Kpna4 (karyopherin subunit alpha 4) - Rat Genome Database

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Gene: Kpna4 (karyopherin subunit alpha 4) Rattus norvegicus
Analyze
Symbol: Kpna4
Name: karyopherin subunit alpha 4
RGD ID: 1311483
Description: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of with a positive effect on dopamine secretion and gene expression. Predicted to act upstream of or within protein import into nucleus and response to hydrogen peroxide. Predicted to be located in male germ cell nucleus and nuclear membrane. Predicted to be part of NLS-dependent protein nuclear import complex and nuclear pore. Predicted to be active in nucleoplasm. Orthologous to human KPNA4 (karyopherin subunit alpha 4); INTERACTS WITH 3,4-methylenedioxymethamphetamine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: importin; importin subunit alpha-3; importin subunit alpha-4; karyopherin (importin) alpha 4; karyopherin alpha 4; karyopherin alpha 4 (importin alpha 3); LOC361959; predicted role in nuclear import
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,635,679 - 155,691,056 (-)NCBIGRCr8
mRatBN7.22153,319,380 - 153,381,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2153,324,273 - 153,381,081 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2160,455,225 - 160,510,312 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,505,743 - 158,560,831 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02153,138,510 - 153,193,599 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,684,345 - 165,739,874 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2165,684,345 - 165,739,874 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02185,045,503 - 185,101,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42159,073,108 - 159,128,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12159,023,070 - 159,078,143 (-)NCBI
Celera2147,676,718 - 147,731,549 (-)NCBICelera
Cytogenetic Map2q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clozapine  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (EXP)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
dimethylarsinous acid  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
graphite  (EXP)
haloperidol  (ISO)
hypochlorous acid  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methidathion  (ISO)
microcystin RR  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15689618   PMID:16906019   PMID:17682055   PMID:23376485   PMID:23773962  


Genomics

Comparative Map Data
Kpna4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,635,679 - 155,691,056 (-)NCBIGRCr8
mRatBN7.22153,319,380 - 153,381,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2153,324,273 - 153,381,081 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2160,455,225 - 160,510,312 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,505,743 - 158,560,831 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02153,138,510 - 153,193,599 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,684,345 - 165,739,874 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2165,684,345 - 165,739,874 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02185,045,503 - 185,101,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42159,073,108 - 159,128,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12159,023,070 - 159,078,143 (-)NCBI
Celera2147,676,718 - 147,731,549 (-)NCBICelera
Cytogenetic Map2q32NCBI
KPNA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383160,495,007 - 160,565,571 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3160,495,007 - 160,565,571 (-)EnsemblGRCh38hg38GRCh38
GRCh373160,212,795 - 160,283,359 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,700,656 - 161,766,070 (-)NCBINCBI36Build 36hg18NCBI36
Build 343161,700,663 - 161,766,078NCBI
Celera3158,639,975 - 158,705,390 (-)NCBICelera
Cytogenetic Map3q25.33NCBI
HuRef3157,611,349 - 157,681,994 (-)NCBIHuRef
CHM1_13160,175,691 - 160,246,276 (-)NCBICHM1_1
T2T-CHM13v2.03163,269,616 - 163,340,186 (-)NCBIT2T-CHM13v2.0
Kpna4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39368,979,554 - 69,034,425 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl368,974,482 - 69,034,446 (-)EnsemblGRCm39 Ensembl
GRCm38369,072,221 - 69,127,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl369,067,149 - 69,127,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv37368,876,143 - 68,931,014 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36369,160,150 - 69,215,021 (-)NCBIMGSCv36mm8
Celera369,178,407 - 69,233,653 (-)NCBICelera
Cytogenetic Map3E1NCBI
cM Map332.18NCBI
Kpna4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544811,025,095 - 11,093,429 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544811,025,095 - 11,094,053 (-)NCBIChiLan1.0ChiLan1.0
KPNA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22158,436,633 - 158,501,115 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13158,440,441 - 158,506,068 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03157,521,009 - 157,586,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13165,565,059 - 165,635,014 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3165,572,140 - 165,635,135 (-)Ensemblpanpan1.1panPan2
KPNA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,549,071 - 26,614,537 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,555,507 - 26,614,542 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3430,591,206 - 30,656,539 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03426,605,763 - 26,671,157 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3426,606,513 - 26,671,281 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13426,535,571 - 26,600,913 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03426,495,988 - 26,561,625 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03426,735,945 - 26,801,570 (-)NCBIUU_Cfam_GSD_1.0
Kpna4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560292,418,725 - 92,482,955 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936708456,365 - 520,743 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936708456,365 - 520,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KPNA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13100,185,092 - 100,253,070 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113100,185,081 - 100,253,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KPNA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11530,272,635 - 30,342,593 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1530,301,078 - 30,335,525 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660412,791,102 - 2,862,415 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kpna4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473038,277,386 - 38,341,611 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473038,277,328 - 38,341,440 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kpna4
180 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:153
Interacting mature miRNAs:191
Transcripts:ENSRNOT00000014384
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
HSC0TF112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,663,989 - 86,664,140 (+)MAPPERmRatBN7.2
mRatBN7.22153,324,291 - 153,324,442 (+)MAPPERmRatBN7.2
Rnor_6.02165,682,932 - 165,683,082NCBIRnor6.0
Rnor_6.0189,867,872 - 89,868,022NCBIRnor6.0
Rnor_5.02185,044,090 - 185,044,240UniSTSRnor5.0
Rnor_5.0191,018,934 - 91,019,084UniSTSRnor5.0
RGSC_v3.4186,488,832 - 86,488,982UniSTSRGSC3.4
RGSC_v3.42159,071,695 - 159,071,845UniSTSRGSC3.4
Celera2147,675,071 - 147,675,221UniSTS
Celera181,030,759 - 81,030,909UniSTS
Cytogenetic Map2q31UniSTS
AA924555  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22153,324,319 - 153,324,503 (+)MAPPERmRatBN7.2
mRatBN7.2186,664,017 - 86,664,201 (+)MAPPERmRatBN7.2
Rnor_6.0189,867,900 - 89,868,083NCBIRnor6.0
Rnor_6.02165,682,960 - 165,683,143NCBIRnor6.0
Rnor_5.02185,044,118 - 185,044,301UniSTSRnor5.0
Rnor_5.0191,018,962 - 91,019,145UniSTSRnor5.0
RGSC_v3.4186,488,860 - 86,489,043UniSTSRGSC3.4
RGSC_v3.42159,071,723 - 159,071,906UniSTSRGSC3.4
Celera2147,675,099 - 147,675,282UniSTS
Celera181,030,787 - 81,030,970UniSTS
RH 3.4 Map2847.4UniSTS
Cytogenetic Map2q31UniSTS
GDB:451532  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22153,325,710 - 153,325,814 (+)MAPPERmRatBN7.2
Rnor_6.02165,684,351 - 165,684,454NCBIRnor6.0
Rnor_5.02185,045,509 - 185,045,612UniSTSRnor5.0
RGSC_v3.42159,073,114 - 159,073,217UniSTSRGSC3.4
RGSC_v3.4186,490,535 - 86,490,638UniSTSRGSC3.4
Celera2147,676,724 - 147,676,827UniSTS
Celera181,032,159 - 81,032,262UniSTS
Cytogenetic Map2q31UniSTS
Cytogenetic Map1q21UniSTS
Kpna4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22153,324,403 - 153,325,314 (+)MAPPERmRatBN7.2
Rnor_6.02165,683,044 - 165,683,954NCBIRnor6.0
Rnor_5.02185,044,202 - 185,045,112UniSTSRnor5.0
RGSC_v3.42159,071,807 - 159,072,717UniSTSRGSC3.4
Celera2147,675,183 - 147,676,093UniSTS
Celera181,030,871 - 81,031,763UniSTS
Cytogenetic Map2q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000014384   ⟹   ENSRNOP00000014384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2153,324,273 - 153,381,081 (-)Ensembl
Rnor_6.0 Ensembl2165,684,345 - 165,739,874 (-)Ensembl
RefSeq Acc Id: NM_001014793   ⟹   NP_001014793
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82155,635,679 - 155,690,751 (-)NCBI
mRatBN7.22153,325,705 - 153,380,779 (-)NCBI
Rnor_6.02165,684,345 - 165,739,874 (-)NCBI
Rnor_5.02185,045,503 - 185,101,032 (-)NCBI
RGSC_v3.42159,073,108 - 159,128,180 (-)RGD
Celera2147,676,718 - 147,731,549 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102632   ⟹   XP_038958560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82155,639,938 - 155,691,056 (-)NCBI
mRatBN7.22153,329,701 - 153,381,085 (-)NCBI
RefSeq Acc Id: XR_010063626
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82155,638,548 - 155,691,056 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001014793 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958560 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAX07455 (Get FASTA)   NCBI Sequence Viewer  
  EDM00909 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014384
  ENSRNOP00000014384.5
RefSeq Acc Id: NP_001014793   ⟸   NM_001014793
- UniProtKB: Q56R17 (UniProtKB/TrEMBL),   F7FQB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014384   ⟸   ENSRNOT00000014384
RefSeq Acc Id: XP_038958560   ⟸   XM_039102632
- Peptide Label: isoform X1
Protein Domains
IBB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q56R17-F1-model_v2 AlphaFold Q56R17 1-521 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311483 AgrOrtholog
BioCyc Gene G2FUF-52835 BioCyc
Ensembl Genes ENSRNOG00000010768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014384 ENTREZGENE
  ENSRNOT00000014384.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.690 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  Importin-a-like_IBB-bd_dom UniProtKB/TrEMBL
  Importin-a_IBB_sf UniProtKB/TrEMBL
  Importing_su_alpha UniProtKB/TrEMBL
KEGG Report rno:361959 UniProtKB/TrEMBL
NCBI Gene 361959 ENTREZGENE
PANTHER IMPORTIN ALPHA UniProtKB/TrEMBL
  IMPORTIN SUBUNIT ALPHA-3 UniProtKB/TrEMBL
Pfam Arm UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
PhenoGen Kpna4 PhenoGen
PIRSF Importin_alpha UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010768 RatGTEx
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt F7FQB8 ENTREZGENE, UniProtKB/TrEMBL
  Q56R17 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kpna4  karyopherin subunit alpha 4  Kpna4  karyopherin alpha 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-27 Kpna4  karyopherin alpha 4  Kpna4  karyopherin alpha 4 (importin alpha 3)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Kpna4  karyopherin alpha 4 (importin alpha 3)  Kpna4  karyopherin (importin) alpha 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Kpna4  karyopherin (importin) alpha 4  Kpna4_predicted  karyopherin (importin) alpha 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Kpna4_predicted  karyopherin (importin) alpha 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED