Nfe2l1 (NFE2 like bZIP transcription factor 1)

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Gene: Nfe2l1 (NFE2 like bZIP transcription factor 1) Rattus norvegicus

Analyze

Symbol:

Nfe2l1

Name:

NFE2 like bZIP transcription factor 1 (Ensembl:nuclear factor, erythroid 2-like 1)

RGD ID:

1311972

Description:

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; cholesterol binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including cell redox homeostasis; regulation of odontoblast differentiation; and regulation of transcription from RNA polymerase II promoter in response to stress. Predicted to act upstream of or within several processes, including cellular response to cholesterol; neurogenesis; and regulation of organelle organization. Predicted to be located in cytosol; endoplasmic reticulum membrane; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human NFE2L1 (NFE2 like bZIP transcription factor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

endoplasmic reticulum membrane sensor NFE2L1; LOC360610; nuclear factor erythroid 2-like 1; nuclear factor erythroid 2-related factor 1; nuclear factor, erythroid 2-like 1; nuclear factor, erythroid derived 2,-like 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	81,796,055 - 81,812,926 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	81,800,366 - 81,832,318 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	86,748,076 - 86,760,626 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	86,246,127 - 86,258,677 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	81,638,722 - 81,651,272 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	84,686,762 - 84,699,313 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	84,682,460 - 84,698,886 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	84,479,677 - 84,492,242 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	85,570,238 - 85,577,636 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	85,588,909 - 85,601,415 (-)	NCBI
Celera	10	80,562,053 - 80,574,604 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Developmental Disabilities (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISS)

type 2 diabetes mellitus (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-tert-butylhydroquinone (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acrolein (ISO)

aldehydo-D-glucose (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atorvastatin calcium (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

brefeldin A (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

choline (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

cocaine (ISO)

curcumin (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

decabromodiphenyl ether (EXP)

deguelin (ISO)

dexamethasone (EXP,ISO)

diarsenic trioxide (ISO)

dioxygen (EXP)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxomicin (ISO)

ethanol (ISO)

fenthion (ISO)

finasteride (EXP)

folic acid (ISO)

gentamycin (EXP)

geraniol (ISO)

glafenine (EXP)

glucose (ISO)

hydrogen peroxide (ISO)

hydroxytyrosol (ISO)

icariin (ISO)

indometacin (ISO)

L-ascorbic acid (ISO)

L-ascorbic acid 2-phosphate (ISO)

L-methionine (ISO)

metformin (ISO)

methidathion (ISO)

methotrexate (ISO)

methylarsonic acid (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nicotine (ISO)

p-toluidine (EXP)

paracetamol (ISO)

patulin (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

piroxicam (ISO)

rac-lactic acid (ISO)

raloxifene (ISO)

reactive oxygen species (ISO)

resveratrol (ISO)

rotenone (ISO)

sodium arsenite (ISO)

sulindac (EXP,ISO)

testosterone (EXP)

trichloroethene (EXP)

triphenyl phosphate (EXP)

triptonide (ISO)

tungsten (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell redox homeostasis (ISO)

cellular homeostasis (ISO)

cellular response to cholesterol (ISO)

cellular response to cold (ISO)

cellular response to copper ion (ISO)

cellular response to oxidative stress (ISO)

cholesterol homeostasis (ISO)

cysteine transport (ISO)

erythrocyte differentiation (ISO)

fructose 6-phosphate metabolic process (ISO)

glial cell fate commitment (ISO)

glucose 6-phosphate metabolic process (ISO)

glutathione metabolic process (ISO)

lipid homeostasis (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

negative regulation of transcription from RNA polymerase II promoter in response to stress (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

protein polyubiquitination (ISO)

regulation of fatty acid metabolic process (ISO)

regulation of gene expression (ISO)

regulation of glucose metabolic process (ISO)

regulation of inflammatory response (ISO)

regulation of lipid metabolic process (ISO)

regulation of mitotic nuclear division (ISO)

regulation of nucleus organization (ISO)

regulation of odontoblast differentiation (ISO)

regulation of proteasomal protein catabolic process (ISO)

regulation of response to endoplasmic reticulum stress (ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

response to endoplasmic reticulum stress (ISO)

spinal cord motor neuron differentiation (ISO)

Cellular Component

cytosol (ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (ISO)

nucleoplasm (ISO)

nucleus (IBA,ISO)

nucleus (ISO)

obsolete integral component of endoplasmic reticulum membrane (ISO)

protein-containing complex (ISO)

RNA polymerase II transcription regulator complex (ISO)

Molecular Function

cholesterol binding (ISO)

chromatin binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

identical protein binding (ISO)

promoter-specific chromatin binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

protein heterodimerization activity (ISO)

protein-containing complex binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

transcription coactivator activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:8932385	PMID:9421508	PMID:9501099	PMID:10037736	PMID:10601325	PMID:11342101	PMID:12477932	PMID:15308669	PMID:15988009	PMID:16581765	PMID:20385086
PMID:21554501	PMID:22586274	PMID:22971132	PMID:23144760	PMID:23702335	PMID:23840004	PMID:24448410	PMID:24462598	PMID:25041126	PMID:25092871	PMID:25290918	PMID:25637874
PMID:25806530	PMID:27528193	PMID:27920251	PMID:28088524	PMID:29149604	PMID:29400713

Genomics

Comparative Map Data

Nfe2l1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	81,796,055 - 81,812,926 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	81,800,366 - 81,832,318 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	86,748,076 - 86,760,626 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	86,246,127 - 86,258,677 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	81,638,722 - 81,651,272 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	84,686,762 - 84,699,313 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	84,682,460 - 84,698,886 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	84,479,677 - 84,492,242 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	85,570,238 - 85,577,636 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	85,588,909 - 85,601,415 (-)	NCBI
Celera	10	80,562,053 - 80,574,604 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

NFE2L1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	48,048,359 - 48,061,545 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	17	48,048,329 - 48,061,545 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	46,125,721 - 46,138,907 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	43,480,745 - 43,493,841 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	43,480,744 - 43,493,840	NCBI
Celera	17	42,578,502 - 42,591,724 (+)	NCBI		Celera
Cytogenetic Map	17	q21.32	NCBI
HuRef	17	41,494,079 - 41,507,301 (+)	NCBI		HuRef
CHM1_1	17	46,190,680 - 46,203,900 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	48,910,172 - 48,923,361 (+)	NCBI		T2T-CHM13v2.0

Nfe2l1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	96,708,239 - 96,720,810 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	96,708,240 - 96,720,794 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	96,817,414 - 96,829,968 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	96,817,414 - 96,829,968 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	96,678,728 - 96,691,282 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	96,633,521 - 96,644,045 (-)	NCBI		MGSCv36	mm8
Celera	11	106,466,769 - 106,479,303 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	60.12	NCBI

Nfe2l1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	13,088,906 - 13,099,839 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	13,088,680 - 13,099,839 (-)	NCBI	ChiLan1.0	ChiLan1.0

NFE2L1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	9,657,847 - 9,671,040 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	9,657,847 - 9,671,040 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	17	9,476,482 - 9,489,661 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

NFE2L1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	24,344,697 - 24,356,918 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	24,346,585 - 24,362,646 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	23,810,726 - 23,822,715 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	25,138,680 - 25,150,670 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	25,138,689 - 25,156,398 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	23,908,140 - 23,920,129 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	24,168,769 - 24,180,752 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	24,296,588 - 24,308,159 (+)	NCBI		UU_Cfam_GSD_1.0

Nfe2l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	23,795,986 - 23,810,579 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	13,266,347 - 13,279,206 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936490	13,265,269 - 13,279,164 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NFE2L1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	24,303,399 - 24,316,763 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	24,303,381 - 24,316,765 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	24,300,897 - 24,308,045 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NFE2L1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	68,449,601 - 68,463,030 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	68,449,898 - 68,461,190 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	39,501,780 - 39,515,234 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nfe2l1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	4,652,637 - 4,662,454 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	4,652,221 - 4,663,341 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nfe2l1
31 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	45
Count of miRNA genes:	37
Interacting mature miRNAs:	45
Transcripts:	ENSRNOT00000067542
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44441699	89441699	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44441699	89441699	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45029650	95600334	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47369470	92369470	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	50574707	95574707	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	51121100	96121100	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	51770177	107211142	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	51770177	107211142	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	51772940	96772940	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	51774612	95600334	Rat
631535	Cm51	Cardiac mass QTL 51	3		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	51786282	91669536	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	53797385	107211142	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	53797494	98952626	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	54809292	99809292	Rat
2312662	Slep8	Serum leptin concentration QTL 8		0.05	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	10	57134272	102134272	Rat
2312668	Scl65	Serum cholesterol level QTL 65		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	57134272	102134272	Rat
2312672	Insul15	Insulin level QTL 15		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	10	57134272	102134272	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	57576521	102576521	Rat
2293698	Bss43	Bone structure and strength QTL 43	5.33	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	10	59209888	104209888	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61345276	98211570	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61345276	99703528	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61345276	99703528	Rat
61402	Niddm3	Non-insulin dependent diabetes mellitus QTL 3	4.58		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	61345413	82564856	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62057807	107057807	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62057807	107057807	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63221094	107211142	Rat
2298481	Eau9	Experimental allergic uveoretinitis QTL 9		0.0169	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	65927233	82565079	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	66743655	98003205	Rat
2317029	Aia19	Adjuvant induced arthritis QTL 19	2.98		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	66978955	107211142	Rat
2317039	Aia6	Adjuvant induced arthritis QTL 6	4.31		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	66978955	107211142	Rat
10450498	Bp384	Blood pressure QTL 384		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	67750049	107211142	Rat
1642980	Bp300	Blood pressure QTL 300			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68383129	107211142	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68420376	107211142	Rat
2300172	Bmd57	Bone mineral density QTL 57	9.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	10	69738412	107211142	Rat
2293646	Bss25	Bone structure and strength QTL 25	10.96	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	10	69738412	107211142	Rat
2293663	Bss33	Bone structure and strength QTL 33	9.34	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	10	69738412	107211142	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70199100	107211142	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72224939	107211142	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	72224939	107211142	Rat
2306793	Ean5	Experimental allergic neuritis QTL 5	4.7		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	72552416	93995749	Rat
12880053	Cm104	Cardiac mass QTL 104		0.009	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	73452992	83463334	Rat
1358188	Ept9	Estrogen-induced pituitary tumorigenesis QTL 9	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73453136	96120911	Rat
2292617	Ept18	Estrogen-induced pituitary tumorigenesis QTL 18	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73453136	96120911	Rat
12880050	Am10	Aortic mass QTL 10		0.016	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	74372084	84007272	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	74372084	94965338	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	75631887	87055282	Rat
2325836	Bp346	Blood pressure QTL 346		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	84007272	Rat
10450495	Bp383	Blood pressure QTL 383		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	94965338	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	107211142	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76452683	107211142	Rat
4889492	Pancm2	Pancreatic morphology QTL 2	3.2		pancreatic beta cell morphology trait (VT:0005217)	ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)	10	76748906	107211142	Rat
724516	Uae17	Urinary albumin excretion QTL 17	3.6		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	78210622	85220348	Rat
1300107	Rf18	Renal function QTL 18	3.41		urine output (VT:0003620)	timed urine volume (CMO:0000260)	10	78775516	98279596	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	78899655	87307728	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	79813789	85160854	Rat
631555	Bp134	Blood pressure QTL 134		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	80515287	91230079	Rat
6893357	Bw102	Body weight QTL 102	0.5	0.36	body mass (VT:0001259)	body weight (CMO:0000012)	10	80515287	101325465	Rat
2303589	Bw87	Body weight QTL 87	2		body mass (VT:0001259)	body weight (CMO:0000012)	10	81285008	107211142	Rat

Markers in Region

AW212678

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	81,800,517 - 81,800,632 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	84,686,905 - 84,687,019	NCBI	Rnor6.0
Rnor_5.0	10	84,479,820 - 84,479,934	UniSTS	Rnor5.0
RGSC_v3.4	10	85,574,696 - 85,574,810	UniSTS	RGSC3.4
Celera	10	80,562,196 - 80,562,310	UniSTS
Cytogenetic Map	10	q31	UniSTS

RH142522

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	81,798,500 - 81,798,766 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	84,684,890 - 84,685,155	NCBI	Rnor6.0
Rnor_5.0	10	84,477,805 - 84,478,070	UniSTS	Rnor5.0
RGSC_v3.4	10	85,572,681 - 85,572,946	UniSTS	RGSC3.4
Celera	10	80,560,181 - 80,560,446	UniSTS
RH 3.4 Map	10	781.7	UniSTS
Cytogenetic Map	10	q31	UniSTS

RH138073

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	81,796,730 - 81,796,943 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	84,683,120 - 84,683,332	NCBI	Rnor6.0
Rnor_5.0	10	84,476,035 - 84,476,247	UniSTS	Rnor5.0
RGSC_v3.4	10	85,570,911 - 85,571,123	UniSTS	RGSC3.4
Celera	10	80,558,411 - 80,558,623	UniSTS
RH 3.4 Map	10	731.8	UniSTS
Cytogenetic Map	10	q31	UniSTS

UniSTS:274184

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	81,802,819 - 81,804,282 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	84,689,207 - 84,690,669	NCBI	Rnor6.0
Rnor_5.0	10	84,482,122 - 84,483,584	UniSTS	Rnor5.0
RGSC_v3.4	10	85,576,998 - 85,578,460	UniSTS	RGSC3.4
Celera	10	80,564,498 - 80,565,960	UniSTS
Cytogenetic Map	10	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001372250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001372251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006220824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006220825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006220826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006220827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC136178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC169095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK839329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230851	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000067542 ⟹ ENSRNOP00000061935

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	81,800,366 - 81,812,484 (-)	Ensembl
Rnor_6.0 Ensembl	10	84,682,460 - 84,698,886 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103907 ⟹ ENSRNOP00000087333

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	81,800,366 - 81,832,318 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111539 ⟹ ENSRNOP00000088301

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	81,800,376 - 81,806,949 (-)	Ensembl

RefSeq Acc Id:

NM_001108293 ⟹ NP_001101763

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	81,800,375 - 81,812,926 (-)	NCBI

RefSeq Acc Id:

NM_001372250 ⟹ NP_001359179

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	81,800,375 - 81,812,481 (-)	NCBI

RefSeq Acc Id:

NM_001372251 ⟹ NP_001359180

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	81,800,375 - 81,806,949 (-)	NCBI

RefSeq Acc Id:

XM_006247238 ⟹ XP_006247300

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	81,800,375 - 81,806,744 (-)	NCBI
Rnor_6.0	10	84,686,762 - 84,693,171 (-)	NCBI
Rnor_5.0	10	84,479,677 - 84,492,242 (-)	NCBI

Sequence:

show sequence

GGCTGCTCCAGGATGGAGGAAGGGGGCTGGGCTGGGCCGCCCAGGCAGCAGCACGGGCGGGGCA
CCTTCCTCGGGCCCCTCGGAGCTACCAAGGGGCCACCCTTCCAGCCTGGTGTGCTTCCTGCAAG
CCACGAGCTCCTTGCAGCCCCCTGTCCGGCTTACCGGCACCGGCTGCTCTGGGGCTCCTCTCGC
AGACCATGACCCGCCTGGACCGCAGCTCTCACAGTGGTGGGGGCCATGCCAAAGACAGGCCCCT
TAACTCTTGGCTGGCTGGTCACCGGGTGGCCCAGCCCCCCTCCACTCCTGGGTCCAGGGCTTCT
GTTCAGGATATAGATCTGATTGACATCCTTTGGCGACAGGATATTGATCTGGGGGCTGGGCGTG
AGGTTTTTGACTACAGTCATCGCCAGAAGGAGCAAGATGTGGATAAGGAACTACAAGATGGAGG
AGAGCGAGAGGACACCTGGTCAGGCGAGGGCGCGGAAGCTCTGGCCCGAGACCTGCTAGTAGAT
GGAGAGACTGGAGAGAGCTTCCCTGCACAGTTCCCAGCGGACGTTTCCAGCATCACAGAAGCAG
TGCCTAGTGAGAGCGAGTCCCCCGCCCTTCAGAACAGCCTTCTATCTCCTCTTCTGACGGGGAC
AGAATCACCATTTGATTTGGAACAACAGTGGCAAGATCTCATGTCCATCATGGAAATGCAGGCT
ATGGAAGTGAATACGTCAGCAAGTGAAATTCTGTACAGTGCCCCTCCTGGAGACCCTCTTACCA
CCAACTACAGCCTTGCTCCCAACACTCCTATCAATCAGAATGTCAGCCTGCATCAGGCCTCCCT
GGGGGGCTGCAGTCAGGACTTTTCCCTCTTCAGCCCCGAGGTGGAGAGCCTGCCTGTGGCCAGC
AGCTCTACACTGCTTCCACTCGTCCCCAGCAACTCCACCAGTCTCAACTCCACCTTTGGCTCTA
CCAACCTAGCAGGGCTTTTCTTTCCATCCCAGCTCAATGGCACCGCCAATGATACATCAGGCCC
TGAGCTGCCTGATCCCCTTGGGGGCCTGTTAGACGAGGCCATGCTGGATGAGATCAGCCTGATG
GACCTGGCCATTGAGGAGGGCTTCAACCCGGGGCAGGCCTCCCAGCTCGAGGAGGAGTTCGACT
CTGACTCTGGCCTCTCCCTGGACTCCAGCCATAGCCCTTCCTCTCTGAGCAGCTCTGAAGGGAG
CTCTTCTTCCTCTTCCTCTTCTTCTTCTGCTTCCTCCTCTGCCTCTTCTTCCTTCTCTGAGGAG
GGTGCTGTTGGTTACAGCTCTGACTCTGAGACCCTAGATCTAGAAGAGGCTGAGGGTGCAGTGG
GCTACCAGCCAGAATACTCCAAGTTCTGCCGCATGAGCTATCAGGATCCTTCTCAGCTCTCTTG
CCTTCCCTACTTAGAGCATGTGGGCCACAATCACACGTACAATATGGCACCCAGTGCCCTTGAC
TCTGCTGATCTACCACCACCCAGCACCCTCAAGAAAGGTAGCAAGGAAAAGCAGGCTGACTTCT
TGGACAAGCAGATGAGCAGAGATGAGCACAGAGCCCGAGCCATGAAGATCCCATTTACCAATGA
CAAAATCATCAACCTGCCTGTAGAAGAATTCAATGAGCTGCTGTCCAAATACCAGTTGAGCGAG
GCCCAGCTGAGCCTCATCAGGGATATCCGGCGCCGGGGCAAAAACAAGATGGCTGCACAGAACT
GCCGCAAGCGCAAGTTGGACACCATCCTGAACCTAGAACGTGATGTGGAGGACTTGCAGCGAGA
TAAGGCCCGATTGCTCCGAGAAAAGGTAGAGTTCCTGCGGTCTCTGCGACAGATGAAGCAGAAG
GTCCAAAGCTTATACCAGGAGGTGTTTGGGCGGCTGCGGGATGAGAATGGGAGGCCCTACTCAC
CCAGTCAGTATGCCCTTCAGTATGCTGGGGATGGCAGTGTCCTCCTCATTCCTCGCACGATGGC
TGACCAGCAGGCCCGGCGACAGGAGAGAAAGCCAAAGGACCGGAGGAAGTGAGCTTGGGGAGGC
AGGGGGTGGACGCTCACTAAGACCGAAACTGGAGAAGGGCTGGGCCTGGACCTAATGTTGGGGA
CTTAAATGCCTTCTTATCCAATATATCTTCTCAGATGGGATGACTGCGGGTCAGTGCACCGAAG
AGGCGGGCGCAGGCGCTGTCTGGCTTAGCTGCCCCACTGGGAGTGGGCAGGGATGACCAGACTA
TTTGGGTGATGGGGGCCCCAGCCCATTTCCTTTCTCCTGAGGGAAGGTGGTTGGCATGCTGGAG
GAAGCAGAGCTGTGTGGAGTGGGGCAGGCAGAGGGAAAGGAGAGAAAGTAGTGGGAAGTCTCAG
TCCTGGACGGAGAAAAGGAAGGATCCCTAAAATCAAAGCAGTCAGAAAGACCAGCGCGCTGTTG
AGGGCTTTGGCCAGCGCTCGAGGCAGTGAGTGCAGGAGACTCCAGTGGGCCTGGGTTGAGTTGG
TAAGGCTGGTATGGAGACACAGACATGGTGGGGCCACTGAAGGGCTCTTTAGCTGTTTCTTGAA
CTCTTGCATCCCTGAAGAGGAAGAAACTCTCGGATGGCACCTGTAATATTTCAGTTACTAAAAC
GAGACATGTAGGGCCCAATACCTCCATGGTTAGGCCCAAGGAGGGCAGAGCTGTAGGAAGTGAT
GATGAGGCCTGTGTTGCAGCAGCCCCAATATCAAGCATGTCACTCACTGCCCCACCACAGCCAC
CTCCTCCCTAGCCATCCCAGAGCTGAGGCTCCCACTGTCCTCAGAGAGCCTGCATGGAAATGCT
GTCCTCTTCCATTCTCTTCCCTTTCGTGGTACCACCCTCACTGGCTGCCTCCAGCTCTGGAGTG
GGGTGCTATTCTGGCGGTATCTGGAACTTGGCCTACAGCTTCCTCTGCAGGGTCTAAACAGGGA
AGGAGATGGTGTGGAGGAGAGGCCCCAGTGACATCCAGGCACTGTTCAGCACAACACTGGGAAG
TGACTCTTCCCTCAGGCCCCTCTGCCTACTAACACCTGGGCTCCTCATGGGGAAACAAAAGCCT
ATAAACCCCAGCAGCAGAACCTAGTCCTCTTAGAATTTTTTGCGCTTTGATTTTTTAGGGCGTG
TGCCCTGTTACACTTACAGGGCCCTAGGATGCTTGTGTTGAGTAAAAAGGAGATGCCCCCATAT
TCAAAGCTGCTAAATGTTCTCTTTGCCATAAAGACTCCGTGTTAACTGTGTAAACACTTGGGAT
TTTTCTCCTCTGTCCCGAGGTCTGGTCTTGCTTTCTTTTTTGGGTTTCTTTCTAGGAAAAGGAG
AAGTGCATGCAAGGGGCAGGAGATGACCCTCCCCTAGGCTTTCAGCTTCAGGCAGCTTCTTCAC
AGCCCGTTTAGCCTGGGGTCCTGGAGGACAGCCCTGGGGAGGCAGTGAGGGGCAGCACCAAGAC
AGCCAGATGGTTCCCGGACCACAGTGTCTTTTTTTTTTTTTTTTTTTTTCTAAACTGCCACTGC
CGCCCCCCAATCTTGATCAGCTCTGGAGTACTGCCTGCCCCAGACTAGCAGGGGTGAGGGGTGG
GAAGCACTGATCCTCCTCCCTGTGCAGGGAGGAGGGGTTTCCTAACTGAGCAGTAGGGATAGAA
AGTGGAGCCTGGGAGTGCTTTTTATAAATTATTTTCCTTGTAGATTTTATTTTTAATTTATCTC
TGTGACCTGCCAGGGAGAGGAGAGAAAGAGAAATGCTGTGAGCACATGACAAAATAAAATCAAA
TAAAATGGA

hide sequence

RefSeq Acc Id:

XM_039086388 ⟹ XP_038942316

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	81,796,055 - 81,812,544 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101763	(Get FASTA)	NCBI Sequence Viewer
	NP_001359179	(Get FASTA)	NCBI Sequence Viewer
	NP_001359180	(Get FASTA)	NCBI Sequence Viewer
	XP_006247300	(Get FASTA)	NCBI Sequence Viewer
	XP_038942316	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM05821	(Get FASTA)	NCBI Sequence Viewer
	EDM05822	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_006247300 ⟸ XM_006247238

- Peptide Label:

isoform X2

- Sequence:

show sequence

MTRLDRSSHSGGGHAKDRPLNSWLAGHRVAQPPSTPGSRASVQDIDLIDILWRQDIDLGAGREV
FDYSHRQKEQDVDKELQDGGEREDTWSGEGAEALARDLLVDGETGESFPAQFPADVSSITEAVP
SESESPALQNSLLSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVNTSASEILYSAPPGDPLTTN
YSLAPNTPINQNVSLHQASLGGCSQDFSLFSPEVESLPVASSSTLLPLVPSNSTSLNSTFGSTN
LAGLFFPSQLNGTANDTSGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPGQASQLEEEFDSD
SGLSLDSSHSPSSLSSSEGSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEEAEGAVGY
QPEYSKFCRMSYQDPSQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSTLKKGSKEKQADFLD
KQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCR
KRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSLYQEVFGRLRDENGRPYSPS
QYALQYAGDGSVLLIPRTMADQQARRQERKPKDRRK

hide sequence

RefSeq Acc Id:

ENSRNOP00000061935 ⟸ ENSRNOT00000067542

RefSeq Acc Id:	XP_038942316 ⟸ XM_039086388
- Peptide Label:	isoform X1

RefSeq Acc Id:	NP_001101763 ⟸ NM_001108293
- Peptide Label:	1
- UniProtKB:	A0A8I6A8A5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001359179 ⟸ NM_001372250
- Peptide Label:	1
- UniProtKB:	A0A8I6A8A5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001359180 ⟸ NM_001372251
- Peptide Label:	2
- UniProtKB:	A0A8I6A9I5 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000087333 ⟸ ENSRNOT00000103907

RefSeq Acc Id:

ENSRNOP00000088301 ⟸ ENSRNOT00000111539

Protein Domains

bZIP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A349-F1-model_v2	AlphaFold	D4A349	1-675	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697640

Promoter ID:

EPDNEW_R8159

Type:

multiple initiation site

Name:

Nfe2l1_1

Description:

nuclear factor, erythroid 2-like 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	84,698,869 - 84,698,929	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311972	AgrOrtholog
BioCyc Gene	G2FUF-23479	BioCyc
Ensembl Genes	ENSRNOG00000008830	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000061935.3	UniProtKB/TrEMBL
	ENSRNOP00000087333	ENTREZGENE
	ENSRNOP00000087333.1	UniProtKB/TrEMBL
	ENSRNOP00000088301	ENTREZGENE
	ENSRNOP00000088301.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000067542.4	UniProtKB/TrEMBL
	ENSRNOT00000103907	ENTREZGENE
	ENSRNOT00000103907.1	UniProtKB/TrEMBL
	ENSRNOT00000111539	ENTREZGENE
	ENSRNOT00000111539.1	UniProtKB/TrEMBL
Gene3D-CATH	Transcription factor, Skn-1-like, DNA-binding domain	UniProtKB/TrEMBL
InterPro	bZIP_Maf	UniProtKB/TrEMBL
	Euk_TF_DNA-bd	UniProtKB/TrEMBL
	TF_bZIP	UniProtKB/TrEMBL
NCBI Gene	360610	ENTREZGENE
PANTHER	NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR	UniProtKB/TrEMBL
	PTHR24411:SF31	UniProtKB/TrEMBL
Pfam	bZIP_Maf	UniProtKB/TrEMBL
PhenoGen	Nfe2l1	PhenoGen
PROSITE	BZIP	UniProtKB/TrEMBL
	BZIP_BASIC	UniProtKB/TrEMBL
SMART	BRLZ	UniProtKB/TrEMBL
Superfamily-SCOP	Euk_transcr_DNA	UniProtKB/TrEMBL
UniProt	A0A8I6A8A5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A9I5	ENTREZGENE, UniProtKB/TrEMBL
	D4A349_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-10-22	Nfe2l1	NFE2 like bZIP transcription factor 1	Nfe2l1	nuclear factor, erythroid 2-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-11-22	Nfe2l1	nuclear factor, erythroid 2-like 1	Nfe2l1	nuclear factor, erythroid derived 2,-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Nfe2l1	nuclear factor, erythroid derived 2,-like 1	Nfe2l1_predicted	nuclear factor, erythroid derived 2,-like 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Nfe2l1_predicted	nuclear factor, erythroid derived 2,-like 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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