382157,174,996 - 157,204,534 (-)NCBI
MGSCv372156,971,629 - 157,030,270 (-)RGD
Celera2163,079,752 - 163,138,173 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011249   ⟹   NP_035379
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392156,987,813 - 157,046,454 (-)NCBI
GRCm382157,145,893 - 157,204,534 (-)ENTREZGENE
MGSCv372156,971,629 - 157,030,270 (-)RGD
Celera2163,079,752 - 163,138,173 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006499018   ⟹   XP_006499081
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392156,987,813 - 157,034,989 (-)NCBI
GRCm382157,145,893 - 157,193,069 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035379   ⟸   NM_011249
- Peptide Label: isoform 1
- UniProtKB: Q3U1D4 (UniProtKB/Swiss-Prot),   Q64701 (UniProtKB/Swiss-Prot),   Q6PAR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001132988   ⟸   NM_001139516
- Peptide Label: isoform 2
- UniProtKB: Q8CCD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006499081   ⟸   XM_006499018
- Peptide Label: isoform X1
- UniProtKB: Q6NTA5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000029170   ⟸   ENSMUST00000029170
Protein Domains
Cyclin-like   Retinoblastoma-associated protein A-box   Retinoblastoma-associated protein C-terminal   Retinoblastoma-associated protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64701-F1-model_v2 AlphaFold Q64701 1-1063 view protein structure

Promoters
RGD ID:6832322
Promoter ID:MM_KWN:32675
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:OTTMUST00000038715,   UC008NOT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362157,018,286 - 157,018,786 (-)MPROMDB
RGD ID:6832276
Promoter ID:MM_KWN:32676
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000038712,   OTTMUST00000038713,   OTTMUST00000038714
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362157,030,229 - 157,030,729 (-)MPROMDB
RGD ID:6879454
Promoter ID:EPDNEW_M3178
Type:initiation region
Name:Rbl1_1
Description:Mus musculus RB transcriptional corepressor like 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382157,204,526 - 157,204,586EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103300 AgrOrtholog
Ensembl Genes ENSMUSG00000027641 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029170 ENTREZGENE
  ENSMUST00000029170.8 UniProtKB/Swiss-Prot
  ENSMUST00000124518 ENTREZGENE
Gene3D-CATH 1.10.472.140 UniProtKB/Swiss-Prot
  Cyclin-like UniProtKB/Swiss-Prot
InterPro Cyclin-like UniProtKB/Swiss-Prot
  Cyclin-like_sf UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  RB_B UniProtKB/Swiss-Prot
  RB_C UniProtKB/Swiss-Prot
  RB_fam UniProtKB/Swiss-Prot
  RB_N UniProtKB/Swiss-Prot
KEGG Report mmu:19650 UniProtKB/Swiss-Prot
MGD MGI:103300 ENTREZGENE
NCBI Gene 19650 ENTREZGENE
PANTHER PTHR13742 UniProtKB/Swiss-Prot
  PTHR13742:SF20 UniProtKB/Swiss-Prot
Pfam DUF3452 UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  RB_B UniProtKB/Swiss-Prot
  Rb_C UniProtKB/Swiss-Prot
PhenoGen Rbl1 PhenoGen
SMART CYCLIN UniProtKB/Swiss-Prot
  DUF3452 UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  Rb_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot
UniProt Q3U1D4 ENTREZGENE
  Q3UI58_MOUSE UniProtKB/TrEMBL
  Q64701 ENTREZGENE
  Q6NTA5 ENTREZGENE, UniProtKB/TrEMBL
  Q6PAR4 ENTREZGENE, UniProtKB/TrEMBL
  Q8CCD4 ENTREZGENE, UniProtKB/TrEMBL
  RBL1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3U1D4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-13 Rbl1  RB transcriptional corepressor like 1    retinoblastoma-like 1 (p107)  Symbol and/or name change 5135510 APPROVED