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Gene: Gbp5 (guanylate binding protein 5) Rattus norvegicus

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Symbol:

Gbp5

Name:

guanylate binding protein 5

RGD ID:

1311040

Description:

Predicted to enable several functions, including GTP binding activity; endopeptidase inhibitor activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of defense response; and protein homotetramerization. Predicted to act upstream of or within several processes, including defense response to bacterium; disruption of plasma membrane integrity in another organism; and protein-containing complex assembly. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi membrane; cytoplasmic vesicle; and symbiont cell surface. Orthologous to human GBP5 (guanylate binding protein 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

guanylate nucleotide binding protein 5; guanylate-binding protein 5; LOC362050

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GBP5 (guanylate binding protein 5)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Gbp5 (guanylate binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gbp5 (guanylate binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GBP5 (guanylate binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GBP5 (guanylate binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gbp5 (guanylate binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GBP2 (guanylate binding protein 2)	HGNC	OrthoDB
Homo sapiens (human):	GBP1 (guanylate binding protein 1)	HGNC	OrthoDB
Homo sapiens (human):	GBP3 (guanylate binding protein 3)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	GBP5 (guanylate binding protein 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gbp5 (guanylate binding protein 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-195h23.3	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	gbp3 (guanylate binding protein 3)	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	gbp2 (guanylate binding protein 2)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:dkeyp-30d6.2	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	si:dkeyp-30d6.2	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	gbp1 (guanylate binding protein 1)	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	gbp1 (guanylate binding protein 1)	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gbp6	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gbp1	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gbp5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gbp3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100488013	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100495160	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100495160	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	233,910,999 - 233,930,320 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	233,902,113 - 233,930,826 (+)	Ensembl				GRCr8
mRatBN7.2	2	231,237,748 - 231,257,071 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	231,237,748 - 231,257,061 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	239,015,471 - 239,029,785 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	236,908,491 - 236,922,804 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	231,773,152 - 231,787,470 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	248,178,441 - 248,196,873 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	248,178,389 - 248,197,160 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	266,707,528 - 266,725,960 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	240,428,472 - 240,447,791 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	223,291,514 - 223,305,610 (+)	NCBI		Celera
RGSC_v3.1	2	240,418,633 - 240,443,372 (+)	NCBI
Cytogenetic Map	2	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

celiac disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (EXP)

acetamide (EXP)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

Dibutyl phosphate (ISO)

dioxygen (EXP)

diquat (ISO)

doxorubicin (ISO)

endosulfan (EXP)

formaldehyde (ISO)

gentamycin (EXP)

lipopolysaccharide (ISO)

malathion (ISO)

manganese(II) chloride (EXP)

methcathinone (ISO)

methylmercury chloride (EXP)

microcystin-LR (ISO)

N-methyl-4-phenylpyridinium (EXP)

nickel atom (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

quercetin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

T-2 toxin (ISO)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (IEA,ISO)

AIM2 inflammasome complex assembly (IEA)

cellular response to lipopolysaccharide (IEA,ISO)

cellular response to type II interferon (IBA,IEA,ISO)

cytolysis in another organism (IEA,ISO)

defense response to bacterium (IEA,ISO)

defense response to virus (IEA,ISO)

disruption of plasma membrane integrity in another organism (IEA)

immune system process (IEA)

innate immune response (IEA)

non-canonical inflammasome complex assembly (IEA)

positive regulation of AIM2 inflammasome complex assembly (IEA,ISO)

positive regulation of cytokine production involved in inflammatory response (IEA,ISO)

positive regulation of innate immune response (IEA,ISO)

positive regulation of interleukin-1 beta production (IEA,ISO)

positive regulation of interleukin-18 production (IEA,ISO)

positive regulation of NLRP3 inflammasome complex assembly (IEA,ISO)

positive regulation of pyroptotic inflammatory response (IEA,ISO)

protein homotetramerization (IEA,ISO)

protein localization to Golgi apparatus (IEA,ISO)

protein maturation (IEA)

protein targeting (IEA,ISO)

regulation of defense response (IEA)

response to bacterium (IEA,ISO)

symbiont entry into host cell (IEA)

Cellular Component

cytoplasm (IEA,ISO)

cytoplasmic vesicle (IBA,IEA,ISO)

Golgi apparatus (IEA,ISO)

Golgi membrane (IEA,ISO)

perinuclear region of cytoplasm (IEA,ISO)

symbiont cell surface (IEA,ISO)

Molecular Function

endopeptidase inhibitor activity (IEA)

GTP binding (IBA,IEA)

GTPase activity (IBA,IEA,ISO)

hydrolase activity (IEA)

identical protein binding (IEA,ISO)

molecular function inhibitor activity (IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:16189514	PMID:17266443	PMID:18025219	PMID:19946888	PMID:20180847	PMID:21151871	PMID:22461501	PMID:23012479	PMID:33615742

Genomics

Comparative Map Data

Gbp5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	233,910,999 - 233,930,320 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	233,902,113 - 233,930,826 (+)	Ensembl				GRCr8
mRatBN7.2	2	231,237,748 - 231,257,071 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	231,237,748 - 231,257,061 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	239,015,471 - 239,029,785 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	236,908,491 - 236,922,804 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	231,773,152 - 231,787,470 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	248,178,441 - 248,196,873 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	248,178,389 - 248,197,160 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	266,707,528 - 266,725,960 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	240,428,472 - 240,447,791 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	223,291,514 - 223,305,610 (+)	NCBI		Celera
RGSC_v3.1	2	240,418,633 - 240,443,372 (+)	NCBI
Cytogenetic Map	2	q44	NCBI

GBP5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	89,256,189 - 89,272,860 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	89,256,189 - 89,272,890 (-)	Ensembl			hg38	GRCh38
GRCh37	1	89,721,872 - 89,738,543 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	89,498,853 - 89,511,119 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	89,438,285 - 89,450,552	NCBI
Celera	1	87,970,432 - 87,984,342 (-)	NCBI		Celera
Cytogenetic Map	1	p22.2	NCBI
HuRef	1	87,841,845 - 87,855,755 (-)	NCBI		HuRef
CHM1_1	1	89,839,681 - 89,853,590 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	89,099,549 - 89,116,218 (-)	NCBI		T2T-CHM13v2.0

Gbp5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	142,202,695 - 142,228,105 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	142,199,739 - 142,228,105 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	142,496,934 - 142,522,344 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	142,493,978 - 142,522,344 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	142,159,898 - 142,185,308 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	142,434,320 - 142,459,728 (+)	NCBI		MGSCv36	mm8
Celera	3	148,919,987 - 148,945,108 (+)	NCBI		Celera
Cytogenetic Map	3	H1	NCBI
cM Map	3	66.69	NCBI

Gbp5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	4,917,590 - 4,926,007 (+)	Ensembl
ChiLan1.0	NW_004955423	4,914,430 - 4,926,850 (+)	NCBI	ChiLan1.0	ChiLan1.0

GBP5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	137,543,196 - 137,719,174 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	136,698,968 - 136,874,934 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	91,969,699 - 92,006,127 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	90,720,805 - 90,733,030 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	90,720,927 - 90,729,757 (-)	Ensembl			panPan2	panpan1.1

GBP5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	59,273,699 - 59,292,563 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	59,273,592 - 59,393,229 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	61,983,014 - 62,001,731 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	59,785,648 - 59,804,382 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	59,785,622 - 59,905,093 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	59,352,041 - 59,370,752 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	59,306,406 - 59,325,133 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	59,791,978 - 59,810,724 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gbp5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624742	8,324,902 - 8,335,965 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Gbp5
218 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	78
Count of miRNA genes:	60
Interacting mature miRNAs:	72
Transcripts:	ENSRNOT00000037339
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	202029709	236904960	Rat
8693697	Alc36	Alcohol consumption QTL 36	2	0.592	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	219814164	239320906	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204795005	249795005	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	192287802	237287802	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	196140964	251540988	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	205135267	250135267	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	221088977	243501206	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	203664411	248664411	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat
8693622	Alc26	Alcohol consumption QTL 26	2.4	0.667	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	223810546	243965570	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	192287802	237287802	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat

Markers in Region

AI171991

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	231,257,295 - 231,257,468 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	248,197,098 - 248,197,270	NCBI	Rnor6.0
Rnor_5.0	2	266,726,185 - 266,726,357	UniSTS	Rnor5.0
RGSC_v3.4	2	240,448,016 - 240,448,188	UniSTS	RGSC3.4
Celera	2	223,305,835 - 223,306,007	UniSTS
RH 3.4 Map	2	1580.3	UniSTS
Cytogenetic Map	2	q44	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

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alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	65	158	91	90	59	92	59	6	354	190	11	137	81	92	31	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ205455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB615696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO559037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO559828	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV121628	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM048046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037339 ⟹ ENSRNOP00000033376

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	233,910,963 - 233,930,826 (+)	Ensembl
mRatBN7.2 Ensembl	2	231,237,748 - 231,257,061 (+)	Ensembl
Rnor_6.0 Ensembl	2	248,178,389 - 248,197,160 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107515 ⟹ ENSRNOP00000082518

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	233,902,113 - 233,930,826 (+)	Ensembl
mRatBN7.2 Ensembl	2	231,237,748 - 231,257,061 (+)	Ensembl

RefSeq Acc Id:

NM_001108569 ⟹ NP_001102039

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	233,910,999 - 233,930,320 (+)	NCBI
mRatBN7.2	2	231,237,748 - 231,257,071 (+)	NCBI
Rnor_6.0	2	248,178,441 - 248,196,873 (+)	NCBI
Rnor_5.0	2	266,707,528 - 266,725,960 (+)	NCBI
RGSC_v3.4	2	240,428,472 - 240,447,791 (+)	RGD
Celera	2	223,291,514 - 223,305,610 (+)	RGD

Sequence:

show sequence

CAAGTTCTCTGCCAGAGAGCTGAGAGAGGAAAGGAAATTCCCAGAGCTGGTCATTATTTCTCAA
AAAAAAAATAATAAAAAAAAAAGAAGAAGAAGCACAGATAAATAAGGGCACGAGGAGTACGTAC
TCTTGCAGAGTCCCGTTTGAAGCGTATCACCGGCACTTGCTCCAGCTCTTCAGTGTTTGTTAAG
AAATTCCAGGTCATTCCACTTCTGACCCCGAGGACAAGTAACATCGCAGACATGGCCCCAGAGA
TTCACATGCCAGAACCCATATGCCTCATTGCGAACACGGATGAACACCTAGTGACTAACCAGGA
AGCCCTGGAGATCCTGTCAGCCATCACACAGCCGGTGGTGGTGGTGGCCATTGTTGGCCTCTAC
CGCACAGGCAAATCCTACCTGATGAACAAGCTGGCTGGGAAGGAGAAAGGCTTTTCCGTGGGCT
CCACTGTTCAGTCTCACACCAAGGGCATCTGGATGTGGTGTGTGCCCCACCCTCAAAAGCCAGA
CCACACTTTGGTTCTGTTGGACACTGAGGGCCTGGGAGATGTGGAGAAGGTTGATGAAAAGAAT
GATATTCAGATCTTCGCACTGGCGATCCTCCTCAGTAGCACCTTCGTATACAACACCATGAGCA
AAATTGACCAGGGGGCTATCGACCTACTGCACAGTGTCACAGAGCTGACAGATCTGCTCCGGAC
AAGGAACACCTCTGATCCCAGTGAAACCAAGGAACCTGATGACATGAGCTTCTTCCCAGACTTG
GTGTGGACTCTGAGAGATTTCTTCCTGGGCCTGGAAGTCAATGGGCAAGCCATCACATCAGATG
AATATCTGGAGAAGTCGCTGATGCTGAAGCAAGGTAGTGATGAAAGGACCCAAACATTCAATCT
ACCTCGGCTGTGCATACAGAAGTTCTTCCCAGTAAAGAAATGCTTTGTTTTTGACTCTCCTGCT
CTCGGAAGTAAACTTTCTCAGCTTCAAACACTCAACAGTGATGAGCTGAACCCTGATTTTGTGC
AGAACCTTTCAGAATTCTGTTCTCACATCTTCACACATTCTAAGACCAAGACTCTTCCAGGAGG
CATCCAGGTCAATGGACCTCGTCTGGAAAGCATGGTGCAGACCTATGTGGATGCTATCAACAGT
GGGGCTCTTCCTTCCATGGAGAACATGGTGGTAACCTTGACCCGGAGAGAGAACACAGCAGCAG
TGCAAAAGGCCATTGCTCACTATGACCAACAGATGAGTCAGAAGGTGCAGCTGCCCACAGAGAC
CCTCCAACTGCTGCTGGACCTGCACAAGACCTGTGAGAAAGAAGCCATAGAAATCTTCAGGAAG
CGTTCTTTCAAGGATGATGACCAATGTTTCCAGAAAGAATTGGAGAGCCTACTAAGTGCAAAGC
GGGATGAGATTTGTAGGAAGAACGAGGATGCTTCTGCAGCCCTCTGCTCAACCCTACTTCAGAG
TACTTTTCAGCCTCTGGAACAAGAAGTGGCACGGGGGGTCTATGCTAAACCAGGAGGACACAGT
CTCTTCCTTCAGAGGATGGAACAGTTGAAGGCACAGTACCGCCAGCAGCCGGGGAAGGGAACAC
AGGCTGAGGAAGTTCTGCAGAAATATCTGAAAGCCAAGGAACCAGTGAGCGCTACAATTCTACA
AACAGACCAGGATCTCACAGCCAAAGAGAAGCAGAAAAAAGAGGAACAAGCAAGAGCGGAGGCT
GCCCGGGCTGAAGCACAGAGGTTGGAGGCTCTTCGAGTCCAGGAAGAGCAAAGGAGAGTAGAGC
AGGAGAGAAGGCATCAAGAGCATCTGAGGCAAATAGAGTTTGAGAGGGCAAACTTCCAGAGAGA
GCAACAGAGGAAGCAGAAGCAGAGGGTCCAGGAAGAGATGGAAAGGATCAAGGCAGAGCAGGAA
GCTCAACTCAGAGCACTTCAACAGCAGCTCCAAAACATGAGGGTAATAAGCCACCACGAACATG
ACCAGTGTATAATAATCTAATACACCAAAACCTGGGTCCTCCCTTTCTTATTGCTTCTCATTGA
AGACACAGAGGAACAAGAGACCGAAGGACTTCAGACAACCAATAGTTAAGAAGCCCCAGCGCCC
CCTGACTAACTGCCACATCTGTCTGGAGATAGTTACTCAGGGGGTGTTAATCAAATAGAACTTG
GCCAATATCTGCAATTGACATGGCATCCCCTTTACTGGTGGACACAGGAAGAAGGGTTACCAAT
GAGAAATCAGAAAAAAATTTGTTTTTCTCAACTGGGTGCGGGCCCCTGCTCCGTGGACAGAGGG
GCTGGCTCCTCAGTACAATCAGCTGACCATCTGCATGATATTCCTTTCCATTTCTTTGTTGCGA
GCCCAAACACATTATAGTCAACCTTGTCACGTGGCTAAGGATCATGTCACTCACACTTGGAGGA
AAATTTGTTCCTCCCGATTGTCTTTTCTGCTGCATCCACCTTCTATCTTTGGTTACGTGATTAA
TGATAAAGAAAGTCTTCCACTAAGGCTTTGCTTTCGATACACAAAATCACCATCTGGCCCCATC
TGTATCCATTTTTCTTCCTTCAAGTCTATGCTTGCCCAGGCATATTGCTCACTTTCAATCAGAT
TCTTAACCACAGTCATTATACTGACGTTTAAATCATTTTGATGATTTAAAATTTAAAGTTTTTA
AACGGTTTGTGACCATTCTAAGCCTGACCCTGTTTCTGGGTCTATTTGCTTTATTTCTTTAAAA
TAAAATTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102039	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68951	(Get FASTA)	NCBI Sequence Viewer
	EDL82348	(Get FASTA)	NCBI Sequence Viewer
	EDL82349	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000033376
	ENSRNOP00000033376.4
	ENSRNOP00000082518.2

RefSeq Acc Id:

NP_001102039 ⟸ NM_001108569

- UniProtKB:

F1M9F6 (UniProtKB/TrEMBL), A0A8I5ZTN7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAPEIHMPEPICLIANTDEHLVTNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKEKG
FSVGSTVQSHTKGIWMWCVPHPQKPDHTLVLLDTEGLGDVEKVDEKNDIQIFALAILLSSTFVY
NTMSKIDQGAIDLLHSVTELTDLLRTRNTSDPSETKEPDDMSFFPDLVWTLRDFFLGLEVNGQA
ITSDEYLEKSLMLKQGSDERTQTFNLPRLCIQKFFPVKKCFVFDSPALGSKLSQLQTLNSDELN
PDFVQNLSEFCSHIFTHSKTKTLPGGIQVNGPRLESMVQTYVDAINSGALPSMENMVVTLTRRE
NTAAVQKAIAHYDQQMSQKVQLPTETLQLLLDLHKTCEKEAIEIFRKRSFKDDDQCFQKELESL
LSAKRDEICRKNEDASAALCSTLLQSTFQPLEQEVARGVYAKPGGHSLFLQRMEQLKAQYRQQP
GKGTQAEEVLQKYLKAKEPVSATILQTDQDLTAKEKQKKEEQARAEAARAEAQRLEALRVQEEQ
RRVEQERRHQEHLRQIEFERANFQREQQRKQKQRVQEEMERIKAEQEAQLRALQQQLQNMRVIS
HHEHDQCIII

hide sequence

Ensembl Acc Id:

ENSRNOP00000033376 ⟸ ENSRNOT00000037339

Ensembl Acc Id:

ENSRNOP00000082518 ⟸ ENSRNOT00000107515

Protein Domains

GB1/RHD3-type G

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M9F6-F1-model_v2	AlphaFold	F1M9F6	1-586	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691795

Promoter ID:

EPDNEW_R2318

Type:

multiple initiation site

Name:

Gbp5_1

Description:

guanylate binding protein 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R2319

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	248,178,436 - 248,178,496	EPDNEW

RGD ID:

13691794

Promoter ID:

EPDNEW_R2319

Type:

single initiation site

Name:

Gbp5_2

Description:

guanylate binding protein 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R2318

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	248,178,573 - 248,178,633	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311040	AgrOrtholog
BioCyc Gene	G2FUF-50999	BioCyc
Ensembl Genes	ENSRNOG00000032240	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037339	ENTREZGENE
	ENSRNOT00000037339.7	UniProtKB/TrEMBL
	ENSRNOT00000107515.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
	Guanylate-binding protein, C-terminal domain	UniProtKB/TrEMBL
InterPro	G_GB1_RHD3_dom	UniProtKB/TrEMBL
	GBP_C	UniProtKB/TrEMBL
	Guanylate-bd_C	UniProtKB/TrEMBL
	Guanylate-bd_C_sf	UniProtKB/TrEMBL
	Guanylate-bd_N	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
KEGG Report	rno:362050	UniProtKB/TrEMBL
NCBI Gene	362050	ENTREZGENE
PANTHER	GUANYLATE BINDING PROTEIN	UniProtKB/TrEMBL
Pfam	GBP	UniProtKB/TrEMBL
	GBP_C	UniProtKB/TrEMBL
PhenoGen	Gbp5	PhenoGen
PROSITE	G_GB1_RHD3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000032240	RatGTEx
Superfamily-SCOP	GBP	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I5ZTN7	ENTREZGENE, UniProtKB/TrEMBL
	B5DF73_RAT	UniProtKB/TrEMBL
	F1M9F6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-30	Gbp5	guanylate binding protein 5	Gbp5	guanylate nucleotide binding protein 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Gbp5	guanylate nucleotide binding protein 5	Gbp5_predicted	guanylate nucleotide binding protein 5 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Gbp5_predicted	guanylate nucleotide binding protein 5 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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