MRPL45 (mitochondrial ribosomal protein L45) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MRPL45 (mitochondrial ribosomal protein L45) Homo sapiens
Analyze
Symbol: MRPL45
Name: mitochondrial ribosomal protein L45
RGD ID: 1312625
HGNC Page HGNC:16651
Description: A structural constituent of ribosome. Involved in mitochondrial translation. Part of mitochondrial large ribosomal subunit. Is active in mitochondrion. Biomarker of atherosclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 39S ribosomal protein L45, mitochondrial; L45mt; large ribosomal subunit protein mL45; Mba1; MGC11321; mitochondrial large ribosomal subunit protein mL45; mL45; MRP-L45
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: MRPL45P1   MRPL45P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381738,297,168 - 38,323,211 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1738,297,023 - 38,323,217 (+)EnsemblGRCh38hg38GRCh38
GRCh371736,453,134 - 36,479,094 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361733,706,517 - 33,732,628 (+)NCBINCBI36Build 36hg18NCBI36
Build 341733,706,516 - 33,732,627NCBI
Celera1733,135,785 - 33,138,385 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1732,251,049 - 32,275,975 (+)NCBIHuRef
CHM1_11736,688,586 - 36,714,781 (+)NCBICHM1_1
T2T-CHM13v2.01739,160,147 - 39,186,117 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Aberrantly Methylated-Differentially Expressed Genes Identify Novel Atherosclerosis Risk Subtypes. Xue Y, etal., Front Genet. 2020 Dec 14;11:569572. doi: 10.3389/fgene.2020.569572. eCollection 2020.
Additional References at PubMed
PMID:8125298   PMID:8889548   PMID:11551941   PMID:12477932   PMID:12706105   PMID:14702039   PMID:15342556   PMID:15489334   PMID:18029348   PMID:19615732   PMID:20186120   PMID:20562859  
PMID:20877624   PMID:21145461   PMID:21873635   PMID:22658674   PMID:22681889   PMID:22904065   PMID:22939629   PMID:23535730   PMID:24981860   PMID:25278503   PMID:25324306   PMID:25416956  
PMID:25609649   PMID:26186194   PMID:26344197   PMID:26496610   PMID:26841866   PMID:26949251   PMID:27023846   PMID:28514442   PMID:28533407   PMID:28892042   PMID:29229926   PMID:29395067  
PMID:29491746   PMID:29507755   PMID:29568061   PMID:29802200   PMID:29845934   PMID:30833792   PMID:31056398   PMID:31540324   PMID:31586073   PMID:31617661   PMID:31871319   PMID:31980649  
PMID:32296183   PMID:32513696   PMID:32628020   PMID:32877691   PMID:33305682   PMID:33602856   PMID:33957083   PMID:33961781   PMID:34011540   PMID:34079125   PMID:34373451   PMID:34578187  
PMID:34800366   PMID:35013218   PMID:35016035   PMID:35944360   PMID:36215168   PMID:36537216   PMID:37267103   PMID:37827155   PMID:37866880   PMID:38569033   PMID:38697112   PMID:39098523  


Genomics

Comparative Map Data
MRPL45
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381738,297,168 - 38,323,211 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1738,297,023 - 38,323,217 (+)EnsemblGRCh38hg38GRCh38
GRCh371736,453,134 - 36,479,094 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361733,706,517 - 33,732,628 (+)NCBINCBI36Build 36hg18NCBI36
Build 341733,706,516 - 33,732,627NCBI
Celera1733,135,785 - 33,138,385 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1732,251,049 - 32,275,975 (+)NCBIHuRef
CHM1_11736,688,586 - 36,714,781 (+)NCBICHM1_1
T2T-CHM13v2.01739,160,147 - 39,186,117 (+)NCBIT2T-CHM13v2.0
Mrpl45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391197,205,749 - 97,220,746 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1197,206,542 - 97,220,746 (+)EnsemblGRCm39 Ensembl
GRCm381197,314,923 - 97,329,920 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1197,315,716 - 97,329,920 (+)EnsemblGRCm38mm10GRCm38
MGSCv371197,177,030 - 97,191,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361197,131,946 - 97,146,010 (+)NCBIMGSCv36mm8
Celera11106,968,314 - 106,982,309 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1160.95NCBI
Mrpl45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81082,805,039 - 82,816,862 (+)NCBIGRCr8
mRatBN7.21082,308,650 - 82,320,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,308,427 - 82,320,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1087,256,991 - 87,268,943 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01086,755,065 - 86,767,018 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01082,147,649 - 82,159,601 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01085,257,876 - 85,269,806 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,257,876 - 85,269,806 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01085,047,843 - 85,059,773 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,046,541 - 86,058,364 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11086,060,932 - 86,072,017 (+)NCBI
Celera1081,068,586 - 81,080,378 (+)NCBICelera
Cytogenetic Map10q31NCBI
Mrpl45
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545113,518,075 - 13,541,981 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545113,518,240 - 13,541,981 (+)NCBIChiLan1.0ChiLan1.0
MRPL45
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21926,626,350 - 26,651,573 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11728,509,868 - 28,535,004 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01718,949,525 - 18,974,651 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11719,264,977 - 19,269,397 (-)NCBIpanpan1.1PanPan1.1panPan2
MRPL45
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1923,829,557 - 23,838,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha923,295,338 - 23,304,526 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0924,621,007 - 24,630,194 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl924,619,197 - 24,630,067 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1923,391,695 - 23,400,880 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0923,653,089 - 23,662,285 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0923,779,665 - 23,788,867 (-)NCBIUU_Cfam_GSD_1.0
Mrpl45
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560223,275,652 - 23,292,416 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649013,782,733 - 13,799,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRPL45
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1223,751,926 - 23,766,459 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11223,751,921 - 23,766,476 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MRPL45
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11667,858,825 - 67,872,482 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607738,898,528 - 38,926,831 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrpl45
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247954,211,539 - 4,225,659 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247954,211,546 - 4,225,747 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MRPL45
34 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
NC_000017.10:g.(34360227_34437475)_(36214026_36473024)del deletion Chromosome 17q12 deletion syndrome [RCV000191150] Chr17:34437475..36214026 [GRCh37]
Chr17:17q12
pathogenic
NM_032351.6(MRPL45):c.644G>A (p.Arg215His) single nucleotide variant not specified [RCV004296281] Chr17:38320751 [GRCh38]
Chr17:36476635 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:36474601-36552916)x3 copy number gain See cases [RCV000445960] Chr17:36474601..36552916 [GRCh37]
Chr17:17q12
likely benign
GRCh37/hg19 17q12(chr17:36474601-36498849)x3 copy number gain See cases [RCV000448081] Chr17:36474601..36498849 [GRCh37]
Chr17:17q12
likely benign
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_032351.6(MRPL45):c.643C>T (p.Arg215Cys) single nucleotide variant not specified [RCV004283938] Chr17:38320750 [GRCh38]
Chr17:36476634 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.679C>T (p.Arg227Trp) single nucleotide variant not specified [RCV004290662] Chr17:38322144 [GRCh38]
Chr17:36478027 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q12(chr17:36353952-36680186)x3 copy number gain not provided [RCV000846603] Chr17:36353952..36680186 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:36473175-36567469)x3 copy number gain Short stature [RCV001250262] Chr17:36473175..36567469 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2
pathogenic
NM_032351.6(MRPL45):c.553T>G (p.Phe185Val) single nucleotide variant not specified [RCV004160498] Chr17:38320660 [GRCh38]
Chr17:36476544 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.646A>T (p.Met216Leu) single nucleotide variant not specified [RCV004128731] Chr17:38320753 [GRCh38]
Chr17:36476637 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.541G>A (p.Val181Ile) single nucleotide variant not specified [RCV004235929] Chr17:38320648 [GRCh38]
Chr17:36476532 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.895G>A (p.Glu299Lys) single nucleotide variant not specified [RCV004108930] Chr17:38322569 [GRCh38]
Chr17:36478452 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.850G>A (p.Gly284Ser) single nucleotide variant not specified [RCV004187035] Chr17:38322524 [GRCh38]
Chr17:36478407 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.437T>C (p.Ile146Thr) single nucleotide variant not specified [RCV004174503] Chr17:38306607 [GRCh38]
Chr17:36462574 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.509C>A (p.Pro170Gln) single nucleotide variant not specified [RCV004112938] Chr17:38318734 [GRCh38]
Chr17:36474633 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.917C>T (p.Ala306Val) single nucleotide variant not specified [RCV004109406] Chr17:38322591 [GRCh38]
Chr17:36478474 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.215C>T (p.Ser72Leu) single nucleotide variant not specified [RCV004242831] Chr17:38298597 [GRCh38]
Chr17:36454563 [GRCh37]
Chr17:17q12
likely benign
NM_032351.6(MRPL45):c.836C>T (p.Thr279Met) single nucleotide variant not specified [RCV004201210] Chr17:38322510 [GRCh38]
Chr17:36478393 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.319G>A (p.Glu107Lys) single nucleotide variant not specified [RCV004111852] Chr17:38299425 [GRCh38]
Chr17:36455391 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.688C>T (p.Arg230Trp) single nucleotide variant not specified [RCV004071107] Chr17:38322153 [GRCh38]
Chr17:36478036 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.95T>C (p.Ile32Thr) single nucleotide variant not specified [RCV004210441] Chr17:38298477 [GRCh38]
Chr17:36454443 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.652A>G (p.Thr218Ala) single nucleotide variant not specified [RCV004158425] Chr17:38320759 [GRCh38]
Chr17:36476643 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.397A>G (p.Lys133Glu) single nucleotide variant not specified [RCV004118418] Chr17:38306567 [GRCh38]
Chr17:36462534 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.481C>T (p.His161Tyr) single nucleotide variant not specified [RCV004121746] Chr17:38318706 [GRCh38]
Chr17:36474605 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.634A>C (p.Ile212Leu) single nucleotide variant not specified [RCV004250268] Chr17:38320741 [GRCh38]
Chr17:36476625 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.11C>G (p.Pro4Arg) single nucleotide variant not specified [RCV004342852] Chr17:38297194 [GRCh38]
Chr17:36453160 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.367C>T (p.Arg123Trp) single nucleotide variant not specified [RCV004338463] Chr17:38306537 [GRCh38]
Chr17:36462504 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.824C>T (p.Pro275Leu) single nucleotide variant not specified [RCV004336322] Chr17:38322289 [GRCh38]
Chr17:36478172 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.143C>T (p.Pro48Leu) single nucleotide variant not specified [RCV004497809] Chr17:38298525 [GRCh38]
Chr17:36454491 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.221G>A (p.Arg74His) single nucleotide variant not specified [RCV004497817] Chr17:38298603 [GRCh38]
Chr17:36454569 [GRCh37]
Chr17:17q12
likely benign
NM_032351.6(MRPL45):c.476G>A (p.Arg159Gln) single nucleotide variant not specified [RCV004497837] Chr17:38318701 [GRCh38]
Chr17:36474600 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.445C>T (p.His149Tyr) single nucleotide variant not specified [RCV004497829] Chr17:38306615 [GRCh38]
Chr17:36462582 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.462C>A (p.Asn154Lys) single nucleotide variant not specified [RCV004497832] Chr17:38318687 [GRCh38]
Chr17:36474586 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.815C>G (p.Pro272Arg) single nucleotide variant not specified [RCV004499936] Chr17:38322280 [GRCh38]
Chr17:36478163 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.168T>G (p.Phe56Leu) single nucleotide variant not specified [RCV004638192] Chr17:38298550 [GRCh38]
Chr17:36454516 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.451T>G (p.Cys151Gly) single nucleotide variant not specified [RCV004631657] Chr17:38306621 [GRCh38]
Chr17:36462588 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.277G>A (p.Gly93Ser) single nucleotide variant not specified [RCV004631658] Chr17:38299383 [GRCh38]
Chr17:36455349 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.359T>G (p.Val120Gly) single nucleotide variant not specified [RCV004638191] Chr17:38299465 [GRCh38]
Chr17:36455431 [GRCh37]
Chr17:17q12
uncertain significance
NM_032351.6(MRPL45):c.814C>T (p.Pro272Ser) single nucleotide variant not specified [RCV004638190] Chr17:38322279 [GRCh38]
Chr17:36478162 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12-22(chr17:41196270-41277589) copy number loss Breast-ovarian cancer, familial, susceptibility to, 1 [RCV004759419] Chr17:41196270..41277589 [GRCh37]
Chr17:17q12-22
pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR148Ahsa-miR-148a-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Target Of
Summary Value
Count of predictions:1103
Count of miRNA genes:627
Interacting mature miRNAs:716
Transcripts:ENST00000312513, ENST00000579911, ENST00000580762, ENST00000581817, ENST00000582535
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597021701GWAS1117775_Hmacrophage inflammatory protein 1b measurement QTL GWAS1117775 (human)0.0000009macrophage inflammatory protein 1b measurement173832179338321794Human
1298406BP16_HBlood pressure QTL 16 (human)0.0004Blood pressurehypertension susceptibility171477864740778647Human

Markers in Region
MRPL45_1285  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371736,478,419 - 36,479,285UniSTSGRCh37
Build 361733,731,946 - 33,732,812RGDNCBI36
Celera1733,137,703 - 33,138,569RGD
HuRef1732,275,293 - 32,276,159UniSTS
RH66148  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371736,478,911 - 36,479,052UniSTSGRCh37
Build 361733,732,438 - 33,732,579RGDNCBI36
Celera1733,138,195 - 33,138,336RGD
Cytogenetic Map17q21.2UniSTS
HuRef1732,275,785 - 32,275,926UniSTS
GeneMap99-GB4 RH Map17305.36UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2351 2788 2245 4861 1484 1991 4 433 1775 275 2231 6612 6234 52 3664 591 1543 1467 171

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001278279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC021317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC183084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC244092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF240534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG719833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG761720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI767984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP374871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB244005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000613675   ⟹   ENSP00000484903
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1738,297,168 - 38,323,211 (+)Ensembl
Ensembl Acc Id: ENST00000619548   ⟹   ENSP00000478397
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1738,297,023 - 38,323,217 (+)Ensembl
RefSeq Acc Id: NM_001278279   ⟹   NP_001265208
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381738,297,168 - 38,323,211 (+)NCBI
GRCh371736,452,989 - 36,479,101 (+)NCBI
HuRef1732,251,049 - 32,275,975 (+)NCBI
CHM1_11736,688,586 - 36,714,781 (+)NCBI
T2T-CHM13v2.01739,160,147 - 39,186,117 (+)NCBI
Sequence:
RefSeq Acc Id: NM_032351   ⟹   NP_115727
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381738,297,168 - 38,323,211 (+)NCBI
GRCh371736,452,989 - 36,479,101 (+)ENTREZGENE
Build 361733,706,517 - 33,732,628 (+)NCBI Archive
Celera1733,135,785 - 33,138,385 (+)RGD
HuRef1732,251,049 - 32,275,975 (+)ENTREZGENE
CHM1_11736,688,586 - 36,714,781 (+)NCBI
T2T-CHM13v2.01739,160,147 - 39,186,117 (+)NCBI
Sequence:
RefSeq Acc Id: NP_115727   ⟸   NM_032351
- Peptide Label: isoform 1
- UniProtKB: Q9BRJ2 (UniProtKB/Swiss-Prot),   Q6ZMJ5 (UniProtKB/Swiss-Prot),   A1L436 (UniProtKB/Swiss-Prot),   A0A087X2D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001265208   ⟸   NM_001278279
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JMS5 (UniProtKB/TrEMBL),   A0A087WU62 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000484903   ⟸   ENST00000613675
Ensembl Acc Id: ENSP00000478397   ⟸   ENST00000619548
Protein Domains
Tim44-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9BRJ2-F1-model_v2 AlphaFold Q9BRJ2 1-306 view protein structure

Promoters
RGD ID:6794344
Promoter ID:HG_KWN:25933
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000256792
Position:
Human AssemblyChrPosition (strand)Source
Build 361733,706,139 - 33,706,639 (+)MPROMDB
RGD ID:7234763
Promoter ID:EPDNEW_H23126
Type:initiation region
Name:MRPL45_1
Description:mitochondrial ribosomal protein L45
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381738,297,173 - 38,297,233EPDNEW
RGD ID:6852660
Promoter ID:EP74112
Type:initiation region
Name:HS_MRPL45
Description:Mitochondrial ribosomal protein L45.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:No map positions available.

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16651 AgrOrtholog
COSMIC MRPL45 COSMIC
Ensembl Genes ENSG00000277936 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000278845 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000613510.1 UniProtKB/TrEMBL
  ENST00000613675 ENTREZGENE
  ENST00000613675.5 UniProtKB/TrEMBL
  ENST00000619548 ENTREZGENE
  ENST00000619548.1 UniProtKB/TrEMBL
  ENST00000621878.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.450.240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000277936 GTEx
  ENSG00000278845 GTEx
HGNC ID HGNC:16651 ENTREZGENE
Human Proteome Map MRPL45 Human Proteome Map
InterPro mtLSU_mL45 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTF2-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tim44-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:84311 UniProtKB/TrEMBL
NCBI Gene 84311 ENTREZGENE
OMIM 611850 OMIM
PANTHER 39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL UniProtKB/Swiss-Prot
  39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL UniProtKB/Swiss-Prot
  39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL UniProtKB/TrEMBL
  39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Tim44 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30977 PharmGKB
SMART Tim44 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54427 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WU62 ENTREZGENE, UniProtKB/TrEMBL
  A0A087X2D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JMS5 ENTREZGENE, UniProtKB/TrEMBL
  A1L436 ENTREZGENE
  B4DEF8_HUMAN UniProtKB/TrEMBL
  Q6ZMJ5 ENTREZGENE
  Q9BRJ2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A1L436 UniProtKB/Swiss-Prot
  Q6ZMJ5 UniProtKB/Swiss-Prot