Nfkbiz (NFKB inhibitor zeta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nfkbiz (NFKB inhibitor zeta) Rattus norvegicus
Analyze
Symbol: Nfkbiz
Name: NFKB inhibitor zeta
RGD ID: 1310834
Description: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coregulator activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune response; and response to bacterium. Predicted to act upstream of or within inflammatory response. Predicted to be located in cytoplasmic ribonucleoprotein granule and nuclear speck. Predicted to be active in nucleus. Orthologous to human NFKBIZ (NFKB inhibitor zeta); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IkappaB-zeta; LOC304005; Mail; molecule possessing ankyrin-repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta; RGD1310834; similar to molecule possessing ankyrin-repeats induced by lipopolysaccharide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81158,251,720 - 58,279,767 (+)NCBIGRCr8
mRatBN7.21144,782,676 - 44,810,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,782,676 - 44,810,723 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1153,559,179 - 53,587,222 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01146,220,825 - 46,248,868 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01145,344,968 - 45,373,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01147,243,342 - 47,271,487 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1147,243,342 - 47,271,487 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,420,563 - 50,447,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,776,027 - 45,811,515 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11145,851,817 - 45,867,783 (+)NCBI
Celera1144,534,358 - 44,562,504 (+)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
fenoldopam  (EXP)
fipronil  (EXP)
fluoranthene  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-nitrosodimethylamine  (EXP)
oroxylin A  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
yohimbine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO)
B cell proliferation  (ISO)
B cell receptor apoptotic signaling pathway  (ISO)
B cell receptor signaling pathway  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to interleukin-17  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromatin organization  (ISO)
chromatin remodeling  (ISO)
chronic inflammatory response  (ISO)
cytokine-mediated signaling pathway  (ISO)
defense response to Gram-negative bacterium  (ISO)
epithelial cell apoptotic process  (ISO)
establishment of skin barrier  (ISO)
execution phase of apoptosis  (ISO)
gene expression  (ISO)
homeostasis of number of cells within a tissue  (ISO)
immunoglobulin mediated immune response  (ISO)
inflammatory response  (ISO)
inflammatory response to wounding  (ISO)
isotype switching  (ISO)
keratinocyte activation  (ISO)
keratinocyte differentiation  (ISO)
keratinocyte proliferation  (ISO)
lymphocyte activation involved in immune response  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
plasma cell differentiation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of T-helper 17 cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of gene expression  (IBA)
regulation of immune response  (ISO)
response to cisplatin  (ISO)
response to cytokine  (ISO)
response to folic acid  (ISO)
response to Gram-positive bacterium  (ISO)
response to lipopolysaccharide  (ISO)
response to xenobiotic stimulus  (ISO)
skin development  (ISO)
skin epidermis development  (ISO)
spleen development  (ISO)
T cell differentiation  (ISO)
T cell mediated immunity  (ISO)
T cell receptor signaling pathway  (ISO)
T-helper 1 cell differentiation  (ISO)
T-helper 17 cell differentiation  (ISO)
toll-like receptor signaling pathway  (ISO)
transcription by RNA polymerase II  (ISO)
transcription preinitiation complex assembly  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11086164   PMID:23071313   PMID:25282160   PMID:28099916  


Genomics

Comparative Map Data
Nfkbiz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81158,251,720 - 58,279,767 (+)NCBIGRCr8
mRatBN7.21144,782,676 - 44,810,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,782,676 - 44,810,723 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1153,559,179 - 53,587,222 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01146,220,825 - 46,248,868 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01145,344,968 - 45,373,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01147,243,342 - 47,271,487 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1147,243,342 - 47,271,487 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,420,563 - 50,447,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,776,027 - 45,811,515 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11145,851,817 - 45,867,783 (+)NCBI
Celera1144,534,358 - 44,562,504 (+)NCBICelera
Cytogenetic Map11q12NCBI
NFKBIZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383101,827,990 - 101,861,022 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3101,827,991 - 101,861,022 (+)EnsemblGRCh38hg38GRCh38
GRCh373101,546,834 - 101,579,866 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363103,029,547 - 103,062,556 (+)NCBINCBI36Build 36hg18NCBI36
Build 343103,051,047 - 103,062,555NCBI
Celera399,940,218 - 99,973,254 (+)NCBICelera
Cytogenetic Map3q12.3NCBI
HuRef398,915,528 - 98,948,489 (+)NCBIHuRef
CHM1_13101,510,104 - 101,543,165 (+)NCBICHM1_1
T2T-CHM13v2.03104,540,783 - 104,573,840 (+)NCBIT2T-CHM13v2.0
Nfkbiz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391655,631,740 - 55,659,018 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1655,631,738 - 55,659,262 (-)EnsemblGRCm39 Ensembl
GRCm381655,811,375 - 55,838,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1655,811,375 - 55,838,899 (-)EnsemblGRCm38mm10GRCm38
MGSCv371655,811,490 - 55,838,754 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361655,736,329 - 55,763,805 (-)NCBIMGSCv36mm8
Celera1656,126,905 - 56,154,128 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1633.65NCBI
Nfkbiz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554273,350,174 - 3,360,379 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554273,350,174 - 3,358,609 (+)NCBIChiLan1.0ChiLan1.0
NFKBIZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2299,765,320 - 99,798,852 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1399,770,109 - 99,803,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0398,914,957 - 98,948,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13105,616,645 - 105,628,300 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3105,616,645 - 105,628,300 (+)Ensemblpanpan1.1panPan2
NFKBIZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1338,147,160 - 8,154,401 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl338,073,840 - 8,154,561 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha338,299,319 - 8,308,950 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0338,263,750 - 8,294,332 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl338,283,254 - 8,294,324 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1338,171,804 - 8,181,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0338,218,093 - 8,227,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0338,558,667 - 8,568,280 (+)NCBIUU_Cfam_GSD_1.0
Nfkbiz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602148,703,296 - 148,734,803 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366301,601,010 - 1,632,745 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366301,601,006 - 1,633,844 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKBIZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13157,261,419 - 157,272,688 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113157,261,419 - 157,273,119 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213166,743,487 - 166,777,576 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFKBIZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12279,044,624 - 79,077,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2279,044,619 - 79,055,776 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604187,478,007 - 87,510,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkbiz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478915,612,335 - 15,624,152 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478915,612,311 - 15,623,878 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfkbiz
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:120
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000041116
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat

Markers in Region
D11Rat67  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21144,803,161 - 44,803,318 (+)MAPPERmRatBN7.2
Rnor_6.01147,263,866 - 47,264,023NCBIRnor6.0
Rnor_5.01150,440,850 - 50,441,007UniSTSRnor5.0
RGSC_v3.41145,797,488 - 45,797,929RGDRGSC3.4
RGSC_v3.41145,797,511 - 45,797,668UniSTSRGSC3.4
RGSC_v3.11145,855,100 - 45,855,257RGD
RH 3.4 Map11332.7UniSTS
RH 3.4 Map11332.7RGD
RH 2.0 Map11292.5RGD
SHRSP x BN Map1118.4899RGD
Cytogenetic Map11q12UniSTS
RH128110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21144,810,424 - 44,810,641 (+)MAPPERmRatBN7.2
Rnor_6.01147,271,189 - 47,271,405NCBIRnor6.0
Rnor_5.01150,446,984 - 50,447,200UniSTSRnor5.0
RGSC_v3.41145,811,217 - 45,811,433UniSTSRGSC3.4
Celera1144,562,206 - 44,562,422UniSTS
RH 3.4 Map11332.9UniSTS
Cytogenetic Map11q12UniSTS
BE110884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21144,799,850 - 44,800,053 (+)MAPPERmRatBN7.2
Rnor_6.01147,260,554 - 47,260,756NCBIRnor6.0
Rnor_5.01150,437,538 - 50,437,740UniSTSRnor5.0
RGSC_v3.41145,794,199 - 45,794,401UniSTSRGSC3.4
Celera1144,551,566 - 44,551,768UniSTS
RH 3.4 Map11318.2UniSTS
Cytogenetic Map11q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000041116   ⟹   ENSRNOP00000040930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,782,676 - 44,810,723 (+)Ensembl
Rnor_6.0 Ensembl1147,243,342 - 47,271,487 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078856   ⟹   ENSRNOP00000073948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,782,676 - 44,810,723 (+)Ensembl
Rnor_6.0 Ensembl1147,260,641 - 47,270,163 (+)Ensembl
RefSeq Acc Id: NM_001401430   ⟹   NP_001388359
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81158,251,721 - 58,279,767 (+)NCBI
mRatBN7.21144,782,676 - 44,810,722 (+)NCBI
RefSeq Acc Id: NM_001415136   ⟹   NP_001402065
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81158,268,898 - 58,279,767 (+)NCBI
mRatBN7.21144,799,853 - 44,810,722 (+)NCBI
RefSeq Acc Id: XM_039088370   ⟹   XP_038944298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81158,251,720 - 58,279,767 (+)NCBI
mRatBN7.21144,782,681 - 44,810,722 (+)NCBI
RefSeq Acc Id: XM_039088371   ⟹   XP_038944299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81158,268,848 - 58,275,126 (+)NCBI
mRatBN7.21144,799,800 - 44,806,102 (+)NCBI
Ensembl Acc Id: ENSRNOP00000040930   ⟸   ENSRNOT00000041116
Ensembl Acc Id: ENSRNOP00000073948   ⟸   ENSRNOT00000078856
RefSeq Acc Id: XP_038944298   ⟸   XM_039088370
- Peptide Label: isoform X1
- UniProtKB: M5AJR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944299   ⟸   XM_039088371
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001388359   ⟸   NM_001401430
- UniProtKB: A0A0G2K6U7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402065   ⟸   NM_001415136
- UniProtKB: A0A0G2K6U7 (UniProtKB/TrEMBL)
Protein Domains
OCA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K6U7-F1-model_v2 AlphaFold A0A0G2K6U7 1-733 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698118
Promoter ID:EPDNEW_R8641
Type:single initiation site
Name:Nfkbiz_1
Description:NFKB inhibitor zeta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01147,260,556 - 47,260,616EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310834 AgrOrtholog
BioCyc Gene G2FUF-21501 BioCyc
Ensembl Genes ENSRNOG00000031163 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041116.5 UniProtKB/TrEMBL
  ENSRNOT00000078856.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  OCA UniProtKB/TrEMBL
NCBI Gene 304005 ENTREZGENE
PANTHER ANKYRIN REPEAT FAMILY A UniProtKB/TrEMBL
  NF-KAPPA-B INHIBITOR ZETA UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
PhenoGen Nfkbiz PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  OCA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031163 RatGTEx
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
UniProt A0A0G2K6U7 ENTREZGENE, UniProtKB/TrEMBL
  D4A1S9_RAT UniProtKB/TrEMBL
  M5AJR0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Nfkbiz  NFKB inhibitor zeta  Nfkbiz  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nfkbiz  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta   Nfkbiz_predicted  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Nfkbiz_predicted  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (predicted)  RGD1310834_predicted  similar to molecule possessing ankyrin-repeats induced by lipopolysaccharide; IkappaB-zeta (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1310834_predicted  similar to molecule possessing ankyrin-repeats induced by lipopolysaccharide; IkappaB-zeta (predicted)  LOC304005_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC304005_predicted  similar to molecule possessing ankyrin-repeats induced by lipopolysaccharide; IkappaB-zeta (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL