Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pdcd6 | Rat | (+)-dexrazoxane | multiple interactions | ISO | Pdcd6 (Mus musculus) | 6480464 | [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDCD6 mRNA | CTD | PMID:26873546 | Pdcd6 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PDCD6 mRNA] | CTD | PMID:31150632 | Pdcd6 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Pdcd6 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PDCD6 mRNA | CTD | PMID:22206623 | Pdcd6 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Pdcd6 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PDCD6 mRNA | CTD | PMID:22206623 | Pdcd6 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Pdcd6 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PDCD6 mRNA | CTD | PMID:17555576 | Pdcd6 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Pdcd6 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDCD6 mRNA | CTD | PMID:17942748 | Pdcd6 | Rat | 17beta-estradiol | increases expression | ISO | Pdcd6 (Mus musculus) | 6480464 | Estradiol results in increased expression of PDCD6 mRNA | CTD | PMID:22467019 | Pdcd6 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pdcd6 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDCD6 mRNA | CTD | PMID:17942748 | Pdcd6 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of PDCD6 mRNA | CTD | PMID:21346803 | Pdcd6 | Rat | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of PDCD6 protein | CTD | PMID:34915118 | Pdcd6 | Rat | aflatoxin B1 | increases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of PDCD6 mRNA | CTD | PMID:27153756 | Pdcd6 | Rat | aflatoxin B1 | increases methylation | ISO | PDCD6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of PDCD6 gene and Aflatoxin B1 results in increased methylation of PDCD6 intron | CTD | PMID:27153756 and PMID:30157460 | Pdcd6 | Rat | Aflatoxin B2 alpha | increases methylation | ISO | PDCD6 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of PDCD6 intron | CTD | PMID:30157460 | Pdcd6 | Rat | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of PDCD6 mRNA | CTD | PMID:30779732 | Pdcd6 | Rat | arsenite(3-) | multiple interactions | ISO | PDCD6 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PDCD6 protein] | CTD | PMID:32406909 | Pdcd6 | Rat | benzo[a]pyrene | increases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of PDCD6 mRNA | CTD | PMID:31255691 | Pdcd6 | Rat | benzo[a]pyrene | affects methylation | ISO | PDCD6 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PDCD6 intron | CTD | PMID:30157460 | Pdcd6 | Rat | benzo[a]pyrene | increases methylation | ISO | PDCD6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PDCD6 promoter | CTD | PMID:27901495 | Pdcd6 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | Pdcd6 | Rat | benzo[a]pyrene diol epoxide I | increases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | Pdcd6 | Rat | benzo[e]pyrene | increases methylation | ISO | PDCD6 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of PDCD6 intron | CTD | PMID:30157460 | Pdcd6 | Rat | beta-lapachone | decreases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of PDCD6 mRNA | CTD | PMID:38218311 | Pdcd6 | Rat | bis(2-chloroethyl) sulfide | increases expression | ISO | Pdcd6 (Mus musculus) | 6480464 | Mustard Gas results in increased expression of PDCD6 mRNA | CTD | PMID:15674843 | Pdcd6 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Pdcd6 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of PDCD6 mRNA | CTD | PMID:19850644 | Pdcd6 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Pdcd6 (Mus musculus) | 6480464 | PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PDCD6 mRNA] | CTD | PMID:19850644 | Pdcd6 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PDCD6 mRNA | CTD | PMID:25181051 | Pdcd6 | Rat | bisphenol A | increases methylation | ISO | PDCD6 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of PDCD6 gene | CTD | PMID:31601247 | Pdcd6 | Rat | bisphenol A | multiple interactions | ISO | PDCD6 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PDCD6 gene more ... | CTD | PMID:31601247 and PMID:33376534 | Pdcd6 | Rat | bisphenol A | increases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PDCD6 protein | CTD | PMID:33376534 more ... | Pdcd6 | Rat | bisphenol A | increases expression | ISO | Pdcd6 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PDCD6 protein | CTD | PMID:28641223 | Pdcd6 | Rat | CGP 52608 | multiple interactions | ISO | PDCD6 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PDCD6 gene] | CTD | PMID:28238834 | Pdcd6 | Rat | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD6 mRNA | CTD | PMID:17602206 | Pdcd6 | Rat | cocaine | affects expression | ISO | Pdcd6 (Mus musculus) | 6480464 | Cocaine affects the expression of PDCD6 mRNA | CTD | PMID:15681117 | Pdcd6 | Rat | cyclosporin A | decreases methylation | ISO | PDCD6 (Homo sapiens) | 6480464 | Cyclosporine results in decreased methylation of PDCD6 promoter | CTD | PMID:27989131 | Pdcd6 | Rat | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of PDCD6 mRNA | CTD | PMID:22546817 | Pdcd6 | Rat | dibenzo[a,l]pyrene | decreases expression | ISO | Pdcd6 (Mus musculus) | 6480464 | dibenzo(a and l)pyrene results in decreased expression of PDCD6 mRNA | CTD | PMID:25908611 | Pdcd6 | Rat | dibenzo[a,l]pyrene | decreases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | dibenzo(a and l)pyrene results in decreased expression of PDCD6 mRNA | CTD | PMID:31255691 | Pdcd6 | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of PDCD6 mRNA | CTD | PMID:21266533 | Pdcd6 | Rat | dibutyl phthalate | decreases expression | ISO | Pdcd6 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of PDCD6 mRNA | CTD | PMID:17361019 | Pdcd6 | Rat | dieldrin | affects expression | EXP | | 6480464 | Dieldrin affects the expression of PDCD6 mRNA | CTD | PMID:22546817 | Pdcd6 | Rat | diethylstilbestrol | increases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | Diethylstilbestrol results in increased expression of PDCD6 mRNA | CTD | PMID:15766595 | Pdcd6 | Rat | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of PDCD6 mRNA | CTD | PMID:21551480 | Pdcd6 | Rat | dorsomorphin | multiple interactions | ISO | PDCD6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD6 mRNA | CTD | PMID:27188386 | Pdcd6 | Rat | doxorubicin | multiple interactions | ISO | Pdcd6 (Mus musculus) | 6480464 | [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDCD6 mRNA | CTD | PMID:26873546 | Pdcd6 | Rat | doxorubicin | decreases expression | ISO | Pdcd6 (Mus musculus) | 6480464 | Doxorubicin results in decreased expression of PDCD6 mRNA | CTD | PMID:26873546 | Pdcd6 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of PDCD6 mRNA | CTD | PMID:29391264 | Pdcd6 | Rat | epoxiconazole | decreases expression | ISO | Pdcd6 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of PDCD6 mRNA | CTD | PMID:35436446 | Pdcd6 | Rat | ethanol | affects splicing | ISO | Pdcd6 (Mus musculus) | 6480464 | Ethanol affects the splicing of PDCD6 mRNA | CTD | PMID:30319688 | Pdcd6 | Rat | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of PDCD6 mRNA | CTD | PMID:34044035 | Pdcd6 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of PDCD6 mRNA | CTD | PMID:24136188 | Pdcd6 | Rat | folic acid | multiple interactions | ISO | Pdcd6 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PDCD6 mRNA | CTD | PMID:22206623 | Pdcd6 | Rat | fulvestrant | multiple interactions | ISO | PDCD6 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PDCD6 gene | CTD | PMID:31601247 | Pdcd6 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PDCD6 mRNA | CTD | PMID:22061828 and PMID:33387578 | Pdcd6 | Rat | glycidyl methacrylate | decreases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | glycidyl methacrylate results in decreased expression of PDCD6 protein | CTD | PMID:36641056 | Pdcd6 | Rat | ivermectin | decreases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PDCD6 protein | CTD | PMID:32959892 | Pdcd6 | Rat | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of PDCD6 mRNA | CTD | PMID:24136188 | Pdcd6 | Rat | lithium atom | increases expression | EXP | | 6480464 | Lithium results in increased expression of PDCD6 protein | CTD | PMID:18296634 | Pdcd6 | Rat | lithium hydride | increases expression | EXP | | 6480464 | Lithium results in increased expression of PDCD6 protein | CTD | PMID:18296634 | Pdcd6 | Rat | methapyrilene | increases methylation | ISO | PDCD6 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of PDCD6 intron | CTD | PMID:30157460 | Pdcd6 | Rat | microcystin RR | decreases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | microcystin RR results in decreased expression of PDCD6 protein | CTD | PMID:19111056 | Pdcd6 | Rat | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD6 mRNA | CTD | PMID:17602206 | Pdcd6 | Rat | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of PDCD6 mRNA | CTD | PMID:22546817 | Pdcd6 | Rat | ouabain | increases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | Ouabain results in increased expression of PDCD6 protein | CTD | PMID:18247327 | Pdcd6 | Rat | ozone | multiple interactions | ISO | PDCD6 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of PDCD6 mRNA | CTD | PMID:35430440 | Pdcd6 | Rat | p-menthan-3-ol | decreases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | Menthol results in decreased expression of PDCD6 mRNA | CTD | PMID:26760959 | Pdcd6 | Rat | SB 431542 | multiple interactions | ISO | PDCD6 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 and PMID:37664457 | Pdcd6 | Rat | sodium arsenite | decreases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PDCD6 mRNA | CTD | PMID:12760830 | Pdcd6 | Rat | sodium arsenite | increases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of PDCD6 mRNA | CTD | PMID:28595984 | Pdcd6 | Rat | sodium arsenite | multiple interactions | ISO | PDCD6 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of and affects the splicing of PDCD6 mRNA | CTD | PMID:25879800 | Pdcd6 | Rat | succimer | multiple interactions | ISO | PDCD6 (Homo sapiens) | 6480464 | [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PDCD6 mRNA | CTD | PMID:26378955 | Pdcd6 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of PDCD6 mRNA | CTD | PMID:31150632 | Pdcd6 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PDCD6 mRNA] | CTD | PMID:31150632 | Pdcd6 | Rat | titanium dioxide | decreases methylation | ISO | Pdcd6 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of PDCD6 gene and titanium dioxide results in decreased methylation of PDCD6 promoter | CTD | PMID:35295148 | Pdcd6 | Rat | triphenyl phosphate | affects expression | ISO | PDCD6 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of PDCD6 mRNA | CTD | PMID:37042841 | Pdcd6 | Rat | tungsten | increases expression | ISO | Pdcd6 (Mus musculus) | 6480464 | Tungsten results in increased expression of PDCD6 mRNA | CTD | PMID:30912803 | Pdcd6 | Rat | valproic acid | decreases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PDCD6 mRNA | CTD | PMID:23179753 more ... | Pdcd6 | Rat | valproic acid | multiple interactions | ISO | PDCD6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD6 mRNA | CTD | PMID:27188386 | Pdcd6 | Rat | vanadyl sulfate | increases expression | ISO | PDCD6 (Homo sapiens) | 6480464 | vanadyl sulfate results in increased expression of PDCD6 mRNA | CTD | PMID:16330358 | |