Mc1r (melanocortin 1 receptor) - Rat Genome Database

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Gene: Mc1r (melanocortin 1 receptor) Rattus norvegicus
Analyze
Symbol: Mc1r
Name: melanocortin 1 receptor
RGD ID: 1312046
Description: Enables hormone binding activity and melanocortin receptor activity. Involved in positive regulation of feeding behavior. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; melanocortin system pathway; INTERACTS WITH acrolein; thioacetamide; (-)-epigallocatechin 3-gallate (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC132057.1; alpha melanocyte stimulating hormone receptor; LOC292083; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocyte-stimulating hormone receptor
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,360,950 - 68,363,877 (+)NCBIGRCr8
mRatBN7.21951,452,448 - 51,455,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,453,239 - 51,454,192 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,246,649 - 58,249,576 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,924,137 - 58,927,064 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,145,249 - 61,148,176 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,215,420 - 56,219,987 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,216,812 - 56,217,766 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01966,926,656 - 66,929,094 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11953,743,365 - 53,744,540 (+)NCBI
Celera1950,684,385 - 50,688,952 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Experimental Data Annotations    Click to see Annotation Detail View

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Mc1rRatcoat/hair pigmentation trait  ISORGD:121752819068941Coat colour, melanistic maskOMIAPMID:12692165|PMID:21353269|PMID:29932470|PMID:33672409|PMID:34751460|PMID:35510419|PMID:35595349|PMID:36427679|PMID:37582787

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Experimental Data Annotations     Click to see Annotation Detail View

Vertebrate Trait

References

References - curated
# Reference Title Reference Citation
1. The melanocortin system in control of inflammation. Catania A, etal., ScientificWorldJournal. 2010 Sep 14;10:1840-53.
2. MC1R: three novel variants identified in a malignant melanoma association study in the Spanish population. Fernandez L, etal., Carcinogenesis. 2007 Aug;28(8):1659-64. Epub 2007 Apr 13.
3. Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation. Flanagan N, etal., Hum Mol Genet. 2000 Oct 12;9(17):2531-7.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Increased alpha-melanocyte-stimulating hormone (alpha-MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis. Hiramoto K, etal., Exp Dermatol. 2010 Feb;19(2):132-6. Epub 2009 Nov 2.
6. Alpha-melanocyte-stimulating hormone plays an important role in the onset of pollinosis in a pollen allergy mouse model. Hiramoto K, etal., Int Arch Allergy Immunol. 2010;153(1):13-8. Epub 2010 Mar 30.
7. Change of melanocortin receptor expression in rat kidney ischemia-reperfusion injury. Lee YS, etal., Transplant Proc. 2008 Sep;40(7):2142-4.
8. Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion. Leoni G, etal., FASEB J. 2008 Dec;22(12):4228-38. Epub 2008 Aug 29.
9. The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans. Loser K, etal., PLoS One. 2010 Feb 1;5(2):e8958.
10. Crucial role of the melanocortin receptor MC1R in experimental colitis. Maaser C, etal., Gut. 2006 Oct;55(10):1415-22. Epub 2006 Mar 16.
11. Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response. Malik IA, etal., Histochem Cell Biol. 2012 Mar;137(3):279-91. Epub 2011 Dec 20.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Effects of MCH and a MCH1-receptor antagonist on (palatable) food and water intake. Morens C, etal., Brain Res. 2005 Nov 16;1062(1-2):32-8. Epub 2005 Oct 28.
14. Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors. Murray JF, etal., J Neuroendocrinol. 2006 Mar;18(3):157-67.
15. Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats. Nair SG, etal., Psychopharmacology (Berl). 2009 Jul;205(1):129-40. Epub 2009 Apr 2.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure. Piedboeuf B, etal., Am J Respir Cell Mol Biol. 1994 Feb;10(2):123-32.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Alpha-MSH promotes spontaneous post-ischemic pneumonia in mice via melanocortin-receptor-1. Schulte-Herbruggen O, etal., Exp Neurol. 2008 Apr;210(2):731-9. Epub 2008 Jan 19.
22. The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma. Valverde P, etal., Hum Mol Genet. 1996 Oct;5(10):1663-6.
23. Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response. Wu GS, etal., Psychiatr Genet. 2011 Feb;21(1):14-8.
Additional References at PubMed
PMID:7665913   PMID:9183385   PMID:9454589   PMID:10233018   PMID:12663858   PMID:18292087   PMID:19329486   PMID:19452503   PMID:19737927   PMID:19743876   PMID:19745571   PMID:21800996  
PMID:30356069   PMID:31486022   PMID:36446431   PMID:37490042   PMID:38185389  


Genomics

Comparative Map Data
Mc1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,360,950 - 68,363,877 (+)NCBIGRCr8
mRatBN7.21951,452,448 - 51,455,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,453,239 - 51,454,192 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,246,649 - 58,249,576 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,924,137 - 58,927,064 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,145,249 - 61,148,176 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,215,420 - 56,219,987 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,216,812 - 56,217,766 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01966,926,656 - 66,929,094 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11953,743,365 - 53,744,540 (+)NCBI
Celera1950,684,385 - 50,688,952 (+)NCBICelera
Cytogenetic Map19q12NCBI
MC1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381689,918,862 - 89,920,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1689,912,119 - 89,920,973 (+)EnsemblGRCh38hg38GRCh38
GRCh371689,985,270 - 89,987,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,512,527 - 88,514,886 (+)NCBINCBI36Build 36hg18NCBI36
Build 341688,512,526 - 88,514,885NCBI
Celera1675,049,377 - 75,052,475 (+)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1675,677,396 - 75,680,494 (+)NCBIHuRef
CHM1_11691,396,407 - 91,399,505 (+)NCBICHM1_1
T2T-CHM13v2.01696,005,107 - 96,007,217 (+)NCBIT2T-CHM13v2.0
Mc1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398124,133,839 - 124,137,483 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8124,133,846 - 124,137,483 (+)EnsemblGRCm39 Ensembl
GRCm388123,407,082 - 123,410,744 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,407,107 - 123,410,744 (+)EnsemblGRCm38mm10GRCm38
MGSCv378125,930,982 - 125,934,644 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368126,293,586 - 126,294,847 (+)NCBIMGSCv36mm8
Celera8127,649,606 - 127,653,268 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map872.1NCBI
MC1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21899,765,927 - 99,787,492 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116105,653,522 - 105,674,638 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01670,676,447 - 70,697,636 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11690,340,876 - 90,362,291 (+)NCBIpanpan1.1PanPan1.1panPan2
MC1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1563,694,296 - 63,695,249 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha563,707,491 - 63,708,444 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0563,922,271 - 63,923,224 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1563,942,798 - 63,943,751 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0563,780,332 - 63,781,285 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0564,186,690 - 64,187,643 (-)NCBIUU_Cfam_GSD_1.0
Mc1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934924,441,187 - 24,444,410 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936641193,885 - 198,730 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MC1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6181,225 - 182,187 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16181,225 - 182,187 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26255,611 - 256,573 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6pNCBI
Mc1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746132,904 - 133,860 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746131,356 - 137,745 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mc1r
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:106
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000058145
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000058145   ⟹   ENSRNOP00000088368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1951,453,239 - 51,454,192 (+)Ensembl
RefSeq Acc Id: NM_001401091   ⟹   NP_001388020
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,360,950 - 68,363,877 (+)NCBI
mRatBN7.21951,452,448 - 51,455,375 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388020 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAG85194 (Get FASTA)   NCBI Sequence Viewer  
  BAU20222 (Get FASTA)   NCBI Sequence Viewer  
  EDL92809 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088368.1
  ENSRNOP00000100524
Ensembl Acc Id: ENSRNOP00000088368   ⟸   ENSRNOT00000058145
RefSeq Acc Id: NP_001388020   ⟸   NM_001401091
- UniProtKB: A0A0U5AX81 (UniProtKB/TrEMBL),   A6IZY1 (UniProtKB/TrEMBL),   B6ZGR5 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312046 AgrOrtholog
BioCyc Gene G2FUF-5326 BioCyc
Ensembl Genes ENSRNOG00000038193 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000074229 ENTREZGENE
Ensembl Transcript ENSRNOT00000058145.4 UniProtKB/TrEMBL
  ENSRNOT00000158200 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Melcrt_ACTH_rcpt UniProtKB/TrEMBL
  MSH_rcpt UniProtKB/TrEMBL
NCBI Gene Mc1r ENTREZGENE
OMIM 155555
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Mc1r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  MCRFAMILY UniProtKB/TrEMBL
  MELNOCYTESHR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038193 RatGTEx
  ENSRNOG00000074229 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0U5AX81 ENTREZGENE, UniProtKB/TrEMBL
  A6IZY1 ENTREZGENE
  B6ZGR5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6IZY1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Mc1r  melanocortin 1 receptor  AC132057.1    Data merged from RGD:15004283 737654 PROVISIONAL
2021-09-02 AC132057.1    Mc1r  melanocortin 1 receptor  Symbol and/or name change 19259462 PROVISIONAL
2021-08-09 Mc1r  melanocortin 1 receptor  AC132057.1    Symbol and/or name change 19259462 PROVISIONAL
2019-11-08 AC132057.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 Mc1r  melanocortin 1 receptor   Mc1r_predicted  melanocortin 1 receptor (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mc1r_predicted  melanocortin 1 receptor (predicted)      Symbol and Name status set to approved 70820 APPROVED