Nfe2l1 (NFE2 like bZIP transcription factor 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nfe2l1 (NFE2 like bZIP transcription factor 1) Rattus norvegicus
Analyze
Symbol: Nfe2l1
Name: NFE2 like bZIP transcription factor 1
RGD ID: 1311972
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; cholesterol binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including cell redox homeostasis; negative regulation of transcription by RNA polymerase II; and regulation of odontoblast differentiation. Predicted to act upstream of or within several processes, including neurogenesis; regulation of organelle organization; and regulation of primary metabolic process. Predicted to be located in cytosol; endoplasmic reticulum membrane; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human NFE2L1 (NFE2 like bZIP transcription factor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endoplasmic reticulum membrane sensor NFE2L1; LOC360610; nuclear factor erythroid 2-like 1; nuclear factor erythroid 2-related factor 1; nuclear factor, erythroid 2-like 1; nuclear factor, erythroid derived 2,-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81082,296,824 - 82,309,472 (-)NCBIGRCr8
GRCr8 Ensembl1082,292,508 - 82,309,375 (-)EnsemblGRCr8 Ensembl
mRatBN7.21081,796,055 - 81,812,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1081,800,366 - 81,832,318 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1086,748,076 - 86,760,626 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01086,246,127 - 86,258,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01081,638,722 - 81,651,272 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01084,686,762 - 84,699,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1084,682,460 - 84,698,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01084,479,677 - 84,492,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41085,570,238 - 85,577,636 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1080,562,053 - 80,574,604 (-)NCBICelera
RGSC_v3.11085,588,909 - 85,601,415 (-)NCBI
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
brefeldin A  (ISO)
cadmium atom  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxomicin  (ISO)
ethanol  (ISO)
fenthion  (ISO)
finasteride  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glafenine  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (ISO)
icariin  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
metformin  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
Mitoquinone  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nicotine  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
patulin  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sulindac  (EXP,ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
triticonazole  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell redox homeostasis  (ISO)
cellular homeostasis  (IEA,ISO)
cellular response to cholesterol  (IEA,ISO)
cellular response to cold  (IEA,ISO)
cellular response to copper ion  (IEA,ISO)
cellular response to oxidative stress  (ISO)
cellular response to stress  (IEA)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (IEA)
cysteine transport  (IEA,ISO)
erythrocyte differentiation  (IEA,ISO)
fructose 6-phosphate metabolic process  (IEA,ISO)
glial cell fate commitment  (IEA,ISO)
glucose 6-phosphate metabolic process  (IEA,ISO)
glutathione metabolic process  (IEA,ISO)
lipid homeostasis  (ISO)
lipid metabolic process  (IEA)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein polyubiquitination  (IEA,ISO)
regulation of cellular response to stress  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of fatty acid metabolic process  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of glucose metabolic process  (IEA,ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of lipid metabolic process  (IEA,ISO)
regulation of mitotic nuclear division  (IEA,ISO)
regulation of nucleus organization  (IEA,ISO)
regulation of odontoblast differentiation  (ISO)
regulation of proteasomal protein catabolic process  (IEA,ISO)
regulation of response to endoplasmic reticulum stress  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
response to endoplasmic reticulum stress  (IEA,ISO)
spinal cord motor neuron differentiation  (IEA,ISO)
steroid metabolic process  (IEA)

Cellular Component
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
endoplasmic reticulum membrane  (IEA,ISO)
membrane  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
protein-containing complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. New targets of urocortin-mediated cardioprotection. Barry SP, etal., J Mol Endocrinol. 2010 Aug;45(2):69-85. doi: 10.1677/JME-09-0148. Epub 2010 May 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:8932385   PMID:9421508   PMID:9501099   PMID:10037736   PMID:10601325   PMID:11342101   PMID:12477932   PMID:15308669   PMID:15988009   PMID:16581765   PMID:20385086  
PMID:21554501   PMID:22586274   PMID:22971132   PMID:23144760   PMID:23702335   PMID:23840004   PMID:24448410   PMID:24462598   PMID:25041126   PMID:25092871   PMID:25290918   PMID:25637874  
PMID:25806530   PMID:27528193   PMID:27920251   PMID:28088524   PMID:29149604   PMID:29400713  


Genomics

Comparative Map Data
Nfe2l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81082,296,824 - 82,309,472 (-)NCBIGRCr8
GRCr8 Ensembl1082,292,508 - 82,309,375 (-)EnsemblGRCr8 Ensembl
mRatBN7.21081,796,055 - 81,812,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1081,800,366 - 81,832,318 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1086,748,076 - 86,760,626 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01086,246,127 - 86,258,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01081,638,722 - 81,651,272 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01084,686,762 - 84,699,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1084,682,460 - 84,698,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01084,479,677 - 84,492,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41085,570,238 - 85,577,636 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1080,562,053 - 80,574,604 (-)NCBICelera
RGSC_v3.11085,588,909 - 85,601,415 (-)NCBI
Cytogenetic Map10q31NCBI
NFE2L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381748,048,359 - 48,061,545 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1748,048,329 - 48,061,545 (+)EnsemblGRCh38hg38GRCh38
GRCh371746,125,721 - 46,138,907 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,480,745 - 43,493,841 (+)NCBINCBI36Build 36hg18NCBI36
Build 341743,480,744 - 43,493,840NCBI
Celera1742,578,502 - 42,591,724 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1741,494,079 - 41,507,301 (+)NCBIHuRef
CHM1_11746,190,680 - 46,203,900 (+)NCBICHM1_1
T2T-CHM13v2.01748,910,172 - 48,923,361 (+)NCBIT2T-CHM13v2.0
Nfe2l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391196,708,239 - 96,720,810 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1196,708,240 - 96,720,794 (-)EnsemblGRCm39 Ensembl
GRCm381196,817,414 - 96,829,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1196,817,414 - 96,829,968 (-)EnsemblGRCm38mm10GRCm38
MGSCv371196,678,728 - 96,691,282 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361196,633,521 - 96,644,045 (-)NCBIMGSCv36mm8
Celera11106,466,769 - 106,479,303 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1160.12NCBI
Nfe2l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545113,088,906 - 13,099,839 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545113,088,680 - 13,099,839 (-)NCBIChiLan1.0ChiLan1.0
NFE2L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21917,042,363 - 17,055,684 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11719,007,939 - 19,021,206 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0179,476,482 - 9,489,661 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1179,657,847 - 9,671,040 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,657,847 - 9,671,040 (-)Ensemblpanpan1.1panPan2
NFE2L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1924,344,697 - 24,356,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl924,346,585 - 24,362,646 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha923,810,726 - 23,822,715 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0925,138,680 - 25,150,670 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl925,138,689 - 25,156,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1923,908,140 - 23,920,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0924,168,769 - 24,180,752 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0924,296,588 - 24,308,159 (+)NCBIUU_Cfam_GSD_1.0
Nfe2l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560223,795,986 - 23,810,579 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649013,266,347 - 13,279,206 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649013,265,269 - 13,279,164 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFE2L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1224,303,399 - 24,316,763 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11224,303,381 - 24,316,765 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,300,897 - 24,308,045 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NFE2L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11668,449,601 - 68,463,030 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1668,449,898 - 68,461,190 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607739,501,780 - 39,515,234 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfe2l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247954,652,637 - 4,662,454 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247954,652,221 - 4,663,341 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfe2l1
114 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:37
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000067542
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)107369533983061459Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)107369533983061459Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107395020983959619Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AW212678  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,800,517 - 81,800,632 (+)MAPPERmRatBN7.2
Rnor_6.01084,686,905 - 84,687,019NCBIRnor6.0
Rnor_5.01084,479,820 - 84,479,934UniSTSRnor5.0
RGSC_v3.41085,574,696 - 85,574,810UniSTSRGSC3.4
Celera1080,562,196 - 80,562,310UniSTS
Cytogenetic Map10q31UniSTS
RH142522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,798,500 - 81,798,766 (+)MAPPERmRatBN7.2
Rnor_6.01084,684,890 - 84,685,155NCBIRnor6.0
Rnor_5.01084,477,805 - 84,478,070UniSTSRnor5.0
RGSC_v3.41085,572,681 - 85,572,946UniSTSRGSC3.4
Celera1080,560,181 - 80,560,446UniSTS
RH 3.4 Map10781.7UniSTS
Cytogenetic Map10q31UniSTS
RH138073  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,796,730 - 81,796,943 (+)MAPPERmRatBN7.2
Rnor_6.01084,683,120 - 84,683,332NCBIRnor6.0
Rnor_5.01084,476,035 - 84,476,247UniSTSRnor5.0
RGSC_v3.41085,570,911 - 85,571,123UniSTSRGSC3.4
Celera1080,558,411 - 80,558,623UniSTS
RH 3.4 Map10731.8UniSTS
Cytogenetic Map10q31UniSTS
UniSTS:274184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,802,819 - 81,804,282 (+)MAPPERmRatBN7.2
Rnor_6.01084,689,207 - 84,690,669NCBIRnor6.0
Rnor_5.01084,482,122 - 84,483,584UniSTSRnor5.0
RGSC_v3.41085,576,998 - 85,578,460UniSTSRGSC3.4
Celera1080,564,498 - 80,565,960UniSTS
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001372250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001372251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006220824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006220825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006220826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006220827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC169095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK839329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000067542   ⟹   ENSRNOP00000061935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1082,296,825 - 82,309,375 (-)Ensembl
mRatBN7.2 Ensembl1081,800,366 - 81,812,484 (-)Ensembl
Rnor_6.0 Ensembl1084,682,460 - 84,698,886 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103907   ⟹   ENSRNOP00000087333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1082,292,508 - 82,307,052 (-)Ensembl
mRatBN7.2 Ensembl1081,800,366 - 81,832,318 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111539   ⟹   ENSRNOP00000088301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1082,296,825 - 82,303,398 (-)Ensembl
mRatBN7.2 Ensembl1081,800,376 - 81,806,949 (-)Ensembl
RefSeq Acc Id: NM_001108293   ⟹   NP_001101763
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81082,296,824 - 82,309,375 (-)NCBI
mRatBN7.21081,800,375 - 81,812,926 (-)NCBI
RefSeq Acc Id: NM_001372250   ⟹   NP_001359179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81082,296,824 - 82,308,930 (-)NCBI
mRatBN7.21081,800,375 - 81,812,481 (-)NCBI
RefSeq Acc Id: NM_001372251   ⟹   NP_001359180
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81082,296,824 - 82,303,398 (-)NCBI
mRatBN7.21081,800,375 - 81,806,949 (-)NCBI
RefSeq Acc Id: XM_006247238   ⟹   XP_006247300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81082,296,824 - 82,309,472 (-)NCBI
mRatBN7.21081,800,375 - 81,806,744 (-)NCBI
Rnor_6.01084,686,762 - 84,693,171 (-)NCBI
Rnor_5.01084,479,677 - 84,492,242 (-)NCBI
Sequence:
RefSeq Acc Id: XP_006247300   ⟸   XM_006247238
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000061935   ⟸   ENSRNOT00000067542
RefSeq Acc Id: NP_001101763   ⟸   NM_001108293
- Peptide Label: 1
- UniProtKB: A0A8I6A8A5 (UniProtKB/TrEMBL),   A6HIG7 (UniProtKB/TrEMBL),   D4A349 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001359179   ⟸   NM_001372250
- Peptide Label: 1
- UniProtKB: A0A8I6A8A5 (UniProtKB/TrEMBL),   A6HIG7 (UniProtKB/TrEMBL),   D4A349 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001359180   ⟸   NM_001372251
- Peptide Label: 2
- UniProtKB: A0A8I6A9I5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087333   ⟸   ENSRNOT00000103907
Ensembl Acc Id: ENSRNOP00000088301   ⟸   ENSRNOT00000111539
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A349-F1-model_v2 AlphaFold D4A349 1-675 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697640
Promoter ID:EPDNEW_R8159
Type:multiple initiation site
Name:Nfe2l1_1
Description:nuclear factor, erythroid 2-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01084,698,869 - 84,698,929EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311972 AgrOrtholog
BioCyc Gene G2FUF-23479 BioCyc
Ensembl Genes ENSRNOG00000008830 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067542 ENTREZGENE
  ENSRNOT00000067542.4 UniProtKB/TrEMBL
  ENSRNOT00000103907 ENTREZGENE
  ENSRNOT00000103907.1 UniProtKB/TrEMBL
  ENSRNOT00000111539 ENTREZGENE
  ENSRNOT00000111539.1 UniProtKB/TrEMBL
Gene3D-CATH Transcription factor, Skn-1-like, DNA-binding domain UniProtKB/TrEMBL
InterPro bZIP_Maf UniProtKB/TrEMBL
  Euk_TF_DNA-bd UniProtKB/TrEMBL
  NFE2-like UniProtKB/TrEMBL
  TF_bZIP UniProtKB/TrEMBL
NCBI Gene 360610 ENTREZGENE
PANTHER NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR UniProtKB/TrEMBL
  PTHR24411:SF31 UniProtKB/TrEMBL
Pfam bZIP_Maf UniProtKB/TrEMBL
PhenoGen Nfe2l1 PhenoGen
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008830 RatGTEx
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP Euk_transcr_DNA UniProtKB/TrEMBL
UniProt A0A8I6A8A5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9I5 ENTREZGENE, UniProtKB/TrEMBL
  A6HIG7 ENTREZGENE, UniProtKB/TrEMBL
  D4A349 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-10-22 Nfe2l1  NFE2 like bZIP transcription factor 1  Nfe2l1  nuclear factor, erythroid 2-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-22 Nfe2l1  nuclear factor, erythroid 2-like 1  Nfe2l1  nuclear factor, erythroid derived 2,-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nfe2l1  nuclear factor, erythroid derived 2,-like 1   Nfe2l1_predicted  nuclear factor, erythroid derived 2,-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nfe2l1_predicted  nuclear factor, erythroid derived 2,-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED