Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pum2 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Pum2 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PUM2 mRNA | CTD | PMID:22206623 | Pum2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pum2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PUM2 mRNA | CTD | PMID:21570461 | Pum2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PUM2 mRNA | CTD | PMID:33387578 | Pum2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pum2 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression more ... | CTD | PMID:25975270 | Pum2 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of PUM2 mRNA | CTD | PMID:21346803 | Pum2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Pum2 | Rat | 4,4'-diaminodiphenylmethane | increases expression | ISO | Pum2 (Mus musculus) | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of PUM2 mRNA | CTD | PMID:18648102 | Pum2 | Rat | acetylsalicylic acid | increases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Aspirin results in increased expression of PUM2 mRNA | CTD | PMID:15928584 | Pum2 | Rat | actinomycin D | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of PUM2 protein | CTD | PMID:38460933 | Pum2 | Rat | aflatoxin B1 | increases expression | ISO | Pum2 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of PUM2 mRNA | CTD | PMID:19770486 | Pum2 | Rat | aristolochic acid A | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PUM2 mRNA | CTD | PMID:33212167 | Pum2 | Rat | arsenite(3-) | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PUM2 mRNA] | CTD | PMID:32406909 | Pum2 | Rat | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of PUM2 mRNA | CTD | PMID:21839799 | Pum2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PUM2 mRNA | CTD | PMID:19150397 | Pum2 | Rat | benzo[a]pyrene diol epoxide I | increases expression | ISO | PUM2 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PUM2 mRNA | CTD | PMID:26238291 | Pum2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PUM2 mRNA | CTD | PMID:25181051 | Pum2 | Rat | bisphenol A | affects splicing | ISO | Pum2 (Mus musculus) | 6480464 | bisphenol A affects the splicing of PUM2 mRNA | CTD | PMID:37894381 | Pum2 | Rat | bisphenol A | increases expression | ISO | Pum2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PUM2 mRNA | CTD | PMID:33221593 | Pum2 | Rat | bisphenol F | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Pum2 | Rat | Butylbenzyl phthalate | decreases methylation | ISO | Pum2 (Mus musculus) | 6480464 | butylbenzyl phthalate results in decreased methylation of PUM2 intron | CTD | PMID:28392331 | Pum2 | Rat | cadmium atom | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PUM2 more ... | CTD | PMID:35301059 | Pum2 | Rat | cadmium atom | multiple interactions | ISO | Pum2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PUM2 more ... | CTD | PMID:37236586 | Pum2 | Rat | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of PUM2 mRNA | CTD | PMID:21297351 | Pum2 | Rat | cadmium dichloride | multiple interactions | ISO | Pum2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PUM2 more ... | CTD | PMID:37236586 | Pum2 | Rat | cadmium dichloride | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PUM2 more ... | CTD | PMID:35301059 | Pum2 | Rat | caffeine | affects phosphorylation | ISO | PUM2 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PUM2 protein | CTD | PMID:35688186 | Pum2 | Rat | calciol | increases expression | ISO | Pum2 (Mus musculus) | 6480464 | Cholecalciferol results in increased expression of PUM2 mRNA | CTD | PMID:16508948 | Pum2 | Rat | carbon nanotube | decreases expression | ISO | Pum2 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of PUM2 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Pum2 | Rat | copper(II) sulfate | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of PUM2 mRNA | CTD | PMID:19549813 | Pum2 | Rat | coumarin | increases phosphorylation | ISO | PUM2 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of PUM2 protein | CTD | PMID:35688186 | Pum2 | Rat | cyclosporin A | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PUM2 mRNA | CTD | PMID:25562108 | Pum2 | Rat | dexamethasone | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Pum2 | Rat | dibenzo[a,l]pyrene | increases expression | ISO | Pum2 (Mus musculus) | 6480464 | dibenzo(a,l)pyrene results in increased expression of PUM2 mRNA | CTD | PMID:25908611 | Pum2 | Rat | doxorubicin | increases expression | ISO | Pum2 (Mus musculus) | 6480464 | Doxorubicin results in increased expression of PUM2 mRNA | CTD | PMID:17888722 | Pum2 | Rat | doxorubicin | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | PUM2 protein inhibits the reaction [Doxorubicin results in increased expression of MFF protein] | CTD | PMID:37406984 | Pum2 | Rat | doxorubicin | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PUM2 mRNA | CTD | PMID:29803840 | Pum2 | Rat | ethanol | multiple interactions | ISO | Pum2 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of PUM2 mRNA | CTD | PMID:30319688 | Pum2 | Rat | folic acid | multiple interactions | ISO | Pum2 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PUM2 mRNA | CTD | PMID:22206623 | Pum2 | Rat | formaldehyde | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PUM2 mRNA | CTD | PMID:20655997 | Pum2 | Rat | FR900359 | affects phosphorylation | ISO | PUM2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PUM2 protein | CTD | PMID:37730182 | Pum2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PUM2 mRNA | CTD | PMID:22061828 | Pum2 | Rat | indometacin | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Pum2 | Rat | ivermectin | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PUM2 protein | CTD | PMID:32959892 | Pum2 | Rat | Nutlin-3 | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of PUM2 protein | CTD | PMID:38460933 | Pum2 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PUM2 mRNA | CTD | PMID:25729387 | Pum2 | Rat | paracetamol | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PUM2 mRNA | CTD | PMID:21420995 | Pum2 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PUM2 mRNA | CTD | PMID:33387578 | Pum2 | Rat | propiconazole | decreases expression | ISO | Pum2 (Mus musculus) | 6480464 | propiconazole results in decreased expression of PUM2 mRNA | CTD | PMID:21278054 | Pum2 | Rat | sunitinib | increases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PUM2 mRNA | CTD | PMID:31533062 | Pum2 | Rat | tamoxifen | affects expression | ISO | Pum2 (Mus musculus) | 6480464 | Tamoxifen affects the expression of PUM2 mRNA | CTD | PMID:20937368 | Pum2 | Rat | tert-butyl hydroperoxide | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of PUM2 mRNA | CTD | PMID:15336504 | Pum2 | Rat | titanium dioxide | increases expression | ISO | Pum2 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of PUM2 mRNA | CTD | PMID:29264374 | Pum2 | Rat | titanium dioxide | decreases methylation | ISO | Pum2 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of PUM2 promoter | CTD | PMID:35295148 | Pum2 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PUM2 mRNA | CTD | PMID:25729387 | Pum2 | Rat | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of PUM2 mRNA | CTD | PMID:25729387 | Pum2 | Rat | trichostatin A | affects expression | ISO | PUM2 (Homo sapiens) | 6480464 | trichostatin A affects the expression of PUM2 mRNA | CTD | PMID:28542535 | Pum2 | Rat | triptonide | decreases expression | ISO | Pum2 (Mus musculus) | 6480464 | triptonide results in decreased expression of PUM2 mRNA | CTD | PMID:33045310 | Pum2 | Rat | troglitazone | decreases expression | ISO | Pum2 (Mus musculus) | 6480464 | troglitazone results in decreased expression of PUM2 mRNA | CTD | PMID:28973697 | Pum2 | Rat | valproic acid | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PUM2 mRNA | CTD | PMID:23179753 | Pum2 | Rat | valproic acid | affects expression | ISO | PUM2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PUM2 mRNA | CTD | PMID:25979313 | Pum2 | Rat | valproic acid | decreases methylation | ISO | PUM2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of PUM2 gene | CTD | PMID:29154799 | Pum2 | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of PUM2 mRNA | CTD | PMID:20566332 | | 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