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Gene: Fam20c (FAM20C, golgi associated secretory pathway kinase) Rattus norvegicus

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Symbol:

Fam20c

Name:

FAM20C, golgi associated secretory pathway kinase

RGD ID:

1311980

Description:

Enables protein serine/threonine kinase activity. Involved in odontoblast differentiation and protein phosphorylation. Predicted to be located in Golgi membrane; extracellular space; and nucleoplasm. Predicted to colocalize with Golgi apparatus. Human ortholog(s) of this gene implicated in amelogenesis imperfecta. Orthologous to human FAM20C (FAM20C golgi associated secretory pathway kinase); INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dentin matrix protein 4; extracellular serine/threonine protein kinase FAM20C; family with sequence similarity 20, member C; LOC304334; RGD1311980; similar to cDNA sequence BC004044

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	20,940,654 - 20,999,072 (-)	NCBI		GRCr8
mRatBN7.2	12	15,826,864 - 15,885,423 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	15,826,871 - 15,884,543 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	16,638,165 - 16,695,811 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	17,261,890 - 17,319,536 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	16,284,652 - 16,341,671 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	17,913,771 - 17,972,733 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	17,913,767 - 17,972,737 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	19,906,233 - 19,965,797 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	16,340,407 - 16,399,325 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	16,371,029 - 16,473,541 (-)	NCBI
Celera	12	17,578,522 - 17,635,987 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fam20c	Rat	amelogenesis imperfecta		ISO	RGD:1323719	11560491	DNA:snp, missense mutation:cds:c.1487C>T, p.P496L (human)	RGD
Fam20c	Rat	amelogenesis imperfecta		ISO	RGD:1323720	11560487		RGD
Fam20c	Rat	COVID-19		ISO	RGD:1323719	9068941	mRNA:increased expression:peripheral blood mononuclear cell (human)	RGD	PMID:32228226\|REF_RGD_ID:28912744
Fam20c	Rat	Hypophosphatemic Rickets		ISO	RGD:1323720	11558021		RGD
Fam20c	Rat	Raine Syndrome		ISO	RGD:1323719	11560486	DNA:deletion, snps, missense mutations:multiple (human)	RGD
Fam20c	Rat	Tooth Demineralization		ISO	RGD:1323719	11558022	associated with Rickets, Hypophosphatemic;DNA:snps, missense mutation, nonsense mutation:multiple (human)	RGD
Fam20c	Rat	X-linked hypophosphatemic rickets		ISO	RGD:1323719	11560488	mRNA:increased expression:long bone, osteoblast, osteocyte (mouse)	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fam20c	Rat	Emery-Dreifuss muscular dystrophy		ISO	RGD:1323719	8554872	ClinVar Annotator: match by term: Emery-Dreifuss muscular dystrophy	ClinVar	PMID:28492532
Fam20c	Rat	genetic disease		ISO	RGD:1323719	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868\|PMID:28492532\|PMID:34633109
Fam20c	Rat	Perinatal Death		ISO	RGD:1323719	8554872	ClinVar Annotator: match by term: Neonatal death	ClinVar	PMID:25558065
Fam20c	Rat	Raine Syndrome		ISO	RGD:1323719	8554872	ClinVar Annotator: match by term: FAM20C-related condition \| ClinVar Annotator: match by term: Lethal osteosclerotic more ...	ClinVar	PMID:12868469\|PMID:14564151\|PMID:17576681\|PMID:17924334\|PMID:19250384\|PMID:2020859\|PMID:20825432\|PMID:22582013\|PMID:24033266\|PMID:25026495\|PMID:25741868\|PMID:27862258\|PMID:28492532\|PMID:32093234\|PMID:32299476\|PMID:32337609\|PMID:9536098

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fam20c	Rat	Raine Syndrome		ISO	RGD:1323719	11554173	CTD Direct Evidence: marker/mechanism	CTD

Imported Disease Annotations - MGI

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fam20c	Rat	rickets		ISS	RGD:1323720	13592920	OMIM:264700 \| OMIM:277440 \| OMIM:600081 \| OMIM:600785	MouseDO

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fam20c	Rat	Raine Syndrome		ISO	RGD:1323719	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fam20c	Rat	(+)-schisandrin B	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of FAM20C mRNA]	CTD	PMID:31150632
Fam20c	Rat	(1->4)-beta-D-glucan	multiple interactions	ISO	RGD:1323720	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of FAM20C mRNA	CTD	PMID:36331819
Fam20c	Rat	1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane	multiple interactions	EXP		6480464	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of FAM20C mRNA]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the more ...	CTD	PMID:19414516
Fam20c	Rat	1,1-dichloroethene	decreases expression	ISO	RGD:1323720	6480464	vinylidene chloride results in decreased expression of FAM20C mRNA	CTD	PMID:26682919
Fam20c	Rat	17beta-estradiol	increases expression	ISO	RGD:1323720	6480464	Estradiol results in increased expression of FAM20C mRNA	CTD	PMID:15289156\|PMID:39298647
Fam20c	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1323720	6480464	[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of FAM20C mRNA	CTD	PMID:16214954
Fam20c	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of FAM20C mRNA	CTD	PMID:33387578\|PMID:34747641
Fam20c	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1323720	6480464	Tetrachlorodibenzodioxin results in decreased expression of FAM20C mRNA	CTD	PMID:26290441
Fam20c	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of FAM20C mRNA	CTD	PMID:21215274
Fam20c	Rat	2,4-dibromophenyl 2,4,5-tribromophenyl ether	affects expression	ISO	RGD:1323720	6480464	2,2',4,4',5-brominated diphenyl ether affects the expression of FAM20C mRNA	CTD	PMID:38648751
Fam20c	Rat	3',5'-cyclic AMP	multiple interactions	EXP		6480464	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of FAM20C mRNA]	CTD	PMID:19414516
Fam20c	Rat	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	ISO	RGD:1323719	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Fam20c	Rat	4,4'-sulfonyldiphenol	decreases expression	ISO	RGD:1323720	6480464	bisphenol S results in decreased expression of FAM20C mRNA	CTD	PMID:39298647
Fam20c	Rat	4-hydroxyphenyl retinamide	decreases expression	ISO	RGD:1323720	6480464	Fenretinide results in decreased expression of FAM20C mRNA	CTD	PMID:28973697
Fam20c	Rat	5-fluorouracil	affects expression	ISO	RGD:1323719	6480464	Fluorouracil affects the expression of FAM20C mRNA	CTD	PMID:16584549
Fam20c	Rat	afimoxifene	multiple interactions	ISO	RGD:1323719	6480464	afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM20C mRNA]	CTD	PMID:21233418
Fam20c	Rat	aflatoxin B1	decreases expression	ISO	RGD:1323719	6480464	Aflatoxin B1 results in decreased expression of FAM20C mRNA	CTD	PMID:22100608\|PMID:27153756
Fam20c	Rat	aflatoxin B1	increases methylation	ISO	RGD:1323719	6480464	Aflatoxin B1 results in increased methylation of FAM20C intron	CTD	PMID:30157460
Fam20c	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:1323719	6480464	Tretinoin results in increased expression of FAM20C mRNA	CTD	PMID:33167477
Fam20c	Rat	aristolochic acid A	decreases expression	ISO	RGD:1323719	6480464	aristolochic acid I results in decreased expression of FAM20C mRNA	CTD	PMID:33212167
Fam20c	Rat	arsane	affects methylation	ISO	RGD:1323719	6480464	Arsenic affects the methylation of FAM20C gene	CTD	PMID:25304211
Fam20c	Rat	arsenic atom	affects methylation	ISO	RGD:1323719	6480464	Arsenic affects the methylation of FAM20C gene	CTD	PMID:25304211
Fam20c	Rat	arsenous acid	decreases expression	ISO	RGD:1323719	6480464	Arsenic Trioxide results in decreased expression of FAM20C mRNA	CTD	PMID:22521957
Fam20c	Rat	atrazine	affects methylation	EXP		6480464	Atrazine affects the methylation of FAM20C gene	CTD	PMID:35440735
Fam20c	Rat	benzene	increases expression	ISO	RGD:1323719	6480464	Benzene results in increased expression of FAM20C mRNA	CTD	PMID:19162166
Fam20c	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1323720	6480464	Benzo(a)pyrene results in decreased expression of FAM20C mRNA	CTD	PMID:19770486
Fam20c	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:1323719	6480464	Benzo(a)pyrene results in decreased methylation of FAM20C promoter	CTD	PMID:27901495
Fam20c	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1323719	6480464	Benzo(a)pyrene results in decreased expression of FAM20C mRNA	CTD	PMID:20064835\|PMID:26238291\|PMID:32234424
Fam20c	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1323720	6480464	Benzo(a)pyrene results in increased expression of FAM20C mRNA	CTD	PMID:22228805
Fam20c	Rat	benzo[a]pyrene	multiple interactions	ISO	RGD:1323720	6480464	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of FAM20C mRNA]	CTD	PMID:22228805
Fam20c	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1323719	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FAM20C mRNA	CTD	PMID:19150397
Fam20c	Rat	benzo[e]pyrene	increases methylation	ISO	RGD:1323719	6480464	benzo(e)pyrene results in increased methylation of FAM20C intron	CTD	PMID:30157460
Fam20c	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of FAM20C mRNA	CTD	PMID:25181051\|PMID:34947998
Fam20c	Rat	bisphenol A	decreases methylation	ISO	RGD:1323719	6480464	bisphenol A results in decreased methylation of FAM20C gene	CTD	PMID:31601247
Fam20c	Rat	bisphenol A	increases expression	ISO	RGD:1323720	6480464	bisphenol A results in increased expression of FAM20C mRNA	CTD	PMID:34585602\|PMID:35479511
Fam20c	Rat	bisphenol F	multiple interactions	ISO	RGD:1323719	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Fam20c	Rat	butan-1-ol	multiple interactions	ISO	RGD:1323719	6480464	[[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ...	CTD	PMID:29432896
Fam20c	Rat	cadmium dichloride	decreases expression	ISO	RGD:1323719	6480464	Cadmium Chloride results in decreased expression of FAM20C mRNA	CTD	PMID:38568856
Fam20c	Rat	calcitriol	increases expression	ISO	RGD:1323719	6480464	Calcitriol results in increased expression of FAM20C mRNA	CTD	PMID:16002434
Fam20c	Rat	carbon nanotube	decreases expression	ISO	RGD:1323720	6480464	Nanotubes, Carbon analog results in decreased expression of FAM20C mRNA; Nanotubes, Carbon results in decreased more ...	CTD	PMID:25620056
Fam20c	Rat	carbon nanotube	increases expression	ISO	RGD:1323720	6480464	Nanotubes, Carbon analog results in increased expression of FAM20C mRNA; Nanotubes, Carbon results in increased more ...	CTD	PMID:25554681
Fam20c	Rat	cisplatin	decreases expression	ISO	RGD:1323719	6480464	Cisplatin results in decreased expression of FAM20C mRNA	CTD	PMID:19561079\|PMID:27392435
Fam20c	Rat	cocaine	affects expression	EXP		6480464	Cocaine affects the expression of FAM20C mRNA	CTD	PMID:20187946
Fam20c	Rat	copper atom	decreases expression	EXP		6480464	Copper results in decreased expression of FAM20C mRNA	CTD	PMID:30556269
Fam20c	Rat	copper(0)	decreases expression	EXP		6480464	Copper results in decreased expression of FAM20C mRNA	CTD	PMID:30556269
Fam20c	Rat	copper(II) chloride	decreases expression	ISO	RGD:1323719	6480464	cupric chloride results in decreased expression of FAM20C mRNA	CTD	PMID:38568856
Fam20c	Rat	copper(II) sulfate	decreases expression	ISO	RGD:1323719	6480464	Copper Sulfate results in decreased expression of FAM20C mRNA	CTD	PMID:19549813
Fam20c	Rat	cyclosporin A	decreases expression	ISO	RGD:1323719	6480464	Cyclosporine results in decreased expression of FAM20C mRNA	CTD	PMID:25562108
Fam20c	Rat	dexamethasone	decreases expression	ISO	RGD:1323720	6480464	Dexamethasone results in decreased expression of FAM20C mRNA	CTD	PMID:27645313
Fam20c	Rat	dexamethasone	multiple interactions	ISO	RGD:1323719	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Fam20c	Rat	dexamethasone	multiple interactions	ISO	RGD:1323720	6480464	apicidin inhibits the reaction [Dexamethasone results in decreased expression of FAM20C mRNA]; Valproic Acid inhibits more ...	CTD	PMID:27645313
Fam20c	Rat	diarsenic trioxide	decreases expression	ISO	RGD:1323719	6480464	Arsenic Trioxide results in decreased expression of FAM20C mRNA	CTD	PMID:22521957
Fam20c	Rat	dibutyl phthalate	increases expression	EXP		6480464	Dibutyl Phthalate results in increased expression of FAM20C mRNA	CTD	PMID:21266533
Fam20c	Rat	dibutyl phthalate	increases expression	ISO	RGD:1323720	6480464	Dibutyl Phthalate results in increased expression of FAM20C mRNA	CTD	PMID:21266533
Fam20c	Rat	diethylstilbestrol	increases expression	ISO	RGD:1323720	6480464	Diethylstilbestrol results in increased expression of FAM20C mRNA	CTD	PMID:15289156
Fam20c	Rat	dorsomorphin	multiple interactions	ISO	RGD:1323719	6480464	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ...	CTD	PMID:27188386
Fam20c	Rat	endosulfan	increases expression	EXP		6480464	Endosulfan results in increased expression of FAM20C mRNA	CTD	PMID:29391264
Fam20c	Rat	entinostat	multiple interactions	ISO	RGD:1323719	6480464	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ...	CTD	PMID:27188386
Fam20c	Rat	entinostat	increases expression	ISO	RGD:1323719	6480464	entinostat results in increased expression of FAM20C mRNA	CTD	PMID:26272509
Fam20c	Rat	ethanol	affects splicing	ISO	RGD:1323720	6480464	Ethanol affects the splicing of FAM20C mRNA	CTD	PMID:30319688
Fam20c	Rat	fipronil	decreases expression	EXP		6480464	fipronil results in decreased expression of FAM20C mRNA	CTD	PMID:23962444
Fam20c	Rat	flutamide	decreases expression	EXP		6480464	Flutamide results in decreased expression of FAM20C mRNA	CTD	PMID:24793618
Fam20c	Rat	genistein	increases expression	ISO	RGD:1323720	6480464	Genistein results in increased expression of FAM20C mRNA	CTD	PMID:15289156
Fam20c	Rat	indometacin	multiple interactions	ISO	RGD:1323719	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Fam20c	Rat	inulin	multiple interactions	ISO	RGD:1323720	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of FAM20C mRNA	CTD	PMID:36331819
Fam20c	Rat	iron atom	decreases expression	ISO	RGD:1323719	6480464	Iron deficiency results in decreased expression of FAM20C mRNA	CTD	PMID:20368581
Fam20c	Rat	iron dichloride	decreases expression	ISO	RGD:1323719	6480464	ferrous chloride results in decreased expression of FAM20C mRNA	CTD	PMID:35984750
Fam20c	Rat	iron(0)	decreases expression	ISO	RGD:1323719	6480464	Iron deficiency results in decreased expression of FAM20C mRNA	CTD	PMID:20368581
Fam20c	Rat	ketoconazole	increases expression	EXP		6480464	Ketoconazole results in increased expression of FAM20C mRNA	CTD	PMID:37077353
Fam20c	Rat	lead diacetate	increases expression	ISO	RGD:1323719	6480464	lead acetate results in increased expression of FAM20C mRNA	CTD	PMID:38568856
Fam20c	Rat	lipopolysaccharide	multiple interactions	ISO	RGD:1323719	6480464	[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of FAM20C mRNA; [S-(1,2-dichlorovinyl)cysteine more ...	CTD	PMID:35811015
Fam20c	Rat	lipopolysaccharide	decreases expression	ISO	RGD:1323719	6480464	Lipopolysaccharides results in decreased expression of FAM20C mRNA	CTD	PMID:35811015
Fam20c	Rat	menadione	affects expression	ISO	RGD:1323719	6480464	Vitamin K 3 affects the expression of FAM20C mRNA	CTD	PMID:20044591
Fam20c	Rat	methapyrilene	increases methylation	ISO	RGD:1323719	6480464	Methapyrilene results in increased methylation of FAM20C intron	CTD	PMID:30157460
Fam20c	Rat	methylparaben	increases expression	ISO	RGD:1323719	6480464	methylparaben results in increased expression of FAM20C mRNA	CTD	PMID:38568856
Fam20c	Rat	nickel atom	increases expression	ISO	RGD:1323719	6480464	Nickel results in increased expression of FAM20C mRNA	CTD	PMID:25583101
Fam20c	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of FAM20C mRNA	CTD	PMID:25729387
Fam20c	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of FAM20C mRNA	CTD	PMID:33387578
Fam20c	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1323720	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of FAM20C mRNA; [perfluorooctane sulfonic more ...	CTD	PMID:36331819
Fam20c	Rat	phenylmercury acetate	decreases expression	ISO	RGD:1323719	6480464	Phenylmercuric Acetate results in decreased expression of FAM20C mRNA	CTD	PMID:26272509
Fam20c	Rat	phenylmercury acetate	multiple interactions	ISO	RGD:1323719	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Fam20c	Rat	pirinixic acid	decreases expression	ISO	RGD:1323720	6480464	pirinixic acid results in decreased expression of FAM20C mRNA	CTD	PMID:23811191
Fam20c	Rat	pregnenolone 16alpha-carbonitrile	decreases expression	ISO	RGD:1323720	6480464	Pregnenolone Carbonitrile results in decreased expression of FAM20C mRNA	CTD	PMID:28903501
Fam20c	Rat	rotenone	increases expression	EXP		6480464	Rotenone results in increased expression of FAM20C mRNA	CTD	PMID:28374803
Fam20c	Rat	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	ISO	RGD:1323719	6480464	[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of FAM20C mRNA; [S-(1,2-dichlorovinyl)cysteine more ...	CTD	PMID:35811015
Fam20c	Rat	SB 431542	multiple interactions	ISO	RGD:1323719	6480464	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ...	CTD	PMID:27188386
Fam20c	Rat	serpentine asbestos	increases expression	ISO	RGD:1323719	6480464	Asbestos, Serpentine results in increased expression of FAM20C mRNA	CTD	PMID:29523930
Fam20c	Rat	silicon dioxide	increases expression	ISO	RGD:1323720	6480464	Silicon Dioxide results in increased expression of FAM20C mRNA	CTD	PMID:29203145
Fam20c	Rat	silver atom	decreases expression	ISO	RGD:1323720	6480464	Silver results in decreased expression of FAM20C mRNA	CTD	PMID:27131904
Fam20c	Rat	silver(0)	decreases expression	ISO	RGD:1323720	6480464	Silver results in decreased expression of FAM20C mRNA	CTD	PMID:27131904
Fam20c	Rat	sodium arsenite	increases expression	ISO	RGD:1323719	6480464	sodium arsenite results in increased expression of FAM20C mRNA	CTD	PMID:28595984
Fam20c	Rat	sodium arsenite	decreases expression	ISO	RGD:1323720	6480464	sodium arsenite results in decreased expression of FAM20C mRNA	CTD	PMID:37682722
Fam20c	Rat	sodium arsenite	affects expression	ISO	RGD:1323719	6480464	sodium arsenite affects the expression of FAM20C mRNA	CTD	PMID:34032870
Fam20c	Rat	sodium arsenite	decreases expression	ISO	RGD:1323719	6480464	sodium arsenite results in decreased expression of FAM20C mRNA	CTD	PMID:38568856
Fam20c	Rat	succimer	multiple interactions	ISO	RGD:1323720	6480464	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of FAM20C mRNA; [Succimer co-treated more ...	CTD	PMID:21641980\|PMID:26378955
Fam20c	Rat	sunitinib	increases expression	ISO	RGD:1323719	6480464	Sunitinib results in increased expression of FAM20C mRNA	CTD	PMID:31533062
Fam20c	Rat	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of FAM20C mRNA	CTD	PMID:31150632
Fam20c	Rat	tetrachloromethane	decreases expression	ISO	RGD:1323720	6480464	Carbon Tetrachloride results in decreased expression of FAM20C mRNA	CTD	PMID:31919559
Fam20c	Rat	tetrachloromethane	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of FAM20C mRNA]	CTD	PMID:31150632
Fam20c	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of FAM20C mRNA	CTD	PMID:34492290
Fam20c	Rat	thiram	decreases expression	ISO	RGD:1323719	6480464	Thiram results in decreased expression of FAM20C mRNA	CTD	PMID:38568856
Fam20c	Rat	titanium dioxide	decreases methylation	ISO	RGD:1323720	6480464	titanium dioxide results in decreased methylation of FAM20C gene; titanium dioxide results in decreased methylation more ...	CTD	PMID:35295148
Fam20c	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of FAM20C mRNA	CTD	PMID:25729387
Fam20c	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of FAM20C mRNA	CTD	PMID:33387578
Fam20c	Rat	trichostatin A	decreases expression	ISO	RGD:1323719	6480464	trichostatin A results in decreased expression of FAM20C mRNA	CTD	PMID:24935251
Fam20c	Rat	triphenyl phosphate	increases expression	EXP		6480464	triphenyl phosphate results in increased expression of FAM20C mRNA	CTD	PMID:30589522
Fam20c	Rat	urethane	decreases expression	ISO	RGD:1323719	6480464	Urethane results in decreased expression of FAM20C mRNA	CTD	PMID:28818685
Fam20c	Rat	valproic acid	multiple interactions	ISO	RGD:1323720	6480464	Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of FAM20C mRNA]	CTD	PMID:27645313
Fam20c	Rat	valproic acid	multiple interactions	ISO	RGD:1323719	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Fam20c	Rat	valproic acid	increases expression	ISO	RGD:1323720	6480464	Valproic Acid results in increased expression of FAM20C mRNA	CTD	PMID:27645313
Fam20c	Rat	valproic acid	affects expression	ISO	RGD:1323719	6480464	Valproic Acid affects the expression of FAM20C mRNA	CTD	PMID:25979313
Fam20c	Rat	valproic acid	increases methylation	ISO	RGD:1323719	6480464	Valproic Acid results in increased methylation of FAM20C gene	CTD	PMID:29154799
Fam20c	Rat	valproic acid	decreases expression	ISO	RGD:1323719	6480464	Valproic Acid results in decreased expression of FAM20C mRNA	CTD	PMID:23179753\|PMID:24383497\|PMID:26272509\|PMID:28001369\|PMID:29154799
Fam20c	Rat	vorinostat	decreases expression	ISO	RGD:1323719	6480464	vorinostat results in decreased expression of FAM20C mRNA	CTD	PMID:27188386

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fam20c	Rat	biomineral tissue development	involved_in	ISO	RGD:1323719	1624291	PMID:22582013, PMID:25789606	RGD	PMID:22582013\|PMID:25789606
Fam20c	Rat	dentinogenesis	acts_upstream_of_or_within	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	dentinogenesis	acts_upstream_of_or_within	ISO	RGD:1323720	1624291	MGI:5432377 PMID:22732358	RGD	PMID:22732358
Fam20c	Rat	enamel mineralization	involved_in	IBA	MGI:2136853\|MGI:2388266\|PANTHER:PTN000278682\|UniProtKB:Q96MK3	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fam20c	Rat	enamel mineralization	acts_upstream_of_or_within	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	enamel mineralization	acts_upstream_of_or_within	ISO	RGD:1323720	1624291	MGI:5432377 PMID:22732358	RGD	PMID:22732358
Fam20c	Rat	odontoblast differentiation		IEP		11560522		RGD
Fam20c	Rat	odontoblast differentiation	acts_upstream_of_or_within	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	odontoblast differentiation	acts_upstream_of_or_within	ISO	RGD:1323720	1624291	PMID:17369251	RGD	PMID:17369251
Fam20c	Rat	osteoclast maturation	acts_upstream_of_or_within	ISO	RGD:1323720	1624291	MGI:2656539\|MGI:5428020 PMID:22615579	RGD	PMID:22615579
Fam20c	Rat	osteoclast maturation	acts_upstream_of_or_within	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	positive regulation of bone mineralization	acts_upstream_of_or_within	ISO	RGD:1323720	1624291	PMID:17369251, PMID:22615579	RGD	PMID:17369251\|PMID:22615579
Fam20c	Rat	positive regulation of bone mineralization	acts_upstream_of_or_within	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	positive regulation of osteoblast differentiation	acts_upstream_of_or_within	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	positive regulation of osteoblast differentiation	acts_upstream_of_or_within	ISO	RGD:1323720	1624291	PMID:22615579	RGD	PMID:22615579
Fam20c	Rat	protein phosphorylation		IDA		11560493		RGD
Fam20c	Rat	protein phosphorylation	involved_in	ISO	RGD:1323720	1624291	PMID:22900076	RGD	PMID:22900076
Fam20c	Rat	protein phosphorylation	involved_in	ISO	RGD:1323719	1624291	PMID:23754375, PMID:25789606, PMID:26091039	RGD	PMID:23754375\|PMID:25789606\|PMID:26091039
Fam20c	Rat	regulation of fibroblast growth factor receptor signaling pathway	acts_upstream_of_or_within	ISO	RGD:1323720	1624291	MGI:2656539\|MGI:5428020 PMID:22615579	RGD	PMID:22615579
Fam20c	Rat	regulation of fibroblast growth factor receptor signaling pathway	acts_upstream_of_or_within	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	regulation of phosphorus metabolic process	acts_upstream_of_or_within	ISO	RGD:1323720	1624291	MGI:2656539\|MGI:5428020 PMID:22615579	RGD	PMID:22615579
Fam20c	Rat	regulation of phosphorus metabolic process	acts_upstream_of_or_within	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	skeletal system development	acts_upstream_of_or_within	ISO	RGD:1323720	1624291	MGI:2656539\|MGI:5428020\|MGI:5432377 PMID:22615579, PMID:22732358	RGD	PMID:22615579\|PMID:22732358
Fam20c	Rat	skeletal system development	acts_upstream_of_or_within	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fam20c	Rat	cytoplasm	located_in	ISO	RGD:1323720	1624291	PMID:21549343	RGD	PMID:21549343
Fam20c	Rat	cytoplasm	located_in	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	extracellular space	located_in	ISO	RGD:1323719	1624291	PMID:22582013, PMID:34349020	RGD	PMID:22582013\|PMID:34349020
Fam20c	Rat	extracellular space	located_in	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	extracellular space	located_in	ISO	RGD:1323720	1624291	PMID:17369251	RGD	PMID:17369251
Fam20c	Rat	Golgi apparatus	located_in	ISO	RGD:1323720	1624291	PMID:22900076	RGD	PMID:22900076
Fam20c	Rat	Golgi apparatus	located_in	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	Golgi apparatus	located_in	IEA	UniProtKB-SubCell:SL-0132	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Fam20c	Rat	Golgi apparatus	located_in	IBA	PANTHER:PTN000966557\|UniProtKB:Q96MK3	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fam20c	Rat	Golgi apparatus	located_in	ISO	RGD:1323719	1624291	PMID:22582013	RGD	PMID:22582013
Fam20c	Rat	Golgi apparatus	located_in	ISO	RGD:1323719\|UniProtKB:Q8IXL6-1	1624291		RGD	GO_REF:0000052
Fam20c	Rat	Golgi apparatus	located_in	IEA	UniProtKB-KW:KW-0333	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Fam20c	Rat	Golgi membrane	located_in	ISO	RGD:1323719	1624291	PMID:34349020	RGD	PMID:34349020
Fam20c	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Fam20c	Rat	nucleoplasm	located_in	ISO	RGD:1323719\|UniProtKB:Q8IXL6-1	1624291		RGD	GO_REF:0000052

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fam20c	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Fam20c	Rat	calcium ion binding	enables	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	calcium ion binding	enables	ISO	RGD:1323720	1624291	PMID:17369251	RGD	PMID:17369251
Fam20c	Rat	manganese ion binding	enables	ISO	RGD:1323719	1624291	PMID:23754375	RGD	PMID:23754375
Fam20c	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Fam20c	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Fam20c	Rat	protease binding	enables	ISO	RGD:1323719	1624291	UniProtKB:Q14703 PMID:34349020	RGD	PMID:34349020
Fam20c	Rat	protein binding	enables	ISO	RGD:1323719	1624291	UniProtKB:O14791\|UniProtKB:O95486\|UniProtKB:P01008\|UniProtKB:P02666\|UniProtKB:P02671\|UniProtKB:P02810\|UniProtKB:P05060\|UniProtKB:P08833\|UniProtKB:P10451\|UniProtKB:P10451-PRO_0000020321\|UniProtKB:Q15436\|UniProtKB:Q6UX39\|UniProtKB:Q96MK3\|UniProtKB:Q9NP70\|UniProtKB:Q9NRM1 PMID:22582013, PMID:25789606, PMID:26091039, PMID:34349020	RGD	PMID:22582013\|PMID:25789606\|PMID:26091039\|PMID:34349020
Fam20c	Rat	protein kinase activity	enables	ISO	RGD:1323719	1624291	PMID:34349020	RGD	PMID:34349020
Fam20c	Rat	protein serine/threonine kinase activity		IDA		11560493		RGD
Fam20c	Rat	protein serine/threonine kinase activity	enables	IEA	UniProtKB:Q5MJS3\|ensembl:ENSMUSP00000026972	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fam20c	Rat	protein serine/threonine kinase activity	enables	IBA	MGI:2136853\|PANTHER:PTN002647017\|RGD:1311980\|UniProtKB:Q8IXL6	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fam20c	Rat	protein serine/threonine kinase activity	enables	ISO	RGD:1323720	1624291	PMID:22900076	RGD	PMID:22900076
Fam20c	Rat	protein serine/threonine kinase activity	enables	ISO	RGD:1323719	1624291	PMID:22582013, PMID:23754375, PMID:25789606, PMID:26091039, PMID:29858230	RGD	PMID:22582013\|PMID:23754375\|PMID:25789606\|PMID:26091039\|PMID:29858230

Disease Annotations Click to see Annotation Detail View

amelogenesis imperfecta (ISO)

COVID-19 (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

genetic disease (ISO)

Hypophosphatemic Rickets (ISO)

Perinatal Death (ISO)

Raine Syndrome (ISO)

rickets (ISS)

Tooth Demineralization (ISO)

X-linked hypophosphatemic rickets (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (EXP)

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3',5'-cyclic AMP (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

fipronil (EXP)

flutamide (EXP)

genistein (ISO)

indometacin (ISO)

inulin (ISO)

iron atom (ISO)

iron dichloride (ISO)

iron(0) (ISO)

ketoconazole (EXP)

lead diacetate (ISO)

lipopolysaccharide (ISO)

menadione (ISO)

methapyrilene (ISO)

methylparaben (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (EXP)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biomineral tissue development (ISO)

dentinogenesis (IEA,ISO)

enamel mineralization (IBA,IEA,ISO)

odontoblast differentiation (IEA,IEP,ISO)

osteoclast maturation (IEA,ISO)

positive regulation of bone mineralization (IEA,ISO)

positive regulation of osteoblast differentiation (IEA,ISO)

protein phosphorylation (IDA,ISO)

regulation of fibroblast growth factor receptor signaling pathway (IEA,ISO)

regulation of phosphorus metabolic process (IEA,ISO)

skeletal system development (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO)

extracellular space (IEA,ISO)

Golgi apparatus (IBA,IEA,ISO)

Golgi membrane (ISO)

membrane (IEA)

nucleoplasm (ISO)

Molecular Function

ATP binding (IEA)

calcium ion binding (IEA,ISO)

manganese ion binding (ISO)

metal ion binding (IEA)

nucleotide binding (IEA)

protease binding (ISO)

protein binding (ISO)

protein kinase activity (ISO)

protein serine/threonine kinase activity (IBA,IDA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Variability of systemic and oro-dental phenotype in two families with non-lethal Raine syndrome with FAM20C mutations.	Acevedo AC, etal., BMC Med Genet. 2015 Feb 21;16:8. doi: 10.1186/s12881-015-0154-5.
2.	Polyhalogenobenzimidazoles: synthesis and their inhibitory activity against casein kinases.	Andrzejewska M, etal., Bioorg Med Chem. 2003 Sep 1;11(18):3997-4002.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation.	Hao J, etal., J Biol Chem. 2007 May 25;282(21):15357-65. Epub 2007 Mar 16.
5.	Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice.	Miyagawa K, etal., PLoS One. 2014 Apr 7;9(4):e93840. doi: 10.1371/journal.pone.0093840. eCollection 2014.
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization.	Oya K, etal., Histochem Cell Biol. 2016 Sep 10.
8.	Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification.	Rafaelsen SH, etal., J Bone Miner Res. 2013 Jun;28(6):1378-85. doi: 10.1002/jbmr.1850.
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development.	Simpson MA, etal., Am J Hum Genet. 2007 Nov;81(5):906-12. Epub 2007 Sep 14.
12.	Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9.	Tibaldi E, etal., FEBS Lett. 2010 Feb 19;584(4):801-5. doi: 10.1016/j.febslet.2009.12.052. Epub 2010 Jan 12.
13.	Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice.	Vogel P, etal., Vet Pathol. 2012 Nov;49(6):998-1017. doi: 10.1177/0300985812453177. Epub 2012 Jun 25.
14.	Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice.	Wang X, etal., PLoS Genet. 2012;8(5):e1002708. doi: 10.1371/journal.pgen.1002708. Epub 2012 May 17.

Additional References at PubMed

PMID:12477932	PMID:15676076	PMID:19056867	PMID:19199708	PMID:22582013	PMID:22900076	PMID:23754375	PMID:24006456	PMID:25789606	PMID:26091039	PMID:31914633

Genomics

Comparative Map Data

Fam20c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	20,940,654 - 20,999,072 (-)	NCBI		GRCr8
mRatBN7.2	12	15,826,864 - 15,885,423 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	15,826,871 - 15,884,543 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	16,638,165 - 16,695,811 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	17,261,890 - 17,319,536 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	16,284,652 - 16,341,671 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	17,913,771 - 17,972,733 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	17,913,767 - 17,972,737 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	19,906,233 - 19,965,797 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	16,340,407 - 16,399,325 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	16,371,029 - 16,473,541 (-)	NCBI
Celera	12	17,578,522 - 17,635,987 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

FAM20C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	192,571 - 260,772 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	192,571 - 260,772 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	192,571 - 300,738 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	288,052 - 304,059 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	288,195 - 304,059	NCBI
Celera	7	211,215 - 273,622 (+)	NCBI		Celera
Cytogenetic Map	7	p22.3	NCBI
HuRef	7	203,619 - 219,084 (+)	NCBI		HuRef
HuRef	7	155,848 - 180,386 (+)	NCBI		HuRef
CHM1_1	7	192,335 - 299,664 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	293,238 - 360,993 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	303,573 - 364,808 (+)	NCBI

Fam20c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	138,740,836 - 138,795,818 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	138,740,269 - 138,795,832 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	138,755,081 - 138,810,063 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	138,754,514 - 138,810,077 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	139,231,035 - 139,286,017 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	139,008,742 - 139,063,705 (+)	NCBI		MGSCv36	mm8
Celera	5	135,807,755 - 135,865,362 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	77.19	NCBI

Fam20c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	8,143,824 - 8,193,825 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955460	8,142,325 - 8,192,044 (+)	NCBI	ChiLan1.0	ChiLan1.0

FAM20C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	5,096,988 - 5,181,447 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	53,421,707 - 53,506,134 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	311,468 - 394,623 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	575,633 - 635,643 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

FAM20C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	16,448,603 - 16,497,064 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	16,448,588 - 16,497,752 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	17,920,483 - 17,969,286 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	16,577,996 - 16,626,815 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	16,578,012 - 16,628,609 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	16,380,418 - 16,429,206 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	16,306,905 - 16,355,670 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	16,596,937 - 16,645,742 (-)	NCBI		UU_Cfam_GSD_1.0

Fam20c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	144,360,748 - 144,413,468 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936754	596,872 - 653,098 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936754	596,878 - 649,585 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FAM20C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	163,421 - 200,459 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	159,107 - 200,462 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	89,974 - 94,208 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FAM20C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	21,299,235 - 21,371,603 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	21,299,213 - 21,371,577 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666090	190,813 - 259,923 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fam20c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	25,984,091 - 26,032,649 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	25,984,642 - 26,032,089 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fam20c
334 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	91
Count of miRNA genes:	70
Interacting mature miRNAs:	83
Transcripts:	ENSRNOT00000001783
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61443	Btemp2	Thermal response to stress QTL 2	3.3	0.000094	body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	12	15025183	20794014	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	8525423	28064601	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	15872653	32974238	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	23297788	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
1600391	Edcs2	Endometrial carcinoma susceptibility QTL2	3.5	0.01	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	12	6833190	17870186	Rat
10755457	Coatc14	Coat color QTL 14		0.01759	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	12	1	22591684	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	28064557	Rat
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	1	19611090	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	11073825	24234895	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	13635523	30827399	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	13008296	19212979	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	36247923	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	8449490	28302290	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat

Markers in Region

D12Rat91

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	15,872,653 - 15,872,803 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	17,960,865 - 17,961,014	NCBI	Rnor6.0
Rnor_5.0	12	19,953,929 - 19,954,078	UniSTS	Rnor5.0
RGSC_v3.4	12	16,387,455 - 16,387,605	RGD	RGSC3.4
RGSC_v3.4	12	16,387,456 - 16,387,605	UniSTS	RGSC3.4
RGSC_v3.1	12	16,417,383 - 16,417,533	RGD
Celera	12	17,624,117 - 17,624,266	UniSTS
SHRSP x BN Map	12	21.58	UniSTS
SHRSP x BN Map	12	21.58	RGD
Cytogenetic Map	12	q11	UniSTS

RH130960

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	15,826,879 - 15,827,061 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	17,913,787 - 17,913,969	NCBI	Rnor6.0
Rnor_5.0	12	19,906,249 - 19,906,431	UniSTS	Rnor5.0
RGSC_v3.4	12	16,340,423 - 16,340,606	UniSTS	RGSC3.4
Celera	12	17,578,538 - 17,578,719	UniSTS
RH 3.4 Map	12	240.8	UniSTS
Cytogenetic Map	12	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BK001522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001783 ⟹ ENSRNOP00000001783

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	15,826,871 - 15,884,528 (-)	Ensembl
Rnor_6.0 Ensembl	12	17,913,767 - 17,972,737 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103199 ⟹ ENSRNOP00000081489

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	15,826,970 - 15,884,543 (-)	Ensembl

RefSeq Acc Id:

NM_001012238 ⟹ NP_001012238

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	20,940,654 - 20,998,318 (-)	NCBI
mRatBN7.2	12	15,826,864 - 15,884,522 (-)	NCBI
Rnor_6.0	12	17,913,771 - 17,972,733 (-)	NCBI
Rnor_5.0	12	19,906,233 - 19,965,797 (-)	NCBI
RGSC_v3.4	12	16,340,407 - 16,399,325 (-)	RGD
Celera	12	17,578,522 - 17,635,987 (-)	RGD

Sequence:

show sequence

GCTGCGCTCCGGGTCGGCCGGCTGCACCTGCCAGATCTCCGCTTCTCCCTGCGCGCCCCCTCGC
GCTCCCCTTCTCACCTCGGTCTCTCAGCCACTACCTGACAGCGCAGAGGAATCGCTTTGTTGCC
CGCCCAGCACCAGGCATGGCCCAGCGGGAGCACCACGCTCTGGATCGGCTCAGTCGCGCCCTGG
CGGGGATGAACAGCCGCGCCTTCTGCTTACACGCCCAATGAGTGTGGTCGCCGTCCCGGAGACT
CTCGTCCGCCTCTGCTTTCTCTGTCACCACTGCCACCCACTCCACCGACGAGTGTCACTGGCCG
ACCCCCGAGATGGCCTGGAGAGCCGGTGCTTTGGTGGCGGGTGTCCTCCACGACGTCCAAATCT
GGGGACAGCCCCCGAGCTGGTAGCTGCTTGTACACCGAATGGACCTTGACCCGCGAGTCGTTGC
CGGCTTGGTGCCAAGCTGAGGGGCACCGGTGGAGCGCGCGTCCGGAACCCCCCAAGCCCGCTGG
CCTGCGCGGTCATGAAGATGATCTTGGTGCGCAGGTTTCGCGTGCTCATCTTGGTGGTATTCCT
ACTGGCTTGCGCTTTGCACATTGCTGTTGACCTGCTACCCAAGCTGGACCGGCGCGCCACAAGA
TCCCCGGGGGAGCCCGGCTGCTCCTGCGCTCAGCCGGCAGCAGAGGCAGCTGGTCCAGGCTGGG
CCCAGGCAAGGAGCCGACCGGGAGAGTCCGCCGGTGGCGACGCAGGCTGGCCCAACAAACACAC
ACTGCGCATCCTGCAAGACTTCAGCTCAGATCCAGCCTCTAACCTCACCTCCCACTCCTTGGAG
AAGCTGCCTCCTGCAGCGGAGCCGGTGGATCACGCTCCGCGGGGTCAGGAGCTGGGTTCCCCGC
CACCCCGTGACTCCGCGCACCGGCCGCTGCTTCGAGACCCTGGGCCCGGACCGCGGGTGCCGCC
CCATGGCCCCAGAGGGGACGGATCGCTCTTAGCCAAGTTGTTTGAGCACCCACTGTACCAGGGG
GCTGTACCTCCTCTGACAGAGGGCGACGTCCTGTTTAATGTGAACAGCGACATCAGATTTAACC
CCAGAGCAGCAGAGAATCCTGACTGGCCGCTGGAAGGTGCTGAAGGTGCAGAATTCTTGCCGAC
TGGTGAGGCAGCGGTGGACCTCTATCCTAACTGGCTCAAATTCCACATCGGCATCAACCGGTAT
GAGCTGTACTCCAGGCACAACCCAGCCATCGATGCCTTACTCCACGACCTCGGCTCTCAGAAGA
TCACCAGTGTCGCCATGAAGTCAGGGGGCACGCAGCTGAAGCTCATCATGACCTTCCAGAATTA
CGGGCAGGCGCTATTCAAACCCATGAAGCAGACGAGGGAGCAGGAGACGCCGCCTGACTTTTTT
TATTTCTCTGACTACGAGAGGCACAATGCGGAGATAGCTGCCTTCCACCTGGACAGGATCCTGG
ATTTCCGCAGAGTGCCTCCAGTGGCCGGCAGGATGATCAACATGACCAAGGAGATCCGGGATGT
CACGAGGGACAAGAAGCTATGGAGAACCTTCTTTGTGTCTCCAGCCAACAACATCTGCTTCTAT
GGGGAGTGTTCCTACTATTGTTCCACTGAGCATGCCCTGTGTGGGAAGCCTGACCAGATAGAAG
GATCCCTGGCGGCATTCCTTCCTGACCTTTCACTGGCCAAGAGGAAGACATGGCGGAACCCCTG
GCGTCGTTCCTACCACAAGCGAAAGAAGGCAGAGTGGGAAGTGGACCCCGATTACTGTGAGGAG
GTGAAGCAGACTCCACCCTACGACAGTGGTCACCGCATCCTGGACATCATGGACATGACTGTCT
TTGACTTCCTCATGGGGAACATGGATCGGCATCACTACGAGACCTTTGAGAAGTTCGGGAATGA
GACCTTCATCATACACTTGGACAACGGGCGTGGGTTTGGGAAGTACTCACACGATGAGCTTTCC
ATTCTAGCACCTCTTCACCAGTGCTGCAGGATCAGGAGGTCCACCTACCTGCGGCTGCAGCTGC
TGGCCAAAGAGGAGTACAAACTGAGCCTGCTGATGGCCGAGTCCCTGCAGCATGACAAGGTGGC
ACCCGTGCTCTACCAGCTGCACCTGGAGGCCCTGGACCGGCGGCTGCGCATAGTGCTGCAGGCT
GTGCGAGACTGTGTGGAGAAGGATGGTGTGAGCAGTGTGGTGGAGGACGACCTAGCCACTGAGC
ACAGAGCCTCCACAGAGAGGTAGTGACCACGCTGCCCCGAGGAAGGAGGAGCACAGAGCCTATC
CACCTGTGAATTCAGTGAATTCGGACGGGATTGGTCACCCCCCATAGGGTGACCTGCAGTAGGG
AGCATGGGGTCTCCCTCATGGCTCTGATAGGGATGTATGGGCCTCCGGTTCCAGCAGAAACCAG
CATTCAGAACATGCAGCAGAGTGGCCAGCGCTCCGTCCTTCCCATAGGGAGGGACCTTTAACTC
ACTATTTTGTATTTAACAAAAGGCTCACACTCCTGTCAATGAAGAACCACCCAGCAGACCAGAG
ATCACCTCCGGGCCACTTCAAGGACCCTCTGTGATGTGATCACACTCTGGCCCTCAATCACAAT
CCACTTTCTGCTCCCCCCGATCCTGGCCTCTCTCAAAGGCCGGAGAGCTCTCGAGAGGGGAGGC
TGTGATGGGCATCACGGCCTGTGTCGGAGCAGATGGGCACCCAAGAGTGGGTTTTGGATGCTAA
TGACCAGCTATCCATTGTCGGCTGCTACACAGCAGTCAGGCCTTACTAGTTGGGTGGTGGGCAC
CGCCTGCCCTGTGCTGAGCTCTGGACAGTGGGTGTCAAGACACTACACAAAGCCCATGGCGCCA
GGACAGCAGGCTAGCCTTGGGACCTTTTTGTGGGAGTAGTTTGCAGTGAGGTAACGGTGCAATA
AAGTACAGCAAGCGTG

hide sequence

RefSeq Acc Id:

XM_039089395 ⟹ XP_038945323

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	20,941,509 - 20,999,054 (-)	NCBI
mRatBN7.2	12	15,826,864 - 15,885,423 (-)	NCBI

RefSeq Acc Id:

XM_039089396 ⟹ XP_038945324

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	20,947,833 - 20,999,072 (-)	NCBI
mRatBN7.2	12	15,834,043 - 15,884,302 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012238	(Get FASTA)	NCBI Sequence Viewer
	XP_038945323	(Get FASTA)	NCBI Sequence Viewer
	XP_038945324	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61825	(Get FASTA)	NCBI Sequence Viewer
	DAA01891	(Get FASTA)	NCBI Sequence Viewer
	EDL89799	(Get FASTA)	NCBI Sequence Viewer
	EDL89800	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001783
	ENSRNOP00000001783.4
	ENSRNOP00000081489.1

RefSeq Acc Id:

NP_001012238 ⟸ NM_001012238

- UniProtKB:

B1WBN7 (UniProtKB/TrEMBL), A6K1Z1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKMILVRRFRVLILVVFLLACALHIAVDLLPKLDRRATRSPGEPGCSCAQPAAEAAGPGWAQAR
SRPGESAGGDAGWPNKHTLRILQDFSSDPASNLTSHSLEKLPPAAEPVDHAPRGQELGSPPPRD
SAHRPLLRDPGPGPRVPPHGPRGDGSLLAKLFEHPLYQGAVPPLTEGDVLFNVNSDIRFNPRAA
ENPDWPLEGAEGAEFLPTGEAAVDLYPNWLKFHIGINRYELYSRHNPAIDALLHDLGSQKITSV
AMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRR
VPPVAGRMINMTKEIRDVTRDKKLWRTFFVSPANNICFYGECSYYCSTEHALCGKPDQIEGSLA
AFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSGHRILDIMDMTVFDFL
MGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILAPLHQCCRIRRSTYLRLQLLAKE
EYKLSLLMAESLQHDKVAPVLYQLHLEALDRRLRIVLQAVRDCVEKDGVSSVVEDDLATEHRAS
TER

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Ensembl Acc Id:

ENSRNOP00000001783 ⟸ ENSRNOT00000001783

RefSeq Acc Id:	XP_038945323 ⟸ XM_039089395
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038945324 ⟸ XM_039089396
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000081489 ⟸ ENSRNOT00000103199

Protein Domains

FAM20 C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B1WBN7-F1-model_v2	AlphaFold	B1WBN7	1-579	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698475

Promoter ID:

EPDNEW_R8999

Type:

single initiation site

Name:

Fam20c_1

Description:

FAM20C, golgi associated secretory pathway kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	17,972,751 - 17,972,811	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311980	AgrOrtholog
BioCyc Gene	G2FUF-19872	BioCyc
Ensembl Genes	ENSRNOG00000001314	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001783	ENTREZGENE
	ENSRNOT00000001783.8	UniProtKB/TrEMBL
	ENSRNOT00000103199.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8373563	IMAGE-MGC_LOAD
InterPro	DUF1193	UniProtKB/TrEMBL
	FAM20	UniProtKB/TrEMBL
KEGG Report	rno:304334	UniProtKB/TrEMBL
MGC_CLONE	MGC:187280	IMAGE-MGC_LOAD
NCBI Gene	304334	ENTREZGENE
PANTHER	DUF1193	UniProtKB/TrEMBL
	EXTRACELLULAR SERINE/THREONINE PROTEIN KINASE FAM20C	UniProtKB/TrEMBL
Pfam	DUF1193	UniProtKB/TrEMBL
PhenoGen	Fam20c	PhenoGen
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001314	RatGTEx
UniProt	A0A8I5ZV45_RAT	UniProtKB/TrEMBL
	A6K1Z1	ENTREZGENE, UniProtKB/TrEMBL
	B1WBN7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-18	Fam20c	FAM20C, golgi associated secretory pathway kinase	Fam20c	family with sequence similarity 20, member C	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Fam20c	family with sequence similarity 20, member C	RGD1311980	similar to cDNA sequence BC004044	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	RGD1311980	similar to cDNA sequence BC004044	Fam20c	family with sequence similarity 20, member C	Symbol and Name updated	1299863	APPROVED
2006-03-07	Fam20c	family with sequence similarity 20, member C	Fam20c_predicted	family with sequence similarity 20, member C (predicted)	Symbol and Name status set to approved	1299863	APPROVED
2005-01-12	Fam20c_predicted	family with sequence similarity 20, member C (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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