Dsg2 (desmoglein 2) - Rat Genome Database

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Gene: Dsg2 (desmoglein 2) Rattus norvegicus
Analyze
Symbol: Dsg2
Name: desmoglein 2
RGD ID: 1311143
Description: Predicted to enable calcium ion binding activity and cell adhesion molecule binding activity. Involved in maternal process involved in female pregnancy and response to progesterone. Located in apical plasma membrane; intercalated disc; and lateral plasma membrane. Biomarker of dilated cardiomyopathy. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 10; dilated cardiomyopathy; and dilated cardiomyopathy 1BB. Orthologous to human DSG2 (desmoglein 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 17beta-estradiol; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: desmoglein-2; LOC307562
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,121,287 - 12,179,590 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1812,121,181 - 12,179,590 (+)EnsemblGRCr8
mRatBN7.21811,846,207 - 11,904,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,846,183 - 11,904,156 (+)EnsemblmRatBN7.2
Rnor_6.01815,579,322 - 15,637,720 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,579,315 - 15,637,715 (-)Ensemblrn6Rnor6.0
Rnor_5.01815,353,348 - 15,411,825 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41812,306,321 - 12,366,719 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1811,860,565 - 11,912,367 (+)NCBICelera
RGSC_v3.11812,366,920 - 12,391,365 (+)NCBI
Cytogenetic Map18p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
FR900359  (ISO)
furfural  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenol red  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
anchoring junction  (IEA)
apical plasma membrane  (IDA)
cell junction  (IEA,ISO)
cell surface  (IEA,ISO)
cytoplasm  (IEA,ISO)
desmosome  (IBA,IEA,ISO)
intercalated disc  (IDA,IEA,ISO)
lateral plasma membrane  (IDA)
membrane  (IEA)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt signalling and miRNA dysregulation. Calore M, etal., Cardiovasc Res. 2019 Mar 15;115(4):739-751. doi: 10.1093/cvr/cvy253.
2. An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesis. Chatterjee D, etal., Eur Heart J. 2018 Nov 21;39(44):3932-3944. doi: 10.1093/eurheartj/ehy567.
3. A founder homozygous DSG2 variant in East Asia results in ARVC with full penetrance and heart failure phenotype. Chen L, etal., Int J Cardiol. 2019 Jan 1;274:263-270. doi: 10.1016/j.ijcard.2018.06.105. Epub 2018 Jun 28.
4. Reduced expression of adherens and gap junction proteins can have a fundamental role in the development of heart failure following cardiac hypertrophy in rats. dos Santos DO, etal., Exp Mol Pathol. 2016 Feb;100(1):167-76. doi: 10.1016/j.yexmp.2015.12.009. Epub 2015 Dec 17.
5. [Dynamic assembly of intercalated disc during postnatal development in the rat myocardium]. Dou JP, etal., Sheng Li Xue Bao. 2014 Oct 25;66(5):569-74.
6. Desmoglein-2 expression is an independent predictor of poor prognosis patients with multiple myeloma. Ebert LM, etal., Mol Oncol. 2022 Mar;16(6):1221-1240. doi: 10.1002/1878-0261.13055. Epub 2021 Jul 24.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Desmoglein 2-Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function. Kant S, etal., Circ Cardiovasc Genet. 2015 Aug;8(4):553-63. doi: 10.1161/CIRCGENETICS.114.000974. Epub 2015 Jun 17.
10. Desmoglein 2 mutant mice develop cardiac fibrosis and dilation. Krusche CA, etal., Basic Res Cardiol. 2011 Jun;106(4):617-33. doi: 10.1007/s00395-011-0175-y. Epub 2011 Apr 1.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy. Posch MG, etal., Mol Genet Metab. 2008 Sep-Oct;95(1-2):74-80. doi: 10.1016/j.ymgme.2008.06.005. Epub 2008 Aug 3.
15. Progesterone treatment and the progress of early pregnancy reduce desmoglein 1&2 staining along the lateral plasma membrane in rat uterine epithelial cells. Preston AM, etal., Acta Histochem. 2004;106(5):345-51.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy. Schinner C, etal., JCI Insight. 2020 May 7;5(9):e130141. doi: 10.1172/jci.insight.130141.
20. Coordinated reassembly of the basement membrane and junctional proteins during corneal epithelial wound healing. Suzuki K, etal., Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2495-500.
21. Desmosomal cadherins are decreased in explanted arrhythmogenic right ventricular dysplasia/cardiomyopathy patient hearts. Vite A, etal., PLoS One. 2013 Sep 23;8(9):e75082. doi: 10.1371/journal.pone.0075082. eCollection 2013.
Additional References at PubMed
PMID:9864371   PMID:12631242   PMID:14673151   PMID:15775979   PMID:16505173   PMID:17559062   PMID:19199708   PMID:19581412   PMID:20859650   PMID:22274697   PMID:23381804  


Genomics

Comparative Map Data
Dsg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,121,287 - 12,179,590 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1812,121,181 - 12,179,590 (+)EnsemblGRCr8
mRatBN7.21811,846,207 - 11,904,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,846,183 - 11,904,156 (+)EnsemblmRatBN7.2
Rnor_6.01815,579,322 - 15,637,720 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,579,315 - 15,637,715 (-)Ensemblrn6Rnor6.0
Rnor_5.01815,353,348 - 15,411,825 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41812,306,321 - 12,366,719 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1811,860,565 - 11,912,367 (+)NCBICelera
RGSC_v3.11812,366,920 - 12,391,365 (+)NCBI
Cytogenetic Map18p12NCBI
DSG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381831,498,177 - 31,549,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1831,497,624 - 31,551,351 (+)Ensemblhg38GRCh38
GRCh371829,078,140 - 29,128,971 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361827,332,170 - 27,380,754 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341827,332,202 - 27,380,855NCBI
Celera1825,885,149 - 25,935,936 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1825,934,972 - 25,985,760 (+)NCBIHuRef
CHM1_11829,005,330 - 29,056,126 (+)NCBICHM1_1
T2T-CHM13v2.01831,688,704 - 31,739,535 (+)NCBIT2T-CHM13v2.0
Dsg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391820,691,247 - 20,737,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1820,691,131 - 20,737,578 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381820,558,074 - 20,604,526 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1820,558,074 - 20,604,521 (+)Ensemblmm10GRCm38
MGSCv371820,716,617 - 20,763,027 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361820,664,999 - 20,713,857 (+)NCBIMGSCv36mm8
MGSCv361820,701,117 - 20,745,819 (+)NCBIMGSCv36mm8
Celera1821,057,703 - 21,106,454 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.42NCBI
Dsg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540218,826,400 - 18,876,188 (+)NCBIChiLan1.0ChiLan1.0
DSG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21748,890,802 - 48,941,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11834,583,398 - 34,634,090 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01824,716,181 - 24,766,837 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11828,313,240 - 28,363,781 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,313,223 - 28,363,786 (+)EnsemblpanPan2panpan1.1
DSG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1757,981,918 - 58,030,197 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl757,982,825 - 58,077,926 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha757,419,009 - 57,467,267 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0757,967,094 - 58,015,339 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl757,967,084 - 58,015,390 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1757,643,638 - 57,691,881 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0757,669,703 - 57,717,915 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0757,958,817 - 58,007,069 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dsg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494453,674,706 - 53,721,731 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366821,676,290 - 1,722,783 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366821,676,301 - 1,725,132 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6115,400,243 - 115,454,340 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16115,400,223 - 115,453,763 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26108,027,813 - 108,079,757 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DSG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11849,174,539 - 49,227,519 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1849,174,409 - 49,227,347 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605023,824,149 - 23,877,098 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dsg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247701,313,916 - 1,364,153 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247701,315,021 - 1,363,472 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Dsg2
440 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:103
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000022270
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18679125112205285Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18679125112205285Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18679125112205285Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18679125112205285Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18679125112205285Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat

Markers in Region
D10S1559  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21755,981,648 - 55,981,773 (-)MAPPERmRatBN7.2
mRatBN7.262,002,659 - 2,002,784 (+)MAPPERmRatBN7.2
mRatBN7.21755,981,648 - 55,981,773 (+)MAPPERmRatBN7.2
mRatBN7.262,002,659 - 2,002,784 (-)MAPPERmRatBN7.2
mRatBN7.21811,855,180 - 11,855,305 (-)MAPPERmRatBN7.2
mRatBN7.21811,855,180 - 11,855,305 (+)MAPPERmRatBN7.2
Rnor_6.01815,628,636 - 15,628,760NCBIRnor6.0
Rnor_6.01760,887,493 - 60,887,617NCBIRnor6.0
Rnor_5.01815,402,667 - 15,402,791UniSTSRnor5.0
Rnor_5.01762,663,608 - 62,663,732UniSTSRnor5.0
RGSC_v3.4616,600,259 - 16,600,383UniSTSRGSC3.4
RGSC_v3.41812,316,769 - 12,316,893UniSTSRGSC3.4
Celera61,804,181 - 1,804,305UniSTS
Celera1811,869,520 - 11,869,644UniSTS
Cytogenetic Map18p12UniSTS
Cytogenetic Map17q12.1UniSTS
RH143169  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,904,484 - 11,904,594 (-)MAPPERmRatBN7.2
Rnor_6.01815,579,356 - 15,579,465NCBIRnor6.0
Rnor_5.01815,353,382 - 15,353,491UniSTSRnor5.0
RGSC_v3.41812,366,576 - 12,366,685UniSTSRGSC3.4
Celera1811,912,224 - 11,912,333UniSTS
RH 3.4 Map18110.2UniSTS
Cytogenetic Map18p12UniSTS
RH136808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,904,465 - 11,904,595 (-)MAPPERmRatBN7.2
Rnor_6.01815,579,355 - 15,579,484NCBIRnor6.0
Rnor_5.01815,353,381 - 15,353,510UniSTSRnor5.0
RGSC_v3.41812,366,557 - 12,366,686UniSTSRGSC3.4
Celera1811,912,205 - 11,912,334UniSTS
RH 3.4 Map18110.3UniSTS
Cytogenetic Map18p12UniSTS
RH134448  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera61,804,572 - 1,804,788UniSTS
Celera1811,869,038 - 11,869,254UniSTS
Cytogenetic Map18p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 63 153 91 90 59 44 59 6 301 137 11 125 81 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000022270   ⟹   ENSRNOP00000022270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1812,121,181 - 12,179,589 (+)Ensembl
mRatBN7.2 Ensembl1811,846,183 - 11,904,156 (+)Ensembl
Rnor_6.0 Ensembl1815,579,315 - 15,637,715 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103330   ⟹   ENSRNOP00000087276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1812,144,644 - 12,179,590 (+)Ensembl
mRatBN7.2 Ensembl1811,869,682 - 11,904,156 (+)Ensembl
RefSeq Acc Id: NM_001427278   ⟹   NP_001414207
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81812,121,287 - 12,179,590 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414207 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022270
  ENSRNOP00000022270.5
  ENSRNOP00000087276.1
Ensembl Acc Id: ENSRNOP00000022270   ⟸   ENSRNOT00000022270
Ensembl Acc Id: ENSRNOP00000087276   ⟸   ENSRNOT00000103330
RefSeq Acc Id: NP_001414207   ⟸   NM_001427278
- Peptide Label: precursor
- UniProtKB: F1LYX9 (UniProtKB/TrEMBL),   A0A8I6AG90 (UniProtKB/TrEMBL)
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LYX9-F1-model_v2 AlphaFold F1LYX9 1-1128 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700661
Promoter ID:EPDNEW_R11181
Type:initiation region
Name:Dsg2_1
Description:desmoglein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01815,637,622 - 15,637,682EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311143 AgrOrtholog
BioCyc Gene G2FUF-8227 BioCyc
Ensembl Genes ENSRNOG00000016526 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022270 ENTREZGENE
  ENSRNOT00000022270.7 UniProtKB/TrEMBL
  ENSRNOT00000103330.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/TrEMBL
  Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-domain_protein UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Catenin_binding_dom UniProtKB/TrEMBL
  Desmo_cadherin UniProtKB/TrEMBL
NCBI Gene 307562 ENTREZGENE
PANTHER DESMOGLEIN FAMILY MEMBER UniProtKB/TrEMBL
  DESMOGLEIN-2 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
PhenoGen Dsg2 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
  DESMOCADHERN UniProtKB/TrEMBL
  DESMOGLEIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016526 RatGTEx
SMART SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
UniProt A0A8I6AG90 ENTREZGENE, UniProtKB/TrEMBL
  F1LYX9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dsg2  desmoglein 2   Dsg2_predicted  desmoglein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dsg2_predicted  desmoglein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED