Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | RGD:1312687 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:22235133 more ... | Ige Responsiveness, Atopic | | ISO | RGD:1312687 | 8554872 | ClinVar more ... | ClinVar | PMID:12700598 more ... | immunodeficiency 31C | | ISO | RGD:1312687 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency 31C | ClinVar | PMID:25741868 | immunodeficiency 56 | | ISO | RGD:1312687 | 8554872 | ClinVar Annotator: match by term: IL21R immunodeficiency | ClinVar | PMID:16199547 more ... | neuronal ceroid lipofuscinosis | | ISO | RGD:1312687 | 8554872 | ClinVar Annotator: match by term: Neuronal ceroid lipofuscinosis | ClinVar | PMID:28492532 more ... | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
Imported Disease Annotations - OMIM
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. | Bubier JA, etal., Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1518-23. Epub 2009 Jan 21. |
| 2. | IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. | Frohlich A, etal., Science. 2009 Jun 19;324(5934):1576-80. Epub 2009 May 28. |
| 3. | Regulatory dendritic cells protect against allergic airway inflammation in a murine asthmatic model. | Fujita S, etal., J Allergy Clin Immunol. 2008 Jan;121(1):95-104.e7. Epub 2007 Oct 17. |
| 4. | Critical role of IL-21 in modulating TH17 and regulatory T cells in Behcet disease. | Geri G, etal., J Allergy Clin Immunol. 2011 Sep;128(3):655-64. Epub 2011 Jul 2. |
| 5. | Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. | Hanash AM, etal., Blood. 2011 Jul 14;118(2):446-55. Epub 2011 May 19. |
| 6. | A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice. | Jang E, etal., J Immunol. 2009 Apr 15;182(8):4649-56. |
| 7. | IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. | Jin H, etal., J Clin Invest. 2009 Jan;119(1):47-60. doi: 10.1172/JCI32310. Epub 2008 Dec 15. |
| 8. | Upregulated IL-21 and IL-21 receptor expression is involved in experimental autoimmune uveitis (EAU). | Liu L, etal., Mol Vis. 2009 Dec 31;15:2938-44. |
| 9. | IL-21 receptor expression determines the temporal phases of experimental autoimmune encephalomyelitis. | Liu R, etal., Exp Neurol. 2008 May;211(1):14-24. Epub 2007 Nov 22. |
| 10. | Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease. | Liu Z, etal., Inflamm Bowel Dis. 2009 Aug;15(8):1133-44. |
| 11. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 12. | MGD IEA | MGD IEA |
| 13. | Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. | Nimmo ER, etal., Inflamm Bowel Dis. 2012 May;18(5):889-99. doi: 10.1002/ibd.21912. Epub 2011 Oct 21. |
| 14. | RGMA and IL21R show association with experimental inflammation and multiple sclerosis. | Nohra R, etal., Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14. |
| 15. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 16. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 17. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 18. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 19. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 20. | Immune activation and increased IL-21R expression are associated with the loss of memory B cells during HIV-1 infection. | Ruffin N, etal., J Intern Med. 2012 Apr 24. doi: 10.1111/j.1365-2796.2012.02550.x. |
| 21. | Screening of functional and positional candidate genes in families with common variable immunodeficiency. | Salzer U, etal., BMC Immunol. 2008 Feb 7;9:3. |
| 22. | IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. | Sonderegger I, etal., Eur J Immunol. 2008 Jul;38(7):1833-8. |
| 23. | IL-21 promotes the pathologic immune response to pneumovirus infection. | Spolski R, etal., J Immunol. 2012 Feb 15;188(4):1924-32. Epub 2012 Jan 11. |
| 24. | Interleukin-21 is required for the development of type 1 diabetes in NOD mice. | Sutherland AP, etal., Diabetes. 2009 May;58(5):1144-55. Epub 2009 Feb 10. |
| 25. | Interleukin-21 modulates Th1 and Th17 responses in giant cell arteritis. | Terrier B, etal., Arthritis Rheum. 2012 Jun;64(6):2001-11. doi: 10.1002/art.34327. Epub 2011 Dec 6. |
| 26. | IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. | Tzartos JS, etal., Am J Pathol. 2011 Feb;178(2):794-802. |
| 27. | The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. | Ueda C, etal., Oncogene. 2002 Jan 17;21(3):368-76. |
| 28. | In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus. | Vugmeyster Y, etal., MAbs. 2010 May-Jun;2(3):335-46. Epub 2010 May 23. |
| 29. | Key role for IL-21 in experimental autoimmune uveitis. | Wang L, etal., Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9542-7. Epub 2011 May 18. |
| 30. | A polymorphism within IL21R confers risk for systemic lupus erythematosus. | Webb R, etal., Arthritis Rheum. 2009 Aug;60(8):2402-7. |
Additional References at PubMed
| PMID:10349636 | PMID:11016959 | PMID:11042159 | PMID:11076861 | PMID:11081504 | PMID:11217851 | PMID:11970879 | PMID:12093291 | PMID:12150892 | PMID:12446913 | PMID:12466851 | PMID:12477932 |
| PMID:15210829 | PMID:15630141 | PMID:16141072 | PMID:16141073 | PMID:16621990 | PMID:16778988 | PMID:17015680 | PMID:17048986 | PMID:17077330 | PMID:17339481 | PMID:17581537 | PMID:17581588 |
| PMID:17911475 | PMID:18276844 | PMID:18474630 | PMID:18490706 | PMID:18602282 | PMID:18773086 | PMID:18779574 | PMID:19168593 | PMID:19234181 | PMID:19423777 | PMID:19443735 | PMID:19570826 |
| PMID:19841075 | PMID:19843883 | PMID:19915059 | PMID:20042469 | PMID:20142429 | PMID:20142430 | PMID:20368279 | PMID:20435882 | PMID:20574002 | PMID:20660710 | PMID:20676095 | PMID:20826721 |
| PMID:20844201 | PMID:20926797 | PMID:20971950 | PMID:21061439 | PMID:21169545 | PMID:21257966 | PMID:21267068 | PMID:21270405 | PMID:21297642 | PMID:21357471 | PMID:21393863 | PMID:21430229 |
| PMID:21511186 | PMID:21518858 | PMID:21590767 | PMID:21708925 | PMID:21873635 | PMID:21964024 | PMID:22013017 | PMID:22120118 | PMID:22177922 | PMID:22231702 | PMID:22345665 | PMID:22442347 |
| PMID:22465422 | PMID:22579473 | PMID:22723520 | PMID:23045607 | PMID:23064231 | PMID:23125412 | PMID:23275601 | PMID:23453633 | PMID:23479229 | PMID:23516660 | PMID:23569233 | PMID:23637417 |
| PMID:23661644 | PMID:23696736 | PMID:23804710 | PMID:23960240 | PMID:23995234 | PMID:24078696 | PMID:24358128 | PMID:24446516 | PMID:24470500 | PMID:24489092 | PMID:24757141 | PMID:24820310 |
| PMID:24973819 | PMID:25373907 | PMID:25545680 | PMID:25763578 | PMID:25838422 | PMID:25849970 | PMID:25875847 | PMID:25941359 | PMID:26269257 | PMID:26287681 | PMID:26363366 | PMID:26413871 |
| PMID:26597007 | PMID:26744522 | PMID:26762709 | PMID:27400126 | PMID:27566940 | PMID:27695002 | PMID:27861835 | PMID:27927647 | PMID:28158305 | PMID:28303891 | PMID:28550395 | PMID:28855309 |
| PMID:28978474 | PMID:29018172 | PMID:29220875 | PMID:29549115 | PMID:29925696 | PMID:30266981 | PMID:30446568 | PMID:30654048 | PMID:30733420 | PMID:30969166 | PMID:31341076 | PMID:31379876 |
| PMID:31653894 | PMID:32130409 | PMID:32859726 | PMID:34433045 | PMID:34721405 | PMID:34852236 | PMID:35008699 | PMID:35693111 | PMID:35896116 |
Genomics
Comparative Map Data
| Il21r (Mus musculus - house mouse) |
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| IL21R (Homo sapiens - human) |
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| Il21r (Rattus norvegicus - Norway rat) |
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| Il21r (Chinchilla lanigera - long-tailed chinchilla) |
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| IL21R (Pan paniscus - bonobo/pygmy chimpanzee) |
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| IL21R (Canis lupus familiaris - dog) |
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| Il21r (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| IL21R (Sus scrofa - pig) |
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| IL21R (Chlorocebus sabaeus - green monkey) |
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| Il21r (Heterocephalus glaber - naked mole-rat) |
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miRNA Target Status
Predicted Target Of
| The detailed report is available here: |  | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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QTLs in Region (GRCm39)
| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |