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Gene: Me2 (malic enzyme 2) Rattus norvegicus

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Symbol:

Me2

Name:

malic enzyme 2

RGD ID:

1310321

Description:

Predicted to enable malate dehydrogenase (decarboxylating) (NAD+) activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and regulation of NADP metabolic process. Predicted to be active in mitochondrial matrix. Orthologous to human ME2 (malic enzyme 2); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC307270; malic enzyme 2, NAD(+)-dependent, mitochondrial; NAD-dependent malic enzyme, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ME2 (malic enzyme 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Me2 (malic enzyme 2, NAD(+)-dependent, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Me2 (malic enzyme 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ME2 (malic enzyme 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ME2 (malic enzyme 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Me2 (malic enzyme 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ME2 (malic enzyme 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ME2 (malic enzyme 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Me2 (malic enzyme 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ME2 (malic enzyme 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Me2 (malic enzyme 2, NAD(+)-dependent, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	me2 (malic enzyme 2, NAD(+)-dependent, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MAE1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MAE1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Men	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Men	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Men-b	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Men-b	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Caenorhabditis elegans (roundworm):	men-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	men-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	me2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	me2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	69,626,073 - 69,676,218 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	69,626,087 - 69,676,218 (-)	Ensembl				GRCr8
mRatBN7.2	18	67,350,833 - 67,400,987 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	67,355,795 - 67,400,987 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	69,463,875 - 69,509,062 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	70,138,497 - 70,183,469 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	68,003,831 - 68,049,018 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	69,737,515 - 69,784,099 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	69,738,686 - 69,784,099 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	68,882,367 - 68,927,780 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	70,545,530 - 70,590,828 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	65,538,881 - 65,583,847 (-)	NCBI		Celera
RGSC_v3.1	18	70,619,765 - 70,655,815 (-)	NCBI
Cytogenetic Map	18	q12.2	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Right Ventricular Hypertrophy (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

2-methoxyethanol (EXP)

2-methylcholine (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrolein (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

bilirubin IXalpha (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

cyclosporin A (ISO)

deguelin (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

etoposide (ISO)

fenvalerate (EXP)

folic acid (ISO)

formaldehyde (ISO)

furfural (ISO)

gallic acid (ISO)

hydralazine (ISO)

indole-3-methanol (EXP)

ivermectin (ISO)

josamycin (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lead(0) (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

nickel atom (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

phenylmercury acetate (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sunitinib (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (ISO)

trichloroethene (EXP)

tris(2-butoxyethyl) phosphate (ISO)

triticonazole (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

malate metabolic process (IBA)

regulation of NADP metabolic process (IEA,ISO)

Cellular Component

mitochondrial matrix (IEA,ISO)

mitochondrion (IBA,IEA,ISO)

Molecular Function

catalytic activity (IEA)

malate dehydrogenase (decarboxylating) (NAD+) activity (IEA,ISO)

malate dehydrogenase (decarboxylating) (NADP+) activity (IBA)

malic enzyme activity (IEA,ISO)

metal ion binding (IEA)

NAD binding (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Leigh disease pathway (ISO)

primary hyperoxaluria type 2 pathway (ISO)

pyruvate decarboxylase deficiency pathway (ISO)

pyruvate dehydrogenase E1 deficiency pathway (ISO)

pyruvate kinase deficiency of red cells pathway (ISO)

pyruvate metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension.	Piao L, etal., J Mol Med (Berl). 2013 Oct;91(10):1185-97. doi: 10.1007/s00109-013-1064-7. Epub 2013 Jun 21.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:14651853	PMID:18614015	PMID:19691144	PMID:23334421	PMID:37087800

Genomics

Comparative Map Data

Me2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	69,626,073 - 69,676,218 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	69,626,087 - 69,676,218 (-)	Ensembl				GRCr8
mRatBN7.2	18	67,350,833 - 67,400,987 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	67,355,795 - 67,400,987 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	69,463,875 - 69,509,062 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	70,138,497 - 70,183,469 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	68,003,831 - 68,049,018 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	69,737,515 - 69,784,099 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	69,738,686 - 69,784,099 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	68,882,367 - 68,927,780 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	70,545,530 - 70,590,828 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	65,538,881 - 65,583,847 (-)	NCBI		Celera
RGSC_v3.1	18	70,619,765 - 70,655,815 (-)	NCBI
Cytogenetic Map	18	q12.2	NCBI

