Pck2 (phosphoenolpyruvate carboxykinase 2 (mitochondrial)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pck2 (phosphoenolpyruvate carboxykinase 2 (mitochondrial)) Rattus norvegicus
Analyze
Symbol: Pck2
Name: phosphoenolpyruvate carboxykinase 2 (mitochondrial)
RGD ID: 1311112
Description: Enables phosphoenolpyruvate carboxykinase (GTP) activity. Involved in several processes, including carboxylic acid metabolic process; gluconeogenesis; and positive regulation of insulin secretion. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial); PARTICIPATES IN gluconeogenesis pathway; citric acid cycle pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102553612; LOC361042; PEPCK-M; phosphoenolpyruvate carboxykinase [GTP], mitochondrial; uncharacterized LOC102553612
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,997,853 - 33,006,691 (+)NCBIGRCr8
mRatBN7.21529,027,891 - 29,036,729 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,027,894 - 29,037,283 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,873,592 - 30,882,430 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,020,798 - 32,029,636 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,263,142 - 30,271,980 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,216,735 - 34,224,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,216,833 - 34,224,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,106,930 - 38,114,552 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,671,834 - 33,680,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,677,328 - 33,696,192 (+)NCBI
Celera1528,603,811 - 28,612,649 (+)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bosentan  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
imidacloprid  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
linalool  (ISO)
methapyrilene  (EXP)
metyrapone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
progesterone  (ISO)
prothioconazole  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salvianolic acid A  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulfluramid  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tuberostemonine  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
xanthosine  (EXP)
XL147  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. Ballard FJ and Hanson RW, Biochem J. 1967 Sep;104(3):866-71.
2. Evidence that stimulation of gluconeogenesis by fatty acid is mediated through thermodynamic mechanisms. Berry MN, etal., FEBS Lett. 1988 Apr 11;231(1):19-24.
3. Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase. Caton PW, etal., Life Sci. 2009 May 22;84(21-22):738-44. doi: 10.1016/j.lfs.2009.02.024. Epub 2009 Mar 4.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Structure, mechanism and regulation of pyruvate carboxylase. Jitrapakdee S, etal., Biochem J. 2008 Aug 1;413(3):369-87.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Prenatal programming of hepatocyte nuclear factor 4alpha in the rat: A key mechanism in the 'foetal origins of hyperglycaemia'? Nyirenda MJ, etal., Diabetologia. 2006 Jun;49(6):1412-20. Epub 2006 Mar 29.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin. Song S, etal., Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E275-82.
15. Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion. Stark R, etal., J Biol Chem. 2009 Sep 25;284(39):26578-90. doi: 10.1074/jbc.M109.011775. Epub 2009 Jul 27.
16. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
Additional References at PubMed
PMID:12477932   PMID:14651853   PMID:18614015   PMID:23376485   PMID:24497630  


Genomics

Comparative Map Data
Pck2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,997,853 - 33,006,691 (+)NCBIGRCr8
mRatBN7.21529,027,891 - 29,036,729 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,027,894 - 29,037,283 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,873,592 - 30,882,430 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,020,798 - 32,029,636 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,263,142 - 30,271,980 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,216,735 - 34,224,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,216,833 - 34,224,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,106,930 - 38,114,552 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,671,834 - 33,680,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,677,328 - 33,696,192 (+)NCBI
Celera1528,603,811 - 28,612,649 (+)NCBICelera
Cytogenetic Map15p13NCBI
PCK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,094,171 - 24,104,125 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,094,053 - 24,110,598 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,563,520 - 24,573,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,633,323 - 23,643,179 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,633,388 - 23,643,173NCBI
Celera144,427,958 - 4,437,809 (+)NCBICelera
Cytogenetic Map14q11.2-q12NCBI
HuRef144,678,408 - 4,688,558 (+)NCBIHuRef
CHM1_11424,562,148 - 24,571,997 (+)NCBICHM1_1
T2T-CHM13v2.01418,292,333 - 18,302,437 (+)NCBIT2T-CHM13v2.0
Pck2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,777,721 - 55,787,477 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,777,723 - 55,788,699 (+)EnsemblGRCm39 Ensembl
GRCm381455,540,263 - 55,550,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,540,266 - 55,551,242 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,159,103 - 56,168,854 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,494,337 - 54,504,088 (+)NCBIMGSCv36mm8
Celera1453,345,110 - 53,354,861 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Pck2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,288,568 - 36,296,828 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,288,402 - 36,296,761 (-)NCBIChiLan1.0ChiLan1.0
PCK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,450,239 - 25,460,233 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,666,731 - 24,676,725 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,872,276 - 4,882,118 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,996,813 - 23,006,775 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,996,813 - 23,006,775 (+)Ensemblpanpan1.1panPan2
PCK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,099,016 - 4,107,870 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,098,671 - 4,107,865 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,020,846 - 4,030,924 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,209,738 - 4,219,816 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,209,258 - 4,220,128 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,900,384 - 3,910,462 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,962,137 - 3,972,205 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,224,247 - 4,234,326 (+)NCBIUU_Cfam_GSD_1.0
Pck2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,951,769 - 35,960,519 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722428,307 - 437,328 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722428,473 - 450,452 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,187,197 - 75,197,733 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,187,195 - 75,197,613 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,458,494 - 80,468,914 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,077,206 - 1,087,306 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,077,447 - 1,087,607 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,759,325 - 12,769,341 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pck2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,426,606 - 8,436,284 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,426,456 - 8,436,484 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pck2
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:29
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000025260
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
BE101384  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,017,066 - 29,017,216 (+)MAPPERmRatBN7.2
Rnor_6.01534,205,913 - 34,206,062NCBIRnor6.0
Rnor_5.01538,096,108 - 38,096,257UniSTSRnor5.0
RGSC_v3.41533,661,012 - 33,661,161UniSTSRGSC3.4
Celera1528,593,033 - 28,593,182UniSTS
RH 3.4 Map15213.2UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000025260   ⟹   ENSRNOP00000025260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,027,894 - 29,037,283 (+)Ensembl
Rnor_6.0 Ensembl1534,216,833 - 34,224,193 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097088   ⟹   ENSRNOP00000082970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,029,149 - 29,037,283 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106981   ⟹   ENSRNOP00000092209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,029,149 - 29,037,283 (+)Ensembl
RefSeq Acc Id: NM_001108377   ⟹   NP_001101847
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,997,853 - 33,006,691 (+)NCBI
mRatBN7.21529,027,891 - 29,036,729 (+)NCBI
Rnor_6.01534,216,735 - 34,224,357 (+)NCBI
Rnor_5.01538,106,930 - 38,114,552 (+)NCBI
RGSC_v3.41533,671,834 - 33,680,613 (+)RGD
Celera1528,603,811 - 28,612,649 (+)RGD
Sequence:
RefSeq Acc Id: XM_063274407   ⟹   XP_063130477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,999,872 - 33,006,691 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101847 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130477 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66766 (Get FASTA)   NCBI Sequence Viewer  
  EDM14236 (Get FASTA)   NCBI Sequence Viewer  
  EDM14237 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025260.7
  ENSRNOP00000082970.1
  ENSRNOP00000092209.1
RefSeq Acc Id: NP_001101847   ⟸   NM_001108377
- UniProtKB: B2RYG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025260   ⟸   ENSRNOT00000025260
Ensembl Acc Id: ENSRNOP00000092209   ⟸   ENSRNOT00000106981
Ensembl Acc Id: ENSRNOP00000082970   ⟸   ENSRNOT00000097088
RefSeq Acc Id: XP_063130477   ⟸   XM_063274407
- Peptide Label: isoform X1
Protein Domains
Phosphoenolpyruvate carboxykinase C-terminal P-loop   Phosphoenolpyruvate carboxykinase GTP-utilising N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQJ7-F1-model_v2 AlphaFold F1LQJ7 1-641 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699693
Promoter ID:EPDNEW_R10192
Type:initiation region
Name:Pck2_1
Description:Phosphoenolpyruvate carboxykinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,216,778 - 34,216,838EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311112 AgrOrtholog
BioCyc Gene G2FUF-13717 BioCyc
BioCyc Pathway PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000018536 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025260.8 UniProtKB/TrEMBL
  ENSRNOT00000097088.1 UniProtKB/TrEMBL
  ENSRNOT00000106981.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.449.10 UniProtKB/TrEMBL
  3.90.228.20 UniProtKB/TrEMBL
  Phosphoenolpyruvate Carboxykinase, domain 2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7932647 IMAGE-MGC_LOAD
InterPro PEP_carboxykin_GTP_CS UniProtKB/TrEMBL
  PEP_carboxykinase_C UniProtKB/TrEMBL
  PEP_carboxykinase_GTP UniProtKB/TrEMBL
  PEP_carboxykinase_GTP_C UniProtKB/TrEMBL
  PEP_carboxykinase_GTP_N UniProtKB/TrEMBL
  PEP_carboxykinase_N UniProtKB/TrEMBL
KEGG Report rno:361042 UniProtKB/TrEMBL
MGC_CLONE MGC:188534 IMAGE-MGC_LOAD
NCBI Gene 361042 ENTREZGENE
PANTHER PEP_carboxykin UniProtKB/TrEMBL
  PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP], MITOCHONDRIAL UniProtKB/TrEMBL
Pfam PEPCK_C UniProtKB/TrEMBL
  PEPCK_N UniProtKB/TrEMBL
PhenoGen Pck2 PhenoGen
PIRSF PEP_carboxykinase_GTP UniProtKB/TrEMBL
PROSITE PEPCK_GTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018536 RatGTEx
Superfamily-SCOP PEP carboxykinase-like UniProtKB/TrEMBL
  PEP_carboxykinase_N UniProtKB/TrEMBL
UniProt A0A8I5ZVZ5_RAT UniProtKB/TrEMBL
  A0A8I6AH39_RAT UniProtKB/TrEMBL
  B2RYG2 ENTREZGENE, UniProtKB/TrEMBL
  F1LQJ7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pck2  phosphoenolpyruvate carboxykinase 2 (mitochondrial)  LOC102553612  uncharacterized LOC102553612  Data merged from RGD:7583690 737654 PROVISIONAL
2013-12-18 LOC102553612  uncharacterized LOC102553612      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Pck2  phosphoenolpyruvate carboxykinase 2 (mitochondrial)   Pck2_predicted  phosphoenolpyruvate carboxykinase 2 (mitochondrial) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pck2_predicted  phosphoenolpyruvate carboxykinase 2 (mitochondrial) (predicted)      Symbol and Name status set to approved 70820 APPROVED