Iqgap1 (IQ motif containing GTPase activating protein 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Iqgap1 (IQ motif containing GTPase activating protein 1) Rattus norvegicus
Analyze
Symbol: Iqgap1
Name: IQ motif containing GTPase activating protein 1
RGD ID: 1311884
Description: Enables mitogen-activated protein kinase binding activity. Involved in several processes, including positive regulation of dendrite development; positive regulation of peptidyl-tyrosine autophosphorylation; and regulation of cell junction assembly. Located in cytoskeleton; focal adhesion; and growth cone. Part of protein-containing complex. Is active in postsynapse. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1); PARTICIPATES IN E-cadherin signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361598; ras GTPase-activating-like protein IQGAP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,088,788 - 144,178,989 (-)NCBIGRCr8
mRatBN7.21134,679,581 - 134,769,776 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,679,586 - 134,769,755 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,588,968 - 142,679,115 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,758,382 - 149,848,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,676,568 - 142,767,383 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,525,041 - 142,615,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,525,046 - 142,615,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,476,882 - 143,567,395 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,552,358 - 136,642,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,631,848 - 136,722,691 (-)NCBI
Celera1126,734,261 - 126,824,269 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3',5'-cyclic AMP  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
afatinib  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
captan  (ISO)
CGP 52608  (ISO)
choline  (ISO)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dihydroartemisinin  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
griseofulvin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
ochratoxin A  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pyrogallol  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
trichostatin A  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Regulation of spine density and morphology by IQGAP1 protein domains. Jausoro I, etal., PLoS One. 2013;8(2):e56574. doi: 10.1371/journal.pone.0056574. Epub 2013 Feb 18.
4. IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Johnson M, etal., Int J Biochem Cell Biol. 2011 Jan;43(1):65-73. doi: 10.1016/j.biocel.2010.09.014. Epub 2010 Sep 29.
5. IQGAP1 links PDGF receptor-beta signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury. Kohno T, etal., Am J Physiol Cell Physiol. 2013 Sep 15;305(6):C591-600. doi: 10.1152/ajpcell.00011.2013. Epub 2013 May 8.
6. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Lehtonen S, etal., Am J Pathol. 2004 Sep;165(3):923-36.
7. IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. Li Z, etal., J Biol Chem. 2005 Apr 8;280(14):13871-8. Epub 2005 Jan 28.
8. IQGAP1 mediates angiotensin II-induced apoptosis of podocytes via the ERK1/2 MAPK signaling pathway. Liu Y, etal., Am J Nephrol. 2013;38(5):430-44. doi: 10.1159/000355970. Epub 2013 Nov 12.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Identification of an IQGAP1/AKAP79 complex in beta-cells. Nauert JB, etal., J Cell Biochem 2003 Sep 1;90(1):97-108.
11. Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4. Nuriya M, etal., J Neurochem. 2005 Oct;95(2):544-52. doi: 10.1111/j.1471-4159.2005.03410.x.
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
17. CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. Swiech L, etal., J Neurosci. 2011 Mar 23;31(12):4555-68. doi: 10.1523/JNEUROSCI.6582-10.2011.
18. Hierarchical scaffolding of an ERK1/2 activation pathway. Vetterkind S, etal., Cell Commun Signal. 2013 Aug 29;11:65. doi: 10.1186/1478-811X-11-65.
19. IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. Yamaoka-Tojo M, etal., Circ Res. 2004 Aug 6;95(3):276-83. Epub 2004 Jun 24.
Additional References at PubMed
PMID:12377780   PMID:12477932   PMID:14516655   PMID:15121898   PMID:15166316   PMID:15263019   PMID:15389538   PMID:16369480   PMID:16380380   PMID:16510873   PMID:17137623   PMID:17563371  
PMID:18504258   PMID:18567582   PMID:18604197   PMID:19056867   PMID:19199708   PMID:20015863   PMID:20458337   PMID:21423176   PMID:21525035   PMID:21709260   PMID:22493426   PMID:22835851  
PMID:23376485   PMID:23533145   PMID:24625528   PMID:24841562   PMID:25468996   PMID:25554515   PMID:26242911   PMID:28839270   PMID:29033352   PMID:30257103   PMID:32364766   PMID:34147590  


Genomics

Comparative Map Data
Iqgap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,088,788 - 144,178,989 (-)NCBIGRCr8
mRatBN7.21134,679,581 - 134,769,776 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,679,586 - 134,769,755 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,588,968 - 142,679,115 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,758,382 - 149,848,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,676,568 - 142,767,383 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,525,041 - 142,615,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,525,046 - 142,615,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,476,882 - 143,567,395 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,552,358 - 136,642,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,631,848 - 136,722,691 (-)NCBI
Celera1126,734,261 - 126,824,269 (-)NCBICelera
Cytogenetic Map1q31NCBI
IQGAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,388,242 - 90,502,239 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,388,242 - 90,502,239 (+)EnsemblGRCh38hg38GRCh38
GRCh371590,931,474 - 91,045,471 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,732,477 - 88,846,479 (+)NCBINCBI36Build 36hg18NCBI36
Build 341588,732,476 - 88,846,479NCBI
Celera1567,336,216 - 67,450,214 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,043,721 - 67,156,752 (+)NCBIHuRef
CHM1_11590,773,219 - 90,887,196 (+)NCBICHM1_1
T2T-CHM13v2.01588,144,255 - 88,258,256 (+)NCBIT2T-CHM13v2.0
Iqgap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,361,331 - 80,453,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,361,331 - 80,475,722 (-)EnsemblGRCm39 Ensembl
GRCm38780,711,583 - 80,815,549 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,711,583 - 80,825,974 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,856,469 - 87,948,217 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,586,294 - 80,676,807 (-)NCBIMGSCv36mm8
Celera778,116,162 - 78,211,858 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map745.68NCBI
Iqgap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,560,292 - 14,650,036 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,558,628 - 14,652,031 (+)NCBIChiLan1.0ChiLan1.0
IQGAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,935,362 - 80,049,434 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,634,820 - 83,748,904 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,076,025 - 69,190,082 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,276,762 - 88,390,721 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,276,851 - 88,388,594 (+)Ensemblpanpan1.1panPan2
IQGAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,683,869 - 53,791,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,683,791 - 53,792,186 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha356,321,230 - 56,429,279 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0354,099,750 - 54,207,801 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl354,098,495 - 54,207,760 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,618,792 - 53,726,768 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,830,202 - 53,938,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,170,507 - 54,278,357 (-)NCBIUU_Cfam_GSD_1.0
Iqgap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640129,739,918 - 129,845,387 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,489,133 - 16,594,783 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,489,127 - 16,594,712 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQGAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1299,363,273 - 9,485,644 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl299,362,926 - 9,485,526 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,209,223 - 37,324,055 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iqgap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,702,728 - 17,799,022 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,703,113 - 17,797,922 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Iqgap1
500 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:506
Count of miRNA genes:224
Interacting mature miRNAs:274
Transcripts:ENSRNOT00000018021
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat

Markers in Region
D1Got124  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01142,624,945 - 142,625,025NCBIRnor6.0
Rnor_5.01143,576,626 - 143,576,706UniSTSRnor5.0
RGSC_v3.41136,652,602 - 136,652,683RGDRGSC3.4
RGSC_v3.41136,652,603 - 136,652,683UniSTSRGSC3.4
RGSC_v3.11136,731,009 - 136,731,089RGD
Celera1126,833,500 - 126,833,582UniSTS
RH 3.4 Map11077.3RGD
RH 3.4 Map11077.3UniSTS
RH 2.0 Map1689.9RGD
Cytogenetic Map1q31UniSTS
RH129224  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,679,647 - 134,679,852 (+)MAPPERmRatBN7.2
Rnor_6.01142,525,108 - 142,525,312NCBIRnor6.0
Rnor_5.01143,476,949 - 143,477,153UniSTSRnor5.0
RGSC_v3.41136,552,425 - 136,552,629UniSTSRGSC3.4
Celera1126,734,328 - 126,734,532UniSTS
RH 3.4 Map11075.5UniSTS
Cytogenetic Map1q31UniSTS
AU047418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,742,669 - 134,742,966 (+)MAPPERmRatBN7.2
Rnor_6.01142,588,533 - 142,588,829NCBIRnor6.0
Rnor_5.01143,540,374 - 143,540,670UniSTSRnor5.0
RGSC_v3.41136,615,441 - 136,615,737UniSTSRGSC3.4
Celera1126,797,222 - 126,797,518UniSTS
Cytogenetic Map1q31UniSTS
RH137092  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,678,465 - 134,678,664 (+)MAPPERmRatBN7.2
Rnor_6.01142,523,926 - 142,524,124NCBIRnor6.0
Rnor_5.01143,475,767 - 143,475,965UniSTSRnor5.0
RGSC_v3.41136,551,243 - 136,551,441UniSTSRGSC3.4
Celera1126,733,146 - 126,733,344UniSTS
RH 3.4 Map11075.5UniSTS
Cytogenetic Map1q31UniSTS
AI011928  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,678,462 - 134,678,748 (+)MAPPERmRatBN7.2
Rnor_6.01142,523,923 - 142,524,208NCBIRnor6.0
Rnor_5.01143,475,764 - 143,476,049UniSTSRnor5.0
RGSC_v3.41136,551,240 - 136,551,525UniSTSRGSC3.4
Celera1126,733,143 - 126,733,428UniSTS
RH 3.4 Map11075.7UniSTS
Cytogenetic Map1q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 45 29 19 29 8 9 73 35 40 11 8
Low 1 12 12 12 2 1 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000018021   ⟹   ENSRNOP00000018021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,679,586 - 134,769,755 (-)Ensembl
Rnor_6.0 Ensembl1142,525,046 - 142,615,673 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118439   ⟹   ENSRNOP00000093807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,679,586 - 134,767,547 (-)Ensembl
RefSeq Acc Id: NM_001108489   ⟹   NP_001101959
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,088,788 - 144,178,953 (-)NCBI
mRatBN7.21134,679,581 - 134,769,755 (-)NCBI
Rnor_6.01142,525,041 - 142,615,673 (-)NCBI
Rnor_5.01143,476,882 - 143,567,395 (-)NCBI
RGSC_v3.41136,552,358 - 136,642,545 (-)RGD
Celera1126,734,261 - 126,824,269 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082350   ⟹   XP_038938278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,105,668 - 144,178,989 (-)NCBI
mRatBN7.21134,696,450 - 134,769,776 (-)NCBI
RefSeq Acc Id: NP_001101959   ⟸   NM_001108489
- UniProtKB: G3V7Q7 (UniProtKB/TrEMBL),   A6JCC7 (UniProtKB/TrEMBL),   A0A8I6AJK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018021   ⟸   ENSRNOT00000018021
RefSeq Acc Id: XP_038938278   ⟸   XM_039082350
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000093807   ⟸   ENSRNOT00000118439
Protein Domains
Calponin-homology (CH)   Ras-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7Q7-F1-model_v2 AlphaFold G3V7Q7 1-1657 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690148
Promoter ID:EPDNEW_R673
Type:initiation region
Name:Iqgap1_1
Description:IQ motif containing GTPase activating protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01142,615,673 - 142,615,733EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311884 AgrOrtholog
BioCyc Gene G2FUF-58724 BioCyc
Ensembl Genes ENSRNOG00000012002 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018021 ENTREZGENE
  ENSRNOT00000018021.6 UniProtKB/TrEMBL
  ENSRNOT00000118439.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
  Myosin, subunit A UniProtKB/TrEMBL
InterPro Calponin-like_dom_sf UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:361598 UniProtKB/TrEMBL
NCBI Gene 361598 ENTREZGENE
PANTHER RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF UniProtKB/TrEMBL
  RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1 UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
PhenoGen Iqgap1 PhenoGen
PROSITE PS50021 UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012002 RatGTEx
SMART RasGAP UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  RGC domain-like UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6AJK7 ENTREZGENE, UniProtKB/TrEMBL
  A6JCC7 ENTREZGENE, UniProtKB/TrEMBL
  B5DFH1_RAT UniProtKB/TrEMBL
  G3V7Q7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Iqgap1  IQ motif containing GTPase activating protein 1   Iqgap1_predicted  IQ motif containing GTPase activating protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Iqgap1_predicted  IQ motif containing GTPase activating protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED