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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ythdf2 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of YTHDF2 mRNA] | CTD | PMID:31150632 | Ythdf2 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of YTHDF2 mRNA | CTD | PMID:22206623 | Ythdf2 | Rat | 1,4-benzoquinone | increases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | quinone results in increased expression of YTHDF2 mRNA | CTD | PMID:36306860 | Ythdf2 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of YTHDF2 mRNA | CTD | PMID:17942748 | Ythdf2 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Ythdf2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of YTHDF2 mRNA | CTD | PMID:17942748 | Ythdf2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Ythdf2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of YTHDF2 mRNA | CTD | PMID:17942748 | Ythdf2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of YTHDF2 mRNA | CTD | PMID:33387578 | Ythdf2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of YTHDF2 mRNA | CTD | PMID:32109520 | Ythdf2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of YTHDF2 mRNA | CTD | PMID:22574217 | Ythdf2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ythdf2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of YTHDF2 mRNA | CTD | PMID:21570461 | Ythdf2 | Rat | 2,4,6-tribromophenol | increases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38157273 | Ythdf2 | Rat | 2,4,6-tribromophenol | increases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:38157273 | Ythdf2 | Rat | 2,4,6-trichlorophenol | increases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38157273 | Ythdf2 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of YTHDF2 mRNA | CTD | PMID:21346803 | Ythdf2 | Rat | 2,6-dimethoxyphenol | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in increased expression of and affects the localization of YTHDF2 protein | CTD | PMID:38598786 | Ythdf2 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of YTHDF2 mRNA | CTD | PMID:21346803 | Ythdf2 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of YTHDF2 mRNA | CTD | PMID:20188158 | Ythdf2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of YTHDF2 mRNA | CTD | PMID:28628672 | Ythdf2 | Rat | 4,4'-diaminodiphenylmethane | increases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of YTHDF2 mRNA | CTD | PMID:18648102 | Ythdf2 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of YTHDF2 gene | CTD | PMID:31601247 | Ythdf2 | Rat | 4-phenylbutyric acid | decreases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | 4-phenylbutyric acid results in decreased expression of YTHDF2 mRNA | CTD | PMID:14583596 | Ythdf2 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of YTHDF2 mRNA | CTD | PMID:30047161 | Ythdf2 | Rat | actinomycin D | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | YTHDF1 protein affects the reaction [YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]] more ... | CTD | PMID:37061066 | Ythdf2 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of YTHDF2 mRNA | CTD | PMID:38685447 | Ythdf2 | Rat | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of YTHDF2 mRNA | CTD | PMID:30047161 | Ythdf2 | Rat | arsane | increases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | Arsenic results in increased expression of YTHDF2 | CTD | PMID:35363433 | Ythdf2 | Rat | arsane | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | YTHDF2 protein affects the reaction [FTO protein affects the reaction [APOBEC3B protein affects the reaction [Arsenic results in increased mutagenesis of TP53 gene]]] and YTHDF2 protein affects the reaction [FTO protein affects the reaction [Arsenic results in increased expression of H2AX protein]] | CTD | PMID:34998823 | Ythdf2 | Rat | arsenic atom | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | YTHDF2 protein affects the reaction [FTO protein affects the reaction [APOBEC3B protein affects the reaction [Arsenic results in increased mutagenesis of TP53 gene]]] and YTHDF2 protein affects the reaction [FTO protein affects the reaction [Arsenic results in increased expression of H2AX protein]] | CTD | PMID:34998823 | Ythdf2 | Rat | arsenic atom | increases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | Arsenic results in increased expression of YTHDF2 | CTD | PMID:35363433 | Ythdf2 | Rat | arsenous acid | increases response to substance | ISO | YTHDF2 (Homo sapiens) | 6480464 | YTHDF2 protein results in increased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | Ythdf2 | Rat | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of YTHDF2 mRNA | CTD | PMID:21839799 | Ythdf2 | Rat | benzo[a]pyrene | increases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of YTHDF2 protein | CTD | PMID:33278487 | Ythdf2 | Rat | benzo[a]pyrene | increases methylation | ISO | YTHDF2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of YTHDF2 promoter | CTD | PMID:27901495 | Ythdf2 | Rat | benzo[a]pyrene | affects expression | ISO | Ythdf2 (Mus musculus) | 6480464 | Benzo(a)pyrene affects the expression of YTHDF2 mRNA | CTD | PMID:22342234 | Ythdf2 | Rat | benzo[a]pyrene | increases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of YTHDF2 mRNA | CTD | PMID:22228805 | Ythdf2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | Ythdf2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of YTHDF2 mRNA | CTD | PMID:25181051 more ... | Ythdf2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of YTHDF2 protein | CTD | PMID:37495067 | Ythdf2 | Rat | bisphenol A | decreases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of YTHDF2 mRNA and bisphenol A results in decreased expression of YTHDF2 protein | CTD | PMID:37567409 and PMID:38354435 | Ythdf2 | Rat | bisphenol A | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of YTHDF2 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of YTHDF2 mRNA | CTD | PMID:28628672 and PMID:31601247 | Ythdf2 | Rat | cadmium dichloride | decreases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of YTHDF2 mRNA | CTD | PMID:38568856 | Ythdf2 | Rat | caffeine | affects phosphorylation | ISO | YTHDF2 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of YTHDF2 protein | CTD | PMID:35688186 | Ythdf2 | Rat | chlordecone | decreases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | Chlordecone results in decreased expression of YTHDF2 mRNA | CTD | PMID:33711761 | Ythdf2 | Rat | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of YTHDF2 mRNA | CTD | PMID:18668222 | Ythdf2 | Rat | chromium(6+) | decreases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | chromium hexavalent ion results in decreased expression of YTHDF2 mRNA and chromium hexavalent ion results in decreased expression of YTHDF2 protein | CTD | PMID:36739042 | Ythdf2 | Rat | chromium(6+) | multiple interactions | ISO | Ythdf2 (Mus musculus) | 6480464 | YTHDF2 protein inhibits the reaction [chromium hexavalent ion affects the expression of and results in increased lipidation of MAP1LC3B protein] more ... | CTD | PMID:36739042 | Ythdf2 | Rat | cisplatin | decreases phosphorylation | ISO | Ythdf2 (Mus musculus) | 6480464 | Cisplatin results in decreased phosphorylation of YTHDF2 protein | CTD | PMID:22006019 | Ythdf2 | Rat | clofibrate | decreases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of YTHDF2 mRNA | CTD | PMID:17585979 | Ythdf2 | Rat | copper(II) sulfate | increases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of YTHDF2 mRNA | CTD | PMID:19549813 | Ythdf2 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of YTHDF2 mRNA | CTD | PMID:26577399 and PMID:27523638 | Ythdf2 | Rat | dexamethasone | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of YTHDF2 mRNA | CTD | PMID:28628672 | Ythdf2 | Rat | diarsenic trioxide | increases response to substance | ISO | YTHDF2 (Homo sapiens) | 6480464 | YTHDF2 protein results in increased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | Ythdf2 | Rat | Dibutyl phosphate | affects expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of YTHDF2 mRNA | CTD | PMID:37042841 | Ythdf2 | Rat | ethanol | affects splicing | ISO | Ythdf2 (Mus musculus) | 6480464 | Ethanol affects the splicing of YTHDF2 mRNA | CTD | PMID:30319688 | Ythdf2 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of YTHDF2 mRNA | CTD | PMID:24136188 | Ythdf2 | Rat | FR900359 | affects phosphorylation | ISO | YTHDF2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of YTHDF2 protein | CTD | PMID:37730182 | Ythdf2 | Rat | fulvestrant | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of YTHDF2 gene and [bisphenol S co-treated with Fulvestrant] results in increased methylation of YTHDF2 gene | CTD | PMID:31601247 | Ythdf2 | Rat | fumonisin B1 | increases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | fumonisin B1 results in increased expression of YTHDF2 mRNA | CTD | PMID:33496827 | Ythdf2 | Rat | furfural | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in decreased expression of and affects the localization of YTHDF2 protein | CTD | PMID:38598786 | Ythdf2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of YTHDF2 mRNA | CTD | PMID:22061828 | Ythdf2 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of YTHDF2 mRNA | CTD | PMID:33387578 | Ythdf2 | Rat | indometacin | decreases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | Indomethacin results in decreased expression of YTHDF2 mRNA | CTD | PMID:16984733 | Ythdf2 | Rat | indometacin | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of YTHDF2 mRNA | CTD | PMID:28628672 | Ythdf2 | Rat | ivermectin | decreases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of YTHDF2 protein | CTD | PMID:32959892 | Ythdf2 | Rat | lead(0) | affects expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | Lead affects the expression of YTHDF2 mRNA | CTD | PMID:28903495 | Ythdf2 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of YTHDF2 mRNA | CTD | PMID:38685447 | Ythdf2 | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of YTHDF2 mRNA | CTD | PMID:30047161 | Ythdf2 | Rat | methotrexate | decreases expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of YTHDF2 mRNA | CTD | PMID:17400583 | Ythdf2 | Rat | mono(2-ethylhexyl) phthalate | increases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of YTHDF2 mRNA | CTD | PMID:36174712 | Ythdf2 | Rat | N(6)-methyladenosine | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [MIR145 mRNA results in decreased expression of YTHDF2 protein] which results in increased abundance of N-methyladenosine and YTHDF2 protein inhibits the reaction [MIR145 mRNA results in increased abundance of N-methyladenosine] | CTD | PMID:28104805 | Ythdf2 | Rat | N(6)-methyladenosine | affects binding | ISO | YTHDF2 (Homo sapiens) | 6480464 | YTHDF2 protein binds to N-methyladenosine | CTD | PMID:34213887 | Ythdf2 | Rat | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of YTHDF2 mRNA | CTD | PMID:19041683 | Ythdf2 | Rat | ozone | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of YTHDF2 mRNA | CTD | PMID:35430440 | Ythdf2 | Rat | paracetamol | affects expression | ISO | Ythdf2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of YTHDF2 mRNA | CTD | PMID:17562736 | Ythdf2 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of YTHDF2 mRNA | CTD | PMID:33387578 | Ythdf2 | Rat | propiconazole | increases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | propiconazole results in increased expression of YTHDF2 mRNA | CTD | PMID:21278054 | Ythdf2 | Rat | sodium arsenite | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | HNRNPA2B1 protein affects the reaction [YTHDF2 protein affects the reaction [sodium arsenite results in increased expression of AKT1 mRNA]] more ... | CTD | PMID:36368553 more ... | Ythdf2 | Rat | sodium chloride | multiple interactions | ISO | YTHDF2 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in decreased expression of and affects the localization of YTHDF2 protein more ... | CTD | PMID:38598786 | Ythdf2 | Rat | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of YTHDF2 mRNA | CTD | PMID:30047161 | Ythdf2 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of YTHDF2 mRNA | CTD | PMID:31150632 | Ythdf2 | Rat | tetrachloromethane | increases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of YTHDF2 mRNA | CTD | PMID:31919559 | Ythdf2 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of YTHDF2 mRNA] | CTD | PMID:31150632 | Ythdf2 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of YTHDF2 mRNA | CTD | PMID:34492290 | Ythdf2 | Rat | titanium dioxide | increases methylation | ISO | Ythdf2 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of YTHDF2 gene | CTD | PMID:35295148 | Ythdf2 | Rat | triadimefon | increases expression | EXP | | 6480464 | triadimefon results in increased expression of YTHDF2 mRNA | CTD | PMID:30047161 | Ythdf2 | Rat | trichostatin A | affects expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | trichostatin A affects the expression of YTHDF2 mRNA | CTD | PMID:28542535 | Ythdf2 | Rat | triphenyl phosphate | affects expression | ISO | YTHDF2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of YTHDF2 mRNA | CTD | PMID:37042841 | Ythdf2 | Rat | valproic acid | decreases expression | ISO | Ythdf2 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of YTHDF2 mRNA | CTD | PMID:19136453 and PMID:21427059 | |