Trim2 (tripartite motif-containing 2) - Rat Genome Database

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Gene: Trim2 (tripartite motif-containing 2) Rattus norvegicus
Analyze
Symbol: Trim2
Name: tripartite motif-containing 2
RGD ID: 1310981
Description: Predicted to enable translation repressor activity and ubiquitin protein ligase activity. Involved in regulation of neuron apoptotic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase TRIM2; LOC361970; RING-type E3 ubiquitin transferase TRIM2; tripartite motif protein 2; tripartite motif-containing protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,798,654 - 171,950,193 (-)NCBIGRCr8
mRatBN7.22169,500,628 - 169,652,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,500,634 - 169,652,927 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,680,473 - 176,744,037 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,700,406 - 174,763,965 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02169,301,891 - 169,365,450 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02183,145,096 - 183,223,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2183,145,089 - 183,213,228 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,557,491 - 202,635,138 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,908,880 - 175,974,709 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,863,388 - 175,937,931 (-)NCBI
Celera2163,500,875 - 163,564,336 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenthion  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glafenine  (EXP)
haloperidol  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
Monobutylphthalate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. Thompson S, etal., J Biol Chem. 2011 Jun 3;286(22):19331-9. doi: 10.1074/jbc.M110.197707. Epub 2011 Apr 8.
Additional References at PubMed
PMID:11331580   PMID:18687884   PMID:20439489   PMID:22871113   PMID:30053369   PMID:34291866  


Genomics

Comparative Map Data
Trim2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,798,654 - 171,950,193 (-)NCBIGRCr8
mRatBN7.22169,500,628 - 169,652,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,500,634 - 169,652,927 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,680,473 - 176,744,037 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,700,406 - 174,763,965 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02169,301,891 - 169,365,450 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02183,145,096 - 183,223,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2183,145,089 - 183,213,228 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,557,491 - 202,635,138 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,908,880 - 175,974,709 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,863,388 - 175,937,931 (-)NCBI
Celera2163,500,875 - 163,564,336 (-)NCBICelera
Cytogenetic Map2q34NCBI
TRIM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384153,152,163 - 153,339,317 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4153,152,163 - 153,339,319 (+)EnsemblGRCh38hg38GRCh38
GRCh374154,073,315 - 154,260,469 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,345,068 - 154,479,918 (+)NCBINCBI36Build 36hg18NCBI36
Build 344154,483,222 - 154,618,073NCBI
Celera4151,399,157 - 151,585,007 (+)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4149,803,365 - 149,990,685 (+)NCBIHuRef
CHM1_14154,052,715 - 154,238,856 (+)NCBICHM1_1
T2T-CHM13v2.04156,476,134 - 156,663,746 (+)NCBIT2T-CHM13v2.0
Trim2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39384,067,746 - 84,215,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl384,067,746 - 84,214,184 (-)EnsemblGRCm39 Ensembl
GRCm38384,160,439 - 84,308,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl384,160,439 - 84,306,877 (-)EnsemblGRCm38mm10GRCm38
MGSCv37383,965,796 - 84,024,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36384,246,372 - 84,306,788 (-)NCBIMGSCv36mm8
Celera384,177,689 - 84,237,141 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map337.48NCBI
Trim2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554717,594,966 - 7,698,436 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554717,523,895 - 7,698,436 (+)NCBIChiLan1.0ChiLan1.0
TRIM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23151,039,730 - 151,226,923 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14151,395,200 - 151,582,377 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04145,494,088 - 145,681,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14157,142,848 - 157,505,076 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4157,194,729 - 157,500,723 (+)Ensemblpanpan1.1panPan2
TRIM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11550,973,758 - 51,104,422 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1551,319,416 - 51,489,077 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01551,659,617 - 51,829,346 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1551,659,268 - 51,914,299 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11550,915,722 - 51,085,018 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01551,020,608 - 51,190,049 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01551,332,156 - 51,501,600 (+)NCBIUU_Cfam_GSD_1.0
Trim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530139,343,970 - 39,533,148 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493657688,024 - 202,958 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493657688,163 - 202,944 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl875,771,048 - 75,890,357 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1875,770,344 - 75,939,812 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2880,265,933 - 80,456,479 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRIM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1799,702,874 - 99,888,024 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl799,807,646 - 99,888,340 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603779,355,282 - 79,541,794 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trim2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248584,554,681 - 4,667,312 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248584,509,893 - 4,683,241 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trim2
825 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000067618
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat

Markers in Region
D2Rat285  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22169,603,652 - 169,603,847 (+)MAPPERmRatBN7.2
Rnor_6.02183,263,650 - 183,263,848NCBIRnor6.0
Rnor_5.02202,674,460 - 202,674,658UniSTSRnor5.0
RGSC_v3.42176,013,955 - 176,014,154RGDRGSC3.4
RGSC_v3.42176,013,956 - 176,014,154UniSTSRGSC3.4
RGSC_v3.12175,964,061 - 175,964,260RGD
Celera2163,603,615 - 163,603,801UniSTS
SHRSP x BN Map270.0198RGD
SHRSP x BN Map270.0198UniSTS
Cytogenetic Map2q34UniSTS
RH142568  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22169,602,894 - 169,603,146 (+)MAPPERmRatBN7.2
Rnor_6.02183,262,892 - 183,263,143NCBIRnor6.0
Rnor_5.02202,673,702 - 202,673,953UniSTSRnor5.0
RGSC_v3.42176,013,198 - 176,013,449UniSTSRGSC3.4
Celera2163,602,857 - 163,603,108UniSTS
RH 3.4 Map21106.8UniSTS
Cytogenetic Map2q34UniSTS
AI103312  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22169,501,362 - 169,501,542 (+)MAPPERmRatBN7.2
Rnor_6.02183,145,825 - 183,146,004NCBIRnor6.0
Rnor_5.02202,558,220 - 202,558,399UniSTSRnor5.0
RGSC_v3.42175,909,609 - 175,909,788UniSTSRGSC3.4
Celera2163,501,604 - 163,501,783UniSTS
RH 3.4 Map21103.4UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 2 2 2 74 34 33 11
Low 37 55 39 19 39 8 10 1 3 8
Below cutoff 1 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY724524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000067618   ⟹   ENSRNOP00000060362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2169,500,634 - 169,564,422 (-)Ensembl
Rnor_6.0 Ensembl2183,149,174 - 183,213,228 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085382   ⟹   ENSRNOP00000072306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2169,500,634 - 169,615,488 (-)Ensembl
Rnor_6.0 Ensembl2183,145,089 - 183,210,799 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107931   ⟹   ENSRNOP00000082573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2169,500,634 - 169,652,927 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115052   ⟹   ENSRNOP00000083943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2169,500,634 - 169,603,901 (-)Ensembl
RefSeq Acc Id: NM_001108552   ⟹   NP_001102022
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,660 - 171,862,444 (-)NCBI
mRatBN7.22169,500,634 - 169,564,422 (-)NCBI
Rnor_6.02183,145,096 - 183,223,819 (-)NCBI
Rnor_5.02202,557,491 - 202,635,138 (-)NCBI
RGSC_v3.42175,908,880 - 175,974,709 (-)RGD
Celera2163,500,875 - 163,564,336 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102638   ⟹   XP_038958566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,654 - 171,902,115 (-)NCBI
mRatBN7.22169,500,628 - 169,604,091 (-)NCBI
RefSeq Acc Id: XM_039102639   ⟹   XP_038958567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,654 - 171,902,115 (-)NCBI
mRatBN7.22169,500,628 - 169,604,091 (-)NCBI
RefSeq Acc Id: XM_039102640   ⟹   XP_038958568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,805,920 - 171,902,115 (-)NCBI
mRatBN7.22169,508,765 - 169,604,091 (-)NCBI
RefSeq Acc Id: XM_039102641   ⟹   XP_038958569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,805,921 - 171,902,115 (-)NCBI
mRatBN7.22169,508,765 - 169,604,091 (-)NCBI
RefSeq Acc Id: XM_039102642   ⟹   XP_038958570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,654 - 171,913,461 (-)NCBI
mRatBN7.22169,500,628 - 169,615,418 (-)NCBI
RefSeq Acc Id: XM_039102643   ⟹   XP_038958571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,654 - 171,862,484 (-)NCBI
mRatBN7.22169,500,628 - 169,564,461 (-)NCBI
RefSeq Acc Id: XM_039102644   ⟹   XP_038958572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,654 - 171,902,115 (-)NCBI
mRatBN7.22169,500,628 - 169,604,091 (-)NCBI
RefSeq Acc Id: XM_039102646   ⟹   XP_038958574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,654 - 171,950,193 (-)NCBI
mRatBN7.22169,500,628 - 169,652,135 (-)NCBI
RefSeq Acc Id: XM_039102648   ⟹   XP_038958576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,654 - 171,862,459 (-)NCBI
mRatBN7.22169,500,628 - 169,564,410 (-)NCBI
RefSeq Acc Id: XM_063282118   ⟹   XP_063138188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,654 - 171,913,461 (-)NCBI
RefSeq Acc Id: XM_063282119   ⟹   XP_063138189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,654 - 171,859,677 (-)NCBI
RefSeq Acc Id: XM_063282120   ⟹   XP_063138190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,798,654 - 171,862,530 (-)NCBI
RefSeq Acc Id: NP_001102022   ⟸   NM_001108552
- UniProtKB: D3ZM62 (UniProtKB/TrEMBL),   A0A8I5ZV62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060362   ⟸   ENSRNOT00000067618
RefSeq Acc Id: ENSRNOP00000072306   ⟸   ENSRNOT00000085382
RefSeq Acc Id: XP_038958574   ⟸   XM_039102646
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038958570   ⟸   XM_039102642
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZV62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958572   ⟸   XM_039102644
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038958567   ⟸   XM_039102639
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZY23 (UniProtKB/TrEMBL),   A0A8I5ZV62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958566   ⟸   XM_039102638
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZV62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958571   ⟸   XM_039102643
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038958576   ⟸   XM_039102648
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZV62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958569   ⟸   XM_039102641
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZV62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958568   ⟸   XM_039102640
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZV62 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083943   ⟸   ENSRNOT00000115052
RefSeq Acc Id: ENSRNOP00000082573   ⟸   ENSRNOT00000107931
RefSeq Acc Id: XP_063138188   ⟸   XM_063282118
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063138190   ⟸   XM_063282120
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063138189   ⟸   XM_063282119
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZV62 (UniProtKB/TrEMBL)
Protein Domains
B box-type   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQG6-F1-model_v2 AlphaFold D3ZQG6 1-744 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310981 AgrOrtholog
BioCyc Gene G2FUF-52642 BioCyc
Ensembl Genes ENSRNOG00000010124 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067618 ENTREZGENE
  ENSRNOT00000067618.3 UniProtKB/TrEMBL
  ENSRNOT00000085382.2 UniProtKB/TrEMBL
  ENSRNOT00000107931.1 UniProtKB/TrEMBL
  ENSRNOT00000115052.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bbox_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Filamin/ABP280_repeat-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Filamin/ABP280_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHL_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf-RING_LisH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_B-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 361970 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIPARTITE MOTIF-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filamin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-B_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-RING_UBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trim2 PhenoGen
PROSITE FILAMIN_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010124 RatGTEx
SMART BBC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_FLMN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHL repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2M8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV62 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZY23 ENTREZGENE, UniProtKB/TrEMBL
  D3ZM62 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQG6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-05-01 Trim2  tripartite motif-containing 2  Trim2  tripartite motif protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Trim2  tripartite motif protein 2  Trim2_predicted  tripartite motif protein 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Trim2_predicted  tripartite motif protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED