Sorcs3 (sortilin-related VPS10 domain containing receptor 3) - Rat Genome Database

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Gene: Sorcs3 (sortilin-related VPS10 domain containing receptor 3) Rattus norvegicus
Analyze
Symbol: Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
RGD ID: 1310974
Description: Predicted to be involved in postsynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within learning; memory; and regulation of long-term synaptic depression. Predicted to be located in postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human SORCS3 (sortilin related VPS10 domain containing receptor 3); INTERACTS WITH 3,4-methylenedioxymethamphetamine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC294043; VPS10 domain-containing receptor SorCS3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Sorcs3em1Mcwi  
Genetic Models: FHH-Chr 1BN-Sorcs3em1Mcwi
Candidate Gene For: Niddm64
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81257,040,442 - 257,675,259 (+)NCBIGRCr8
mRatBN7.21247,099,178 - 247,734,027 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1247,099,408 - 247,734,027 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1255,232,260 - 255,850,872 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01261,925,106 - 262,543,709 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01254,569,425 - 255,196,136 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01267,986,305 - 268,620,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1268,189,277 - 268,620,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01275,416,357 - 276,060,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41254,125,935 - 254,345,330 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11254,170,074 - 254,608,437 (+)NCBI
Celera1242,858,847 - 243,481,607 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:24069373  


Genomics

Comparative Map Data
Sorcs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81257,040,442 - 257,675,259 (+)NCBIGRCr8
mRatBN7.21247,099,178 - 247,734,027 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1247,099,408 - 247,734,027 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1255,232,260 - 255,850,872 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01261,925,106 - 262,543,709 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01254,569,425 - 255,196,136 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01267,986,305 - 268,620,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1268,189,277 - 268,620,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01275,416,357 - 276,060,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41254,125,935 - 254,345,330 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11254,170,074 - 254,608,437 (+)NCBI
Celera1242,858,847 - 243,481,607 (+)NCBICelera
Cytogenetic Map1q55NCBI
SORCS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810104,641,290 - 105,265,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10104,641,290 - 105,265,242 (+)EnsemblGRCh38hg38GRCh38
GRCh3710106,401,048 - 107,025,000 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610106,390,849 - 107,014,983 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410106,390,848 - 107,014,983NCBI
Celera10100,141,671 - 100,765,737 (+)NCBICelera
Cytogenetic Map10q25.1NCBI
HuRef10100,032,497 - 100,656,979 (+)NCBIHuRef
CHM1_110106,685,564 - 107,309,603 (+)NCBICHM1_1
T2T-CHM13v2.010105,529,365 - 106,155,464 (+)NCBIT2T-CHM13v2.0
Sorcs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391948,194,464 - 48,793,944 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1948,194,464 - 48,793,944 (+)EnsemblGRCm39 Ensembl
GRCm381948,206,025 - 48,805,505 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1948,206,025 - 48,805,505 (+)EnsemblGRCm38mm10GRCm38
MGSCv371948,280,515 - 48,879,995 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361948,259,336 - 48,858,816 (+)NCBIMGSCv36mm8
Celera1949,156,016 - 49,565,154 (+)NCBICelera
Cytogenetic Map19D1NCBI
cM Map1941.32NCBI
Sorcs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554855,475,942 - 5,884,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554855,474,081 - 6,048,912 (-)NCBIChiLan1.0ChiLan1.0
SORCS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28116,526,661 - 117,143,392 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110116,531,986 - 117,148,724 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010101,239,765 - 101,856,507 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110104,697,769 - 105,314,224 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10104,697,113 - 105,312,364 (+)Ensemblpanpan1.1panPan2
SORCS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12816,909,908 - 17,491,097 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2816,909,856 - 17,489,418 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2817,081,570 - 17,662,475 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02817,388,943 - 17,978,933 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2817,387,965 - 17,978,934 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12816,934,694 - 17,515,723 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02816,969,837 - 17,553,022 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02817,102,540 - 17,684,150 (+)NCBIUU_Cfam_GSD_1.0
LOC101961565
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721329,437,059 - 30,007,274 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366001,042,135 - 1,609,783 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366001,040,284 - 1,610,474 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SORCS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14115,587,821 - 116,198,106 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114115,587,176 - 116,202,433 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214125,749,549 - 126,181,434 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SORCS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1997,688,826 - 98,299,715 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl997,883,836 - 98,299,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604858,813,649 - 59,431,355 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sorcs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248313,665,233 - 4,240,825 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248313,665,218 - 4,241,384 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sorcs3
4497 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:31
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000065001
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1247683763248192604Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1245907761257976495Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat

Markers in Region
D1Got247  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21247,683,763 - 247,683,883 (+)MAPPERmRatBN7.2
Rnor_6.01268,570,074 - 268,570,193NCBIRnor6.0
Rnor_5.01276,009,949 - 276,010,068UniSTSRnor5.0
RGSC_v3.41254,291,806 - 254,291,924RGDRGSC3.4
RGSC_v3.41254,291,807 - 254,291,926UniSTSRGSC3.4
RGSC_v3.11254,556,550 - 254,556,668RGD
Celera1243,431,391 - 243,431,510UniSTS
RH 3.4 Map11647.7UniSTS
RH 3.4 Map11647.7RGD
RH 2.0 Map11250.7RGD
Cytogenetic Map1q54-q55UniSTS
D1Got249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21247,115,893 - 247,116,042 (+)MAPPERmRatBN7.2
Rnor_6.01268,003,021 - 268,003,169NCBIRnor6.0
Rnor_5.01275,433,073 - 275,433,221UniSTSRnor5.0
RGSC_v3.41253,688,040 - 253,688,189RGDRGSC3.4
RGSC_v3.41253,688,041 - 253,688,189UniSTSRGSC3.4
RGSC_v3.11253,952,785 - 253,952,933RGD
Celera1242,875,508 - 242,875,656UniSTS
RH 3.4 Map11647.9UniSTS
RH 3.4 Map11647.9RGD
RH 2.0 Map11262.4RGD
Cytogenetic Map1q54-q55UniSTS
D1Hmgc2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21247,043,567 - 247,043,744 (-)MAPPERmRatBN7.2
mRatBN7.21247,043,567 - 247,043,744 (+)MAPPERmRatBN7.2
Rnor_6.01271,634,068 - 271,634,244NCBIRnor6.0
Rnor_6.01267,930,651 - 267,930,827NCBIRnor6.0
Rnor_5.01279,062,109 - 279,062,285UniSTSRnor5.0
Rnor_5.01275,360,757 - 275,360,933UniSTSRnor5.0
RGSC_v3.41253,613,367 - 253,613,543UniSTSRGSC3.4
RGSC_v3.41253,613,347 - 253,613,632RGDRGSC3.4
Celera1242,803,303 - 242,803,479UniSTS
RH 3.4 Map11647.9RGD
RH 3.4 Map11647.9UniSTS
Cytogenetic Map1q54-q55UniSTS


Genetic Models
This gene Sorcs3 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 48 6 5
Low 4 2 26 16 25 8
Below cutoff 2 22 25 11 10 11 7 10 13 9 3 7

Sequence


RefSeq Acc Id: ENSRNOT00000065001   ⟹   ENSRNOP00000059656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1247,099,408 - 247,734,027 (+)Ensembl
Rnor_6.0 Ensembl1268,189,277 - 268,620,331 (+)Ensembl
RefSeq Acc Id: NM_001106367   ⟹   NP_001099837
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81257,040,442 - 257,675,259 (+)NCBI
mRatBN7.21247,099,178 - 247,734,027 (+)NCBI
Rnor_6.01267,986,305 - 268,620,331 (+)NCBI
Rnor_5.01275,416,357 - 276,060,204 (+)NCBI
RGSC_v3.41254,125,935 - 254,345,330 (+)RGD
Celera1242,858,847 - 243,481,607 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099837 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94398 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059656.4
RefSeq Acc Id: NP_001099837   ⟸   NM_001106367
- Peptide Label: precursor
- UniProtKB: D4A2I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059656   ⟸   ENSRNOT00000065001
Protein Domains
PKD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2I9-F1-model_v2 AlphaFold D4A2I9 1-1013 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310974 AgrOrtholog
BioCyc Gene G2FUF-55452 BioCyc
Ensembl Genes ENSRNOG00000028832 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065001.4 UniProtKB/TrEMBL
Gene3D-CATH 2.10.70.80 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  3.30.60.270 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  PKD_dom UniProtKB/TrEMBL
  PKD_dom_sf UniProtKB/TrEMBL
  Sortilin_C UniProtKB/TrEMBL
  Sortilin_N UniProtKB/TrEMBL
  VPS10 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
KEGG Report rno:294043 UniProtKB/TrEMBL
NCBI Gene 294043 ENTREZGENE
PANTHER SORTILIN RELATED UniProtKB/TrEMBL
  VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3 UniProtKB/TrEMBL
Pfam PKD UniProtKB/TrEMBL
  Sortilin-Vps10 UniProtKB/TrEMBL
  Sortilin_C UniProtKB/TrEMBL
PhenoGen Sorcs3 PhenoGen
PROSITE PKD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028832 RatGTEx
SMART VPS10 UniProtKB/TrEMBL
Superfamily-SCOP Oligoxyloglucan reducing end-specific cellobiohydrolase UniProtKB/TrEMBL
  PKD UniProtKB/TrEMBL
UniProt D4A2I9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Sorcs3  sortilin-related VPS10 domain containing receptor 3   Sorcs3_predicted  sortilin-related VPS10 domain containing receptor 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sorcs3_predicted  sortilin-related VPS10 domain containing receptor 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED