Dsc3 (desmocollin 3) - Rat Genome Database

Name: Dsc3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Dsc3 (desmocollin 3) Rattus norvegicus

Analyze

Symbol:

Dsc3

Name:

desmocollin 3

RGD ID:

1311782

Description:

Predicted to enable calcium ion binding activity and gamma-catenin binding activity. Predicted to be involved in cell-cell adhesion and protein stabilization. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in several cellular components, including cell junction; extracellular region; and plasma membrane. Predicted to be active in desmosome. Orthologous to human DSC3 (desmocollin 3); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

desmocollin-3; LOC307563

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DSC3 (desmocollin 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Dsc3 (desmocollin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dsc3 (desmocollin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DSC3 (desmocollin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DSC3 (desmocollin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dsc3 (desmocollin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DSC3 (desmocollin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DSC3 (desmocollin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dsc3 (desmocollin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DSC2 (desmocollin 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	DSC3 (desmocollin 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dsc3 (desmocollin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dsc2l (desmocollin 2 like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	11,379,759 - 11,413,797 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	11,377,347 - 11,413,797 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	11,574,466 - 11,608,498 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	18	12,362,111 - 12,396,145 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	18	11,633,767 - 11,667,803 (-)	NCBI	Rnor_WKY
Rnor_6.0	18	11,753,047 - 11,789,846 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	11,753,047 - 11,789,708 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	11,554,588 - 11,588,850 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	11,831,071 - 11,865,107 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	11,857,716 - 11,891,578 (-)	NCBI
Celera	18	11,397,921 - 11,431,839 (-)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

genetic disease (ISO)

Hypotrichosis and Recurrent Skin Vesicles (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-tert-butylhydroquinone (ISO)

4,4'-diaminodiphenylmethane (ISO)

5-aza-2'-deoxycytidine (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

butanal (ISO)

calcitriol (ISO)

chromium atom (ISO)

cisplatin (ISO)

cytarabine (ISO)

dibenzo[a,l]pyrene (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

fonofos (ISO)

lipopolysaccharide (ISO)

mercury dibromide (ISO)

methapyrilene (ISO)

methylmercury chloride (ISO)

N-acetyl-1,4-benzoquinone imine (ISO)

parathion (ISO)

potassium chromate (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

terbufos (ISO)

tert-butyl hydroperoxide (ISO)

trichostatin A (ISO)

triclosan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell-cell adhesion (IBA)

homophilic cell adhesion via plasma membrane adhesion molecules (IEA)

in utero embryonic development (ISO)

protein stabilization (ISO)

Cellular Component

cell junction (ISO)

cytoplasm (ISO)

desmosome (IBA,ISO)

extracellular region (ISO)

plasma membrane (ISO)

Molecular Function

calcium ion binding (IBA)

gamma-catenin binding (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7983064	PMID:14673151	PMID:16418220	PMID:17015624

Genomics

Comparative Map Data

Dsc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	11,379,759 - 11,413,797 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	11,377,347 - 11,413,797 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	11,574,466 - 11,608,498 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	18	12,362,111 - 12,396,145 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	18	11,633,767 - 11,667,803 (-)	NCBI	Rnor_WKY
Rnor_6.0	18	11,753,047 - 11,789,846 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	11,753,047 - 11,789,708 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	11,554,588 - 11,588,850 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	11,831,071 - 11,865,107 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	11,857,716 - 11,891,578 (-)	NCBI
Celera	18	11,397,921 - 11,431,839 (-)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

DSC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	30,989,365 - 31,042,742 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	18	30,989,365 - 31,042,815 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	28,569,331 - 28,622,708 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	26,824,050 - 26,876,779 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	26,825,028 - 26,876,687	NCBI
Celera	18	25,378,198 - 25,430,941 (-)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI
HuRef	18	25,425,914 - 25,478,635 (-)	NCBI		HuRef
CHM1_1	18	28,497,074 - 28,549,808 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	31,179,590 - 31,233,008 (-)	NCBI		T2T-CHM13v2.0

Dsc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	20,093,987 - 20,135,465 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	20,093,987 - 20,135,408 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	19,960,930 - 20,002,410 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	19,960,930 - 20,002,351 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	20,119,431 - 20,160,598 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	20,106,382 - 20,145,107 (-)	NCBI		MGSCv36	mm8
Celera	18	20,463,199 - 20,504,347 (-)	NCBI		Celera
Cytogenetic Map	18	A2	NCBI
cM Map	18	11.11	NCBI

Dsc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	18,399,220 - 18,439,878 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	18,401,065 - 18,439,827 (-)	NCBI	ChiLan1.0	ChiLan1.0

DSC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	18	27,818,830 - 27,871,498 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	27,817,639 - 27,871,602 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	18	24,220,429 - 24,273,547 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

DSC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	58,412,769 - 58,457,593 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	57,849,240 - 57,898,797 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	58,397,433 - 58,444,156 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	7	58,073,592 - 58,123,113 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	58,098,278 - 58,147,954 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	58,389,185 - 58,438,756 (+)	NCBI		UU_Cfam_GSD_1.0

Dsc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	54,118,723 - 54,162,850 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936682	2,057,190 - 2,164,429 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936682	2,126,394 - 2,161,672 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DSC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	114,916,767 - 114,963,609 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	114,916,759 - 114,963,688 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DSC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	49,660,067 - 49,709,762 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	49,662,094 - 49,709,529 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	24,308,080 - 24,359,720 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dsc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	1,803,296 - 1,843,687 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	1,799,731 - 1,846,379 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dsc3
252 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	22
Count of miRNA genes:	22
Interacting mature miRNAs:	22
Transcripts:	ENSRNOT00000064554
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552968	Pigfal19	Plasma insulin-like growth factor 1 level QTL 19	11.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	18	1	25758124	Rat
9590248	Scort10	Serum corticosterone level QTL 10	19.71	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	1	25758124	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
1641910	Colcr3	Colorectal carcinoma resistance QTL 3	5.02	0.000007	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)	18	2249477	22066430	Rat
1641910	Colcr3	Colorectal carcinoma resistance QTL 3	5.02	0.000007	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	2249477	22066430	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	6791251	12205285	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	6791251	12205285	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	6791251	12205285	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	6791251	12205285	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	6791251	12205285	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			1		1
Low	1		7		7		1	1			9	7	1
Below cutoff	1	14	6	6	2	6	2	2	14	1	18	1	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000064554 ⟹ ENSRNOP00000063301

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	18	11,755,446 - 11,789,708 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000077304 ⟹ ENSRNOP00000072083

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	11,377,347 - 11,413,797 (-)	Ensembl
Rnor_6.0 Ensembl	18	11,753,047 - 11,789,697 (-)	Ensembl

RefSeq Acc Id:

NM_001107402 ⟹ NP_001100872

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	11,379,759 - 11,413,797 (-)	NCBI
Rnor_6.0	18	11,755,446 - 11,789,708 (-)	NCBI
Rnor_5.0	18	11,554,588 - 11,588,850 (-)	NCBI
RGSC_v3.4	18	11,831,071 - 11,865,107 (-)	RGD
Celera	18	11,397,921 - 11,431,839 (-)	RGD

Sequence:

show sequence

ACTGAGCGTCTCCTTAGTCCAATCCAGTTTCAGGCGAGAACATGCTTCTAGGCAAAGAAGCTTG
AGAGAGGCCAGAACAACTTCTAGACAAGCTGCTGTGGAAAACCTCCTGTGCCCTGGCTCTTAGA
GTCCTTACTTGGTGCCCGCCTGCGTCCTCCTGAGGCAGCACCGAACGATGGCGATGGCGATGGC
GGTCCCTGAGCTCCGGAGCCTGCCGTACAGGGCACCATTCACGAAGTTCCTGCTGACCCTCTGG
GTCTTCAGTTTTGTTGGTGAAGCCTGTAAAGATGTGACCTTTTATGTACCTTCAACACTAGAGG
CAGACAAGATCATCGGAAGAGTTAGTTTGAAGGAGTGTCTCAGCTCGGCTGATGGTATCATGCC
AAGCGATCCTGACTTCAGAGTTCTAGATGACGGGTCAGTTTATCCTACCAGAGCTGTTGTGTTG
TCTGATGAGAAAAGATCATTTACCATTCAGCTTTCTGATTCAAAGATGCGGAAACAGAAAGAGA
TCACTGTAATCCTGGAGCGCCAGAAGGAGGTAATGATGAAAAGACACACTAATGAAACTGTCCT
CAGAAGAGCCAAGAGGAGATGGGCACCCATTCCGTGTTCAATGCAAGAAAATTCCTTGGGTCCC
TTCCCATTGTTTCTTCAACAGGTTCAGTCTGATTCAGCTCAGAACTACAATATCTTCTACTCAA
TAAGCGGGCGTGGAGTTGACCAAGAACCACTGAATTTGTTTTTCATTGAGAGAGACACTGGGAA
TCTTTATTGTACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCCTATGCA
TCCACTGCAGATGGCTACTCAGCAGATTTACCTCTCCCCCTGCCCATCAAAGTAGAGGATGAAA
ATGACAATTACCCTCTTTTTACAGAAGCAATTTACAATTTTGAAGTTCCAGAAAGCAGTAGACT
TGGTACCGTGGTGGGAACGGTGTGTGCTACGGACAAAGATGAACCCGATACGATGCACACGCGC
CTCAAGTACAGCATCTTGGAGCAGAGTCCGCCGTCCCCAGGGCTCTTTTCTGTGCACCCTGACA
CCGGCGTCATCACCACTGTCTCTCACTACATGGACAGAGAGGTTGTAGACAAGTACAAACTGAT
CTTGAAAGTCCAGGACATGAATGGCCAATTCTTTGGACTCATCAGCACATCAACTTGTATCATA
ACAGTGCAAGATTCCAATGACAATGCTCCCACATTCAGACAAAATGCTTATGAAACTTCTGTGG
AGGAAAATACATATAATGTTGAGATCTTGCGCATACCTGTAGATGATAAGGACATGGTTAACAG
TGCCAACTGGAAGGCAAATTTCACCATCTTAAAAGGAAATGAAAACGGCTGGTTCAAAATCACG
ACAGACCCAGCGACAAATGAGGGTGTTCTGTGTGTCGTGAAGCCACTGGATTATGAAGAAAATC
GTCAAGTGACCCTAGAGATCGGTGTGAACAACGAAGCTCCATTCATTAGAGATGTTGCAAGCCG
AATACCCACCATGAATCGGGCCATGGTTACAGTCCAAGTGAGGGATCAGAATGAGGGGCCGGAA
TGCAAGCCCCGTGAGCAGATTGTACGGATCAAAGAGAACTCAGCAATTGGGTCTAAGATCAATG
GCTACAAGGCCTATGACCCCGAAACCAAGAATAGCAATGGTTTAAGGTACAAAAAATTGCAGGA
TCCTAAAGACTGGGTCAGCATTGAAGAAGTTTCAGGATCACTCACCATATCAAAAATCCTGGAC
AGAGAAATCATGGCTCCAAGAAATGACCTATACAATATTACAGTCATGGCAATTGACCAAGAGG
GTAGATCATGCACAGGGACGCTTGCAGTGAACATTGAGGATATGAATGACAACGCACCAGAGAT
AATTCAAGATGACATTGTCATCTGCAAGCCAAGGATGGGTTATACAGACATTTCAGCTGTGGAT
CCTGATGAACCTATTCACGGCCCTCCCTTCCAGTTCGCCTTGGCAAGCTCTTCTCCAGAAGTCA
ACAGAATCTGGACCCTCAACCAAGTTAATGATACAGCTGCCCGCCTGTCCTATCAGAAAACCGC
GGATGTTCAGATATACTCCGTTCCTGTAACTGTAACAGACAGAGCAGGCCAATCTGCGACCAAG
ATCTTGAGAGTTAACCTGTGCGATTGTACTCACCCCAGCCAGTGTCTGCTCAGATCAAGAAGAG
CGGGGATCACCCTGGGGAAGTGGGCAATCCTTGCCATCTTGCTGGGCATCGCTCTGCTATTCTC
GGTACTGCTAACTTTAGTATGTGGGGTTGTTACTGCTCAAAAAGGAAAACATTTTCCTGAAGAT
TTAGCACAGCAAAACTTAATTATATCAAATACCGAAGCACCCGGGGACGACAGAGTGTGCTCTG
CCAATGGATTCACCACCCACACTGCCAACAACTCCAGCCAAGGCTTCTGTGGCACAATGGGGTC
AGGAATGAGGAACGGTGGGCAGGAGACCATCGAGATGATGAAAGGCCACCAGACCTTGGACTCC
TGCCGTGTTGCTGGGCATCACCACACCCTGGACTCCTGCAGGGGAGGACACATGGAAACCGACA
ACTGCAGATACACGTACTCAGAGTGGCACAGCTTCACTCAGCCCCGACTCGGCGAAAAATTGCA
TGTGTGTAATCAGAACGAAGACCACATCCCATCTCAAGACTATGTCCTCACCTATAACTACGAA
GGCAGGGGATCTCCAGCCGGTTCTGTAGGTTGCTGCAGTGAAAAGCAGGAAGAAGAGGGACTCG
ACTTTTTAAACAATTTGGAGCCCAAATTTCTTACATTGGCAGAAACATGTACAAAGAGATAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100872	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL76084	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001100872 ⟸ NM_001107402

- UniProtKB:

D3ZZI6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAMAMAVPELRSLPYRAPFTKFLLTLWVFSFVGEACKDVTFYVPSTLEADKIIGRVSLKECLSS
ADGIMPSDPDFRVLDDGSVYPTRAVVLSDEKRSFTIQLSDSKMRKQKEITVILERQKEVMMKRH
TNETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVQSDSAQNYNIFYSISGRGVDQEPLNLFFI
ERDTGNLYCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIKVEDENDNYPLFTEAIYNFEV
PESSRLGTVVGTVCATDKDEPDTMHTRLKYSILEQSPPSPGLFSVHPDTGVITTVSHYMDREVV
DKYKLILKVQDMNGQFFGLISTSTCIITVQDSNDNAPTFRQNAYETSVEENTYNVEILRIPVDD
KDMVNSANWKANFTILKGNENGWFKITTDPATNEGVLCVVKPLDYEENRQVTLEIGVNNEAPFI
RDVASRIPTMNRAMVTVQVRDQNEGPECKPREQIVRIKENSAIGSKINGYKAYDPETKNSNGLR
YKKLQDPKDWVSIEEVSGSLTISKILDREIMAPRNDLYNITVMAIDQEGRSCTGTLAVNIEDMN
DNAPEIIQDDIVICKPRMGYTDISAVDPDEPIHGPPFQFALASSSPEVNRIWTLNQVNDTAARL
SYQKTADVQIYSVPVTVTDRAGQSATKILRVNLCDCTHPSQCLLRSRRAGITLGKWAILAILLG
IALLFSVLLTLVCGVVTAQKGKHFPEDLAQQNLIISNTEAPGDDRVCSANGFTTHTANNSSQGF
CGTMGSGMRNGGQETIEMMKGHQTLDSCRVAGHHHTLDSCRGGHMETDNCRYTYSEWHSFTQPR
LGEKLHVCNQNEDHIPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEEGLDFLNNLEPKFLTLAET
CTKR

hide sequence

RefSeq Acc Id:

ENSRNOP00000072083 ⟸ ENSRNOT00000077304

RefSeq Acc Id:

ENSRNOP00000063301 ⟸ ENSRNOT00000064554

Protein Domains

Cadherin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZZI6-F1-model_v2	AlphaFold	D3ZZI6	1-900	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700654

Promoter ID:

EPDNEW_R11174

Type:

single initiation site

Name:

Dsc3_1

Description:

desmocollin 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	11,789,635 - 11,789,695	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311782	AgrOrtholog
BioCyc Gene	G2FUF-8241	BioCyc
Ensembl Genes	ENSRNOG00000017159	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000072083	ENTREZGENE
	ENSRNOP00000072083.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000077304	ENTREZGENE
	ENSRNOT00000077304.2	UniProtKB/TrEMBL
Gene3D-CATH	4.10.900.10	UniProtKB/TrEMBL
	Cadherins	UniProtKB/TrEMBL
InterPro	Cadherin	UniProtKB/TrEMBL
	Cadherin-like	UniProtKB/TrEMBL
	Cadherin_CS	UniProtKB/TrEMBL
	Cadherin_cytoplasmic-dom	UniProtKB/TrEMBL
	Cadherin_pro	UniProtKB/TrEMBL
	Catenin-bd_sf	UniProtKB/TrEMBL
	Desmosomal_cadherin	UniProtKB/TrEMBL
NCBI Gene	307563	ENTREZGENE
PANTHER	DESMOCOLLIN-3	UniProtKB/TrEMBL
	DESMOGLEIN FAMILY MEMBER	UniProtKB/TrEMBL
Pfam	Cadherin	UniProtKB/TrEMBL
	Cadherin_C	UniProtKB/TrEMBL
	Cadherin_pro	UniProtKB/TrEMBL
PhenoGen	Dsc3	PhenoGen
PRINTS	CADHERIN	UniProtKB/TrEMBL
	DESMOCADHERN	UniProtKB/TrEMBL
	DESMOCOLLIN	UniProtKB/TrEMBL
PROSITE	CADHERIN_1	UniProtKB/TrEMBL
	CADHERIN_2	UniProtKB/TrEMBL
SMART	Cadherin_pro	UniProtKB/TrEMBL
	SM00112	UniProtKB/TrEMBL
Superfamily-SCOP	Cadherin	UniProtKB/TrEMBL
UniProt	A0A0G2K230_RAT	UniProtKB/TrEMBL
	D3ZZI6	ENTREZGENE
UniProt Secondary	D3ZZI6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Dsc3	desmocollin 3	Dsc3_predicted	desmocollin 3 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Dsc3_predicted	desmocollin 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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