Kbtbd3 (kelch repeat and BTB domain containing 3) - Rat Genome Database

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Gene: Kbtbd3 (kelch repeat and BTB domain containing 3) Rattus norvegicus
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Symbol: Kbtbd3
Name: kelch repeat and BTB domain containing 3
RGD ID: 1310895
Description: Orthologous to human KBTBD3 (kelch repeat and BTB domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kelch repeat and BTB (POZ) domain containing 3; kelch repeat and BTB domain-containing protein 3; LOC315394
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr889,749,229 - 9,780,036 (+)NCBIGRCr8
mRatBN7.281,464,162 - 1,491,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl81,473,247 - 1,487,943 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx85,460,724 - 5,475,419 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.083,758,459 - 3,773,154 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.081,704,609 - 1,719,304 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.081,450,345 - 1,477,250 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl81,459,526 - 1,476,837 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.081,444,771 - 1,475,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48867,248 - 881,944 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18867,416 - 881,706 (+)NCBI
Celera81,356,521 - 1,371,217 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics

Comparative Map Data
Kbtbd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr889,749,229 - 9,780,036 (+)NCBIGRCr8
mRatBN7.281,464,162 - 1,491,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl81,473,247 - 1,487,943 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx85,460,724 - 5,475,419 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.083,758,459 - 3,773,154 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.081,704,609 - 1,719,304 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.081,450,345 - 1,477,250 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl81,459,526 - 1,476,837 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.081,444,771 - 1,475,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48867,248 - 881,944 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18867,416 - 881,706 (+)NCBI
Celera81,356,521 - 1,371,217 (+)NCBICelera
Cytogenetic Map8q11NCBI
KBTBD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811106,051,098 - 106,077,347 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11106,051,098 - 106,077,459 (-)EnsemblGRCh38hg38GRCh38
GRCh3711105,921,825 - 105,948,074 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611105,427,035 - 105,453,396 (-)NCBINCBI36Build 36hg18NCBI36
Celera11103,086,081 - 103,112,731 (-)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11101,852,912 - 101,879,565 (-)NCBIHuRef
CHM1_111105,804,799 - 105,831,434 (-)NCBICHM1_1
T2T-CHM13v2.011106,055,698 - 106,081,959 (-)NCBIT2T-CHM13v2.0
Kbtbd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3994,309,743 - 4,331,829 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl94,309,833 - 4,331,732 (+)EnsemblGRCm39 Ensembl
GRCm3894,309,743 - 4,331,829 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl94,309,833 - 4,331,732 (+)EnsemblGRCm38mm10GRCm38
MGSCv3794,309,743 - 4,331,732 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3694,309,835 - 4,331,711 (+)NCBIMGSCv36mm8
Celera3118,371,675 - 118,393,631 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Kbtbd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554128,703,075 - 8,713,929 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554128,703,075 - 8,723,628 (-)NCBIChiLan1.0ChiLan1.0
KBTBD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29106,799,342 - 106,825,681 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111107,893,916 - 107,920,243 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011100,938,438 - 100,969,353 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111104,426,554 - 104,453,162 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11104,426,554 - 104,453,162 (-)Ensemblpanpan1.1panPan2
KBTBD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1526,193,776 - 26,225,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl526,194,536 - 26,225,471 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha526,118,723 - 26,150,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0526,222,004 - 26,254,114 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl526,222,145 - 26,254,030 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1526,272,609 - 26,304,462 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0526,157,912 - 26,189,839 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0526,307,496 - 26,339,464 (+)NCBIUU_Cfam_GSD_1.0
Kbtbd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494789,179,024 - 89,200,649 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365512,335,283 - 2,354,099 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365512,335,860 - 2,353,936 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KBTBD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl935,874,041 - 35,903,729 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1935,870,911 - 35,903,870 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2939,910,814 - 39,940,142 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KBTBD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,451,496 - 97,475,592 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,449,724 - 97,475,364 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604328,408,260 - 28,435,514 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kbtbd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624784849,924 - 868,991 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624784843,934 - 869,184 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kbtbd3
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:14
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000034503
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)813402289Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 6 117 9
Low 21 141 215 147 63 147 36 45 133 115 136 57 24
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000034503   ⟹   ENSRNOP00000035320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl81,459,526 - 1,476,837 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120313   ⟹   ENSRNOP00000085465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl81,473,247 - 1,487,943 (+)Ensembl
RefSeq Acc Id: NM_001108121   ⟹   NP_001101591
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,758,190 - 9,772,886 (+)NCBI
mRatBN7.281,473,247 - 1,487,943 (+)NCBI
Rnor_6.081,459,351 - 1,474,047 (+)NCBI
Rnor_5.081,444,771 - 1,475,837 (+)NCBI
RGSC_v3.48867,248 - 881,944 (+)RGD
Celera81,356,521 - 1,371,217 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242474   ⟹   XP_006242536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,749,229 - 9,776,087 (+)NCBI
mRatBN7.281,464,194 - 1,491,144 (+)NCBI
Rnor_6.081,450,345 - 1,477,250 (+)NCBI
Rnor_5.081,444,771 - 1,475,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242476   ⟹   XP_006242538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,749,395 - 9,780,036 (+)NCBI
mRatBN7.281,464,430 - 1,491,144 (+)NCBI
Rnor_6.081,450,535 - 1,477,250 (+)NCBI
Rnor_5.081,444,771 - 1,475,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242477   ⟹   XP_006242539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,749,395 - 9,780,036 (+)NCBI
mRatBN7.281,471,287 - 1,491,144 (+)NCBI
Rnor_6.081,457,429 - 1,477,250 (+)NCBI
Rnor_5.081,444,771 - 1,475,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242478   ⟹   XP_006242540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,749,288 - 9,780,036 (+)NCBI
mRatBN7.281,464,162 - 1,491,144 (+)NCBI
Rnor_6.081,450,345 - 1,477,250 (+)NCBI
Rnor_5.081,444,771 - 1,475,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081335   ⟹   XP_038937263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,749,488 - 9,780,036 (+)NCBI
mRatBN7.281,464,430 - 1,491,144 (+)NCBI
RefSeq Acc Id: XM_039081336   ⟹   XP_038937264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,749,634 - 9,780,036 (+)NCBI
mRatBN7.281,470,571 - 1,491,144 (+)NCBI
RefSeq Acc Id: NP_001101591   ⟸   NM_001108121
- UniProtKB: D4A7F5 (UniProtKB/TrEMBL),   A6KQJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242536   ⟸   XM_006242474
- Peptide Label: isoform X1
- UniProtKB: D4A7F5 (UniProtKB/TrEMBL),   A6KQJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242540   ⟸   XM_006242478
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006242538   ⟸   XM_006242476
- Peptide Label: isoform X1
- UniProtKB: D4A7F5 (UniProtKB/TrEMBL),   A6KQJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242539   ⟸   XM_006242477
- Peptide Label: isoform X1
- UniProtKB: D4A7F5 (UniProtKB/TrEMBL),   A6KQJ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035320   ⟸   ENSRNOT00000034503
RefSeq Acc Id: XP_038937263   ⟸   XM_039081335
- Peptide Label: isoform X1
- UniProtKB: D4A7F5 (UniProtKB/TrEMBL),   A6KQJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937264   ⟸   XM_039081336
- Peptide Label: isoform X1
- UniProtKB: D4A7F5 (UniProtKB/TrEMBL),   A6KQJ4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085465   ⟸   ENSRNOT00000120313
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7F5-F1-model_v2 AlphaFold D4A7F5 1-607 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310895 AgrOrtholog
BioCyc Gene G2FUF-31837 BioCyc
Ensembl Genes ENSRNOG00000022252 Ensembl
  ENSRNOG00000069206 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000120313.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  KBTBD3 UniProtKB/TrEMBL
  KBTBD3_BACK UniProtKB/TrEMBL
  Kelch-like_gigaxonin UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
KEGG Report rno:315394 UniProtKB/TrEMBL
NCBI Gene 315394 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/TrEMBL
  PTHR24412:SF418 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PhenoGen Kbtbd3 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022252 RatGTEx
  ENSRNOG00000069206 RatGTEx
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
UniProt A6KQJ4 ENTREZGENE, UniProtKB/TrEMBL
  D4A7F5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kbtbd3  kelch repeat and BTB domain containing 3  Kbtbd3  kelch repeat and BTB (POZ) domain containing 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Kbtbd3  kelch repeat and BTB (POZ) domain containing 3   Kbtbd3_predicted  kelch repeat and BTB (POZ) domain containing 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Kbtbd3_predicted  kelch repeat and BTB (POZ) domain containing 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED