Palb2 (partner and localizer of BRCA2) - Rat Genome Database

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Gene: Palb2 (partner and localizer of BRCA2) Mus musculus
Analyze
Symbol: Palb2
Name: partner and localizer of BRCA2
RGD ID: 1312388
MGI Page MGI
Description: Predicted to enable DNA binding activity. Acts upstream of or within several processes, including chordate embryonic development; mesoderm development; and post-anal tail morphogenesis. Predicted to be located in nuclear speck. Predicted to be part of DNA repair complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group N; female breast cancer; hereditary breast ovarian cancer syndrome; and pancreatic cancer. Orthologous to human PALB2 (partner and localizer of BRCA2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4732427B05; BC066140
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,706,485 - 121,732,203 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,706,485 - 121,732,208 (-)EnsemblGRCm39 Ensembl
GRCm387122,107,262 - 122,132,980 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,107,262 - 122,132,985 (-)EnsemblGRCm38mm10GRCm38
MGSCv377129,250,779 - 129,276,460 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367121,898,410 - 121,924,094 (-)NCBIMGSCv36mm8
Celera7121,997,482 - 122,023,184 (-)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
DNA binding  (IBA,ISO,ISS)
protein binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing. Girard E, etal., Int J Cancer. 2019 Apr 15;144(8):1962-1974. doi: 10.1002/ijc.31921. Epub 2018 Nov 13.
2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
3. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Jones S, etal., Science. 2009 Apr 10;324(5924):217. Epub 2009 Mar 5.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466305   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:17967808   PMID:18799693   PMID:20484223   PMID:21267068   PMID:21404276   PMID:21873635   PMID:23435420   PMID:23650262   PMID:23657012   PMID:24194600   PMID:25016020   PMID:27490902  
PMID:27626380   PMID:28240985   PMID:29426838   PMID:29739757   PMID:30289697   PMID:30704900   PMID:31242413   PMID:31877165   PMID:35006619   PMID:35404932   PMID:38355793  


Genomics

Comparative Map Data
Palb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,706,485 - 121,732,203 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,706,485 - 121,732,208 (-)EnsemblGRCm39 Ensembl
GRCm387122,107,262 - 122,132,980 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,107,262 - 122,132,985 (-)EnsemblGRCm38mm10GRCm38
MGSCv377129,250,779 - 129,276,460 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367121,898,410 - 121,924,094 (-)NCBIMGSCv36mm8
Celera7121,997,482 - 122,023,184 (-)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.42NCBI
PALB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381623,603,165 - 23,641,310 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1623,603,160 - 23,641,321 (-)EnsemblGRCh38hg38GRCh38
GRCh371623,614,486 - 23,652,631 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,521,984 - 23,560,179 (-)NCBINCBI36Build 36hg18NCBI36
Celera1622,392,663 - 22,430,856 (-)NCBICelera
Cytogenetic Map16p12.2NCBI
HuRef1621,704,596 - 21,742,312 (-)NCBIHuRef
CHM1_11624,626,195 - 24,664,406 (-)NCBICHM1_1
T2T-CHM13v2.01623,878,974 - 23,917,118 (-)NCBIT2T-CHM13v2.0
Palb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,096,312 - 186,120,284 (-)NCBIGRCr8
mRatBN7.21176,665,076 - 176,689,053 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,665,076 - 176,688,990 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1184,992,979 - 185,016,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01192,178,931 - 192,202,778 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,862,806 - 184,886,736 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,064,586 - 192,088,547 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,064,589 - 192,088,520 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,127,037 - 199,151,000 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41180,928,710 - 180,952,518 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,068,861 - 181,092,509 (-)NCBI
Celera1174,374,846 - 174,398,646 (-)NCBICelera
Cytogenetic Map1q36NCBI
Palb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,147,862 - 2,175,781 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,149,053 - 2,175,482 (-)NCBIChiLan1.0ChiLan1.0
PALB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21825,014,158 - 25,051,771 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11629,533,625 - 29,571,237 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01614,470,367 - 14,507,841 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11623,855,535 - 23,892,117 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1623,855,535 - 23,892,117 (-)Ensemblpanpan1.1panPan2
PALB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1622,209,711 - 22,237,798 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl622,209,384 - 22,237,745 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha623,776,491 - 23,804,551 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0622,353,561 - 22,380,176 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl622,353,713 - 22,380,121 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1622,156,874 - 22,184,970 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0622,059,465 - 22,087,651 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0622,454,545 - 22,482,727 (+)NCBIUU_Cfam_GSD_1.0
Palb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,149,046 - 120,175,487 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365018,246,927 - 8,273,258 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PALB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl322,586,856 - 22,612,834 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1322,586,881 - 22,612,837 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21017,289 - 43,988 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PALB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,322,952 - 21,358,363 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,322,975 - 21,358,198 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660688,438,801 - 8,475,516 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Palb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,751,866 - 8,780,884 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247828,752,510 - 8,780,972 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Palb2
838 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2578
Count of miRNA genes:830
Interacting mature miRNAs:1113
Transcripts:ENSMUST00000063587, ENSMUST00000098068, ENSMUST00000106468, ENSMUST00000106469, ENSMUST00000130149, ENSMUST00000131657, ENSMUST00000142952, ENSMUST00000154508
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
1558745Tsiq1_mT-cell secretion of IL-4 QTL 1 (mouse)Not determined7119485219125141349Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse

Markers in Region
AW742216  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387122,133,161 - 122,133,400UniSTSGRCm38
MGSCv377129,276,675 - 129,276,914UniSTSGRCm37
Celera7122,023,399 - 122,023,638UniSTS
Cytogenetic Map7F3UniSTS
Whitehead/MRC_RH71245.81UniSTS
Palb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F3UniSTS
cM Map765.42UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001081238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_869708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB061170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB757034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ560264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000063587   ⟹   ENSMUSP00000063514
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,706,485 - 121,732,132 (-)Ensembl
GRCm38.p6 Ensembl7122,107,262 - 122,132,909 (-)Ensembl
Ensembl Acc Id: ENSMUST00000098068   ⟹   ENSMUSP00000095675
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,706,485 - 121,732,169 (-)Ensembl
GRCm38.p6 Ensembl7122,107,262 - 122,132,946 (-)Ensembl
Ensembl Acc Id: ENSMUST00000106468   ⟹   ENSMUSP00000102076
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,710,795 - 121,732,140 (-)Ensembl
GRCm38.p6 Ensembl7122,111,572 - 122,132,917 (-)Ensembl
Ensembl Acc Id: ENSMUST00000106469   ⟹   ENSMUSP00000102077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,706,485 - 121,732,067 (-)Ensembl
GRCm38.p6 Ensembl7122,107,262 - 122,132,844 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130149
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,724,805 - 121,732,142 (-)Ensembl
GRCm38.p6 Ensembl7122,125,582 - 122,132,919 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131657   ⟹   ENSMUSP00000118059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,706,490 - 121,723,668 (-)Ensembl
GRCm38.p6 Ensembl7122,107,267 - 122,124,445 (-)Ensembl
Ensembl Acc Id: ENSMUST00000142952   ⟹   ENSMUSP00000123041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,710,795 - 121,732,111 (-)Ensembl
GRCm38.p6 Ensembl7122,111,572 - 122,132,888 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154508
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,706,488 - 121,711,263 (-)Ensembl
GRCm38.p6 Ensembl7122,107,265 - 122,112,040 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205352
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,730,064 - 121,732,208 (-)Ensembl
GRCm38.p6 Ensembl7122,130,841 - 122,132,985 (-)Ensembl
RefSeq Acc Id: NM_001081238   ⟹   NP_001074707
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,706,485 - 121,732,169 (-)NCBI
GRCm387122,107,262 - 122,132,946 (-)NCBI
MGSCv377129,250,779 - 129,276,460 (-)RGD
Celera7121,997,479 - 122,023,184 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001289842   ⟹   NP_001276771
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,710,795 - 121,732,169 (-)NCBI
GRCm387122,111,572 - 122,132,946 (-)NCBI
Celera7121,997,479 - 122,023,184 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289843   ⟹   NP_001276772
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,710,795 - 121,732,169 (-)NCBI
GRCm387122,111,572 - 122,132,946 (-)NCBI
Celera7121,997,479 - 122,023,184 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289844   ⟹   NP_001276773
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,706,485 - 121,732,169 (-)NCBI
GRCm387122,107,262 - 122,132,946 (-)NCBI
Celera7121,997,479 - 122,023,184 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289845   ⟹   NP_001276774
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,706,485 - 121,732,169 (-)NCBI
GRCm387122,107,262 - 122,132,946 (-)NCBI
Celera7121,997,479 - 122,023,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241755   ⟹   XP_011240057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,706,487 - 121,732,115 (-)NCBI
GRCm387122,107,262 - 122,132,892 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003946461
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,706,485 - 121,732,203 (-)NCBI
GRCm387122,107,262 - 122,132,980 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003946462
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,706,485 - 121,732,203 (-)NCBI
GRCm387122,107,262 - 122,132,980 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003946463
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,706,485 - 121,732,203 (-)NCBI
GRCm387122,107,262 - 122,132,980 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003946464
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,706,485 - 121,732,169 (-)NCBI
GRCm387122,107,262 - 122,132,946 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934089
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,706,485 - 121,731,968 (-)NCBI
Sequence:
RefSeq Acc Id: XR_869708
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,706,485 - 121,732,203 (-)NCBI
GRCm387122,107,262 - 122,132,980 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001074707   ⟸   NM_001081238
- Peptide Label: isoform 1
- UniProtKB: Q7TMQ4 (UniProtKB/Swiss-Prot),   Q6NZG9 (UniProtKB/Swiss-Prot),   Q8CEA9 (UniProtKB/Swiss-Prot),   Q3U0P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276774   ⟸   NM_001289845
- Peptide Label: isoform 5
- UniProtKB: Q80VS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276773   ⟸   NM_001289844
- Peptide Label: isoform 4
- UniProtKB: Q3U0P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276772   ⟸   NM_001289843
- Peptide Label: isoform 3
- UniProtKB: Q3U0P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276771   ⟸   NM_001289842
- Peptide Label: isoform 2
- UniProtKB: D3YVU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240057   ⟸   XM_011241755
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000102077   ⟸   ENSMUST00000106469
Ensembl Acc Id: ENSMUSP00000102076   ⟸   ENSMUST00000106468
Ensembl Acc Id: ENSMUSP00000118059   ⟸   ENSMUST00000131657
Ensembl Acc Id: ENSMUSP00000095675   ⟸   ENSMUST00000098068
Ensembl Acc Id: ENSMUSP00000123041   ⟸   ENSMUST00000142952
Ensembl Acc Id: ENSMUSP00000063514   ⟸   ENSMUST00000063587
Protein Domains
Partner and localiser of BRCA2 WD40

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3U0P1-F1-model_v2 AlphaFold Q3U0P1 1-1104 view protein structure

Promoters
RGD ID:8665463
Promoter ID:EPDNEW_M10763
Type:initiation region
Name:Palb2_1
Description:Mus musculus partner and localizer of BRCA2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387122,132,870 - 122,132,930EPDNEW
RGD ID:6840961
Promoter ID:MM_KWN:52577
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000106469,   NM_021608,   OTTMUST00000054252,   OTTMUST00000054269,   OTTMUST00000054271,   UC009JOK.1,   UC009JOL.1,   UC009JOM.1,   UC009JOO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367129,276,299 - 129,276,799 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3040695 AgrOrtholog
Ensembl Genes ENSMUSG00000044702 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000063587 ENTREZGENE
  ENSMUST00000063587.13 UniProtKB/Swiss-Prot
  ENSMUST00000098068 ENTREZGENE
  ENSMUST00000098068.10 UniProtKB/Swiss-Prot
  ENSMUST00000106468 ENTREZGENE
  ENSMUST00000106468.7 UniProtKB/TrEMBL
  ENSMUST00000106469 ENTREZGENE
  ENSMUST00000106469.8 UniProtKB/Swiss-Prot
  ENSMUST00000131657.8 UniProtKB/TrEMBL
  ENSMUST00000142952.8 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PALB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PALB2_WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:233826 UniProtKB/Swiss-Prot
MGD MGI:3040695 ENTREZGENE
NCBI Gene 233826 ENTREZGENE
PANTHER PARTNER AND LOCALIZER OF BRCA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14662 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PALB2_WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Palb2 PhenoGen
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YVU6 ENTREZGENE, UniProtKB/TrEMBL
  D6RDD1_MOUSE UniProtKB/TrEMBL
  F6VTV6_MOUSE UniProtKB/TrEMBL
  PALB2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6NZG9 ENTREZGENE
  Q7TMQ4 ENTREZGENE
  Q80VS5 ENTREZGENE, UniProtKB/TrEMBL
  Q8CEA9 ENTREZGENE
UniProt Secondary Q6NZG9 UniProtKB/Swiss-Prot
  Q7TMQ4 UniProtKB/Swiss-Prot
  Q8CEA9 UniProtKB/Swiss-Prot