Kat8 (lysine acetyltransferase 8) - Rat Genome Database

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Gene: Kat8 (lysine acetyltransferase 8) Rattus norvegicus
Analyze
Symbol: Kat8 (Ensembl: Bckdk)
Name: lysine acetyltransferase 8 (Ensembl:branched chain ketoacid dehydrogenase kinase)
RGD ID: 1311512
Description: Predicted to enable several functions, including N-acyltransferase activity; promoter-specific chromatin binding activity; and transcription coactivator activity. Predicted to contribute to histone H4K5 acetyltransferase activity and histone H4K8 acetyltransferase activity. Predicted to be involved in several processes, including hemopoiesis; positive regulation of skeletal muscle satellite cell differentiation; and regulation of gene expression. Predicted to act upstream of or within regulation of autophagy. Predicted to be located in chromosome; mitochondrion; and nuclear lumen. Predicted to be part of H4 histone acetyltransferase complex and MLL1 complex. Predicted to be active in chromosome and nucleus. Orthologous to human KAT8 (lysine acetyltransferase 8); PARTICIPATES IN histone modification pathway; p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; endosulfan; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histone acetyltransferase KAT8; K (lysine) acetyltransferase 8; LOC310194; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST histone acetyltransferase 1; MYST protein 1; MYST-1; Myst1; probable histone acetyltransferase MYST1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,954,827 - 191,967,107 (+)NCBIGRCr8
mRatBN7.21182,524,355 - 182,536,638 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,515,327 - 182,536,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,874,896 - 190,887,176 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,060,988 - 198,073,268 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,731,410 - 190,743,669 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,360,645 - 199,372,925 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,360,645 - 199,372,923 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,383,425 - 206,395,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,198,682 - 187,210,962 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,348,562 - 187,360,841 (+)NCBI
Celera1180,175,157 - 180,187,444 (+)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA,IEA)
chromosome  (ISO,ISS)
histone acetyltransferase complex  (ISO,ISS)
kinetochore  (IEA,ISO)
mitochondrion  (IEA,ISO,ISS)
MLL1 complex  (IEA,ISO,ISS)
MSL complex  (IBA,IEA,ISO,ISS)
NSL complex  (IBA,IEA,ISO,ISS)
NuA4 histone acetyltransferase complex  (IBA)
nuclear matrix  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO,ISS)
protein-containing complex  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer. Patani N, etal., Anticancer Res. 2011 Dec;31(12):4115-25.
5. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. The histone acetyltransferase MOF overexpression blunts cardiac hypertrophy by targeting ROS in mice. Qiao W, etal., Biochem Biophys Res Commun. 2014 Jun 13;448(4):379-84. doi: 10.1016/j.bbrc.2014.04.112. Epub 2014 May 4.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma. Wang Y, etal., J Exp Clin Cancer Res. 2013 Feb 9;32:8. doi: 10.1186/1756-9966-32-8.
Additional References at PubMed
PMID:11742995   PMID:11965546   PMID:12477932   PMID:14519686   PMID:15489334   PMID:15960975   PMID:19578370   PMID:20018852   PMID:21746928   PMID:23863932   PMID:31794431  


Genomics

Comparative Map Data
Kat8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,954,827 - 191,967,107 (+)NCBIGRCr8
mRatBN7.21182,524,355 - 182,536,638 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,515,327 - 182,536,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,874,896 - 190,887,176 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,060,988 - 198,073,268 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,731,410 - 190,743,669 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,360,645 - 199,372,925 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,360,645 - 199,372,923 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,383,425 - 206,395,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,198,682 - 187,210,962 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,348,562 - 187,360,841 (+)NCBI
Celera1180,175,157 - 180,187,444 (+)NCBICelera
Cytogenetic Map1q37NCBI
KAT8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,117,664 - 31,131,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,114,489 - 31,131,393 (+)EnsemblGRCh38hg38GRCh38
GRCh371631,128,985 - 31,142,714 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,036,488 - 31,050,206 (+)NCBINCBI36Build 36hg18NCBI36
Build 341631,036,487 - 31,050,206NCBI
Celera1629,155,307 - 29,169,042 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,690,132 - 28,703,867 (+)NCBIHuRef
CHM1_11632,446,704 - 32,460,437 (+)NCBICHM1_1
T2T-CHM13v2.01631,505,140 - 31,518,874 (+)NCBIT2T-CHM13v2.0
Kat8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,511,689 - 127,525,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,511,688 - 127,525,009 (+)EnsemblGRCm39 Ensembl
GRCm387127,912,517 - 127,925,838 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,912,516 - 127,925,837 (+)EnsemblGRCm38mm10GRCm38
MGSCv377135,056,031 - 135,069,276 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,703,665 - 127,716,910 (+)NCBIMGSCv36mm8
Celera7127,747,729 - 127,760,951 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.83NCBI
KAT8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,322,838 - 34,337,375 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,124,227 - 39,138,774 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,837,540 - 23,851,376 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,486,288 - 31,500,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,486,098 - 31,500,185 (+)Ensemblpanpan1.1panPan2
KAT8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,114,528 - 17,125,287 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,114,528 - 17,125,203 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,689,882 - 18,700,649 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,245,427 - 17,256,213 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,245,447 - 17,256,189 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,045,632 - 17,056,401 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,964,664 - 16,975,476 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,276,850 - 17,287,643 (-)NCBIUU_Cfam_GSD_1.0
Kat8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,377,812 - 125,389,760 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,474,735 - 13,489,341 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,475,676 - 13,487,617 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KAT8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,362,267 - 17,373,110 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,362,326 - 17,373,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,499,203 - 17,510,009 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KAT8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,806,082 - 27,820,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,805,844 - 27,820,748 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,646,095 - 1,660,826 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kat8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,157,823 - 14,169,231 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,157,905 - 14,169,231 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kat8
50 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:28
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000026527
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat

Markers in Region
RH144608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,524,006 - 182,524,218 (+)MAPPERmRatBN7.2
Rnor_6.01199,360,297 - 199,360,508NCBIRnor6.0
Rnor_5.01206,383,077 - 206,383,288UniSTSRnor5.0
RGSC_v3.41187,198,334 - 187,198,545UniSTSRGSC3.4
Celera1180,174,809 - 180,175,020UniSTS
Cytogenetic Map1q36UniSTS
RH135325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,535,741 - 182,536,093 (+)MAPPERmRatBN7.2
mRatBN7.2279,485,084 - 79,485,282 (+)MAPPERmRatBN7.2
Rnor_6.0281,566,109 - 81,566,306NCBIRnor6.0
Rnor_6.01199,372,032 - 199,372,383NCBIRnor6.0
Rnor_5.02101,229,751 - 101,229,948UniSTSRnor5.0
Rnor_5.01206,394,812 - 206,395,163UniSTSRnor5.0
RGSC_v3.41187,210,069 - 187,210,420UniSTSRGSC3.4
RGSC_v3.4280,630,086 - 80,630,283UniSTSRGSC3.4
Celera275,105,730 - 75,105,927UniSTS
Celera1180,186,544 - 180,186,895UniSTS
Cytogenetic Map2q22UniSTS
Cytogenetic Map1q36UniSTS
RH136638  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,529,083 - 182,529,276 (+)MAPPERmRatBN7.2
Rnor_6.01199,365,374 - 199,365,566NCBIRnor6.0
Rnor_5.01206,388,154 - 206,388,346UniSTSRnor5.0
RGSC_v3.41187,203,411 - 187,203,603UniSTSRGSC3.4
Celera1180,179,886 - 180,180,078UniSTS
Cytogenetic Map1q36UniSTS
AI179378  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,536,658 - 182,536,802 (+)MAPPERmRatBN7.2
Rnor_6.01199,372,949 - 199,373,092NCBIRnor6.0
Rnor_5.01206,395,729 - 206,395,872UniSTSRnor5.0
RGSC_v3.41187,210,986 - 187,211,129UniSTSRGSC3.4
Celera1180,187,468 - 180,187,611UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026466   ⟹   ENSRNOP00000026466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,515,349 - 182,536,633 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000026527   ⟹   ENSRNOP00000026527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,523,777 - 182,536,633 (+)Ensembl
Rnor_6.0 Ensembl1199,360,645 - 199,372,923 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078578   ⟹   ENSRNOP00000069014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,515,327 - 182,520,007 (+)Ensembl
RefSeq Acc Id: NM_001017378   ⟹   NP_001017378
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,954,827 - 191,967,107 (+)NCBI
mRatBN7.21182,524,355 - 182,536,635 (+)NCBI
Rnor_6.01199,360,645 - 199,372,925 (+)NCBI
Rnor_5.01206,383,425 - 206,395,705 (+)NCBI
RGSC_v3.41187,198,682 - 187,210,962 (+)RGD
Celera1180,175,157 - 180,187,444 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080867   ⟹   XP_038936795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,955,121 - 191,967,107 (+)NCBI
mRatBN7.21182,524,643 - 182,536,638 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001017378 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936795 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83891 (Get FASTA)   NCBI Sequence Viewer  
  EDM17213 (Get FASTA)   NCBI Sequence Viewer  
  EDM17214 (Get FASTA)   NCBI Sequence Viewer  
  EDM17215 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026466.5
  ENSRNOP00000026527.4
GenBank Protein Q5XI06 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001017378   ⟸   NM_001017378
- UniProtKB: Q5XI06 (UniProtKB/Swiss-Prot),   A6I9W5 (UniProtKB/TrEMBL),   A6I9W6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026527   ⟸   ENSRNOT00000026527
RefSeq Acc Id: XP_038936795   ⟸   XM_039080867
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000069014   ⟸   ENSRNOT00000078578
Ensembl Acc Id: ENSRNOP00000026466   ⟸   ENSRNOT00000026466
Protein Domains
MYST-type HAT   Tudor-knot

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI06-F1-model_v2 AlphaFold Q5XI06 1-458 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690446
Promoter ID:EPDNEW_R971
Type:multiple initiation site
Name:Kat8_1
Description:lysine acetyltransferase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,360,635 - 199,360,695EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311512 AgrOrtholog
BioCyc Gene G2FUF-57329 BioCyc
Ensembl Genes ENSRNOG00000019485 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000019585 Ensembl
Ensembl Transcript ENSRNOT00000026466.6 UniProtKB/TrEMBL
  ENSRNOT00000026527.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.630.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  N-acetyl transferase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132551 IMAGE-MGC_LOAD
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo/chromo_shadow_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAT_MYST-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYST_HAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor-knot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zf-MYST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310194 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95220 IMAGE-MGC_LOAD
NCBI Gene 310194 ENTREZGENE
PANTHER HISTONE ACETYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10615:SF82 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MOZ_SAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor-knot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-MYST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kat8 PhenoGen
PROSITE MYST_HAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019485 RatGTEx
  ENSRNOG00000019585 RatGTEx
SMART CHROMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55729 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHR5_RAT UniProtKB/TrEMBL
  A0A8L2QED5_RAT UniProtKB/TrEMBL
  A6I9W5 ENTREZGENE, UniProtKB/TrEMBL
  A6I9W6 ENTREZGENE, UniProtKB/TrEMBL
  KAT8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kat8  lysine acetyltransferase 8  Kat8  K (lysine) acetyltransferase 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Kat8  K (lysine) acetyltransferase 8  Myst1  MYST histone acetyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Myst1  MYST histone acetyltransferase 1  Myst1_predicted  MYST histone acetyltransferase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Myst1_predicted  MYST histone acetyltransferase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED