Uros (uroporphyrinogen III synthase)

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Gene: Uros (uroporphyrinogen III synthase) Rattus norvegicus

Analyze

Symbol:

Uros

Name:

uroporphyrinogen III synthase

RGD ID:

1310396

Description:

Enables folic acid binding activity. Contributes to uroporphyrinogen-III synthase activity. Involved in several processes, including cellular response to amine stimulus; response to platinum ion; and uroporphyrinogen III biosynthetic process. Predicted to be active in cytosol. Used to study cutaneous porphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC309070; urogen III synthase; uroporphyrinogen III co-synthase; uroporphyrinogen-III synthase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UROS (uroporphyrinogen III synthase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Uros (uroporphyrinogen III synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Uros (uroporphyrinogen III synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UROS (uroporphyrinogen III synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UROS (uroporphyrinogen III synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Uros (uroporphyrinogen III synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UROS (uroporphyrinogen III synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UROS (uroporphyrinogen III synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Uros (uroporphyrinogen III synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CANT1 (calcium activated nucleotidase 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	UROS (uroporphyrinogen III synthase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Uros (uroporphyrinogen III synthase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	uros (uroporphyrinogen III synthase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1885	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HEM4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG9589	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	uros	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	188,490,832 - 188,513,659 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	188,490,323 - 188,512,249 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	196,841,463 - 196,861,991 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	204,018,077 - 204,038,605 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	196,691,597 - 196,712,125 (-)	NCBI	Rnor_WKY
Rnor_6.0	1	205,755,766 - 205,778,170 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	205,756,640 - 205,777,167 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	212,704,834 - 212,727,235 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	193,184,946 - 193,205,475 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	193,334,828 - 193,355,356 (-)	NCBI
Celera	1	186,229,349 - 186,249,866 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cutaneous porphyria (IAGP,ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

4-hydroxyphenyl retinamide (ISO)

all-trans-retinoic acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

gentamycin (EXP)

isobutanol (ISO)

lead diacetate (EXP)

methylmercury chloride (ISO)

nicotine (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

tamibarotene (ISO)

tetrachloromethane (EXP)

topotecan (EXP)

triphenyl phosphate (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to amine stimulus (IEP)

cellular response to arsenic-containing substance (IEP)

heme biosynthetic process (ISO)

porphyrin-containing compound biosynthetic process (ISO)

protoporphyrinogen IX biosynthetic process (IEA)

response to platinum ion (IEP)

uroporphyrinogen III biosynthetic process (IBA,IDA,ISO)

Cellular Component

cytosol (IBA)

Molecular Function

folic acid binding (IDA)

uroporphyrinogen-III synthase activity (IDA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acute intermittent porphyria pathway (ISO)

erythropoietic porphyria pathway (ISO)

heme biosynthetic pathway (IEA,ISO,TAS)

hereditary coproporphyria pathway (ISO)

porphyrin and chlorophyll metabolic pathway (IEA)

porphyrin metabolic pathway (ISO)

variegate porphyria pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Arsenite alters heme synthesis in long-term cultures of adult rat hepatocytes.	Aguilar-Gonzalez MG, etal., Toxicol Sci. 1999 Jun;49(2):281-9.
2.	Biosynthesis of heme in mammals.	Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
3.	Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors.	Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
4.	Point mutations in the uroporphyrinogen III synthase gene in congenital erythropoietic porphyria (Gunther's disease).	Deybach JC, etal., Blood. 1990 May 1;75(9):1763-5.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	GenMAPP: Gene Map Annotator and Pathway Profiler	GenMAPP
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	Irgasan DP 300 (5-chloro-2-(2,4-dichlorophenoxy)-phenol) induces cytochrome P450s and inhibits haem biosynthesis in rat hepatocytes cultured on Matrigel.	Jinno H, etal., Xenobiotica. 1997 Jul;27(7):681-92.
9.	Rat hepatic uroporphyrinogen III co-synthase. Purification and evidence for a bound folate coenzyme participating in the biosynthesis of uroporphyrinogen III.	Kohashi M, etal., Biochem J. 1984 Jun 15;220(3):755-65.
10.	Characterization of his-tagged rat uroporphyrinogen III synthase wild-type and variant enzymes.	Li N, etal., Protein J. 2007 Dec;26(8):569-76.
11.	Enzymes of heme metabolism in the kidney: regulation by trace metals which do not form heme complexes.	Maines MD and Kappas A, J Exp Med. 1977 Nov 1;146(5):1286-93.
12.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	Alterations in renal heme biosynthesis during metal nephrotoxicity.	Oskarsson A and Fowler BA, Ann N Y Acad Sci. 1987;514:268-77.
15.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
16.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Comprehensive gene review and curation	RGD comprehensive gene curation
21.	Biosynthesis of uroporphyrinogens. Interaction among 2-(aminomethyl)bilanes and the enzymatic system.	Sburlati A, etal., Biochemistry. 1983 Aug 16;22(17):4006-13.
22.	Congenital erythropoietic porphyria and erythropoietic protoporphyria: Identification of 7 uroporphyrinogen III synthase and 20 ferrochelatase novel mutations.	Weiss Y, etal., Mol Genet Metab. 2019 Nov;128(3):358-362. doi: 10.1016/j.ymgme.2018.08.015. Epub 2018 Aug 31.

Additional References at PubMed

PMID:3174619	PMID:3805019	PMID:7607680	PMID:12477932	PMID:14651853	PMID:18004775

Genomics

Comparative Map Data

Uros
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	188,490,832 - 188,513,659 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	188,490,323 - 188,512,249 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	196,841,463 - 196,861,991 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	204,018,077 - 204,038,605 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	196,691,597 - 196,712,125 (-)	NCBI	Rnor_WKY
Rnor_6.0	1	205,755,766 - 205,778,170 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	205,756,640 - 205,777,167 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	212,704,834 - 212,727,235 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	193,184,946 - 193,205,475 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	193,334,828 - 193,355,356 (-)	NCBI
Celera	1	186,229,349 - 186,249,866 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

UROS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	125,784,980 - 125,823,258 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	125,784,980 - 125,823,258 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	127,473,549 - 127,511,827 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	127,467,142 - 127,501,757 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	127,467,141 - 127,501,757	NCBI
Celera	10	121,252,582 - 121,287,272 (-)	NCBI		Celera
Cytogenetic Map	10	q26.2	NCBI
HuRef	10	121,166,434 - 121,201,129 (-)	NCBI		HuRef
CHM1_1	10	127,758,882 - 127,793,568 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	126,667,433 - 126,705,738 (-)	NCBI		T2T-CHM13v2.0

Uros
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	133,287,871 - 133,312,176 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	133,287,972 - 133,311,801 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	133,686,142 - 133,710,467 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	133,686,243 - 133,710,072 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	140,878,013 - 140,900,978 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	133,524,673 - 133,547,638 (-)	NCBI		MGSCv36	mm8
Celera	7	133,491,254 - 133,514,229 (-)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	77.26	NCBI

Uros
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955477	3,673,532 - 3,707,760 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955477	3,673,583 - 3,707,761 (-)	NCBI	ChiLan1.0	ChiLan1.0

UROS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	10	137,640,826 - 137,679,159 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	122,346,072 - 122,384,405 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	126,610,621 - 126,648,363 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	126,613,732 - 126,648,363 (-)	Ensembl	panpan1.1		panPan2

UROS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	34,952,074 - 34,983,532 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	34,948,003 - 34,983,532 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	35,010,678 - 35,042,131 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	35,509,930 - 35,540,636 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	35,504,435 - 35,540,634 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	35,063,739 - 35,095,183 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	35,055,275 - 35,086,722 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	35,315,163 - 35,346,614 (-)	NCBI		UU_Cfam_GSD_1.0

Uros
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	11,744,646 - 11,770,000 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	13,791,286 - 13,817,238 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936486	13,792,354 - 13,816,744 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UROS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	135,101,610 - 135,131,072 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	135,101,609 - 135,131,082 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	146,730,875 - 146,760,513 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UROS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	118,405,674 - 118,450,544 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	118,410,802 - 118,440,915 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	79,769,188 - 79,808,154 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Uros
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624737	21,340,193 - 21,383,452 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Uros
112 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	367
Count of miRNA genes:	206
Interacting mature miRNAs:	248
Transcripts:	ENSRNOT00000024279
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642722	214537671	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383635	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	156677124	201278233	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	158633083	203633083	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164747424	209747424	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
2312558	Glom17	Glomerulus QTL 17	3.9	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	166532971	191278129	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169112897	197261052	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	169112897	197261052	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
631670	Iddm10	Insulin dependent diabetes mellitus QTL 10	1.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	174133260	196383635	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
61378	Bp43	Blood pressure QTL 43	22.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	181746937	196383635	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	182623426	219932796	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	185145134	221264292	Rat
1359018	Hrtrt20	Heart rate QTL 20	3.08		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	185356336	202902618	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat

Markers in Region

RH138448

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	188,494,624 - 188,494,744 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	205,759,555 - 205,759,674	NCBI	Rnor6.0
Rnor_5.0	1	212,708,623 - 212,708,742	UniSTS	Rnor5.0
RGSC_v3.4	1	193,187,863 - 193,187,982	UniSTS	RGSC3.4
Celera	1	186,232,266 - 186,232,385	UniSTS
RH 3.4 Map	1	1432.7	UniSTS
Cytogenetic Map	1	q41	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		10	22	22	9	22		2	12	3	15
Low	3	33	35	19	10	19	8	9	62	32	26	11	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008759890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008759891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC135404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000024279 ⟹ ENSRNOP00000024278

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	188,490,323 - 188,512,249 (-)	Ensembl
Rnor_6.0 Ensembl	1	205,756,640 - 205,777,167 (-)	Ensembl

RefSeq Acc Id:

NM_001012068 ⟹ NP_001012068

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	188,491,708 - 188,512,237 (-)	NCBI
Rnor_6.0	1	205,756,638 - 205,777,167 (-)	NCBI
Rnor_5.0	1	212,704,834 - 212,727,235 (-)	NCBI
RGSC_v3.4	1	193,184,946 - 193,205,475 (-)	RGD
Celera	1	186,229,349 - 186,249,866 (-)	RGD

Sequence:

show sequence

GTAGGAGCACCGGAACGCTGGCTGCTGGACGAGAGGCCACTCTCGGTTATCGGTACTTAGCAGC
CCCGGTCTGGACCGTGAGACTCCTGCCCCGCGGCGTGCAGGTTGTCCTGCCTCTTAGCCCGCGA
GGACCTTTTATAAGAGCTGCCAGGCACAATGAAGGTTCTCTTACTCAAAGATGCCAAGGATGAT
GACAGCGGCCAGGATCCATATATCCAGGAGCTGCGGTTGTGTGGCCTGGAAGCTACGCTGATTC
CTGTTCTGTCGTTTGAATTTATGTCTCTGCCCAGTTTGTCAGAAAAGCTGTCTCATCCTGAAGG
CTTTGGAGGACTCATTTTCACCAGCCCCAGGGCAGTGGAAGCAGTGAAGCTGTGTTTGGAGAAG
GACAATAAAACTGAAGCCTGGGAGAAGTCTCTGAAAGACAGATGGAATGCCAAGTCTGTGTACG
TGGTTGGAAGTGCCACCGCTTCTCTAGTGAATAAAATTGGCCTGGATGCAGAAGGAGCTGGCAG
TGGAAATGCAGAAAAGCTCGCTGAATATATTTGCTCAAAGCCATCTTCAGAGCTGCCTCTTCTC
TTTCCCTGTGGAACTATCAAAGGAGACACTCTTCCGAAAATGCTCAGAGACAAAGGGATTCCCA
TGGAAAGCATGCACGTCTATCAGACAATTCCACACCCTGGAATCCAAGGGAGCCTGGAGAGCTA
CTATGAAAATCAGGGCATCCCAGCCAGCATCACATTCTTCAGCCCCTCCGGCCTTAAATACAGC
CTCGAGTATATTCAGGCGTTATCTGGTGGCAGCTTCGACCAGATCAAGTTTGTAGCCATCGGCC
CCAGTACAACTCGTGCTATGGCTGCCAAGGGCCTTCCGGTGAGCTGCACTGCCGAAAGCCCCAC
ACCACAAGCCCTGGCTGCAGGCATCAGGAAAGCGCTGAAGCCAAACAGCTGCTGCTGAGGTCTG
TGCAGAGCCAGCTCCTTCCCTGTGCATGGGACAGCTCACTGCTGCCCGAAGATGAACCCAAATT
CAGAAAGGAGCTCTGGAGAAGCTGTGTGTGAGCATGTCGCCGTCCACCATCCACTGAGTCCAGC
TTGGAACCTAGGCCAGGTTCACTGGCCATTAGACCCAGGGAGAGAGAACTTCCTGTGCCTAGAA
AGAAGGAAACGAAATGGACCACGTGGTGACTTGTGGTTGCTGCCCACTCTTTAACAAACTGTGT
TTCTTTCATGTGTACCGGTGTCTTGTCTGCATGCACATCTGTGTGCCACCTGCATACCTGGTGC
CTGGAGAAGCAAGGCAAGGGTGGCAGATCCCCTAGAACTGTGAGTTGGGGACAGCTGTGAGCAG
CCATCTGGGTACTGGGAATTGAACCCAGGTCCTCTGAAAGAATAAGTCCTCTCAACCACTGAGC
CATCACTCCGGCCCACGGTTTTCATCTGTGGTTCTCAGGGCAAAGCGGTGTTCTGGGGCAACAG
AACGTCATAGTCTCGCTGATGCTGACCTGTTAAGAATGACAAATCGCTATGTGTGAAGTAGATT
TAGTCGTCATACAAAATAAAATAAAAATAAGACTAGGCCAAAAAAAAAAAAAAAAAAAAAAAAA
AA

hide sequence

RefSeq Acc Id:

XM_008759891 ⟹ XP_008758113

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	188,490,836 - 188,512,247 (-)	NCBI
Rnor_6.0	1	205,755,766 - 205,777,126 (-)	NCBI

Sequence:

show sequence

CTCGGTTATCGGTACTTAGCAGCCCCGGTCTGGACCGTGAGACTCCTGCCCCGCGGCGTGCAGG
TTGTCCTGCCTCTTAGCCCGCGAGGACCTTTTATAAGAGCTGCCAGGCACAATGAAGGTTCTCT
TACTCAAAGATGCCAAGGATGATGACAGCGGCCAGGATCCATATATCCAGGAGCTGCGGTTGTG
TGGCCTGGAAGCTACGCTGATTCCTGTTCTGTCGTTTGAATTTATGTCTCTGCCCAGTTTGTCA
GAAAAGCTGTCTCATCCTGAAGGCTTTGGAGGACTCATTTTCACCAGCCCCAGGGCAGTGGAAG
CAGTGAAGCTGTGTTTGGAGAAGGACAATAAAACTGAAGCCTGGGAGAAGTCTCTGAAAGACAG
ATGGAATGCCAAGTCTGTGTACGTGGTTGGAAGTGCCACCGCTTCTCTAGGTGAGGAGTCACAG
AAAGATGAAGTGAATAAAATTGGCCTGGATGCAGAAGGAGCTGGCAGTGGAAATGCAGAAAAGC
TCGCTGAATATATTTGCTCAAAGCCATCTTCAGAGCTGCCTCTTCTCTTTCCCTGTGGAACTAT
CAAAGGAGACACTCTTCCGAAAATGCTCAGAGACAAAGGGATTCCCATGGAAAGCATGCACGTC
TATCAGACAATTCCACACCCTGGAATCCAAGGGAGCCTGGAGAGCTACTATGAAAATCAGGGCA
TCCCAGCCAGCATCACATTCTTCAGCCCCTCCGGCCTTAAATACAGCCTCGAGTATATTCAGGC
GTTATCTGGTGGCAGCTTCGACCAGATCAAGTTTGTAGCCATCGGCCCCAGTACAACTCGTGCT
ATGGCTGCCAAGGGCCTTCCGGTGAGCTGCACTGCCGAAAGCCCCACACCACAAGCCCTGGCTG
CAGGCATCAGGAAAGCGCTGAAGCCAAACAGCTGCTGCTGAGGTCTGTGCAGAGCCAGCTCCTT
CCCTGTGCATGGGACAGCTCACTGCTGCCCGAAGATGAACCCAAATTCAGAAAGGAGCTCTGGA
GAAGCTGTGTGTGAGCATGTCGCCGTCCACCATCCACTGAGTCCAGCTTGGAACCTAGGCCAGG
TTCACTGGCCATTAGACCCAGGGAGAGAGAACTTCCTGTGCCTAGAAAGAAGGAAACGAAATGG
ACCACGTGGTGACTTGTGGTTGCTGCCCACTCTTTAACAAACTGTGTTTCTTTCATGTGTACCG
GTGTCTTGTCTGCATGCACATCTGTGTGCCACCTGCATACCTGGTGCCTGGAGAAGCAAGGCAA
GGGTGGCAGATCCCCTAGAACTGTGAGTTGGGGACAGCTGTGAGCAGCCATCTGGGTACTGGGA
ATTGAACCCAGGTCCTCTGAAAGAATAAGTCCTCTCAACCACTGAGCCATCACTCCGGCCCACG
GTTTTCATCTGTGGTTCTCAGGGCAAAGCGGTGTTCTGGGGCAACAGAACGTCATAGTCTCGCT
GATGCTGACCTGTTAAGAATGACAAATCGCTATGTGTGAAGTAGATTTAGTCGTCATACAAAAT
AAAATAAAAATAAGACTAGGCCAAGCATGGTAGCCCACTCATGAACTCAGCACTGCAGGAATGG
AGACGACAGTCATGAGCTTAAGAATGGAGCTTAAGTCATGAGCCAGGACTATATAGTGAGACAT
TATACACTATATCTAAATATTTGGAAAAAAAAGACTTAAAGGTCTGCCTTTTTGTCCCCTGTGG
ATAATATGCAGATAATTACGAGATTTTTATCTCATTCTGAAACATAATGGCAGCTTATCTATCA
AGCCAGCTGCTTCTGGACTGTGTGCATACATGTGGATGTGTGTGTTAGAAATGTCAGCCCTGCA
GAAAGGCTCTGAAAACTGTGTTCCCAGACTAGATTTCTACTAGGCAATCCTGGACTAGATTAGA
GCTGTGTTAAGAAAATCGATATTTGTCTCTCAGCAGCCGTGGGCTGGTGGTGGGGAGGACGGCT
GTGTACTCATGCAGCTGTCTACATTGGAAGGCATCTTCTCTTAAGTGCACACCATGCCCAGCCT
CATGCACTAAGCTTTACACATGTGATCTGATCCTCAGAGCAACTCTGAAATCCCTGAGCCACCT
CACATCATCCCAACAGTCGAGGAAGAAGGGTCTAGTGCCATGGTTCAGTGCTGCAGTTCGGGTA
TGGTTTGGAGTGTGTCCCTCAAAGTTTGATATGGTAGGTTCTCAGTCCCCAGATGTTCATGGAA
TCCTTAAGAGGCTTGGCATACGGCTGGCAAGTTGTCAGATCCTCGGTGGAGCAAAGAGCTTGAT
GCCGACTTTATAACTAAATCCAGTCTCTGGAATGCACATGGTAGAAAGAAAACTGACTCCCGCG
GGTGGTTCCCTGACTCTGACACATGGTGTGGTGGTAAATAAATAAATAAATGAATGAGTGTTAA

hide sequence

RefSeq Acc Id:

XM_017589229 ⟹ XP_017444718

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	188,490,832 - 188,513,659 (-)	NCBI
Rnor_6.0	1	205,755,766 - 205,778,170 (-)	NCBI

Sequence:

show sequence

AATCTGAAGAAAGGACATCAGTTCCGTGAGGCCATAAAACCAGTCTGACCTGGTTGGCTGTCCC
AGATTGGCAGTCAATACGGTCTAGCTATGATGTATATAAAGGGAAAACTGCAGGTTAAAGAGCA
TTTGAAAACTGTACAAGAGGACAAAGCAAGTAGCGTTTAATCAACTACAGCGGGCCAGGGTGAG
CTTGGGTGTGTAGAAGGTGGAGAGCTGCTGCAGGGAAGAGGAGAGACTAAACTTCGCAGGTCTA
ACTAAACTTGCGCCACTAAAGGACCTTTTATAAGAGCTGCCAGGCACAATGAAGGTTCTCTTAC
TCAAAGATGCCAAGGATGATGACAGCGGCCAGGATCCATATATCCAGGAGCTGCGGTTGTGTGG
CCTGGAAGCTACGCTGATTCCTGTTCTGTCGTTTGAATTTATGTCTCTGCCCAGTTTGTCAGAA
AAGCTGTCTCATCCTGAAGGCTTTGGAGGACTCATTTTCACCAGCCCCAGGGCAGTGGAAGCAG
TGAAGCTGTGTTTGGAGAAGGACAATAAAACTGAAGCCTGGGAGAAGTCTCTGAAAGACAGATG
GAATGCCAAGTCTGTGTACGTGGTTGGAAGTGCCACCGCTTCTCTAGGTGAGGAGTCACAGAAA
GATGAAGTGAATAAAATTGGCCTGGATGCAGAAGGAGCTGGCAGTGGAAATGCAGAAAAGCTCG
CTGAATATATTTGCTCAAAGCCATCTTCAGAGCTGCCTCTTCTCTTTCCCTGTGGAACTATCAA
AGGAGACACTCTTCCGAAAATGCTCAGAGACAAAGGGATTCCCATGGAAAGCATGCACGTCTAT
CAGACAATTCCACACCCTGGAATCCAAGGGAGCCTGGAGAGCTACTATGAAAATCAGGGCATCC
CAGCCAGCATCACATTCTTCAGCCCCTCCGGCCTTAAATACAGCCTCGAGTATATTCAGGCGTT
ATCTGGTGGCAGCTTCGACCAGATCAAGTTTGTAGCCATCGGCCCCAGTACAACTCGTGCTATG
GCTGCCAAGGGCCTTCCGGTGAGCTGCACTGCCGAAAGCCCCACACCACAAGCCCTGGCTGCAG
GCATCAGGAAAGCGCTGAAGCCAAACAGCTGCTGCTGAGGTCTGTGCAGAGCCAGCTCCTTCCC
TGTGCATGGGACAGCTCACTGCTGCCCGAAGATGAACCCAAATTCAGAAAGGAGCTCTGGAGAA
GCTGTGTGTGAGCATGTCGCCGTCCACCATCCACTGAGTCCAGCTTGGAACCTAGGCCAGGTTC
ACTGGCCATTAGACCCAGGGAGAGAGAACTTCCTGTGCCTAGAAAGAAGGAAACGAAATGGACC
ACGTGGTGACTTGTGGTTGCTGCCCACTCTTTAACAAACTGTGTTTCTTTCATGTGTACCGGTG
TCTTGTCTGCATGCACATCTGTGTGCCACCTGCATACCTGGTGCCTGGAGAAGCAAGGCAAGGG
TGGCAGATCCCCTAGAACTGTGAGTTGGGGACAGCTGTGAGCAGCCATCTGGGTACTGGGAATT
GAACCCAGGTCCTCTGAAAGAATAAGTCCTCTCAACCACTGAGCCATCACTCCGGCCCACGGTT
TTCATCTGTGGTTCTCAGGGCAAAGCGGTGTTCTGGGGCAACAGAACGTCATAGTCTCGCTGAT
GCTGACCTGTTAAGAATGACAAATCGCTATGTGTGAAGTAGATTTAGTCGTCATACAAAATAAA
ATAAAAATAAGACTAGGCCAAGCATGGTAGCCCACTCATGAACTCAGCACTGCAGGAATGGAGA
CGACAGTCATGAGCTTAAGAATGGAGCTTAAGTCATGAGCCAGGACTATATAGTGAGACATTAT
ACACTATATCTAAATATTTGGAAAAAAAAGACTTAAAGGTCTGCCTTTTTGTCCCCTGTGGATA
ATATGCAGATAATTACGAGATTTTTATCTCATTCTGAAACATAATGGCAGCTTATCTATCAAGC
CAGCTGCTTCTGGACTGTGTGCATACATGTGGATGTGTGTGTTAGAAATGTCAGCCCTGCAGAA
AGGCTCTGAAAACTGTGTTCCCAGACTAGATTTCTACTAGGCAATCCTGGACTAGATTAGAGCT
GTGTTAAGAAAATCGATATTTGTCTCTCAGCAGCCGTGGGCTGGTGGTGGGGAGGACGGCTGTG
TACTCATGCAGCTGTCTACATTGGAAGGCATCTTCTCTTAAGTGCACACCATGCCCAGCCTCAT
GCACTAAGCTTTACACATGTGATCTGATCCTCAGAGCAACTCTGAAATCCCTGAGCCACCTCAC
ATCATCCCAACAGTCGAGGAAGAAGGGTCTAGTGCCATGGTTCAGTGCTGCAGTTCGGGTATGG
TTTGGAGTGTGTCCCTCAAAGTTTGATATGGTAGGTTCTCAGTCCCCAGATGTTCATGGAATCC
TTAAGAGGCTTGGCATACGGCTGGCAAGTTGTCAGATCCTCGGTGGAGCAAAGAGCTTGATGCC
GACTTTATAACTAAATCCAGTCTCTGGAATGCACATGGTAGAAAGAAAACTGACTCCCGCGGGT
GGTTCCCTGACTCTGACACATGGTGTGGTGGTAAATAAATAAATAAATGAATGAGTGTTAA

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Protein Sequences


Protein RefSeqs	NP_001012068	(Get FASTA)	NCBI Sequence Viewer
	XP_008758113	(Get FASTA)	NCBI Sequence Viewer
	XP_017444718	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83730	(Get FASTA)	NCBI Sequence Viewer
	EDM11755	(Get FASTA)	NCBI Sequence Viewer
	EDM11756	(Get FASTA)	NCBI Sequence Viewer
	EDM11757	(Get FASTA)	NCBI Sequence Viewer
	EDM11758	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001012068 ⟸ NM_001012068

- UniProtKB:

Q5XIF2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKVLLLKDAKDDDSGQDPYIQELRLCGLEATLIPVLSFEFMSLPSLSEKLSHPEGFGGLIFTSP
RAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEY
ICSKPSSELPLLFPCGTIKGDTLPKMLRDKGIPMESMHVYQTIPHPGIQGSLESYYENQGIPAS
ITFFSPSGLKYSLEYIQALSGGSFDQIKFVAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIR
KALKPNSCC

hide sequence

RefSeq Acc Id:

XP_008758113 ⟸ XM_008759891

- Peptide Label:

isoform X1

- Sequence:

show sequence

MKVLLLKDAKDDDSGQDPYIQELRLCGLEATLIPVLSFEFMSLPSLSEKLSHPEGFGGLIFTSP
RAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLGEESQKDEVNKIGLDAEGAGSG
NAEKLAEYICSKPSSELPLLFPCGTIKGDTLPKMLRDKGIPMESMHVYQTIPHPGIQGSLESYY
ENQGIPASITFFSPSGLKYSLEYIQALSGGSFDQIKFVAIGPSTTRAMAAKGLPVSCTAESPTP
QALAAGIRKALKPNSCC

hide sequence

RefSeq Acc Id:

XP_017444718 ⟸ XM_017589229

- Peptide Label:

isoform X1

- Sequence:

show sequence

MKVLLLKDAKDDDSGQDPYIQELRLCGLEATLIPVLSFEFMSLPSLSEKLSHPEGFGGLIFTSP
RAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLGEESQKDEVNKIGLDAEGAGSG
NAEKLAEYICSKPSSELPLLFPCGTIKGDTLPKMLRDKGIPMESMHVYQTIPHPGIQGSLESYY
ENQGIPASITFFSPSGLKYSLEYIQALSGGSFDQIKFVAIGPSTTRAMAAKGLPVSCTAESPTP
QALAAGIRKALKPNSCC

hide sequence

RefSeq Acc Id:

ENSRNOP00000024278 ⟸ ENSRNOT00000024279

Protein Domains

Tetrapyrrole biosynthesis uroporphyrinogen III

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XIF2-F1-model_v2	AlphaFold	Q5XIF2	1-265	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690489

Promoter ID:

EPDNEW_R1014

Type:

multiple initiation site

Name:

Uros_1

Description:

uroporphyrinogen III synthase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	205,777,177 - 205,777,237	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310396	AgrOrtholog
BioCyc Gene	G2FUF-57180	BioCyc
BioCyc Pathway	PWY-5189 [tetrapyrrole biosynthesis II (from glycine)]	BioCyc
Ensembl Genes	ENSRNOG00000017810	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000024278	ENTREZGENE
	ENSRNOP00000024278.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024279	ENTREZGENE
	ENSRNOT00000024279.5	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.10090	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7191339	IMAGE-MGC_LOAD
InterPro	4pyrrol_syn_uPrphyn_synt_sf	UniProtKB/TrEMBL
	4pyrrol_synth_uPrphyn_synth	UniProtKB/TrEMBL
	UROS/Hem4	UniProtKB/TrEMBL
KEGG Report	rno:309070	UniProtKB/TrEMBL
MGC_CLONE	MGC:94633	IMAGE-MGC_LOAD
NCBI Gene	309070	ENTREZGENE
PANTHER	PTHR12390	UniProtKB/TrEMBL
	UROPORPHYRINOGEN-III SYNTHASE	UniProtKB/TrEMBL
Pfam	HEM4	UniProtKB/TrEMBL
PhenoGen	Uros	PhenoGen
Superfamily-SCOP	HEM4_synth	UniProtKB/TrEMBL
UniProt	Q5XIF2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Uros	uroporphyrinogen III synthase	Uros_predicted	uroporphyrinogen III synthase (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Uros_predicted	uroporphyrinogen III synthase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)