Apoh (apolipoprotein H) - Rat Genome Database

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Gene: Apoh (apolipoprotein H) Rattus norvegicus
Analyze
Symbol: Apoh
Name: apolipoprotein H
RGD ID: 1310625
Description: Enables lipid binding activity. Involved in several processes, including negative regulation of respiratory burst; positive regulation of triglyceride catabolic process; and triglyceride transport. Located in cell surface and extracellular space. Used to study myocardial infarction and thrombosis. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H); PARTICIPATES IN coagulation cascade pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apo-H; apolipoprotein H (beta-2-glycoprotein I); B2GPI; beta(2)GPI; beta-2-glycoprotein 1; beta-2-glycoprotein I; LOC287774
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81093,841,992 - 93,855,897 (+)NCBIGRCr8
mRatBN7.21093,342,435 - 93,356,334 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1093,310,977 - 93,356,329 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1098,400,040 - 98,413,944 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,863,118 - 97,877,037 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01093,267,097 - 93,280,941 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01096,640,013 - 96,653,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1096,639,924 - 96,653,938 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01096,364,217 - 96,378,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,725,088 - 97,739,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11097,739,457 - 97,753,582 (+)NCBI
Celera1092,007,324 - 92,020,973 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cyclosporin A  (ISO)
dicrotophos  (ISO)
diisopropyl fluorophosphate  (EXP)
diquat  (ISO)
dorsomorphin  (ISO)
gamma-linolenic acid  (ISO)
gemcitabine  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
L-ethionine  (EXP)
menadione  (ISO)
methidathion  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosomorpholine  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
olanzapine  (ISO)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A non-complement-fixing antibody to beta2 glycoprotein I as a novel therapy for antiphospholipid syndrome. Agostinis C, etal., Blood. 2014 May 29;123(22):3478-87. doi: 10.1182/blood-2013-11-537704. Epub 2014 Mar 18.
2. Beta2-glycoprotein I-dependent and -independent anticardiolipin antibody in non-obese diabetic (NOD) mice. Anzai K, etal., Clin Exp Immunol. 1998 Jan;111(1):173-80.
3. Beta-2-glycoprotein I is growth regulated and plays a role as survival factor for hepatocytes. Averna M, etal., Int J Biochem Cell Biol. 2004 Jul;36(7):1297-305.
4. Relation of preexisting anti-beta2GPI antibodies to infarct size in a rat model. Barshack I, etal., Cardiovasc Pathol. 2003 Jul-Aug;12(4):195-201.
5. Anti-beta 2-glycoprotein I antibodies bind to central nervous system. Caronti B, etal., J Neurol Sci. 1998 Apr 1;156(2):211-9.
6. Apolipoprotein H is increased in type 2 diabetic patients with microalbuminuria. Cavallo Perin P, etal., Nutr Metab Cardiovasc Dis. 2000 Dec;10(6):311-4.
7. Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor. Fischetti F, etal., Blood. 2005 Oct 1;106(7):2340-6. Epub 2005 Jun 14.
8. Autoantibodies to the atheroma component beta2-glycoprotein I and risk of symptomatic peripheral artery disease. Franck M, etal., Angiology. 2007 Jun-Jul;58(3):295-302.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. beta 2-glycoprotein I (apolipoprotein H) modulates uptake and endocytosis associated chemiluminescence in rat Kupffer cells. Gomes LF, etal., Free Radic Res. 2002 Jul;36(7):741-7.
11. Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and autoantibodies in patients with type 2 diabetes mellitus. Lopez LR, etal., Ann N Y Acad Sci. 2005 Jun;1051:97-103.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Beta 2 glycoprotein I--function in health and disease. Miyakis S, etal., Thromb Res. 2004;114(5-6):335-46.
14. [Beta 2 glycoprotein I analysis in patients with hyperlipoproteinemia, arteriosclerotic occlusive disease and diabetes mellitus] Muller G, etal., Z Gesamte Inn Med. 1983 May 15;38(10):282-4.
15. Identification of novel liver-specific mRNAs in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds. Okubo S, etal., Toxicol Sci. 2013 Mar;132(1):21-31. doi: 10.1093/toxsci/kfs340. Epub 2013 Jan 3.
16. Proteomic analysis of vitreous from diabetic macular edema. Ouchi M, etal., Exp Eye Res. 2005 Aug;81(2):176-82.
17. Investigations on beta 2-glycoprotein-I in the rat: isolation from serum and demonstration in lipoprotein density fractions. Polz E, etal., Int J Biochem. 1980;11(3-4):265-70.
18. Anti-beta2-glycoprotein I antibodies as risk factors for acute myocardial infarction. Ranzolin A, etal., Arq Bras Cardiol. 2004 Aug;83(2):141-4; 137-40. Epub 2004 Aug 17.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Influence of APOH protein polymorphism on apoH levels in normal and diabetic subjects. Ruiu G, etal., Clin Genet. 1997 Sep;52(3):167-72.
22. Dietary oil modifies the plasma proteome during aging in the rat. Santos-Gonzalez M, etal., Age (Dordr). 2011 Apr 7.
23. Elevation of apolipoprotein A-I and apolipoprotein H levels in the vitreous fluid and overexpression in the retina of diabetic patients. Simo R, etal., Arch Ophthalmol. 2008 Aug;126(8):1076-81.
24. Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia. Staub HL, etal., Arq Neuropsiquiatr. 2003 Sep;61(3B):757-63. Epub 2003 Oct 28.
25. Beta 2-glycoprotein I is a good indicator of certain adverse pregnancy conditions. Ulcova-Gallova Z, etal., Int J Fertil Womens Med. 2001 Nov-Dec;46(6):304-8.
26. Studies on the possible function of beta 2-glycoprotein-I: influence in the triglyceride metabolism in the rat. Wurm H, etal., Metabolism. 1982 May;31(5):484-6.
27. The role of beta2-glycoprotein I in liposome-hepatocyte interaction. Yan X, etal., Biochim Biophys Acta. 2004 Dec 15;1667(2):208-14.
Additional References at PubMed
PMID:222615   PMID:2771654   PMID:4052628   PMID:7417307   PMID:11145969   PMID:12477932   PMID:14726399   PMID:15486070   PMID:15534879   PMID:16480936   PMID:16502470   PMID:17872974  
PMID:18822289   PMID:19805618   PMID:19895376   PMID:20551380   PMID:23376485   PMID:23533145   PMID:27068509   PMID:27559042   PMID:30442725  


Genomics

Comparative Map Data
Apoh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81093,841,992 - 93,855,897 (+)NCBIGRCr8
mRatBN7.21093,342,435 - 93,356,334 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1093,310,977 - 93,356,329 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1098,400,040 - 98,413,944 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,863,118 - 97,877,037 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01093,267,097 - 93,280,941 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01096,640,013 - 96,653,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1096,639,924 - 96,653,938 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01096,364,217 - 96,378,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,725,088 - 97,739,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11097,739,457 - 97,753,582 (+)NCBI
Celera1092,007,324 - 92,020,973 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
APOH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381766,212,033 - 66,229,415 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1766,212,033 - 66,256,525 (-)EnsemblGRCh38hg38GRCh38
GRCh371764,208,151 - 64,225,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361761,638,609 - 61,656,018 (-)NCBINCBI36Build 36hg18NCBI36
Build 341761,638,613 - 61,655,992NCBI
Celera1760,780,183 - 60,797,591 (-)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1759,599,926 - 59,617,004 (-)NCBIHuRef
CHM1_11764,272,419 - 64,289,828 (-)NCBICHM1_1
T2T-CHM13v2.01767,082,811 - 67,100,218 (-)NCBIT2T-CHM13v2.0
Apoh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911108,286,123 - 108,305,222 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11108,234,180 - 108,305,222 (+)EnsemblGRCm39 Ensembl
GRCm3811108,395,297 - 108,414,396 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11108,343,354 - 108,414,396 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711108,256,611 - 108,275,710 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611108,211,403 - 108,230,481 (+)NCBIMGSCv36mm8
Celera11120,134,821 - 120,148,689 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1171.8NCBI
Apoh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554785,610,164 - 5,626,020 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554785,612,258 - 5,626,061 (-)NCBIChiLan1.0ChiLan1.0
APOH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21982,247,480 - 82,339,338 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11787,066,978 - 87,158,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01760,154,389 - 60,171,762 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11765,365,250 - 65,382,483 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1765,365,250 - 65,382,483 (-)Ensemblpanpan1.1panPan2
APOH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1914,082,648 - 14,095,186 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl914,082,541 - 14,095,185 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha914,976,443 - 14,988,978 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0915,744,714 - 15,757,283 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl915,744,709 - 15,757,972 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1914,691,324 - 14,703,853 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0912,829,414 - 12,841,962 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0912,830,254 - 12,842,800 (-)NCBIUU_Cfam_GSD_1.0
Apoh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560212,499,435 - 12,511,134 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365416,683,534 - 6,695,066 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365416,683,483 - 6,695,094 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1212,827,201 - 12,839,175 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11212,827,195 - 12,839,172 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21213,142,347 - 13,154,323 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11655,209,142 - 55,231,176 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607726,257,256 - 26,290,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248702,081,968 - 2,099,517 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248702,082,050 - 2,096,220 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apoh
106 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:65
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000004756
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 29 29 29
Medium 14 12 12 2 2 2 2 2 2
Low 1 10 14 16 6 7 35 29 24 6 6
Below cutoff 2 6 2 1 29 11 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001009626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AM071386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000004756   ⟹   ENSRNOP00000004756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1093,310,977 - 93,356,329 (+)Ensembl
Rnor_6.0 Ensembl1096,639,924 - 96,653,938 (+)Ensembl
RefSeq Acc Id: NM_001009626   ⟹   NP_001009626
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81093,841,992 - 93,855,897 (+)NCBI
mRatBN7.21093,342,435 - 93,356,334 (+)NCBI
Rnor_6.01096,640,013 - 96,653,939 (+)NCBI
Rnor_5.01096,364,217 - 96,378,118 (+)NCBI
RGSC_v3.41097,725,088 - 97,739,213 (+)RGD
Celera1092,007,324 - 92,020,973 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009626 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88180 (Get FASTA)   NCBI Sequence Viewer  
  CAJ29887 (Get FASTA)   NCBI Sequence Viewer  
  EDM06447 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004756
  ENSRNOP00000004756.4
GenBank Protein P26644 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009626   ⟸   NM_001009626
- Peptide Label: precursor
- UniProtKB: P26644 (UniProtKB/Swiss-Prot),   Q5I0M1 (UniProtKB/TrEMBL),   A6HK92 (UniProtKB/TrEMBL),   F7FC04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004756   ⟸   ENSRNOT00000004756
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26644-F1-model_v2 AlphaFold P26644 1-297 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697854
Promoter ID:EPDNEW_R8379
Type:initiation region
Name:Apoh_1
Description:apolipoprotein H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01096,639,990 - 96,640,050EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310625 AgrOrtholog
BioCyc Gene G2FUF-22879 BioCyc
Ensembl Genes ENSRNOG00000003566 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004756 ENTREZGENE
  ENSRNOT00000004756.8 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7364928 IMAGE-MGC_LOAD
InterPro Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287774 UniProtKB/TrEMBL
MGC_CLONE MGC:108825 IMAGE-MGC_LOAD
NCBI Gene 287774 ENTREZGENE
PANTHER C4B-BINDING PROTEIN BETA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOCOMOTION-RELATED PROTEIN HIKARU GENKI UniProtKB/TrEMBL
Pfam Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apoh PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003566 RatGTEx
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HK92 ENTREZGENE, UniProtKB/TrEMBL
  APOH_RAT UniProtKB/Swiss-Prot
  F7FC04 ENTREZGENE, UniProtKB/TrEMBL
  P26644 ENTREZGENE
  Q3T940_RAT UniProtKB/TrEMBL
  Q5I0M1 ENTREZGENE
UniProt Secondary Q5I0M1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Apoh  apolipoprotein H  Apoh  apolipoprotein H (beta-2-glycoprotein I)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Apoh  apolipoprotein H (beta-2-glycoprotein I)  Apoh  apolipoprotein H  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Apoh  apolipoprotein H  Apoh_predicted  apolipoprotein H (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Apoh_predicted  apolipoprotein H (predicted)      Symbol and Name status set to approved 70820 APPROVED