Nfatc4 (nuclear factor of activated T-cells 4) - Rat Genome Database

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Gene: Nfatc4 (nuclear factor of activated T-cells 4) Rattus norvegicus
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Symbol: Nfatc4
Name: nuclear factor of activated T-cells 4
RGD ID: 1310749
Description: Enables DNA-binding transcription factor activity and peroxisome proliferator activated receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of synaptic plasticity. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NFATC4 (nuclear factor of activated T cells 4); PARTICIPATES IN calcineurin signaling pathway; nuclear factor of activated T-cells signaling pathway; B cell receptor signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 20-HETE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC102552386; NF-AT3; NF-ATc4; nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; T-cell transcription factor NFAT3; uncharacterized LOC102552386
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,256,912 - 33,284,522 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,274,153 - 33,285,582 (+)EnsemblGRCr8
mRatBN7.21529,286,998 - 29,314,610 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,305,535 - 29,314,610 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,151,202 - 31,160,277 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,298,412 - 32,307,487 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,540,765 - 30,549,840 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,493,163 - 34,502,238 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,493,138 - 34,504,326 (+)Ensemblrn6Rnor6.0
Rnor_5.01538,381,669 - 38,390,744 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,969,774 - 33,978,848 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,880,299 - 28,889,401 (+)NCBICelera
RGSC_v3.11533,985,319 - 33,994,626 (+)NCBI
Cytogenetic Map15p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-colchicine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
20-HETE  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP)
antirheumatic drug  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
capsaicin  (EXP)
carboplatin  (EXP,ISO)
carvedilol  (EXP)
chlordecone  (ISO)
chlorohydrocarbon  (EXP)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
cytochalasin D  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
gallic acid  (ISO)
harmine  (ISO)
ionomycin  (EXP)
lead(0)  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (EXP)
metoprolol  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel subsulfide  (EXP)
panobinostat  (ISO)
paracetamol  (EXP)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tacrolimus hydrate  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
WIN 55212-2  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,ISO,NAS)
cytosol  (ISO)
nuclear speck  (ISO)
nucleus  (IBA,IDA,IEA,ISO)
transcription regulator complex  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Opposing roles of FoxP1 and Nfat3 in transcriptional control of cardiomyocyte hypertrophy. Bai S and Kerppola TK, Mol Cell Biol. 2011 Jul;31(14):3068-80. doi: 10.1128/MCB.00925-10. Epub 2011 May 23.
2. Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway. Bao Y, etal., Mol Cell Biochem. 2008 Oct;317(1-2):189-96. Epub 2008 Jul 4.
3. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. Cai YQ, etal., J Pharmacol Exp Ther. 2013 Apr;345(1):161-8. doi: 10.1124/jpet.112.202192. Epub 2013 Feb 5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Brain-derived neurotrophic factor activation of NFAT (nuclear factor of activated T-cells)-dependent transcription: a role for the transcription factor NFATc4 in neurotrophin-mediated gene expression. Groth RD and Mermelstein PG, J Neurosci. 2003 Sep 3;23(22):8125-34.
7. Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis. Jayanthi S, etal., Proc Natl Acad Sci U S A 2005 Jan 18;102(3):868-73. Epub 2005 Jan 11.
8. Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. Kalivendi SV, etal., Biochem J. 2005 Jul 15;389(Pt 2):527-39.
9. PPARalpha activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4. Le K, etal., Arch Biochem Biophys. 2012 Feb 1;518(1):71-8. Epub 2011 Dec 16.
10. Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling. Li H, etal., Nat Struct Mol Biol. 2012 Feb 19;19(3):337-45. doi: 10.1038/nsmb.2238.
11. Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli. Manukyan I, etal., J Cell Mol Med. 2010 Jun;14(6B):1707-16. doi: 10.1111/j.1582-4934.2009.00804.x. Epub 2009 Jun 16.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Molkentin JD, etal., Cell. 1998 Apr 17;93(2):215-28.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Polymorphisms of genes of the cardiac calcineurin pathway and cardiac hypertrophy. Poirier O, etal., Eur J Hum Genet. 2003 Sep;11(9):659-64.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1. Song DW, etal., Biochem J. 2014 Jan 1;457(1):151-62. doi: 10.1042/BJ20130833.
19. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
Additional References at PubMed
PMID:8889548   PMID:11439183   PMID:11827959   PMID:12370307   PMID:12750314   PMID:12796475   PMID:16644691   PMID:16803872   PMID:17044076   PMID:17108007   PMID:17229811   PMID:17242187  
PMID:17430895   PMID:18258855   PMID:18354019   PMID:19179536   PMID:19955386   PMID:20092996   PMID:20173049   PMID:20385772   PMID:20530871   PMID:21880741   PMID:22586092   PMID:22977251  
PMID:23407945   PMID:23543060   PMID:23852416   PMID:24389074   PMID:25450864   PMID:26118953   PMID:26945895   PMID:27155398   PMID:29637744   PMID:31486013   PMID:31789412  


Genomics

Comparative Map Data
Nfatc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,256,912 - 33,284,522 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,274,153 - 33,285,582 (+)EnsemblGRCr8
mRatBN7.21529,286,998 - 29,314,610 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,305,535 - 29,314,610 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,151,202 - 31,160,277 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,298,412 - 32,307,487 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,540,765 - 30,549,840 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,493,163 - 34,502,238 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,493,138 - 34,504,326 (+)Ensemblrn6Rnor6.0
Rnor_5.01538,381,669 - 38,390,744 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,969,774 - 33,978,848 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,880,299 - 28,889,401 (+)NCBICelera
RGSC_v3.11533,985,319 - 33,994,626 (+)NCBI
Cytogenetic Map15p13NCBI
NFATC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,366,911 - 24,379,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,365,673 - 24,379,604 (+)Ensemblhg38GRCh38
GRCh371424,836,117 - 24,848,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,907,094 - 23,918,650 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341423,907,093 - 23,918,648NCBI
Celera144,700,788 - 4,713,452 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,950,950 - 4,963,469 (+)NCBIHuRef
CHM1_11424,834,722 - 24,847,385 (+)NCBICHM1_1
T2T-CHM13v2.01418,565,666 - 18,578,358 (+)NCBIT2T-CHM13v2.0
Nfatc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,062,252 - 56,071,400 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,060,601 - 56,071,400 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381455,824,795 - 55,833,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,823,144 - 55,833,943 (+)Ensemblmm10GRCm38
MGSCv371456,443,632 - 56,452,780 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361454,779,079 - 54,788,014 (+)NCBIMGSCv36mm8
Celera1453,626,552 - 53,635,649 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Nfatc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,931,173 - 35,940,696 (-)Ensembl
ChiLan1.0NW_00495540935,931,208 - 35,941,555 (-)NCBIChiLan1.0ChiLan1.0
NFATC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,722,011 - 25,733,084 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,936,780 - 24,949,576 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,141,699 - 5,156,021 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,267,667 - 23,279,249 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,266,702 - 23,279,249 (+)EnsemblpanPan2panpan1.1
NFATC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,337,098 - 4,346,409 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,336,450 - 4,346,100 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha84,259,072 - 4,268,379 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.084,448,860 - 4,458,168 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,448,341 - 4,458,173 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,138,640 - 4,147,945 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,201,033 - 4,210,339 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,463,303 - 4,472,610 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nfatc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,201,144 - 36,210,126 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722179,200 - 187,800 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936722178,866 - 187,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,918,984 - 74,929,600 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1774,918,982 - 74,929,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,189,893 - 80,200,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,352,173 - 1,362,150 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,352,291 - 1,362,680 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603613,036,667 - 13,046,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfatc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,136,156 - 8,146,312 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248208,136,231 - 8,145,395 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfatc4
69 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:129
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000027789
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
D15Got106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,313,540 - 29,313,785 (+)MAPPERmRatBN7.2
Rnor_6.01534,501,169 - 34,501,413NCBIRnor6.0
Rnor_5.01538,389,675 - 38,389,919UniSTSRnor5.0
RGSC_v3.41533,977,778 - 33,978,023RGDRGSC3.4
RGSC_v3.41533,977,779 - 33,978,023UniSTSRGSC3.4
Celera1528,888,332 - 28,888,576UniSTS
RGSC_v3.11533,993,478 - 33,993,723RGD
RH 2.0 Map15178.6RGD
Cytogenetic Map15p13UniSTS
RH137353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,314,375 - 29,314,595 (+)MAPPERmRatBN7.2
Rnor_6.01534,502,004 - 34,502,223NCBIRnor6.0
Rnor_5.01538,390,510 - 38,390,729UniSTSRnor5.0
RGSC_v3.41533,978,614 - 33,978,833UniSTSRGSC3.4
Celera1528,889,167 - 28,889,386UniSTS
RH 3.4 Map15260.81UniSTS
Cytogenetic Map15p13UniSTS
PMC135666P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,310,058 - 29,310,582 (+)MAPPERmRatBN7.2
Rnor_6.01534,497,687 - 34,498,210NCBIRnor6.0
Rnor_5.01538,386,193 - 38,386,716UniSTSRnor5.0
RGSC_v3.41533,974,297 - 33,974,820UniSTSRGSC3.4
Celera1528,884,850 - 28,885,373UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 91 59 6 355 191 11 138 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000027789   ⟹   ENSRNOP00000027789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,275,447 - 33,284,522 (+)Ensembl
mRatBN7.2 Ensembl1529,305,535 - 29,314,610 (+)Ensembl
Rnor_6.0 Ensembl1534,493,163 - 34,502,238 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089584   ⟹   ENSRNOP00000071490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,274,153 - 33,284,406 (+)Ensembl
mRatBN7.2 Ensembl1529,305,535 - 29,314,605 (+)Ensembl
Rnor_6.0 Ensembl1534,493,138 - 34,504,326 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153752   ⟹   ENSRNOP00000101662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,274,787 - 33,285,582 (+)Ensembl
RefSeq Acc Id: NM_001107264   ⟹   NP_001100734
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,275,447 - 33,284,522 (+)NCBI
mRatBN7.21529,305,535 - 29,314,610 (+)NCBI
Rnor_6.01534,493,163 - 34,502,238 (+)NCBI
Rnor_5.01538,381,669 - 38,390,744 (+)NCBI
RGSC_v3.41533,969,774 - 33,978,848 (+)RGD
Celera1528,880,299 - 28,889,401 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093302   ⟹   XP_038949230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,256,914 - 33,284,512 (+)NCBI
mRatBN7.21529,286,998 - 29,314,600 (+)NCBI
RefSeq Acc Id: XM_039093303   ⟹   XP_038949231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,256,912 - 33,284,512 (+)NCBI
mRatBN7.21529,287,000 - 29,314,600 (+)NCBI
RefSeq Acc Id: XM_063274257   ⟹   XP_063130327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,266,473 - 33,284,512 (+)NCBI
RefSeq Acc Id: XM_063274258   ⟹   XP_063130328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,261,189 - 33,284,512 (+)NCBI
RefSeq Acc Id: XM_063274259   ⟹   XP_063130329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,261,191 - 33,284,512 (+)NCBI
RefSeq Acc Id: XM_063274260   ⟹   XP_063130330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,256,919 - 33,284,512 (+)NCBI
RefSeq Acc Id: NP_001100734   ⟸   NM_001107264
- UniProtKB: A0A0G2K0L1 (UniProtKB/Swiss-Prot),   D3Z9H7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071490   ⟸   ENSRNOT00000089584
Ensembl Acc Id: ENSRNOP00000027789   ⟸   ENSRNOT00000027789
RefSeq Acc Id: XP_038949230   ⟸   XM_039093302
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949231   ⟸   XM_039093303
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063130330   ⟸   XM_063274260
- Peptide Label: isoform X1
- UniProtKB: D3Z9H7 (UniProtKB/Swiss-Prot),   A0A0G2K0L1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063130328   ⟸   XM_063274258
- Peptide Label: isoform X1
- UniProtKB: D3Z9H7 (UniProtKB/Swiss-Prot),   A0A0G2K0L1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063130329   ⟸   XM_063274259
- Peptide Label: isoform X1
- UniProtKB: D3Z9H7 (UniProtKB/Swiss-Prot),   A0A0G2K0L1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063130327   ⟸   XM_063274257
- Peptide Label: isoform X1
- UniProtKB: D3Z9H7 (UniProtKB/Swiss-Prot),   A0A0G2K0L1 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000101662   ⟸   ENSRNOT00000153752
Protein Domains
IPT/TIG   RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9H7-F1-model_v2 AlphaFold D3Z9H7 1-901 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699696
Promoter ID:EPDNEW_R10215
Type:multiple initiation site
Name:Nfatc4_2
Description:nuclear factor of activated T-cells 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10216  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,493,142 - 34,493,202EPDNEW
RGD ID:13699692
Promoter ID:EPDNEW_R10216
Type:initiation region
Name:Nfatc4_1
Description:nuclear factor of activated T-cells 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10215  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,493,250 - 34,493,310EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310749 AgrOrtholog
BioCyc Gene G2FUF-13684 BioCyc
Ensembl Genes ENSRNOG00000020482 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027789 ENTREZGENE
  ENSRNOT00000027789.6 UniProtKB/Swiss-Prot
  ENSRNOT00000089584.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  2.60.40.340 UniProtKB/Swiss-Prot
InterPro Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  IPT_dom UniProtKB/Swiss-Prot
  NFAT UniProtKB/Swiss-Prot
  p53-like_TF_DNA-bd UniProtKB/Swiss-Prot
  RHD_dimer UniProtKB/Swiss-Prot
  RHD_DNA_bind_dom UniProtKB/Swiss-Prot
  RHD_DNA_bind_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:305897 UniProtKB/Swiss-Prot
NCBI Gene 305897 ENTREZGENE
PANTHER NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4 UniProtKB/Swiss-Prot
  PTHR12533 UniProtKB/Swiss-Prot
Pfam RHD_dimer UniProtKB/Swiss-Prot
  RHD_DNA_bind UniProtKB/Swiss-Prot
PhenoGen Nfatc4 PhenoGen
PRINTS NUCFACTORATC UniProtKB/Swiss-Prot
PROSITE REL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020482 RatGTEx
SMART IPT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt A0A0G2K0L1 ENTREZGENE
  D3Z9H7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2K0L1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Nfatc4  nuclear factor of activated T-cells 4  LOC102552386  uncharacterized LOC102552386  Data merged from RGD:7591152 737654 PROVISIONAL
2016-03-29 Nfatc4  nuclear factor of activated T-cells 4  Nfatc4  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102552386  uncharacterized LOC102552386      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Nfatc4  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4  Nfatc4_predicted  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Nfatc4_predicted  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED