Gbp4 (guanylate binding protein 4) - Rat Genome Database

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Gene: Gbp4 (guanylate binding protein 4) Rattus norvegicus
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Symbol: Gbp4
Name: guanylate binding protein 4
RGD ID: 1310579
Description: Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; defense response to other organism; and positive regulation of defense response. Predicted to act upstream of or within adhesion of symbiont to host and cellular response to interferon-beta. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and perinuclear region of cytoplasm. Predicted to be active in cytoplasmic vesicle. Orthologous to several human genes including GBP7 (guanylate binding protein 7); INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gbp3; guanylate nucleotide binding protein 3; guanylate nucleotide binding protein 4; guanylate-binding protein 4; guanylate-binding protein 4-like; LOC100911495; LOC310917
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82233,978,163 - 233,992,124 (+)NCBIGRCr8
mRatBN7.22231,304,910 - 231,318,883 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2231,305,244 - 231,318,879 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2239,078,909 - 239,092,524 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02236,973,203 - 236,986,820 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02231,836,590 - 231,850,207 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02248,249,232 - 248,263,104 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2248,249,468 - 248,263,168 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02266,777,820 - 266,791,543 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42240,495,963 - 240,509,393 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12240,453,144 - 240,495,609 (+)NCBI
Celera2223,352,892 - 223,366,524 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corosolic acid  (ISO)
cyclophosphamide  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
diiodine  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethylparaben  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
inulin  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18025219   PMID:21551061  


Genomics

Comparative Map Data
Gbp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82233,978,163 - 233,992,124 (+)NCBIGRCr8
mRatBN7.22231,304,910 - 231,318,883 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2231,305,244 - 231,318,879 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2239,078,909 - 239,092,524 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02236,973,203 - 236,986,820 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02231,836,590 - 231,850,207 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02248,249,232 - 248,263,104 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2248,249,468 - 248,263,168 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02266,777,820 - 266,791,543 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42240,495,963 - 240,509,393 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12240,453,144 - 240,495,609 (+)NCBI
Celera2223,352,892 - 223,366,524 (+)NCBICelera
Cytogenetic Map2q44NCBI
GBP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,181,144 - 89,198,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,181,144 - 89,198,942 (-)EnsemblGRCh38hg38GRCh38
GRCh37189,646,827 - 89,664,625 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,420,044 - 89,437,150 (-)NCBINCBI36Build 36hg18NCBI36
Build 34189,359,480 - 89,376,583NCBI
Celera187,892,646 - 87,910,446 (-)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef187,764,057 - 87,781,858 (-)NCBIHuRef
CHM1_1189,761,894 - 89,779,694 (-)NCBICHM1_1
T2T-CHM13v2.0189,024,523 - 89,042,320 (-)NCBIT2T-CHM13v2.0
Gbp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393142,265,781 - 142,278,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3142,265,787 - 142,278,970 (+)EnsemblGRCm39 Ensembl
GRCm383142,560,016 - 142,573,213 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3142,560,026 - 142,573,209 (+)EnsemblGRCm38mm10GRCm38
MGSCv373142,223,016 - 142,236,176 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363142,497,531 - 142,510,595 (+)NCBIMGSCv36mm8
Celera3148,982,608 - 148,995,787 (+)NCBICelera
Cytogenetic Map3H1NCBI
cM Map366.69NCBI
GBP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,799,420 - 137,843,619 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11136,955,167 - 136,999,366 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,841,867 - 91,886,638 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1190,593,577 - 90,637,789 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl190,590,242 - 90,660,565 (-)Ensemblpanpan1.1panPan2

Variants

.
Variants in Gbp4
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:90
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000022648
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2221136523241305619Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000022648   ⟹   ENSRNOP00000022648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2231,305,244 - 231,318,879 (+)Ensembl
Rnor_6.0 Ensembl2248,249,468 - 248,263,168 (+)Ensembl
RefSeq Acc Id: NM_001305261   ⟹   NP_001292190
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82233,978,486 - 233,992,120 (+)NCBI
mRatBN7.22231,305,244 - 231,318,879 (+)NCBI
Rnor_6.02248,249,470 - 248,263,104 (+)NCBI
Celera2223,352,892 - 223,366,524 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233424   ⟹   XP_006233486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82233,978,163 - 233,992,124 (+)NCBI
mRatBN7.22231,304,910 - 231,318,883 (+)NCBI
Rnor_6.02248,249,232 - 248,263,104 (+)NCBI
Rnor_5.02266,777,820 - 266,791,543 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001292190 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233486 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL82351 (Get FASTA)   NCBI Sequence Viewer  
  EDL82352 (Get FASTA)   NCBI Sequence Viewer  
  EDL82353 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022648.3
RefSeq Acc Id: XP_006233486   ⟸   XM_006233424
- Peptide Label: isoform X1
- UniProtKB: A6HW65 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001292190   ⟸   NM_001305261
- UniProtKB: D3ZQL3 (UniProtKB/TrEMBL),   A6HW67 (UniProtKB/TrEMBL),   A6HW65 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022648   ⟸   ENSRNOT00000022648
Protein Domains
GB1/RHD3-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQL3-F1-model_v2 AlphaFold D3ZQL3 1-620 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310579 AgrOrtholog
BioCyc Gene G2FUF-50997 BioCyc
Ensembl Genes ENSRNOG00000028768 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022648.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Guanylate-binding protein, C-terminal domain UniProtKB/TrEMBL
InterPro G_GB1_RHD3_dom UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
  Guanylate-bd_C UniProtKB/TrEMBL
  Guanylate-bd_C_sf UniProtKB/TrEMBL
  Guanylate-bd_N UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:310917 UniProtKB/TrEMBL
NCBI Gene 310917 ENTREZGENE
PANTHER GUANYLATE BINDING PROTEIN UniProtKB/TrEMBL
  GUANYLATE-BINDING PROTEIN 4 UniProtKB/TrEMBL
Pfam GBP UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
PhenoGen Gbp4 PhenoGen
PROSITE G_GB1_RHD3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028768 RatGTEx
Superfamily-SCOP GBP UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A6HW65 ENTREZGENE, UniProtKB/TrEMBL
  A6HW67 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQL3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gbp4  guanylate binding protein 4  LOC100911495  guanylate-binding protein 4-like  Data merged from RGD:6492963 737654 PROVISIONAL
2012-07-05 LOC100911495  guanylate-binding protein 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-12 Gbp4  guanylate binding protein 4  Gbp4_predicted  guanylate nucleotide binding protein 4 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gbp4_predicted  guanylate nucleotide binding protein 4 (predicted)  Gbp3_predicted  guanylate nucleotide binding protein 3 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Gbp3_predicted  guanylate nucleotide binding protein 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED