Hexim2 (HEXIM P-TEFb complex subunit 2) - Rat Genome Database

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Gene: Hexim2 (HEXIM P-TEFb complex subunit 2) Rattus norvegicus
Analyze
Symbol: Hexim2
Name: HEXIM P-TEFb complex subunit 2
RGD ID: 1311635
Description: Predicted to enable 7SK snRNA binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear speck. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human HEXIM2 (HEXIM P-TEFb complex subunit 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hexamethylene bis-acetamide inducible 2; hexamthylene bis-acetamide inducible 2; LOC303580; MAQ1 paralog; RGD1311635; similar to hypothetical protein MGC39389
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Hexim2em4Mcwi  
Genetic Models: SS-Hexim2em4Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,572,102 - 88,584,856 (+)NCBIGRCr8
mRatBN7.21088,077,870 - 88,084,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,079,014 - 88,084,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,115,155 - 93,120,921 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,581,799 - 92,587,566 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,975,151 - 87,980,918 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,212,296 - 91,222,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,217,079 - 91,222,840 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,988,728 - 90,994,491 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,306,494 - 92,312,256 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,320,794 - 92,329,877 (+)NCBI
Celera1086,780,500 - 86,786,262 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)
nuclear speck  (ISO)
nucleoplasm  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Glycosylation analysis of IgLON family proteins in rat brain by liquid chromatography and multiple-stage mass spectrometry. Itoh S, etal., Biochemistry. 2008 Sep 23;47(38):10132-54. Epub 2008 Aug 26.
3. Neurotrimin is an estrogen-regulated determinant of peripheral sympathetic innervation. Krizsan-Agbas D, etal., J Neurosci Res. 2008 Nov 1;86(14):3086-95.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:15713662   PMID:19883659   PMID:21516116   PMID:25416956  


Genomics

Comparative Map Data
Hexim2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,572,102 - 88,584,856 (+)NCBIGRCr8
mRatBN7.21088,077,870 - 88,084,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,079,014 - 88,084,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,115,155 - 93,120,921 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,581,799 - 92,587,566 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,975,151 - 87,980,918 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,212,296 - 91,222,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,217,079 - 91,222,840 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,988,728 - 90,994,491 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,306,494 - 92,312,256 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,320,794 - 92,329,877 (+)NCBI
Celera1086,780,500 - 86,786,262 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
HEXIM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381745,160,174 - 45,170,040 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1745,160,700 - 45,170,040 (+)EnsemblGRCh38hg38GRCh38
GRCh371743,237,541 - 43,247,407 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361740,594,047 - 40,603,189 (+)NCBINCBI36Build 36hg18NCBI36
Celera1739,947,916 - 39,957,031 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1739,001,091 - 39,009,915 (+)NCBIHuRef
CHM1_11743,473,807 - 43,482,952 (+)NCBICHM1_1
T2T-CHM13v2.01746,014,059 - 46,023,937 (+)NCBIT2T-CHM13v2.0
Hexim2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911103,014,086 - 103,030,734 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11103,023,255 - 103,030,702 (+)EnsemblGRCm39 Ensembl
GRCm3811103,123,260 - 103,139,908 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11103,132,429 - 103,139,876 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711102,994,653 - 103,001,222 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,949,404 - 102,955,998 (+)NCBIMGSCv36mm8
Celera11114,816,349 - 114,849,525 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1166.71NCBI
HEXIM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21919,667,571 - 19,676,969 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11721,636,155 - 21,646,713 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01712,157,392 - 12,167,281 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11712,333,957 - 12,343,424 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1712,333,957 - 12,343,399 (-)Ensemblpanpan1.1panPan2
HEXIM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1918,373,761 - 18,379,185 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl918,373,992 - 18,377,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha917,758,535 - 17,763,959 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,046,798 - 19,052,222 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,046,986 - 19,050,297 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1917,925,068 - 17,930,491 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,103,901 - 18,109,325 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,259,869 - 18,265,293 (-)NCBIUU_Cfam_GSD_1.0
Hexim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560217,717,605 - 17,722,656 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365411,472,027 - 1,477,048 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365411,472,041 - 1,476,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEXIM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,251,428 - 18,258,295 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,251,424 - 18,263,032 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,500,139 - 18,509,293 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HEXIM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11661,236,919 - 61,251,203 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1661,236,566 - 61,248,252 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607731,985,644 - 31,996,088 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Hexim2
66 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:111
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000004218
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat


Genetic Models
This gene Hexim2 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 5 4 4 44 4 31
Low 3 37 52 37 19 37 8 11 30 31 10 11 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC167046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000004218   ⟹   ENSRNOP00000052039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1088,079,014 - 88,084,775 (+)Ensembl
Rnor_6.0 Ensembl1091,217,079 - 91,222,840 (+)Ensembl
RefSeq Acc Id: NM_001107054   ⟹   NP_001100524
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,579,094 - 88,584,856 (+)NCBI
mRatBN7.21088,079,014 - 88,084,776 (+)NCBI
Rnor_6.01091,217,079 - 91,222,841 (+)NCBI
Rnor_5.01090,988,728 - 90,994,491 (+)NCBI
RGSC_v3.41092,306,494 - 92,312,256 (+)RGD
Celera1086,780,500 - 86,786,262 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247514   ⟹   XP_006247576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,572,102 - 88,584,856 (+)NCBI
mRatBN7.21088,077,872 - 88,084,776 (+)NCBI
Rnor_6.01091,212,296 - 91,222,841 (+)NCBI
Rnor_5.01090,988,728 - 90,994,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247515   ⟹   XP_006247577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,572,102 - 88,584,856 (+)NCBI
mRatBN7.21088,077,870 - 88,084,776 (+)NCBI
Rnor_6.01091,212,296 - 91,222,841 (+)NCBI
Rnor_5.01090,988,728 - 90,994,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247516   ⟹   XP_006247578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,579,683 - 88,584,856 (+)NCBI
mRatBN7.21088,079,678 - 88,084,776 (+)NCBI
Rnor_6.01091,217,677 - 91,222,841 (+)NCBI
Rnor_5.01090,988,728 - 90,994,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247517   ⟹   XP_006247579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,579,703 - 88,584,856 (+)NCBI
mRatBN7.21088,079,790 - 88,084,776 (+)NCBI
Rnor_6.01091,217,677 - 91,222,841 (+)NCBI
Rnor_5.01090,988,728 - 90,994,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247518   ⟹   XP_006247580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,572,102 - 88,584,856 (+)NCBI
mRatBN7.21088,077,870 - 88,084,776 (+)NCBI
Rnor_6.01091,212,296 - 91,222,841 (+)NCBI
Rnor_5.01090,988,728 - 90,994,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247520   ⟹   XP_006247582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,579,703 - 88,584,856 (+)NCBI
mRatBN7.21088,079,687 - 88,084,776 (+)NCBI
Rnor_6.01091,217,677 - 91,222,841 (+)NCBI
Rnor_5.01090,988,728 - 90,994,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247521   ⟹   XP_006247583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,579,703 - 88,584,856 (+)NCBI
mRatBN7.21088,079,703 - 88,084,776 (+)NCBI
Rnor_6.01091,217,677 - 91,222,841 (+)NCBI
Rnor_5.01090,988,728 - 90,994,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247522   ⟹   XP_006247584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,579,703 - 88,584,856 (+)NCBI
mRatBN7.21088,079,649 - 88,084,776 (+)NCBI
Rnor_6.01091,217,677 - 91,222,841 (+)NCBI
Rnor_5.01090,988,728 - 90,994,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768289   ⟹   XP_008766511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,579,703 - 88,584,856 (+)NCBI
mRatBN7.21088,079,755 - 88,084,776 (+)NCBI
Rnor_6.01091,217,677 - 91,222,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597329   ⟹   XP_017452818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,572,102 - 88,584,856 (+)NCBI
mRatBN7.21088,077,870 - 88,084,776 (+)NCBI
Rnor_6.01091,212,296 - 91,222,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063269172   ⟹   XP_063125242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,579,703 - 88,584,856 (+)NCBI
RefSeq Acc Id: XM_063269173   ⟹   XP_063125243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,579,683 - 88,584,856 (+)NCBI
RefSeq Acc Id: NP_001100524   ⟸   NM_001107054
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247577   ⟸   XM_006247515
- Peptide Label: isoform X1
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247576   ⟸   XM_006247514
- Peptide Label: isoform X1
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247580   ⟸   XM_006247518
- Peptide Label: isoform X1
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247579   ⟸   XM_006247517
- Peptide Label: isoform X1
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247578   ⟸   XM_006247516
- Peptide Label: isoform X1
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247583   ⟸   XM_006247521
- Peptide Label: isoform X1
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247584   ⟸   XM_006247522
- Peptide Label: isoform X1
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247582   ⟸   XM_006247520
- Peptide Label: isoform X1
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766511   ⟸   XM_008768289
- Peptide Label: isoform X1
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452818   ⟸   XM_017597329
- Peptide Label: isoform X1
- UniProtKB: B2RZ69 (UniProtKB/TrEMBL),   A6HJQ2 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052039   ⟸   ENSRNOT00000004218
RefSeq Acc Id: XP_063125243   ⟸   XM_063269173
- Peptide Label: isoform X1
- UniProtKB: A6HJQ2 (UniProtKB/TrEMBL),   B2RZ69 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125242   ⟸   XM_063269172
- Peptide Label: isoform X1
- UniProtKB: A6HJQ2 (UniProtKB/TrEMBL),   B2RZ69 (UniProtKB/TrEMBL),   F6T841 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ69-F1-model_v2 AlphaFold B2RZ69 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697805
Promoter ID:EPDNEW_R8330
Type:initiation region
Name:Hexim2_1
Description:hexamethylene bis-acetamide inducible 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01091,216,979 - 91,217,039EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311635 AgrOrtholog
BioCyc Gene G2FUF-23056 BioCyc
Ensembl Genes ENSRNOG00000021287 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004218 ENTREZGENE
  ENSRNOT00000004218.6 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.2910 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132762 IMAGE-MGC_LOAD
InterPro HEXIM UniProtKB/TrEMBL
KEGG Report rno:303580 UniProtKB/TrEMBL
MGC_CLONE MGC:189324 IMAGE-MGC_LOAD
NCBI Gene 303580 ENTREZGENE
PANTHER PTHR13469 UniProtKB/TrEMBL
  PTHR13469:SF3 UniProtKB/TrEMBL
Pfam HEXIM UniProtKB/TrEMBL
PhenoGen Hexim2 PhenoGen
PRINTS HEXIMFAMILY UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021287 RatGTEx
UniProt A6HJQ2 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ69 ENTREZGENE
  F6T841 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2RZ69 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Hexim2  hexamethylene bis-acetamide inducible 2  Hexim2  hexamthylene bis-acetamide inducible 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Hexim2  hexamthylene bis-acetamide inducible 2   Hexim2_predicted  hexamthylene bis-acetamide inducible 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Hexim2_predicted  hexamthylene bis-acetamide inducible 2 (predicted)  RGD1311635_predicted  similar to hypothetical protein MGC39389; MAQ1 paralog (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1311635_predicted  similar to hypothetical protein MGC39389; MAQ1 paralog (predicted)  LOC303580_predicted  similar to hypothetical protein MGC39389; MAQ1 paralog (predicted)  Symbol and Name status set to approved 1331353 APPROVED