Dux4 (double homeobox 4) - Rat Genome Database

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Gene: Dux4 (double homeobox 4) Rattus norvegicus
Analyze
Symbol: Dux4
Name: double homeobox 4
RGD ID: 1311053
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of G0 to G1 transition; negative regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of T cell differentiation. Predicted to be located in Golgi apparatus; cytosol; and nucleus. Predicted to be active in nucleus. Orthologous to several human genes including DUXB (double homeobox B); INTERACTS WITH amphetamine; Cuprizon; methamphetamine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: double homeobox B-like; double homeobox B-like 1; double homeobox protein 4C-like; double homeobox protein B; Duxbl; Duxbl1; LOC306226; RGD1311053; similar to double homeobox protein
RGD Orthologs
Human
Mouse
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2161,558,430 - 1,570,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl161,558,766 - 1,568,565 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0163,754,968 - 3,766,532 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl163,754,968 - 3,765,917 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0163,720,950 - 3,732,462 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4161,600,636 - 1,606,916 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1161,597,461 - 1,606,066 (+)NCBI
Celera161,534,238 - 1,545,775 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
Golgi apparatus  (ISO)
nuclear membrane  (ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17588759   PMID:17984056   PMID:24589735   PMID:30315230   PMID:30322619  


Genomics

Comparative Map Data
Dux4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2161,558,430 - 1,570,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl161,558,766 - 1,568,565 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0163,754,968 - 3,766,532 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl163,754,968 - 3,765,917 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0163,720,950 - 3,732,462 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4161,600,636 - 1,606,916 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1161,597,461 - 1,606,066 (+)NCBI
Celera161,534,238 - 1,545,775 (+)NCBICelera
Cytogenetic Map16p16NCBI
DUX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384190,173,774 - 190,185,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4190,173,774 - 190,185,942 (+)EnsemblGRCh38hg38GRCh38
Cytogenetic Map4q35.2NCBI
CHM1_14190,981,942 - 190,983,445 (+)NCBICHM1_1
T2T-CHM13v2.04193,541,579 - 193,553,139 (+)NCBIT2T-CHM13v2.0
Duxbl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391425,979,011 - 25,990,590 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1425,979,001 - 25,990,512 (+)EnsemblGRCm39 Ensembl
GRCm381425,978,560 - 25,990,166 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,118,349 - 26,129,763 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1425,978,577 - 25,990,088 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,257,962 - 26,269,436 (+)EnsemblGRCm38mm10GRCm38
MGSCv371426,802,491 - 26,809,318 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361424,816,189 - 24,823,016 (+)NCBIMGSCv36mm8
Cytogenetic Map14A3NCBI
cM Map1415.3NCBI
LOC100683783
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11764,277,421 - 64,282,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1763,676,530 - 63,684,952 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01765,398,792 - 65,407,412 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11764,194,207 - 64,199,472 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01764,260,323 - 64,264,770 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01764,995,675 - 64,998,742 (-)NCBIUU_Cfam_GSD_1.0
UU_Cfam_GSD_1.01764,999,186 - 65,004,132 (-)NCBIUU_Cfam_GSD_1.0
DUX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666037116,205,175 - 116,206,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Dux4
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:91
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000052224
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2325838Bp347Blood pressure QTL 3470.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1613080679Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)163802452995463Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
12903278Am16Aortic mass QTL 160.019aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)168323802995225Rat
12903279Cm115Cardiac mass QTL 1150.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)168323802995225Rat
12903281Cm116Cardiac mass QTL 1160.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)168323802995225Rat
12903952Cm117Cardiac mass QTL 1170.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)168323802995225Rat
12903954Bw186Body weight QTL 1860.011body mass (VT:0001259)body weight (CMO:0000012)168323802995225Rat
2301404Bp321Blood pressure QTL 3210.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)168323802995225Rat
12903955Kidm69Kidney mass QTL 690.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)168323804227609Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 4 26 5
Low 3 41 48 32 19 32 8 9 48 28 10 6 8
Below cutoff 9 9 9 2 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000052224   ⟹   ENSRNOP00000044374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl161,558,766 - 1,568,565 (+)Ensembl
Rnor_6.0 Ensembl163,754,968 - 3,762,877 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088284   ⟹   ENSRNOP00000075215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl163,759,627 - 3,765,917 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099184   ⟹   ENSRNOP00000079337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl161,558,766 - 1,566,240 (+)Ensembl
RefSeq Acc Id: XM_006252678   ⟹   XP_006252740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2161,558,430 - 1,570,045 (+)NCBI
Rnor_6.0163,754,968 - 3,766,531 (-)NCBI
Rnor_5.0163,720,950 - 3,732,462 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771031   ⟹   XP_008769253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2161,558,430 - 1,570,045 (+)NCBI
Rnor_6.0163,754,968 - 3,766,531 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006252740 (Get FASTA)   NCBI Sequence Viewer  
  XP_008769253 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75080 (Get FASTA)   NCBI Sequence Viewer  
  EDL75081 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_006252740   ⟸   XM_006252678
- UniProtKB: D3ZTT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769253   ⟸   XM_008771031
- UniProtKB: D3ZTT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075215   ⟸   ENSRNOT00000088284
RefSeq Acc Id: ENSRNOP00000044374   ⟸   ENSRNOT00000052224
RefSeq Acc Id: ENSRNOP00000079337   ⟸   ENSRNOT00000099184
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTT0-F1-model_v2 AlphaFold D3ZTT0 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311053 AgrOrtholog
BioCyc Gene G2FUF-12261 BioCyc
Ensembl Genes ENSRNOG00000025408 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000044374 ENTREZGENE
  ENSRNOP00000044374.4 UniProtKB/TrEMBL
  ENSRNOP00000079337.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000052224 ENTREZGENE
  ENSRNOT00000052224.6 UniProtKB/TrEMBL
  ENSRNOT00000099184.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
KEGG Report rno:306226 UniProtKB/TrEMBL
NCBI Gene 306226 ENTREZGENE
PANTHER DOUBLE HOMEOBOX PROTEIN 1-RELATED UniProtKB/TrEMBL
  MIX-TYPE HOMEOBOX GENE 1-RELATED UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Dux4 PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A8I5ZML2_RAT UniProtKB/TrEMBL
  D3ZTT0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Dux4  double homeobox 4  Duxbl1  double homeobox B-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Duxbl1  double homeobox B-like 1  Duxbl  double homeobox B-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-18 Duxbl  double homeobox B-like  RGD1311053_predicted  similar to double homeobox protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311053_predicted  similar to double homeobox protein (predicted)  LOC306226_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306226_predicted  similar to double homeobox protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL