Afg3l2 (AFG3-like AAA ATPase 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Afg3l2 (AFG3-like AAA ATPase 2) Mus musculus
Analyze
Symbol: Afg3l2
Name: AFG3-like AAA ATPase 2
RGD ID: 1313184
MGI Page MGI
Description: Predicted to enable metalloendopeptidase activity. Involved in protein autoprocessing. Acts upstream of or within several processes, including mitochondrion organization; nervous system development; and righting reflex. Located in mitochondrial inner membrane. Part of m-AAA complex. Is expressed in central nervous system and sensory organ. Used to study spinocerebellar ataxia type 28. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia; spastic ataxia 5; and spinocerebellar ataxia type 28. Orthologous to human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310036I02Rik; AFG3 (ATPase family gene 3)-like 2; AFG3(ATPase family gene 3)-like 2; AFG3-like protein 2; AW260507; Emv6; Emv66; mitochondrial inner membrane m-AAA protease component AFG3L2; par
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391867,537,830 - 67,582,277 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1867,537,834 - 67,582,242 (-)EnsemblGRCm39 Ensembl
GRCm381867,404,764 - 67,449,192 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1867,404,764 - 67,449,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv371867,564,418 - 67,608,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361867,530,647 - 67,573,748 (-)NCBIMGSCv36mm8
MGSCv361867,744,570 - 67,787,917 (-)NCBIMGSCv36mm8
Celera1868,681,846 - 68,732,097 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
m-AAA complex  (IBA,IDA)
membrane  (IEA)
mitochondrial inner membrane  (HDA,IDA,ISO)
mitochondrion  (HDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axon morphology  (IAGP)
abnormal Bergmann glial cell morphology  (IAGP)
abnormal brain white matter morphology  (IAGP)
abnormal cellular respiration  (IAGP)
abnormal cerebellar granule cell morphology  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal gait  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal melanoblast morphology  (IAGP)
abnormal miniature endplate potential  (IEA)
abnormal mitochondrial ATP synthesis coupled electron transport  (IAGP)
abnormal mitochondrial crista morphology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal mitochondrial shape  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal neuron mitochondrial morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal oligodendrocyte morphology  (IAGP)
abnormal oligodendrocyte physiology  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal Purkinje cell mitochondrial morphology  (IAGP)
abnormal reflex  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal spinal cord lateral motor column morphology  (IAGP)
abnormal spinal cord white matter morphology  (IAGP)
astrocytosis  (IAGP)
axon degeneration  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
decreased body fat mass  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased melanocyte number  (IAGP)
decreased motor neuron number  (IAGP)
decreased myelin sheath thickness  (IAGP)
decreased neuron number  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
decreased spinal cord size  (IAGP)
demyelination  (IAGP)
dilated mitochondrion  (IAGP)
dysmyelination  (IAGP)
gliosis  (IAGP)
impaired balance  (IAGP)
impaired coordination  (IAGP)
impaired righting response  (IAGP)
increased mitochondrial size  (IAGP)
increased myelin sheath thickness  (IAGP)
limb grasping  (IAGP)
microgliosis  (IAGP)
muscle weakness  (IAGP)
muscular atrophy  (IAGP)
neurodegeneration  (IAGP)
oxidative stress  (IAGP)
paralysis  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
progressive muscle weakness  (IAGP)
Purkinje cell degeneration  (IAGP)
thin cerebellar granule layer  (IAGP)
thin cerebellar molecular layer  (IAGP)
tremors  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Missense mutations in the AFG3L2 proteolytic domain account for approximately 1.5% of European autosomal dominant cerebellar ataxias. Cagnoli C, etal., Hum Mutat. 2010 Oct;31(10):1117-24. doi: 10.1002/humu.21342.
2. Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Di Bella D, etal., Nat Genet. 2010 Apr;42(4):313-21. doi: 10.1038/ng.544. Epub 2010 Mar 7.
3. Early onset and slow progression of SCA28, a rare dominant ataxia in a large four-generation family with a novel AFG3L2 mutation. Edener U, etal., Eur J Hum Genet. 2010 Aug;18(8):965-8. doi: 10.1038/ejhg.2010.40. Epub 2010 Mar 31.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model. Maltecca F, etal., J Clin Invest. 2015 Jan;125(1):263-74. doi: 10.1172/JCI74770. Epub 2014 Dec 8.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases. Pierson TM, etal., PLoS Genet. 2011 Oct;7(10):e1002325. doi: 10.1371/journal.pgen.1002325. Epub 2011 Oct 13.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Partial deletion of AFG3L2 causing spinocerebellar ataxia type 28. Smets K, etal., Neurology. 2014 Jun 10;82(23):2092-100. doi: 10.1212/WNL.0000000000000491. Epub 2014 May 9.
14. SCA28: Novel Mutation in the AFG3L2 Proteolytic Domain Causes a Mild Cerebellar Syndrome with Selective Type-1 Muscle Fiber Atrophy. Svenstrup K, etal., Cerebellum. 2016 Feb 11.
Additional References at PubMed
PMID:2917690   PMID:8642395   PMID:9455973   PMID:9678332   PMID:10349636   PMID:10498884   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12865426   PMID:14610273  
PMID:15489334   PMID:15782199   PMID:16033648   PMID:16141072   PMID:16141073   PMID:16916647   PMID:17101804   PMID:18337413   PMID:18614015   PMID:19289403   PMID:19625515   PMID:19656850  
PMID:20038678   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22678058   PMID:23041622   PMID:24681487   PMID:24856930   PMID:24906954   PMID:26504172   PMID:27642048   PMID:27689697  
PMID:27911893   PMID:28378742   PMID:29518331   PMID:30389403   PMID:30910913   PMID:30989755   PMID:31781336   PMID:32325033   PMID:33230847   PMID:34815492   PMID:36114006   PMID:36417873  
PMID:36604605  


Genomics

Comparative Map Data
Afg3l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391867,537,830 - 67,582,277 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1867,537,834 - 67,582,242 (-)EnsemblGRCm39 Ensembl
GRCm381867,404,764 - 67,449,192 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1867,404,764 - 67,449,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv371867,564,418 - 67,608,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361867,530,647 - 67,573,748 (-)NCBIMGSCv36mm8
MGSCv361867,744,570 - 67,787,917 (-)NCBIMGSCv36mm8
Celera1868,681,846 - 68,732,097 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.96NCBI
AFG3L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381812,328,944 - 12,377,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1812,328,944 - 12,377,227 (-)EnsemblGRCh38hg38GRCh38
GRCh371812,328,943 - 12,377,226 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361812,319,108 - 12,367,194 (-)NCBINCBI36Build 36hg18NCBI36
Build 341812,319,107 - 12,367,194NCBI
Celera1812,209,592 - 12,258,040 (-)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1812,282,720 - 12,330,985 (-)NCBIHuRef
CHM1_11812,328,344 - 12,376,662 (-)NCBICHM1_1
T2T-CHM13v2.01812,491,960 - 12,540,204 (-)NCBIT2T-CHM13v2.0
Afg3l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81863,224,163 - 63,269,000 (-)NCBIGRCr8
mRatBN7.21860,954,268 - 60,999,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1860,954,268 - 60,999,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1863,024,645 - 63,069,520 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,723,408 - 63,768,273 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,575,667 - 61,620,477 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01863,141,418 - 63,185,510 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1863,141,418 - 63,185,510 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01862,325,697 - 62,369,789 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41863,930,652 - 63,976,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11864,004,342 - 64,049,237 (-)NCBI
Celera1859,060,862 - 59,105,674 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
Afg3l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554021,037,402 - 1,069,165 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554021,037,414 - 1,069,165 (+)NCBIChiLan1.0ChiLan1.0
AFG3L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21725,668,723 - 25,717,054 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11811,361,288 - 11,409,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0181,951,279 - 1,999,313 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11817,062,250 - 17,109,400 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1817,062,250 - 17,109,400 (+)Ensemblpanpan1.1panPan2
AFG3L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1777,749,029 - 77,787,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl777,737,808 - 77,787,472 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha777,150,018 - 77,188,528 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0777,807,611 - 77,846,122 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl777,807,620 - 77,846,169 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1777,504,323 - 77,543,062 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0777,551,535 - 77,590,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0777,837,991 - 77,876,512 (-)NCBIUU_Cfam_GSD_1.0
Afg3l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404944922,646 - 961,521 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936626150,974 - 189,218 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936626150,953 - 189,980 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AFG3L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl697,200,922 - 97,235,366 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1697,200,890 - 97,234,577 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2690,816,080 - 90,833,767 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AFG3L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11870,890,939 - 70,939,504 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1870,891,554 - 70,939,352 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605045,917,807 - 45,966,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Afg3l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477019,591,215 - 19,631,722 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477019,590,829 - 19,631,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Afg3l2
1757 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:180
Interacting mature miRNAs:191
Transcripts:ENSMUST00000025408
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
12910791Pwgrq8_mpre-weaning growth rate QTL 8 (mouse)185802139969349142Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184513060468778777Mouse
12798542Ett1_mexperimentally induced testicular teratoma 1 (mouse)186667414968668468Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
4142239Idd21.2_minsulin dependent diabetes susceptibility 21.2 (mouse)Not determined186127244874562414Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
1302050Radpf4_mradiation pulmonary fibrosis 4 (mouse)Not determined185296615668778777Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
1301798Hdlq31_mHDL QTL 31 (mouse)Not determined186714438990720763Mouse
11039518Ltpr8_mLeishmania tropica response 8 (mouse)186387490376180241Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse

Markers in Region
AW260507  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381867,404,995 - 67,405,085UniSTSGRCm38
MGSCv371867,564,649 - 67,564,739UniSTSGRCm37
Celera1868,682,077 - 68,682,167UniSTS
Cytogenetic Map18E1UniSTS
Whitehead/MRC_RH18844.81UniSTS
1810073H04Rik  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E1UniSTS
Cytogenetic Map19C3UniSTS
cM Map19 UniSTS
Afg3l2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E1UniSTS
cM Map18 UniSTS
D8Mit9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,706,614 - 71,706,763UniSTSGRCm38
MGSCv37874,230,513 - 74,230,662UniSTSGRCm37
Celera874,221,040 - 74,221,189UniSTS
Celera1868,727,326 - 68,728,208UniSTS
Cytogenetic Map18E1UniSTS
cM Map833.5UniSTS
Whitehead Genetic835.0UniSTS
Whitehead_YAC8 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_027130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC154125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB871099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB885617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC928508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC943026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000025408   ⟹   ENSMUSP00000025408
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1867,537,834 - 67,582,242 (-)Ensembl
GRCm38.p6 Ensembl1867,404,764 - 67,449,172 (-)Ensembl
Ensembl Acc Id: ENSMUST00000235409
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1867,566,921 - 67,582,177 (-)Ensembl
GRCm38.p6 Ensembl1867,433,851 - 67,449,107 (-)Ensembl
Ensembl Acc Id: ENSMUST00000236810
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1867,577,516 - 67,582,179 (-)Ensembl
GRCm38.p6 Ensembl1867,444,446 - 67,449,109 (-)Ensembl
Ensembl Acc Id: ENSMUST00000237178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1867,542,153 - 67,569,018 (-)Ensembl
GRCm38.p6 Ensembl1867,409,083 - 67,435,948 (-)Ensembl
RefSeq Acc Id: NM_027130   ⟹   NP_081406
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391867,537,834 - 67,582,262 (-)NCBI
GRCm381867,404,764 - 67,449,192 (-)NCBI
MGSCv371867,564,418 - 67,608,790 (-)RGD
Celera1868,681,846 - 68,732,097 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011246998   ⟹   XP_011245300
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391867,537,830 - 67,581,954 (-)NCBI
GRCm381867,404,764 - 67,448,884 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161273   ⟹   XP_036017166
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391867,537,830 - 67,582,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161274   ⟹   XP_036017167
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391867,537,830 - 67,581,954 (-)NCBI
Sequence:
RefSeq Acc Id: NP_081406   ⟸   NM_027130
- UniProtKB: Q8JZQ2 (UniProtKB/Swiss-Prot),   Q3U7C0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011245300   ⟸   XM_011246998
- Peptide Label: isoform X1
- UniProtKB: Q3U7C0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000025408   ⟸   ENSMUST00000025408
RefSeq Acc Id: XP_036017166   ⟸   XM_036161273
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036017167   ⟸   XM_036161274
- Peptide Label: isoform X2
Protein Domains
AAA+ ATPase   Peptidase M41   Peptidase M41 FtsH extracellular

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8JZQ2-F1-model_v2 AlphaFold Q8JZQ2 1-802 view protein structure

Promoters
RGD ID:13678070
Promoter ID:EPDNEW_M23184
Type:initiation region
Name:Afg3l2_1
Description:Mus musculus AFG3-like AAA ATPase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381867,449,171 - 67,449,231EPDNEW
RGD ID:6829036
Promoter ID:MM_KWN:25594
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:UC008FMG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361867,596,246 - 67,596,746 (-)MPROMDB
RGD ID:6829038
Promoter ID:MM_KWN:25595
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000025408,   UC008FMH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361867,608,509 - 67,609,009 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916847 AgrOrtholog
Ensembl Genes ENSMUSG00000024527 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025408 ENTREZGENE
  ENSMUST00000025408.10 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.760 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1690.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-dep_Zn_Metalloprotease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FtsH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M41_FtsH_extracell UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M41-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:69597 UniProtKB/Swiss-Prot
MGD MGI:1916847 ENTREZGENE
NCBI Gene 69597 ENTREZGENE
PANTHER AFG3-LIKE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-DEPENDENT PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FtsH_ext UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Afg3l2 PhenoGen
PROSITE AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF140990 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AFG32_MOUSE UniProtKB/Swiss-Prot
  Q3U7C0 ENTREZGENE, UniProtKB/TrEMBL
  Q3UDQ7_MOUSE UniProtKB/TrEMBL
  Q8JZQ2 ENTREZGENE
  Q8R5F1_MOUSE UniProtKB/TrEMBL
  Q9D736_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-10 Afg3l2  AFG3-like AAA ATPase 2    AFG3(ATPase family gene 3)-like 2 (yeast)  Symbol and/or name change 5135510 APPROVED