Arhgef3 (Rho guanine nucleotide exchange factor 3) - Rat Genome Database

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Gene: Arhgef3 (Rho guanine nucleotide exchange factor 3) Rattus norvegicus
Analyze
Symbol: Arhgef3
Name: Rho guanine nucleotide exchange factor 3
RGD ID: 1310672
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Orthologous to human ARHGEF3 (Rho guanine nucleotide exchange factor 3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC290541; Rho guanine nucleotide exchange factor (GEF) 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8162,308,311 - 2,588,634 (+)NCBIGRCr8
mRatBN7.2162,301,573 - 2,581,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl162,300,138 - 2,581,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx162,519,162 - 2,588,620 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0163,664,854 - 3,734,303 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,523,968 - 2,593,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,743,714 - 3,026,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,743,823 - 3,026,760 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,716,264 - 2,994,163 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4162,595,636 - 2,665,051 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1162,473,664 - 2,663,130 (+)NCBI
Celera162,477,340 - 2,546,773 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fluvastatin  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
lead(0)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Arhgef3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8162,308,311 - 2,588,634 (+)NCBIGRCr8
mRatBN7.2162,301,573 - 2,581,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl162,300,138 - 2,581,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx162,519,162 - 2,588,620 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0163,664,854 - 3,734,303 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,523,968 - 2,593,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,743,714 - 3,026,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,743,823 - 3,026,760 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,716,264 - 2,994,163 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4162,595,636 - 2,665,051 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1162,473,664 - 2,663,130 (+)NCBI
Celera162,477,340 - 2,546,773 (+)NCBICelera
Cytogenetic Map16p16NCBI
ARHGEF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38356,727,420 - 57,079,268 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl356,727,418 - 57,079,329 (-)EnsemblGRCh38hg38GRCh38
GRCh37356,761,448 - 57,113,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36356,736,486 - 56,810,993 (-)NCBINCBI36Build 36hg18NCBI36
Build 34356,736,485 - 56,810,993NCBI
Celera356,727,164 - 57,078,931 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef356,809,905 - 57,161,427 (-)NCBIHuRef
CHM1_1356,712,114 - 57,063,671 (-)NCBICHM1_1
T2T-CHM13v2.0356,767,765 - 57,119,568 (-)NCBIT2T-CHM13v2.0
Arhgef3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,836,418 - 27,125,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1426,836,856 - 27,125,868 (+)EnsemblGRCm39 Ensembl
GRCm381427,114,461 - 27,403,916 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1427,114,899 - 27,403,911 (+)EnsemblGRCm38mm10GRCm38
MGSCv371428,051,225 - 28,217,090 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361426,064,923 - 26,230,788 (+)NCBIMGSCv36mm8
Celera1423,496,924 - 23,635,464 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.09NCBI
Arhgef3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554306,513,765 - 6,834,892 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554306,515,949 - 6,837,997 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2256,714,391 - 57,058,722 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1356,719,160 - 57,063,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0356,663,382 - 57,012,955 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1357,878,054 - 58,223,189 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl357,878,054 - 58,179,339 (-)Ensemblpanpan1.1panPan2
ARHGEF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12033,318,255 - 33,625,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2033,311,630 - 33,623,704 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2033,245,620 - 33,552,246 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02033,590,514 - 33,894,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2033,590,505 - 33,895,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12033,039,576 - 33,340,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02033,398,192 - 33,701,068 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02033,569,536 - 33,873,906 (+)NCBIUU_Cfam_GSD_1.0
Arhgef3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118173,981,524 - 174,282,332 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364737,119,501 - 7,291,495 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364737,120,097 - 7,387,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1338,581,574 - 38,657,128 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11338,582,618 - 38,925,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21342,429,458 - 42,455,396 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12218,059,377 - 18,398,742 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2218,058,302 - 18,398,213 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041148,467,024 - 148,812,742 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624822347,001 - 539,196 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624822226,276 - 536,381 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef3
1691 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:434
Count of miRNA genes:238
Interacting mature miRNAs:288
Transcripts:ENSRNOT00000019511
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)163802452995463Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
12903952Cm117Cardiac mass QTL 1170.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)168323802995225Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
12903954Bw186Body weight QTL 1860.011body mass (VT:0001259)body weight (CMO:0000012)168323802995225Rat
12903955Kidm69Kidney mass QTL 690.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)168323804227609Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
12903278Am16Aortic mass QTL 160.019aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)168323802995225Rat
12903279Cm115Cardiac mass QTL 1150.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)168323802995225Rat
2325838Bp347Blood pressure QTL 3470.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1613080679Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
12903281Cm116Cardiac mass QTL 1160.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)168323802995225Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301404Bp321Blood pressure QTL 3210.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)168323802995225Rat

Markers in Region
D16Chm16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2162,552,512 - 2,552,695 (+)MAPPERmRatBN7.2
Rnor_6.0162,997,172 - 2,997,352NCBIRnor6.0
Rnor_5.0162,964,567 - 2,964,747UniSTSRnor5.0
RGSC_v3.4162,635,636 - 2,635,816UniSTSRGSC3.4
Celera162,517,339 - 2,517,519UniSTS
Cytogenetic Map16p16UniSTS
D16Chm43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2162,526,783 - 2,526,987 (+)MAPPERmRatBN7.2
Rnor_6.0162,971,447 - 2,971,646NCBIRnor6.0
Rnor_5.0162,938,842 - 2,939,041UniSTSRnor5.0
RGSC_v3.4162,609,911 - 2,610,110UniSTSRGSC3.4
Celera162,491,614 - 2,491,813UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019511   ⟹   ENSRNOP00000019511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,512,511 - 2,581,937 (+)Ensembl
Rnor_6.0 Ensembl162,958,283 - 3,026,760 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087873   ⟹   ENSRNOP00000070700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,301,668 - 2,581,939 (+)Ensembl
Rnor_6.0 Ensembl162,743,823 - 3,025,019 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096646   ⟹   ENSRNOP00000086642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,418,116 - 2,581,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101017   ⟹   ENSRNOP00000095441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,302,207 - 2,581,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106161   ⟹   ENSRNOP00000085357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,306,807 - 2,581,939 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108807   ⟹   ENSRNOP00000092034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,360,574 - 2,581,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118865   ⟹   ENSRNOP00000086947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,360,837 - 2,581,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119297   ⟹   ENSRNOP00000097424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,538,241 - 2,581,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119548   ⟹   ENSRNOP00000097457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,300,138 - 2,581,945 (+)Ensembl
RefSeq Acc Id: NM_001106061   ⟹   NP_001099531
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,519,211 - 2,588,626 (+)NCBI
mRatBN7.2162,512,511 - 2,581,937 (+)NCBI
Rnor_6.0162,958,283 - 3,026,760 (+)NCBI
Rnor_5.0162,716,264 - 2,994,163 (+)NCBI
RGSC_v3.4162,595,636 - 2,665,051 (+)RGD
Celera162,477,340 - 2,546,773 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252574   ⟹   XP_006252636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,308,700 - 2,588,634 (+)NCBI
mRatBN7.2162,301,979 - 2,581,951 (+)NCBI
Rnor_6.0162,744,176 - 3,026,768 (+)NCBI
Rnor_5.0162,716,264 - 2,994,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252575   ⟹   XP_006252637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,308,568 - 2,588,634 (+)NCBI
mRatBN7.2162,301,844 - 2,581,951 (+)NCBI
Rnor_6.0162,744,049 - 3,026,768 (+)NCBI
Rnor_5.0162,716,264 - 2,994,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252576   ⟹   XP_006252638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,424,688 - 2,588,634 (+)NCBI
mRatBN7.2162,418,176 - 2,581,951 (+)NCBI
Rnor_6.0162,860,525 - 3,026,768 (+)NCBI
Rnor_5.0162,716,264 - 2,994,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600022   ⟹   XP_017455511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,544,634 - 2,588,634 (+)NCBI
mRatBN7.2162,538,106 - 2,581,951 (+)NCBI
Rnor_6.0162,980,878 - 3,026,768 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600023   ⟹   XP_017455512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,308,311 - 2,588,634 (+)NCBI
mRatBN7.2162,301,573 - 2,581,951 (+)NCBI
Rnor_6.0162,743,714 - 3,026,768 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001099531   ⟸   NM_001106061
- UniProtKB: D4A1J1 (UniProtKB/TrEMBL),   A6KMK9 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252637   ⟸   XM_006252575
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYL3 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252636   ⟸   XM_006252574
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYL3 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252638   ⟸   XM_006252576
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A424 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455512   ⟸   XM_017600023
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYL3 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455511   ⟸   XM_017600022
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GMI2 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070700   ⟸   ENSRNOT00000087873
Ensembl Acc Id: ENSRNOP00000019511   ⟸   ENSRNOT00000019511
Ensembl Acc Id: ENSRNOP00000097424   ⟸   ENSRNOT00000119297
Ensembl Acc Id: ENSRNOP00000092034   ⟸   ENSRNOT00000108807
Ensembl Acc Id: ENSRNOP00000086947   ⟸   ENSRNOT00000118865
Ensembl Acc Id: ENSRNOP00000085357   ⟸   ENSRNOT00000106161
Ensembl Acc Id: ENSRNOP00000086642   ⟸   ENSRNOT00000096646
Ensembl Acc Id: ENSRNOP00000095441   ⟸   ENSRNOT00000101017
Ensembl Acc Id: ENSRNOP00000097457   ⟸   ENSRNOT00000119548
Protein Domains
DH   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JYL3-F1-model_v2 AlphaFold A0A0G2JYL3 1-551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699901
Promoter ID:EPDNEW_R10422
Type:initiation region
Name:Arhgef3_2
Description:Rho guanine nucleotide exchange factor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10423  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0162,743,823 - 2,743,883EPDNEW
RGD ID:13699899
Promoter ID:EPDNEW_R10423
Type:multiple initiation site
Name:Arhgef3_1
Description:Rho guanine nucleotide exchange factor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10422  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0162,958,284 - 2,958,344EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310672 AgrOrtholog
BioCyc Gene G2FUF-12239 BioCyc
Ensembl Genes ENSRNOG00000014363 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019511.6 UniProtKB/TrEMBL
  ENSRNOT00000087873.2 UniProtKB/TrEMBL
  ENSRNOT00000096646.1 UniProtKB/TrEMBL
  ENSRNOT00000101017.1 UniProtKB/TrEMBL
  ENSRNOT00000106161.1 UniProtKB/TrEMBL
  ENSRNOT00000108807.1 UniProtKB/TrEMBL
  ENSRNOT00000118865.1 UniProtKB/TrEMBL
  ENSRNOT00000119297.1 UniProtKB/TrEMBL
  ENSRNOT00000119548.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Endocytic_GEF_Adapter UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH_RhoGEF3_XPLN UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
KEGG Report rno:290541 UniProtKB/TrEMBL
NCBI Gene 290541 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PhenoGen Arhgef3 PhenoGen
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014363 RatGTEx
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0A0G2JYL3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZX2_RAT UniProtKB/TrEMBL
  A0A8I6A399_RAT UniProtKB/TrEMBL
  A0A8I6A424 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASZ8_RAT UniProtKB/TrEMBL
  A0A8I6B2L7_RAT UniProtKB/TrEMBL
  A0A8I6GK05 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMI2 ENTREZGENE, UniProtKB/TrEMBL
  A6KMK9 ENTREZGENE, UniProtKB/TrEMBL
  D4A1J1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef3  Rho guanine nucleotide exchange factor 3  Arhgef3  Rho guanine nucleotide exchange factor (GEF) 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Arhgef3  Rho guanine nucleotide exchange factor (GEF) 3   Arhgef3_predicted  Rho guanine nucleotide exchange factor (GEF) 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arhgef3_predicted  Rho guanine nucleotide exchange factor (GEF) 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED