Ezh1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) - Rat Genome Database

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Gene: Ezh1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) Mus musculus
Analyze
Symbol: Ezh1
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
RGD ID: 1312814
MGI Page MGI
Description: Enables histone H3K27 methyltransferase activity and transcription corepressor activity. Contributes to histone binding activity. Involved in facultative heterochromatin formation; negative regulation of transcription by RNA polymerase II; and subtelomeric heterochromatin formation. Acts upstream of or within hepatocyte homeostasis; liver regeneration; and response to tetrachloromethane. Located in chromosome, telomeric region and nucleus. Part of ESC/E(Z) complex and heterochromatin. Is expressed in several structures, including genitourinary system; immune system; retina nuclear layer; tail; and trunk. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AW557915; enhancer of zeste homolog 1; ENX-2; histone-lysine N-methyltransferase EZH1; mKIAA0388
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,081,941 - 101,117,268 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,081,941 - 101,117,289 (-)EnsemblGRCm39 Ensembl
GRCm3811101,191,115 - 101,226,463 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,191,115 - 101,226,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,052,429 - 101,087,764 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,007,206 - 101,044,038 (-)NCBIMGSCv36mm8
Celera11112,487,231 - 112,522,681 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, etal., Trends Biochem Sci. 2013 Dec;38(12):621-39. doi: 10.1016/j.tibs.2013.09.004. Epub 2013 Oct 20.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
Additional References at PubMed
PMID:8921387   PMID:9214638   PMID:9473645   PMID:9584197   PMID:10051331   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11390661   PMID:11471062   PMID:12465718  
PMID:12477932   PMID:12589020   PMID:12781685   PMID:14610273   PMID:15226823   PMID:15733677   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18287559   PMID:18799693   PMID:19026780  
PMID:19026781   PMID:19303854   PMID:20059953   PMID:20064376   PMID:20144788   PMID:20227405   PMID:21122108   PMID:21317239   PMID:21677750   PMID:21873635   PMID:22042701   PMID:22158708  
PMID:22196887   PMID:22267199   PMID:22312437   PMID:22438827   PMID:23122289   PMID:23673358   PMID:23932971   PMID:24352422   PMID:25477280   PMID:25680957   PMID:25687760   PMID:26219303  
PMID:26621269   PMID:26994968   PMID:27414999   PMID:27526204   PMID:27626380   PMID:27823969   PMID:27897169   PMID:28049658   PMID:28254491   PMID:28512107   PMID:29342143   PMID:29523590  
PMID:30099093   PMID:30396150   PMID:30522506   PMID:30689973   PMID:31189531   PMID:31451685   PMID:32428001   PMID:32554463   PMID:32820269   PMID:32937136   PMID:33678755   PMID:34368113  
PMID:34531374   PMID:34994686   PMID:35084365   PMID:35212626   PMID:35796552   PMID:37105173   PMID:37435868   PMID:38355793   PMID:38419656   PMID:38529784  


Genomics

Comparative Map Data
Ezh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,081,941 - 101,117,268 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,081,941 - 101,117,289 (-)EnsemblGRCm39 Ensembl
GRCm3811101,191,115 - 101,226,463 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,191,115 - 101,226,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,052,429 - 101,087,764 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,007,206 - 101,044,038 (-)NCBIMGSCv36mm8
Celera11112,487,231 - 112,522,681 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.37NCBI
EZH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,700,275 - 42,745,040 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,700,275 - 42,745,049 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,852,293 - 40,897,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,105,819 - 38,150,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 341738,105,819 - 38,150,574NCBI
Celera1737,507,762 - 37,552,422 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,617,368 - 36,662,170 (-)NCBIHuRef
CHM1_11741,087,908 - 41,132,634 (-)NCBICHM1_1
T2T-CHM13v2.01743,557,412 - 43,602,180 (-)NCBIT2T-CHM13v2.0
Ezh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,626,307 - 86,662,257 (-)NCBIGRCr8
mRatBN7.21086,126,023 - 86,162,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,126,015 - 86,161,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,162,463 - 91,188,804 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,641,259 - 90,667,579 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,034,424 - 86,060,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,104,026 - 89,139,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,104,027 - 89,130,339 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,902,522 - 88,938,413 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,211,249 - 90,237,563 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,227,546 - 90,252,203 (-)NCBI
Celera1084,843,423 - 84,869,785 (-)NCBICelera
Cytogenetic Map10q31NCBI
Ezh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,548,858 - 16,564,310 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,548,898 - 16,563,449 (-)NCBIChiLan1.0ChiLan1.0
EZH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,240,711 - 22,285,877 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,130,797 - 24,175,862 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,572,868 - 14,618,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,814,061 - 14,842,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,814,054 - 14,842,295 (+)Ensemblpanpan1.1panPan2
EZH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,271,729 - 20,292,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,264,552 - 20,290,712 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,724,769 - 19,754,876 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,981,842 - 21,011,945 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,981,878 - 21,011,945 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,767,995 - 19,797,890 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,032,956 - 20,063,052 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,136,953 - 20,167,063 (+)NCBIUU_Cfam_GSD_1.0
Ezh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,609,211 - 19,644,761 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,428,677 - 17,465,877 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,430,383 - 17,465,889 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EZH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,115,297 - 20,141,749 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,107,744 - 20,139,764 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,304,800 - 20,338,128 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EZH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,544,483 - 63,592,651 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,558,551 - 63,587,501 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,337,734 - 34,385,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ezh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,454,361 - 1,470,079 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ezh1
792 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2967
Count of miRNA genes:840
Interacting mature miRNAs:1115
Transcripts:ENSMUST00000100417, ENSMUST00000107284, ENSMUST00000107285, ENSMUST00000128974, ENSMUST00000134622, ENSMUST00000138835, ENSMUST00000146884, ENSMUST00000151291, ENSMUST00000154211
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
AW557915  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,191,619 - 101,191,706UniSTSGRCm38
MGSCv3711101,052,933 - 101,053,020UniSTSGRCm37
Celera11112,487,735 - 112,487,822UniSTS
Cytogenetic Map11C-DUniSTS
Whitehead/MRC_RH111350.0UniSTS
AB004817  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,191,687 - 101,191,835UniSTSGRCm38
MGSCv3711101,053,001 - 101,053,149UniSTSGRCm37
Celera11112,487,803 - 112,487,951UniSTS
Cytogenetic Map11C-DUniSTS
Whitehead/MRC_RH111352.86UniSTS
UniSTS:236736  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,224,359 - 101,224,584UniSTSGRCm38
MGSCv3711101,085,673 - 101,085,898UniSTSGRCm37
Celera11112,520,590 - 112,520,815UniSTS
Cytogenetic Map11C-DUniSTS
UniSTS:236745  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,224,897 - 101,225,039UniSTSGRCm38
MGSCv3711101,086,211 - 101,086,353UniSTSGRCm37
Celera11112,521,128 - 112,521,270UniSTS
Cytogenetic Map11C-DUniSTS
Ezh1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,209,631 - 101,209,834UniSTSGRCm38
MGSCv3711101,070,945 - 101,071,148UniSTSGRCm37
Celera11112,505,852 - 112,506,055UniSTS
Cytogenetic Map11C-DUniSTS
cM Map1162.0UniSTS
PMC108938P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,192,437 - 101,192,953UniSTSGRCm38
MGSCv3711101,053,751 - 101,054,267UniSTSGRCm37
Celera11112,488,553 - 112,489,069UniSTS
Cytogenetic Map11C-DUniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
MARC_15753-15754:1017935735:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,193,767 - 101,194,528UniSTSGRCm38
MGSCv3711101,055,081 - 101,055,842UniSTSGRCm37
Celera11112,489,883 - 112,490,644UniSTS
Cytogenetic Map11C-DUniSTS
BARC0021  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,194,476 - 101,194,951UniSTSGRCm38
MGSCv3711101,055,790 - 101,056,265UniSTSGRCm37
Celera11112,490,592 - 112,491,067UniSTS
Cytogenetic Map11C-DUniSTS
Ezh1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11C-DUniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001403807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB004817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF104360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF483490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF483491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ033903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000100417   ⟹   ENSMUSP00000097984
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,088,215 - 101,117,252 (-)Ensembl
GRCm38.p6 Ensembl11101,197,389 - 101,226,426 (-)Ensembl
Ensembl Acc Id: ENSMUST00000107284   ⟹   ENSMUSP00000102905
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,081,941 - 101,117,289 (-)Ensembl
GRCm38.p6 Ensembl11101,191,115 - 101,226,463 (-)Ensembl
Ensembl Acc Id: ENSMUST00000107285   ⟹   ENSMUSP00000102906
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,081,942 - 101,117,276 (-)Ensembl
GRCm38.p6 Ensembl11101,191,116 - 101,226,450 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128974
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,090,129 - 101,101,404 (-)Ensembl
GRCm38.p6 Ensembl11101,199,303 - 101,210,578 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134622
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,084,101 - 101,085,248 (-)Ensembl
GRCm38.p6 Ensembl11101,193,275 - 101,194,422 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138835
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,084,556 - 101,094,131 (-)Ensembl
GRCm38.p6 Ensembl11101,193,730 - 101,203,305 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146884
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,089,464 - 101,091,769 (-)Ensembl
GRCm38.p6 Ensembl11101,198,638 - 101,200,943 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151291
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,109,221 - 101,117,268 (-)Ensembl
GRCm38.p6 Ensembl11101,218,395 - 101,226,442 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154211
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,098,480 - 101,100,231 (-)Ensembl
GRCm38.p6 Ensembl11101,207,654 - 101,209,405 (-)Ensembl
RefSeq Acc Id: NM_001403807   ⟹   NP_001390736
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,081,941 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403809   ⟹   NP_001390738
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,081,941 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403810   ⟹   NP_001390739
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,081,941 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403811   ⟹   NP_001390740
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,081,941 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403812   ⟹   NP_001390741
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,081,941 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403813   ⟹   NP_001390742
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,088,220 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403814   ⟹   NP_001390743
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,088,220 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403815   ⟹   NP_001390744
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,088,220 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403816   ⟹   NP_001390745
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,088,220 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403818   ⟹   NP_001390747
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,088,220 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403821   ⟹   NP_001390750
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,081,941 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_001403822   ⟹   NP_001390751
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,081,941 - 101,117,268 (-)NCBI
RefSeq Acc Id: NM_007970   ⟹   NP_031996
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,081,941 - 101,117,268 (-)NCBI
GRCm3811101,191,115 - 101,226,463 (-)NCBI
MGSCv3711101,052,429 - 101,087,764 (-)RGD
Celera11112,487,231 - 112,522,694 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001390736 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390738 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390739 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390740 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390741 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390742 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390743 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390744 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390745 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390747 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390750 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390751 (Get FASTA)   NCBI Sequence Viewer  
  NP_031996 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53279 (Get FASTA)   NCBI Sequence Viewer  
  AAD54021 (Get FASTA)   NCBI Sequence Viewer  
  AAH07135 (Get FASTA)   NCBI Sequence Viewer  
  AAL90764 (Get FASTA)   NCBI Sequence Viewer  
  AAL90765 (Get FASTA)   NCBI Sequence Viewer  
  BAA25018 (Get FASTA)   NCBI Sequence Viewer  
  BAC32334 (Get FASTA)   NCBI Sequence Viewer  
  BAE23827 (Get FASTA)   NCBI Sequence Viewer  
  BAE24446 (Get FASTA)   NCBI Sequence Viewer  
  BAE32680 (Get FASTA)   NCBI Sequence Viewer  
  BAE37674 (Get FASTA)   NCBI Sequence Viewer  
  EDL03898 (Get FASTA)   NCBI Sequence Viewer  
  EDL03899 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000097984
  ENSMUSP00000097984.3
  ENSMUSP00000102905
  ENSMUSP00000102905.2
  ENSMUSP00000102906
  ENSMUSP00000102906.2
GenBank Protein P70351 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031996   ⟸   NM_007970
- Peptide Label: isoform 1
- UniProtKB: A0A0R4J1C0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000102905   ⟸   ENSMUST00000107284
Ensembl Acc Id: ENSMUSP00000102906   ⟸   ENSMUST00000107285
Ensembl Acc Id: ENSMUSP00000097984   ⟸   ENSMUST00000100417
RefSeq Acc Id: NP_001390740   ⟸   NM_001403811
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001390741   ⟸   NM_001403812
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001390736   ⟸   NM_001403807
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001390739   ⟸   NM_001403810
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001390751   ⟸   NM_001403822
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001390738   ⟸   NM_001403809
- Peptide Label: isoform 3
- UniProtKB: Q922L1 (UniProtKB/Swiss-Prot),   Q8BR85 (UniProtKB/Swiss-Prot),   Q3UU02 (UniProtKB/Swiss-Prot),   Q3U3V5 (UniProtKB/Swiss-Prot),   Q3TPR1 (UniProtKB/Swiss-Prot),   P70351 (UniProtKB/Swiss-Prot),   A2A4K5 (UniProtKB/Swiss-Prot),   Q9R089 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001390750   ⟸   NM_001403821
- Peptide Label: isoform 1
- UniProtKB: A0A0R4J1C0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001390745   ⟸   NM_001403816
- Peptide Label: isoform 10
RefSeq Acc Id: NP_001390747   ⟸   NM_001403818
- Peptide Label: isoform 11
RefSeq Acc Id: NP_001390743   ⟸   NM_001403814
- Peptide Label: isoform 8
RefSeq Acc Id: NP_001390742   ⟸   NM_001403813
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001390744   ⟸   NM_001403815
- Peptide Label: isoform 9
Protein Domains
CXC   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70351-F1-model_v2 AlphaFold P70351 1-747 view protein structure

Promoters
RGD ID:6820846
Promoter ID:MM_KWN:9860
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:OTTMUST00000005493
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,055,409 - 101,055,909 (-)MPROMDB
RGD ID:6820847
Promoter ID:MM_KWN:9861
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:OTTMUST00000005494
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,062,271 - 101,062,771 (-)MPROMDB
RGD ID:6820853
Promoter ID:MM_KWN:9866
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000107284,   OTTMUST00000005490,   UC007LNW.1,   UC007LNX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,087,424 - 101,087,924 (-)MPROMDB
RGD ID:8676776
Promoter ID:EPDNEW_M16418
Type:multiple initiation site
Name:Ezh1_1
Description:Mus musculus enhancer of zeste 1 polycomb repressive complex2 subunit , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811101,226,426 - 101,226,486EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1097695 AgrOrtholog
Ensembl Genes ENSMUSG00000006920 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000100417 ENTREZGENE
  ENSMUST00000100417.3 UniProtKB/Swiss-Prot
  ENSMUST00000107284 ENTREZGENE
  ENSMUST00000107284.8 UniProtKB/Swiss-Prot
  ENSMUST00000107285 ENTREZGENE
  ENSMUST00000107285.8 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CXC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH1/2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH1/2_MCSS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH1/EZH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH1_SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRC2_HTH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pre-SET_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT/Myb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tesmin/TSO1-like_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14055 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1097695 ENTREZGENE
NCBI Gene 14055 ENTREZGENE
PANTHER PTHR45747 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45747:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ezh2_MCSS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH2_WD-Binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRC2_HTH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  preSET_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ezh1 PhenoGen
PROSITE CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF82199 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1C0 ENTREZGENE, UniProtKB/TrEMBL
  A2A4K5 ENTREZGENE
  EZH1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TPR1 ENTREZGENE
  Q3U3V5 ENTREZGENE
  Q3UU02 ENTREZGENE
  Q8BR85 ENTREZGENE
  Q922L1 ENTREZGENE
  Q9R089 ENTREZGENE
UniProt Secondary A2A4K5 UniProtKB/Swiss-Prot
  Q3TPR1 UniProtKB/Swiss-Prot
  Q3U3V5 UniProtKB/Swiss-Prot
  Q3UU02 UniProtKB/Swiss-Prot
  Q8BR85 UniProtKB/Swiss-Prot
  Q922L1 UniProtKB/Swiss-Prot
  Q9R089 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 Ezh1  enhancer of zeste 1 polycomb repressive complex 2 subunit    enhancer of zeste homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED