Pik3c2a (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha) - Rat Genome Database

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Gene: Pik3c2a (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha) Rattus norvegicus
Analyze
Symbol: Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
RGD ID: 1310389
Description: Predicted to enable clathrin binding activity and phosphatidylinositol kinase activity. Predicted to be involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; phosphatidylinositol-3-phosphate biosynthetic process; and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to act upstream of or within autophagosome organization; cellular response to starvation; and negative regulation of zinc ion transmembrane transport. Predicted to be located in several cellular components, including clathrin-coated vesicle; nucleoplasm; and trans-Golgi network. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha); PARTICIPATES IN phosphoinositide metabolic pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; DDT.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361632; phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphoinositide-3-kinase, class 2 alpha polypeptide; phosphoinositide-3-kinase, class 2, alpha polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21170,577,942 - 170,684,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,577,942 - 170,683,472 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1178,895,808 - 179,001,695 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,082,327 - 186,188,218 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,795,249 - 178,900,740 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01185,210,922 - 185,326,314 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1185,210,922 - 185,326,314 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,182,647 - 192,297,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41174,430,831 - 174,537,706 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11174,572,538 - 174,676,951 (-)NCBI
Celera1168,399,225 - 168,504,593 (-)NCBICelera
Cytogenetic Map1q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
heptanal  (ISO)
hexadecanoic acid  (ISO)
hexanal  (ISO)
hypochlorous acid  (ISO)
inulin  (ISO)
isoflavones  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
nonanal  (ISO)
octanal  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
propanal  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sorafenib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tetracycline  (ISO)
thimerosal  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. Dominguez V, etal., J Biol Chem. 2011 Feb 11;286(6):4216-25. doi: 10.1074/jbc.M110.200295. Epub 2010 Dec 2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:8663140   PMID:16336212   PMID:17179444   PMID:19056867   PMID:19946888   PMID:21081650   PMID:23823722   PMID:24098492   PMID:25357130   PMID:26175229   PMID:28910396   PMID:33999393  
PMID:36132983  


Genomics

Comparative Map Data
Pik3c2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21170,577,942 - 170,684,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,577,942 - 170,683,472 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1178,895,808 - 179,001,695 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,082,327 - 186,188,218 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,795,249 - 178,900,740 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01185,210,922 - 185,326,314 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1185,210,922 - 185,326,314 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,182,647 - 192,297,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41174,430,831 - 174,537,706 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11174,572,538 - 174,676,951 (-)NCBI
Celera1168,399,225 - 168,504,593 (-)NCBICelera
Cytogenetic Map1q35NCBI
PIK3C2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,086,575 - 17,207,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,077,730 - 17,207,986 (-)EnsemblGRCh38hg38GRCh38
GRCh371117,108,122 - 17,229,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,064,698 - 17,147,930 (-)NCBINCBI36Build 36hg18NCBI36
Build 341117,067,860 - 17,147,864NCBI
Celera1117,236,314 - 17,320,701 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1116,791,536 - 16,875,065 (-)NCBIHuRef
CHM1_11117,107,728 - 17,190,971 (-)NCBICHM1_1
T2T-CHM13v2.01117,184,463 - 17,305,651 (-)NCBIT2T-CHM13v2.0
Pik3c2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397115,936,500 - 116,042,693 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7115,936,500 - 116,042,684 (-)EnsemblGRCm39 Ensembl
GRCm387116,337,265 - 116,443,465 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7116,337,265 - 116,443,449 (-)EnsemblGRCm38mm10GRCm38
MGSCv377123,480,790 - 123,586,972 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367116,130,710 - 116,209,201 (-)NCBIMGSCv36mm8
Celera7116,275,791 - 116,376,830 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map761.62NCBI
Pik3c2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541431,896,161 - 31,999,730 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541431,896,161 - 31,999,730 (-)NCBIChiLan1.0ChiLan1.0
PIK3C2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11119,382,544 - 19,503,423 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,143,024 - 17,263,920 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11116,828,959 - 16,949,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1116,828,966 - 16,949,856 (-)Ensemblpanpan1.1panPan2
PIK3C2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,693,211 - 39,868,603 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,695,520 - 39,784,639 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,193,753 - 39,309,848 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02140,798,394 - 40,914,802 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2140,799,161 - 40,914,780 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12139,813,119 - 39,927,798 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,018,167 - 40,133,971 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,357,482 - 40,473,688 (-)NCBIUU_Cfam_GSD_1.0
Pik3c2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,811,389 - 45,932,425 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,869,527 - 1,964,183 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365281,845,372 - 1,964,908 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3C2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,829,916 - 42,024,362 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,829,969 - 42,024,062 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,958,962 - 45,079,401 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3C2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,759,850 - 47,874,458 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,795,954 - 47,877,028 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038145,200,659 - 145,318,077 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3c2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247668,701,642 - 8,776,578 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247668,698,836 - 8,834,928 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3c2a
582 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:548
Count of miRNA genes:272
Interacting mature miRNAs:346
Transcripts:ENSRNOT00000055120
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat

Markers in Region
RH136965  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,578,275 - 170,578,459 (-)MAPPERmRatBN7.2
Rnor_6.01185,325,797 - 185,325,980NCBIRnor6.0
Rnor_5.01192,296,517 - 192,296,700UniSTSRnor5.0
RGSC_v3.41174,431,165 - 174,431,348UniSTSRGSC3.4
Celera1168,399,559 - 168,399,742UniSTS
RH 3.4 Map11562.2UniSTS
Cytogenetic Map1q34-q35UniSTS
RH140296  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,611,306 - 170,611,490 (-)MAPPERmRatBN7.2
Rnor_6.01185,292,766 - 185,292,949NCBIRnor6.0
Rnor_5.01192,263,486 - 192,263,669UniSTSRnor5.0
RGSC_v3.41174,464,196 - 174,464,379UniSTSRGSC3.4
Celera1168,432,590 - 168,432,773UniSTS
Cytogenetic Map1q34-q35UniSTS
AI236381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,598,205 - 170,598,421 (-)MAPPERmRatBN7.2
Rnor_6.01185,305,835 - 185,306,050NCBIRnor6.0
Rnor_5.01192,276,555 - 192,276,770UniSTSRnor5.0
RGSC_v3.41174,451,095 - 174,451,310UniSTSRGSC3.4
Celera1168,419,489 - 168,419,704UniSTS
Cytogenetic Map1q34-q35UniSTS
BM387076  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,580,147 - 170,580,355 (-)MAPPERmRatBN7.2
Rnor_6.01185,323,901 - 185,324,108NCBIRnor6.0
Rnor_5.01192,294,621 - 192,294,828UniSTSRnor5.0
RGSC_v3.41174,433,037 - 174,433,244UniSTSRGSC3.4
Celera1168,401,431 - 168,401,638UniSTS
RH 3.4 Map11562.91UniSTS
Cytogenetic Map1q34-q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 30 28 12 16 12 2 2 74 33 38 11 2
Low 2 13 29 29 3 29 6 8 2 3 6
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000055120   ⟹   ENSRNOP00000051993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1170,577,942 - 170,683,472 (-)Ensembl
Rnor_6.0 Ensembl1185,210,922 - 185,326,314 (+)Ensembl
RefSeq Acc Id: NM_001108500   ⟹   NP_001101970
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21170,577,942 - 170,683,472 (-)NCBI
Rnor_6.01185,210,922 - 185,326,314 (+)NCBI
Rnor_5.01192,182,647 - 192,297,034 (+)NCBI
RGSC_v3.41174,430,831 - 174,537,706 (-)RGD
Celera1168,399,225 - 168,504,593 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082801   ⟹   XP_038938729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21170,594,837 - 170,684,353 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001101970   ⟸   NM_001108500
- UniProtKB: D3ZTF6 (UniProtKB/TrEMBL),   A6I8E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051993   ⟸   ENSRNOT00000055120
RefSeq Acc Id: XP_038938729   ⟸   XM_039082801
- Peptide Label: isoform X1
Protein Domains
C2   C2 PI3K-type   PI3K-RBD   PI3K/PI4K catalytic   PIK helical   PX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTF6-F1-model_v2 AlphaFold D3ZTF6 1-1687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310389 AgrOrtholog
BioCyc Gene G2FUF-57715 BioCyc
Ensembl Genes ENSRNOG00000020479 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000051993 ENTREZGENE
  ENSRNOP00000051993.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055120 ENTREZGENE
  ENSRNOT00000055120.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.30.1520.10 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  IPR001683 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K-C2-alpha_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_ras-bd UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/TrEMBL
  PX_PI3K_C2_alpha UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:361632 UniProtKB/TrEMBL
NCBI Gene 361632 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/TrEMBL
  PF00787 UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
PhenoGen Pik3c2a PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  PS50195 UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00312 UniProtKB/TrEMBL
Superfamily-SCOP 64268 UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A6I8E5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTF6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Pik3c2a  phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha  Pik3c2a  phosphoinositide-3-kinase, class 2, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Pik3c2a  phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha  Pik3c2a  phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pik3c2a  phosphoinositide-3-kinase, class 2, alpha polypeptide  Pik3c2a  phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pik3c2a  phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide   Pik3c2a_predicted  phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pik3c2a_predicted  phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (predicted)      Symbol and Name status set to approved 70820 APPROVED