Mrtfa (myocardin related transcription factor A) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Mrtfa (myocardin related transcription factor A) Mus musculus
Analyze
Symbol: Mrtfa
Name: myocardin related transcription factor A
RGD ID: 1312565
MGI Page MGI
Description: Enables several functions, including actin monomer binding activity; transcription cis-regulatory region binding activity; and transcription coactivator activity. Involved in actin cytoskeleton organization and positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic process; nervous system development; and positive regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; epithelium; gonad; skeletal muscle; and telencephalon. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI852829; AMKL; AW743281; AW821984; basic SAP and coiled-coil domains; basic SAP coiled-coil transcription activator; Bs; Bsac; M; Mal; megakaryoblastic leukemia (translocation) 1 homolog; megakaryoblastic leukemia 1 protein homolog; megakaryocytic acute leukemia protein homolog; Mkl; MKL (megakaryoblastic leukemia)/myocardin-like 1; MKL/myocardin-like protein 1; Mkl1; MRTF; Mrtf-A; myocardial related transcription factor A; myocardin-related transcription factor A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,896,482 - 81,074,937 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,896,482 - 81,074,958 (-)EnsemblGRCm39 Ensembl
GRCm381581,012,281 - 81,190,736 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,012,281 - 81,190,757 (-)EnsemblGRCm38mm10GRCm38
MGSCv371580,842,711 - 81,021,187 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361580,840,540 - 80,932,073 (-)NCBIMGSCv36mm8
Celera1583,132,403 - 83,308,218 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (ISO)
glutamatergic synapse  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)
postsynapse  (ISO)
presynapse  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiac outflow tract development  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus neuron morphology  (IAGP)
abnormal hippocampus pyramidal cell layer  (IAGP)
abnormal involution of the mammary gland  (IAGP)
abnormal lactation  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal mammary gland morphology  (IAGP)
abnormal mammary gland myoepithelium morphology  (IAGP)
abnormal mammary gland myoepithelium physiology  (IAGP)
abnormal mammary gland physiology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal muscle fiber mitochondrial morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal olfactory bulb morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal rostral migratory stream morphology  (IAGP)
abnormal skeletal muscle satellite cell proliferation  (IAGP)
absent anterior commissure  (IAGP)
absent corpus callosum  (IAGP)
cachexia  (IAGP)
decreased body weight  (IAGP)
decreased skeletal muscle weight  (IAGP)
decreased striatum size  (IAGP)
dilated heart atrium  (IAGP)
dilated heart ventricle  (IAGP)
galactostasis  (IAGP)
impaired fibroblast cell migration  (IAGP)
impaired skeletal muscle regeneration  (IAGP)
increased mammary gland apoptosis  (IAGP)
increased neuron apoptosis  (IAGP)
muscular atrophy  (IAGP)
myocardium necrosis  (IAGP)
pale mammary gland  (IAGP)
pericardial edema  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Kuwahara K, etal., Mol Cell Biol 2005 Apr;25(8):3173-81.
2. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Ma Z, etal., Nat Genet. 2001 Jul;28(3):220-1.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12019265   PMID:12397177   PMID:12477932   PMID:12520002   PMID:12732141   PMID:12904583  
PMID:14610273   PMID:14970199   PMID:15292266   PMID:15618518   PMID:16098147   PMID:16141072   PMID:16141073   PMID:16204380   PMID:16705166   PMID:16847332   PMID:16847333   PMID:16945101  
PMID:17183527   PMID:17363709   PMID:17588931   PMID:17599918   PMID:17714703   PMID:17991879   PMID:18025109   PMID:18334560   PMID:18442487   PMID:18477564   PMID:18498732   PMID:18498735  
PMID:18799693   PMID:18945672   PMID:19008859   PMID:19136660   PMID:19198601   PMID:19350017   PMID:19542562   PMID:19683494   PMID:20019329   PMID:20059953   PMID:20211142   PMID:20236507  
PMID:20338973   PMID:20412781   PMID:20428204   PMID:20534669   PMID:20558820   PMID:20606005   PMID:20816842   PMID:20818336   PMID:21267068   PMID:21673315   PMID:21705668   PMID:21799516  
PMID:21873635   PMID:21964294   PMID:21984612   PMID:22049076   PMID:22185759   PMID:22223881   PMID:22262458   PMID:22279050   PMID:22405202   PMID:22461426   PMID:22806889   PMID:22996691  
PMID:23103763   PMID:23434591   PMID:23558171   PMID:23563308   PMID:23644458   PMID:23656782   PMID:23798429   PMID:23811404   PMID:23946491   PMID:24082095   PMID:24340092   PMID:24569594  
PMID:24732378   PMID:24758171   PMID:24797074   PMID:24906914   PMID:24910328   PMID:25344251   PMID:25349198   PMID:25380769   PMID:25446178   PMID:25516967   PMID:25573994   PMID:25579684  
PMID:25585691   PMID:25646298   PMID:25681733   PMID:25885656   PMID:25888165   PMID:25955164   PMID:26024305   PMID:26098211   PMID:26221020   PMID:26241940   PMID:26295164   PMID:26386146  
PMID:26693892   PMID:26719331   PMID:26976641   PMID:27094722   PMID:27304076   PMID:27385017   PMID:27492266   PMID:27689009   PMID:27708220   PMID:27825966   PMID:27930960   PMID:28125644  
PMID:28576971   PMID:28729363   PMID:28739141   PMID:29114040   PMID:29716942   PMID:29768198   PMID:29908908   PMID:30018168   PMID:30463620   PMID:30796970   PMID:30867502   PMID:30979898  
PMID:31128166   PMID:31191527   PMID:31201155   PMID:31356989   PMID:31481470   PMID:31681772   PMID:31773302   PMID:31776330   PMID:31928221   PMID:32061777   PMID:32160132   PMID:32208430  
PMID:32440986   PMID:32554809   PMID:32603734   PMID:32692361   PMID:33075202   PMID:33361330   PMID:33597582   PMID:33637797   PMID:33667992   PMID:33752236   PMID:33779332   PMID:33969828  
PMID:34230480   PMID:34347392   PMID:34944031   PMID:35145145   PMID:35604830   PMID:35977484   PMID:36587486   PMID:36758668   PMID:37121967   PMID:37289107   PMID:37770456   PMID:37982489  
PMID:38713765   PMID:39222836  


Genomics

Comparative Map Data
Mrtfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,896,482 - 81,074,937 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,896,482 - 81,074,958 (-)EnsemblGRCm39 Ensembl
GRCm381581,012,281 - 81,190,736 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,012,281 - 81,190,757 (-)EnsemblGRCm38mm10GRCm38
MGSCv371580,842,711 - 81,021,187 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361580,840,540 - 80,932,073 (-)NCBIMGSCv36mm8
Celera1583,132,403 - 83,308,218 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.98NCBI
MRTFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,410,289 - 40,636,719 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,410,281 - 40,636,719 (-)EnsemblGRCh38hg38GRCh38
GRCh372240,806,293 - 41,032,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,136,238 - 39,362,636 (-)NCBINCBI36Build 36hg18NCBI36
Build 342239,130,791 - 39,357,190NCBI
Celera2224,608,353 - 24,836,358 (-)NCBICelera
Cytogenetic Map22q13.1-q13.2NCBI
HuRef2223,769,395 - 23,994,500 (-)NCBIHuRef
CHM1_12240,765,195 - 40,992,703 (-)NCBICHM1_1
T2T-CHM13v2.02240,880,672 - 41,108,683 (-)NCBIT2T-CHM13v2.0
Mrtfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,424,481 - 114,594,594 (-)NCBIGRCr8
mRatBN7.27112,544,305 - 112,714,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,544,312 - 112,714,418 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7114,306,865 - 114,477,102 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,530,410 - 116,700,653 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,499,783 - 116,670,016 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,233,196 - 122,403,661 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,234,012 - 122,403,667 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07122,217,533 - 122,387,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47119,306,220 - 119,415,012 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17119,340,456 - 119,511,326 (-)NCBI
Celera7108,866,997 - 109,036,998 (-)NCBICelera
Cytogenetic Map7q34NCBI
Mrtfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,139,843 - 26,222,580 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541326,139,060 - 26,311,272 (-)NCBIChiLan1.0ChiLan1.0
MRTFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22350,247,445 - 50,469,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,950,372 - 53,172,160 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,314,829 - 21,536,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12239,411,890 - 39,581,958 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2239,413,002 - 39,467,402 (-)Ensemblpanpan1.1panPan2
MRTFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,561,161 - 24,759,586 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,561,161 - 24,759,081 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1024,496,201 - 24,694,602 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01025,311,403 - 25,509,948 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1025,311,348 - 25,509,944 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11025,024,155 - 25,222,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,346,404 - 25,544,515 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01025,520,463 - 25,718,833 (+)NCBIUU_Cfam_GSD_1.0
Mrtfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049458,223,715 - 8,374,424 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364921,282,674 - 1,383,696 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364921,234,025 - 1,384,838 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRTFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,959,312 - 7,972,574 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.157,751,350 - 7,975,927 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,981,649 - 5,208,382 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MRTFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,980,071 - 23,197,199 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,981,216 - 23,034,179 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045102,390,890 - 102,610,530 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrtfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247527,878,876 - 8,050,274 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247527,836,545 - 8,050,176 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrtfa
4962 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2726
Count of miRNA genes:706
Interacting mature miRNAs:883
Transcripts:ENSMUST00000109579, ENSMUST00000123243, ENSMUST00000131235, ENSMUST00000134469, ENSMUST00000135047, ENSMUST00000138769, ENSMUST00000145779, ENSMUST00000147921, ENSMUST00000149582, ENSMUST00000154797
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157410054082674156Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156338964681086436Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
15092080Igly7_mIgG glycosylation 7, GP10 (mouse)157779491982674156Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154730633481306479Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1301472Pain1_mpain 1 (mouse)Not determined157532084690813185Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154740959681409691Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse

Markers in Region
AW743281  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381581,012,904 - 81,013,132UniSTSGRCm38
MGSCv371580,843,334 - 80,843,562UniSTSGRCm37
Celera1583,133,026 - 83,133,262UniSTS
Cytogenetic Map15E1UniSTS
Whitehead/MRC_RH15680.01UniSTS
AW821984  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381581,012,355 - 81,012,505UniSTSGRCm38
MGSCv371580,842,785 - 80,842,935UniSTSGRCm37
Celera1583,132,477 - 83,132,627UniSTS
Cytogenetic Map15E1UniSTS
Whitehead/MRC_RH15713.67UniSTS
BB175482  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381581,011,839 - 81,011,947UniSTSGRCm38
MGSCv371580,842,269 - 80,842,377UniSTSGRCm37
Celera1583,131,961 - 83,132,069UniSTS
Cytogenetic Map15E1UniSTS
Whitehead/MRC_RH15713.56UniSTS
11.MMHAP54FRD8.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381581,085,626 - 81,085,726UniSTSGRCm38
MGSCv371580,916,056 - 80,916,156UniSTSGRCm37
Celera1583,207,770 - 83,207,870UniSTS
Cytogenetic Map15E1UniSTS
Whitehead/MRC_RH15676.86UniSTS
RH118361  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381581,097,764 - 81,097,931UniSTSGRCm38
MGSCv371580,928,194 - 80,928,361UniSTSGRCm37
Celera1583,220,646 - 83,220,813UniSTS
Cytogenetic Map15E1UniSTS
Whitehead/MRC_RH15714.39UniSTS
RH125181  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381581,012,014 - 81,012,199UniSTSGRCm38
MGSCv371580,842,444 - 80,842,629UniSTSGRCm37
Celera1583,132,136 - 83,132,321UniSTS
Cytogenetic Map15E1UniSTS
RH125357  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381581,040,337 - 81,040,640UniSTSGRCm38
MGSCv371580,870,767 - 80,871,070UniSTSGRCm37
Cytogenetic Map15E1UniSTS
Mkl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15E1UniSTS
cM Map15 UniSTS
UniSTS:237357  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381581,187,407 - 81,187,650UniSTSGRCm38
MGSCv371581,017,837 - 81,018,080UniSTSGRCm37
Celera1583,304,907 - 83,305,150UniSTS
Cytogenetic Map15E1UniSTS
AI852829  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381581,012,311 - 81,012,419UniSTSGRCm38
MGSCv371580,842,741 - 80,842,849UniSTSGRCm37
Celera1583,132,433 - 83,132,541UniSTS
Cytogenetic Map15E1UniSTS
Whitehead/MRC_RH15720.33UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001082536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF385582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF532597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB850443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY200528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY208699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY749697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY750304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA318154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX562326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000109579   ⟹   ENSMUSP00000105207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,896,492 - 80,989,284 (-)Ensembl
GRCm38.p6 Ensembl1581,012,291 - 81,105,083 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123243
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,910,620 - 81,074,929 (-)Ensembl
GRCm38.p6 Ensembl1581,026,419 - 81,190,728 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131235   ⟹   ENSMUSP00000120116
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,896,492 - 81,074,924 (-)Ensembl
GRCm38.p6 Ensembl1581,012,291 - 81,190,723 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134469   ⟹   ENSMUSP00000119530
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,896,482 - 81,074,934 (-)Ensembl
GRCm38.p6 Ensembl1581,012,281 - 81,190,733 (-)Ensembl
Ensembl Acc Id: ENSMUST00000135047   ⟹   ENSMUSP00000118451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,900,055 - 80,929,747 (-)Ensembl
GRCm38.p6 Ensembl1581,015,854 - 81,045,546 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138769
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,900,964 - 80,902,389 (-)Ensembl
GRCm38.p6 Ensembl1581,016,763 - 81,018,188 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145779
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,904,439 - 80,905,503 (-)Ensembl
GRCm38.p6 Ensembl1581,020,238 - 81,021,302 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147921
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,929,334 - 81,074,723 (-)Ensembl
GRCm38.p6 Ensembl1581,045,133 - 81,190,522 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149582   ⟹   ENSMUSP00000117745
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,896,482 - 81,074,958 (-)Ensembl
GRCm38.p6 Ensembl1581,012,281 - 81,190,757 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154797
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,906,690 - 80,908,171 (-)Ensembl
GRCm38.p6 Ensembl1581,022,489 - 81,023,970 (-)Ensembl
Ensembl Acc Id: ENSMUST00000239114   ⟹   ENSMUSP00000159052
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,896,482 - 81,074,958 (-)Ensembl
GRCm38.p6 Ensembl1581,012,281 - 81,190,757 (-)Ensembl
Ensembl Acc Id: ENSMUST00000239267   ⟹   ENSMUSP00000159228
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1580,910,863 - 80,951,213 (-)Ensembl
GRCm38.p6 Ensembl1581,026,662 - 81,067,012 (-)Ensembl
RefSeq Acc Id: NM_001082536   ⟹   NP_001076005
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391580,896,482 - 81,074,937 (-)NCBI
GRCm381581,012,281 - 81,190,736 (-)NCBI
MGSCv371580,842,711 - 81,021,187 (-)RGD
Celera1583,132,403 - 83,308,218 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_153049   ⟹   NP_694629
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391580,896,482 - 80,989,248 (-)NCBI
GRCm381581,012,281 - 81,105,047 (-)NCBI
MGSCv371580,842,711 - 81,021,187 (-)RGD
Celera1583,132,403 - 83,308,218 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001076005   ⟸   NM_001082536
- Peptide Label: isoform 2
- UniProtKB: A0A5F8MQ33 (UniProtKB/TrEMBL),   D3YUI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_694629   ⟸   NM_153049
- Peptide Label: isoform 1
- UniProtKB: Q642U1 (UniProtKB/Swiss-Prot),   Q8K4J6 (UniProtKB/Swiss-Prot),   Q3U1I6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000159228   ⟸   ENSMUST00000239267
Ensembl Acc Id: ENSMUSP00000159052   ⟸   ENSMUST00000239114
Ensembl Acc Id: ENSMUSP00000120116   ⟸   ENSMUST00000131235
Ensembl Acc Id: ENSMUSP00000118451   ⟸   ENSMUST00000135047
Ensembl Acc Id: ENSMUSP00000117745   ⟸   ENSMUST00000149582
Ensembl Acc Id: ENSMUSP00000105207   ⟸   ENSMUST00000109579
Ensembl Acc Id: ENSMUSP00000119530   ⟸   ENSMUST00000134469
Protein Domains
SAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4J6-F1-model_v2 AlphaFold Q8K4J6 1-964 view protein structure

Promoters
RGD ID:6826221
Promoter ID:MM_KWN:19138
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung
Transcripts:OTTMUST00000086068
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361580,848,341 - 80,849,542 (-)MPROMDB
RGD ID:6826220
Promoter ID:MM_KWN:19139
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung,   Spleen
Transcripts:OTTMUST00000086067
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361580,851,626 - 80,852,662 (-)MPROMDB
RGD ID:6826216
Promoter ID:MM_KWN:19140
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Lung
Transcripts:OTTMUST00000086066
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361580,854,006 - 80,855,082 (-)MPROMDB
RGD ID:6826212
Promoter ID:MM_KWN:19141
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Lung
Transcripts:ENSMUST00000042239,   ENSMUST00000100406
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361580,858,184 - 80,858,684 (-)MPROMDB
RGD ID:6826224
Promoter ID:MM_KWN:19143
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Lung,   Spleen
Transcripts:UC007WWE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361580,875,584 - 80,876,084 (-)MPROMDB
RGD ID:6826222
Promoter ID:MM_KWN:19145
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B6,   Spleen
Transcripts:UC007WWC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361580,935,161 - 80,935,661 (-)MPROMDB
RGD ID:6826215
Promoter ID:MM_KWN:19147
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   MEF_B4
Transcripts:NM_001082536,   OTTMUST00000086062,   OTTMUST00000086063,   OTTMUST00000086064,   OTTMUST00000086065
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361581,021,064 - 81,021,564 (-)MPROMDB
RGD ID:8684422
Promoter ID:EPDNEW_M20241
Type:initiation region
Name:Mkl1_3
Description:Mus musculus MKL /myocardin-like 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20242  EPDNEW_M20243  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381581,045,479 - 81,045,539EPDNEW
RGD ID:8684424
Promoter ID:EPDNEW_M20242
Type:initiation region
Name:Mkl1_2
Description:Mus musculus MKL /myocardin-like 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20241  EPDNEW_M20243  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381581,105,021 - 81,105,081EPDNEW
RGD ID:8684426
Promoter ID:EPDNEW_M20243
Type:multiple initiation site
Name:Mkl1_1
Description:Mus musculus MKL /myocardin-like 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20241  EPDNEW_M20242  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381581,190,736 - 81,190,796EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384495 AgrOrtholog
Ensembl Genes ENSMUSG00000042292 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000109579 ENTREZGENE
  ENSMUST00000109579.9 UniProtKB/Swiss-Prot
  ENSMUST00000131235.9 UniProtKB/TrEMBL
  ENSMUST00000134469.9 UniProtKB/TrEMBL
  ENSMUST00000135047.2 UniProtKB/TrEMBL
  ENSMUST00000149582.8 UniProtKB/Swiss-Prot
  ENSMUST00000239114 ENTREZGENE
  ENSMUST00000239114.2 UniProtKB/TrEMBL
  ENSMUST00000239267.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.2040 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Myocardin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RPEL_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:223701 UniProtKB/Swiss-Prot
MGD MGI:2384495 ENTREZGENE
NCBI Gene 223701 ENTREZGENE
PANTHER PTHR22793 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22793:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RPEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mrtfa PhenoGen
PROSITE RPEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RPEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5F8MQ33 ENTREZGENE, UniProtKB/TrEMBL
  A0A668KL76_MOUSE UniProtKB/TrEMBL
  D3YUG5_MOUSE UniProtKB/TrEMBL
  D3YUI2 ENTREZGENE, UniProtKB/TrEMBL
  MRTFA_MOUSE UniProtKB/Swiss-Prot
  Q3U1I6 ENTREZGENE, UniProtKB/TrEMBL
  Q3U3V7_MOUSE UniProtKB/TrEMBL
  Q642U1 ENTREZGENE
  Q8K4J6 ENTREZGENE
UniProt Secondary Q642U1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-18 Mrtfa  myocardin related transcription factor A    myocardial related transcription factor A  Symbol and/or name change 5135510 APPROVED
2018-11-13 Mrtfa  myocardial related transcription factor A  Mkl1  MKL (megakaryoblastic leukemia)/myocardin-like 1  Symbol and/or name change 5135510 APPROVED