Prorp (protein only RNase P catalytic subunit) - Rat Genome Database

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Gene: Prorp (protein only RNase P catalytic subunit) Mus musculus
Analyze
Symbol: Prorp
Name: protein only RNase P catalytic subunit
RGD ID: 1312914
MGI Page MGI
Description: Predicted to enable ribonuclease P activity. Predicted to be involved in mitochondrial tRNA 5'-end processing and tRNA 5'-leader removal. Located in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 54. Orthologous to human PRORP (protein only RNase P catalytic subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110008L16Rik; KIAA0391; mitochondrial ribonuclease P catalytic subunit; mitochondrial ribonuclease P protein 3; mitochondrial RNase P protein 3; mKIAA0391; Mr; Mrpp3; RIKEN cDNA 1110008L16 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,349,422 - 55,429,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,346,362 - 55,429,318 (+)EnsemblGRCm39 Ensembl
GRCm381255,302,637 - 55,382,492 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,299,577 - 55,382,533 (+)EnsemblGRCm38mm10GRCm38
MGSCv371256,403,624 - 56,483,478 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361256,220,753 - 56,300,617 (+)NCBIMGSCv36mm8
Celera1256,446,616 - 56,531,738 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1223.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15368895   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:18799693   PMID:21267068   PMID:21873635   PMID:24703694   PMID:27498866   PMID:28201688   PMID:29222160   PMID:32325033  


Genomics

Comparative Map Data
Prorp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,349,422 - 55,429,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,346,362 - 55,429,318 (+)EnsemblGRCm39 Ensembl
GRCm381255,302,637 - 55,382,492 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,299,577 - 55,382,533 (+)EnsemblGRCm38mm10GRCm38
MGSCv371256,403,624 - 56,483,478 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361256,220,753 - 56,300,617 (+)NCBIMGSCv36mm8
Celera1256,446,616 - 56,531,738 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1223.91NCBI
PRORP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381435,121,839 - 35,277,622 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1435,121,846 - 35,277,622 (+)EnsemblGRCh38hg38GRCh38
GRCh371435,591,045 - 35,746,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,661,527 - 34,813,022 (+)NCBINCBI36Build 36hg18NCBI36
Celera1415,455,607 - 15,607,100 (+)NCBICelera
Cytogenetic Map14q13.2NCBI
HuRef1415,704,222 - 15,857,638 (+)NCBIHuRef
CHM1_11435,591,261 - 35,743,020 (+)NCBICHM1_1
T2T-CHM13v2.01429,318,793 - 29,465,226 (+)NCBIT2T-CHM13v2.0
Prorp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,404,821 - 78,497,562 (+)NCBIGRCr8
mRatBN7.2672,669,659 - 72,762,419 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,670,847 - 72,762,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,093,590 - 73,182,668 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,399,942 - 73,489,024 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0672,828,549 - 72,917,703 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,079,880 - 76,171,298 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,079,880 - 76,171,296 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,614,276 - 85,708,817 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,539,870 - 75,633,118 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1675,543,495 - 75,636,184 (+)NCBI
Celera671,512,144 - 71,602,932 (+)NCBICelera
Cytogenetic Map6q23NCBI
Prorp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540925,791,575 - 25,920,077 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540925,791,209 - 25,920,651 (-)NCBIChiLan1.0ChiLan1.0
PRORP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21536,432,152 - 36,590,190 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11435,648,655 - 35,808,108 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01415,871,707 - 16,027,634 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11434,056,234 - 34,209,657 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1434,056,620 - 34,209,657 (+)Ensemblpanpan1.1panPan2
PRORP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1813,885,734 - 14,007,224 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha813,681,902 - 13,803,857 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0813,991,929 - 14,113,298 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl813,992,144 - 14,113,292 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1813,693,596 - 13,814,946 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0813,758,157 - 13,879,746 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0814,047,450 - 14,169,639 (+)NCBIUU_Cfam_GSD_1.0
Prorp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864045,776,936 - 45,908,465 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364949,282,894 - 9,414,350 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRORP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,620,517 - 64,762,428 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1764,620,514 - 64,763,272 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,530,089 - 69,535,675 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRORP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12411,936,410 - 12,081,721 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2411,936,410 - 12,083,519 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666053897,654 - 1,044,936 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prorp
2650 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:569
Count of miRNA genes:175
Interacting mature miRNAs:180
Transcripts:ENSMUST00000021411, ENSMUST00000183475, ENSMUST00000183654, ENSMUST00000184249, ENSMUST00000184766, ENSMUST00000184980
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904004Opfaq11_mopen field activity QTL 11 (mouse)125315562457276756Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
12903999Opfaq8_mopen field activity QTL 8 (mouse)125490765357870585Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse

Markers in Region
BB305285  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381255,382,338 - 55,382,454UniSTSGRCm38
MGSCv371256,483,325 - 56,483,441UniSTSGRCm37
Celera1256,531,558 - 56,531,701UniSTS
Cytogenetic Map12C1UniSTS
Whitehead/MRC_RH12567.07UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000021411   ⟹   ENSMUSP00000021411
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1255,349,422 - 55,429,281 (+)Ensembl
GRCm38.p6 Ensembl1255,302,637 - 55,382,496 (+)Ensembl
Ensembl Acc Id: ENSMUST00000183475   ⟹   ENSMUSP00000139252
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1255,350,046 - 55,429,318 (+)Ensembl
GRCm38.p6 Ensembl1255,303,261 - 55,382,533 (+)Ensembl
Ensembl Acc Id: ENSMUST00000183654   ⟹   ENSMUSP00000138821
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1255,350,071 - 55,429,298 (+)Ensembl
GRCm38.p6 Ensembl1255,303,286 - 55,382,513 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184249
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1255,349,535 - 55,354,374 (+)Ensembl
GRCm38.p6 Ensembl1255,302,750 - 55,307,589 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184766   ⟹   ENSMUSP00000139204
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1255,350,028 - 55,429,298 (+)Ensembl
GRCm38.p6 Ensembl1255,303,243 - 55,382,513 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184980   ⟹   ENSMUSP00000139123
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1255,346,362 - 55,429,205 (+)Ensembl
GRCm38.p6 Ensembl1255,299,577 - 55,382,420 (+)Ensembl
RefSeq Acc Id: NM_025373   ⟹   NP_079649
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391255,349,422 - 55,429,276 (+)NCBI
GRCm381255,302,637 - 55,382,491 (+)NCBI
MGSCv371256,403,624 - 56,483,478 (+)RGD
Celera1256,446,616 - 56,531,738 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_079649   ⟸   NM_025373
- Peptide Label: precursor
- UniProtKB: Q9CTH1 (UniProtKB/Swiss-Prot),   Q8BSN8 (UniProtKB/Swiss-Prot),   Q6A076 (UniProtKB/Swiss-Prot),   Q9D7W9 (UniProtKB/Swiss-Prot),   Q8JZY4 (UniProtKB/Swiss-Prot),   V9GXP4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000139123   ⟸   ENSMUST00000184980
Ensembl Acc Id: ENSMUSP00000139204   ⟸   ENSMUST00000184766
Ensembl Acc Id: ENSMUSP00000139252   ⟸   ENSMUST00000183475
Ensembl Acc Id: ENSMUSP00000138821   ⟸   ENSMUST00000183654
Ensembl Acc Id: ENSMUSP00000021411   ⟸   ENSMUST00000021411
Protein Domains
PRORP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8JZY4-F1-model_v2 AlphaFold Q8JZY4 1-584 view protein structure

Promoters
RGD ID:8678294
Promoter ID:EPDNEW_M17178
Type:multiple initiation site
Name:1110008L16Rik_1
Description:Mus musculus RIKEN cDNA 1110008L16 gene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381255,303,256 - 55,303,316EPDNEW
RGD ID:6822527
Promoter ID:MM_KWN:11678
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_025373,   UC007NOO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361256,402,841 - 56,404,377 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913382 AgrOrtholog
Ensembl Genes ENSMUSG00000021023 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021411 ENTREZGENE
  ENSMUST00000021411.15 UniProtKB/Swiss-Prot
  ENSMUST00000183475.8 UniProtKB/TrEMBL
  ENSMUST00000183654.2 UniProtKB/TrEMBL
  ENSMUST00000184766.8 UniProtKB/Swiss-Prot
  ENSMUST00000184980.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.11980 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MRPP3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRORP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66132 UniProtKB/Swiss-Prot
MGD MGI:1913382 ENTREZGENE
NCBI Gene 66132 ENTREZGENE
PANTHER PTHR13547:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PRORP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prorp PhenoGen
UniProt MRPP3_MOUSE UniProtKB/Swiss-Prot
  Q6A076 ENTREZGENE
  Q8BSN8 ENTREZGENE
  Q8JZY4 ENTREZGENE
  Q9CTH1 ENTREZGENE
  Q9D7W9 ENTREZGENE
  V9GWT5_MOUSE UniProtKB/TrEMBL
  V9GXF2_MOUSE UniProtKB/TrEMBL
  V9GXP4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6A076 UniProtKB/Swiss-Prot
  Q8BSN8 UniProtKB/Swiss-Prot
  Q9CTH1 UniProtKB/Swiss-Prot
  Q9D7W9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-14 Prorp  protein only RNase P catalytic subunit  1110008L16Rik  RIKEN cDNA 1110008L16 gene  Symbol and/or name change 5135510 APPROVED