Zfp35 (zinc finger protein 35) - Rat Genome Database

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Pathways
Gene: Zfp35 (zinc finger protein 35) Rattus norvegicus
Analyze
Symbol: Zfp35
Name: zinc finger protein 35
RGD ID: 1312031
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II; INTERACTS WITH 17beta-estradiol (ortholog); acrylamide (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC307547; MGC108880; Zfp239; zinc finger protein 239; zinc finger protein 271
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21815,268,852 - 15,284,334 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1815,268,814 - 15,285,088 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1815,453,988 - 15,469,485 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01816,236,692 - 16,252,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01815,526,432 - 15,541,938 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01815,883,182 - 15,898,803 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,883,182 - 15,898,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01815,648,791 - 15,664,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41815,749,584 - 15,765,238 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11815,776,229 - 15,791,877 (+)NCBI
Celera1815,217,050 - 15,232,381 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19783676  


Genomics

Comparative Map Data
Zfp35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21815,268,852 - 15,284,334 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1815,268,814 - 15,285,088 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1815,453,988 - 15,469,485 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01816,236,692 - 16,252,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01815,526,432 - 15,541,938 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01815,883,182 - 15,898,803 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,883,182 - 15,898,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01815,648,791 - 15,664,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41815,749,584 - 15,765,238 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11815,776,229 - 15,791,877 (+)NCBI
Celera1815,217,050 - 15,232,381 (+)NCBICelera
Cytogenetic Map18p12NCBI
ZNF79
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,424,382 - 127,445,372 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,424,374 - 127,445,372 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,186,661 - 130,207,651 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,226,482 - 129,247,471 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,266,214 - 127,287,204NCBI
Celera9100,837,528 - 100,858,526 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef999,802,632 - 99,823,635 (+)NCBIHuRef
CHM1_19130,337,099 - 130,358,946 (+)NCBICHM1_1
T2T-CHM13v2.09139,631,324 - 139,652,321 (+)NCBIT2T-CHM13v2.0
Znf79
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554191,157,721 - 1,168,330 (-)NCBIChiLan1.0ChiLan1.0
ZNF79
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1911,911,311 - 11,932,400 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,548,125 - 98,565,632 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,238,713 - 127,239,349 (+)NCBIpanpan1.1PanPan1.1panPan2
ZNF79
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,900,765 - 55,916,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,900,911 - 55,915,770 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha955,104,542 - 55,120,100 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,822,116 - 56,837,840 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,822,272 - 56,837,818 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,581,820 - 55,597,582 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,896,859 - 55,912,625 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,987,591 - 56,003,544 (-)NCBIUU_Cfam_GSD_1.0
ZNF79
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1267,942,101 - 267,966,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11267,941,953 - 267,959,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21301,852,461 - 301,870,278 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF79
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,683,634 - 10,704,116 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,683,852 - 10,698,004 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660795,510,648 - 5,531,887 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zfp35
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:36
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000073081
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat

Markers in Region
D18Mit14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21815,275,597 - 15,275,693 (+)MAPPERmRatBN7.2
Rnor_6.01815,889,927 - 15,890,022NCBIRnor6.0
Rnor_5.01815,655,536 - 15,655,631UniSTSRnor5.0
RGSC_v3.41815,756,328 - 15,756,424RGDRGSC3.4
RGSC_v3.41815,756,329 - 15,756,424UniSTSRGSC3.4
RGSC_v3.11815,782,975 - 15,783,070RGD
Celera1815,223,795 - 15,223,890UniSTS
RH 3.4 Map18177.6UniSTS
RH 3.4 Map18177.6RGD
RH 2.0 Map18706.5RGD
SHRSP x BN Map188.17RGD
FHH x ACI Map1810.57RGD
Cytogenetic Map18p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 11 4 17 4 72 20 36 11
Low 3 41 46 37 2 37 8 11 2 15 5 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000076137   ⟹   ENSRNOP00000067944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1815,268,814 - 15,285,088 (+)Ensembl
Rnor_6.0 Ensembl1815,883,182 - 15,898,821 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088353   ⟹   ENSRNOP00000071577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1815,883,182 - 15,898,796 (+)Ensembl
RefSeq Acc Id: NM_001013141   ⟹   NP_001013159
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,268,852 - 15,284,334 (+)NCBI
Rnor_6.01815,883,182 - 15,898,803 (+)NCBI
Rnor_5.01815,648,791 - 15,664,412 (+)NCBI
RGSC_v3.41815,749,584 - 15,765,238 (+)RGD
Celera1815,217,050 - 15,232,381 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013159 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89850 (Get FASTA)   NCBI Sequence Viewer  
  EDL76125 (Get FASTA)   NCBI Sequence Viewer  
  EDL76126 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013159   ⟸   NM_001013141
- UniProtKB: Q5FVP4 (UniProtKB/TrEMBL),   A0A096MJ05 (UniProtKB/TrEMBL),   A0A9K3Y763 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071577   ⟸   ENSRNOT00000088353
RefSeq Acc Id: ENSRNOP00000067944   ⟸   ENSRNOT00000076137

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K0T7-F1-model_v2 AlphaFold A0A0G2K0T7 1-580 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312031 AgrOrtholog
BioCyc Gene G2FUF-8166 BioCyc
Ensembl Genes ENSRNOG00000049137 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067944 ENTREZGENE
  ENSRNOP00000067944.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076137 ENTREZGENE
  ENSRNOT00000076137.3 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7375328 IMAGE-MGC_LOAD
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:307547 UniProtKB/TrEMBL
MGC_CLONE MGC:108880 IMAGE-MGC_LOAD
NCBI Gene 307547 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 391 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PhenoGen Zfp35 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A096MJ05 ENTREZGENE
  A0A9K3Y763 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVP4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A096MJ05 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Zfp35  zinc finger protein 35  Zfp239  zinc finger protein 239  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Zfp239  zinc finger protein 239  Zfp239_predicted  zinc finger protein 239 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Zfp239_predicted  zinc finger protein 239 (predicted)      Symbol and Name status set to approved 70820 APPROVED