ME2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	50,879,118 - 50,954,257 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	50,879,080 - 50,954,257 (+)	Ensembl			hg38	GRCh38
GRCh37	18	48,405,488 - 48,480,627 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	46,659,433 - 46,728,258 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	18	46,659,599 - 46,727,631	NCBI
Celera	18	45,262,199 - 45,332,954 (+)	NCBI		Celera
Cytogenetic Map	18	q21.2	NCBI
HuRef	18	45,260,837 - 45,331,606 (+)	ENTREZGENE		HuRef
CHM1_1	18	48,400,883 - 48,471,611 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	51,080,843 - 51,155,984 (+)	NCBI		T2T-CHM13v2.0

Me2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	73,898,025 - 73,949,326 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	73,902,974 - 73,948,520 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	73,764,954 - 73,815,438 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	73,769,903 - 73,815,449 (-)	Ensembl			mm10	GRCm38
MGSCv37	18	73,929,694 - 73,975,046 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	73,895,409 - 73,940,761 (-)	NCBI		MGSCv36	mm8
Celera	18	75,007,068 - 75,052,694 (-)	NCBI		Celera
Cytogenetic Map	18	E2	NCBI
cM Map	18	49.95	NCBI

Me2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	35,835,578 - 35,894,051 (+)	Ensembl
ChiLan1.0	NW_004955402	35,816,474 - 35,894,051 (+)	NCBI	ChiLan1.0	ChiLan1.0

ME2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	68,396,745 - 68,466,631 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	54,090,030 - 54,159,235 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	44,250,067 - 44,319,206 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	47,613,446 - 47,665,330 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	47,613,446 - 47,665,330 (+)	Ensembl			panPan2	panpan1.1

ME2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	23,985,482 - 24,032,642 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	23,985,994 - 24,025,747 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	24,972,260 - 25,020,810 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	23,876,884 - 23,925,519 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	23,876,879 - 23,925,505 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	23,937,287 - 23,985,836 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	23,823,416 - 23,872,201 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	24,096,731 - 24,145,314 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Me2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	37,109,234 - 37,174,800 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	12,353,053 - 12,401,125 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936497	12,352,406 - 12,414,014 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ME2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	100,419,760 - 100,476,733 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	100,419,404 - 100,475,778 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	110,333,103 - 110,399,885 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ME2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	30,025,734 - 30,095,692 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	30,026,431 - 30,095,691 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	4,156,451 - 4,226,675 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Me2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	14,443,650 - 14,500,017 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624778	14,423,219 - 14,501,472 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Me2
263 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	459
Count of miRNA genes:	233
Interacting mature miRNAs:	279
Transcripts:	ENSRNOT00000049759
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
1331730	Scl27	Serum cholesterol level QTL 27	3.826		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	54490801	86134022	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
1298072	Cia26	Collagen induced arthritis QTL 26	3.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	64383762	79484311	Rat
631834	Sach3	Saccharin preference QTL 3	3.9	0.01	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	18	38575919	83575919	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26822186	71822186	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26822186	71822186	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26822186	71822186	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	45620306	86134022	Rat
7794793	Mcs34	Mammary carcinoma susceptibility QTL 34	1.54		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	18	65635567	85897775	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26822186	71822186	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	48915737	86134022	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	48915737	86134022	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26822186	71822186	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26822186	71822186	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	31990891	76990891	Rat
1331770	Bp234	Blood pressure QTL 234	3.807		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	45620306	86134022	Rat
2301969	Bp324	Blood pressure QTL 324	4.05		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	61982204	76619168	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31610505	85493247	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	33379158	78379158	Rat
724542	Kidm2	Kidney mass QTL 2	2.6		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	18	61446853	86134022	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	40462383	85462383	Rat
1359020	Ppulsi2	Prepulse inhibition QTL 2	2.71		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	18	54490801	76272247	Rat
2312600	Bp341	Blood pressure QTL 341		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	61600384	72538878	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	31990891	76990891	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	33379158	78379158	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	33379158	78379158	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	33379158	78379158	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	50795212	86134022	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26822186	71822186	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31522783	76522783	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	33379158	78379158	Rat
61384	Bp48	Blood pressure QTL 48	19.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	62892257	79484461	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	33379158	78379158	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	33379158	78379158	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	57825243	85493247	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31610505	77371277	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	36121626	81121626	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	31990891	76990891	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	48915737	86134022	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	26415821	71415821	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31644508	79484311	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	65846447	86134022	Rat
1598832	Glom11	Glomerulus QTL 11	2.9		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	53266671	86134022	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	31990891	76990891	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	50795212	86134022	Rat
631675	Iddm15	Insulin dependent diabetes mellitus QTL 15			urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	18	62892257	79484461	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31610505	72538878	Rat

Markers in Region

RH130986

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	67,355,851 - 67,356,031 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	69,738,743 - 69,738,922	NCBI	Rnor6.0
Rnor_5.0	18	68,882,424 - 68,882,603	UniSTS	Rnor5.0
RGSC_v3.4	18	70,545,587 - 70,545,766	UniSTS	RGSC3.4
Celera	18	65,538,938 - 65,539,117	UniSTS
RH 3.4 Map	18	685.4	UniSTS
Cytogenetic Map	18	q12.2	UniSTS

RH142588

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	67,356,807 - 67,356,934 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	69,739,699 - 69,739,825	NCBI	Rnor6.0
Rnor_5.0	18	68,883,380 - 68,883,506	UniSTS	Rnor5.0
RGSC_v3.4	18	70,546,543 - 70,546,669	UniSTS	RGSC3.4
Celera	18	65,539,894 - 65,540,020	UniSTS
RH 3.4 Map	18	681.4	UniSTS
Cytogenetic Map	18	q12.2	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BF522605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB556640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB794492	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV796911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV771591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000049759 ⟹ ENSRNOP00000041737

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	69,631,034 - 69,676,218 (-)	Ensembl
mRatBN7.2 Ensembl	18	67,355,795 - 67,400,987 (-)	Ensembl
Rnor_6.0 Ensembl	18	69,738,686 - 69,784,099 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079093 ⟹ ENSRNOP00000073241

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	69,631,034 - 69,675,917 (-)	Ensembl
mRatBN7.2 Ensembl	18	67,355,795 - 67,400,898 (-)	Ensembl
Rnor_6.0 Ensembl	18	69,739,675 - 69,780,922 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000163051 ⟹ ENSRNOP00000100974

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	69,626,087 - 69,676,218 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000173790 ⟹ ENSRNOP00000103470

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	69,631,034 - 69,675,796 (-)	Ensembl

RefSeq Acc Id:

NM_001107376 ⟹ NP_001100846

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	69,631,034 - 69,676,218 (-)	NCBI
mRatBN7.2	18	67,355,795 - 67,400,987 (-)	NCBI
Rnor_6.0	18	69,738,686 - 69,784,099 (-)	NCBI
Rnor_5.0	18	68,882,367 - 68,927,780 (-)	NCBI
RGSC_v3.4	18	70,545,530 - 70,590,828 (-)	RGD
Celera	18	65,538,881 - 65,583,847 (-)	RGD

Sequence:

show sequence

CGGCAGGGCGGCGCCAGGGCCGAGCATCTCTGGCTATAGCGCCGCGGCCTCTCTGCTTGCTGCA
CTACCTGGCACGGGCCAGGCGTCCGGAGAGAGAAGATGTTTTCCCGGTTAAGAGCTGTTACCAC
TCCTTGCACTTTGACCTGCCGCAGAGTGCACCTGAAGGAGAAGGGCAAGCCACTCATGTTGAAT
CCAAGAACAAACAAGGGGATGGCGTTTACATTACAAGAACGACAAATGCTTGGTCTTCAAGGAC
TTTTACCTCCTAAAATAGAGACACAGGATATTCAAGCCTTACGATTCCATAGAAACTTGAAAAA
AATGACTAGCCCTTTGGAAAAATACATCTATATAATGGGCATACAAGAAAGAAACGAGAAACTG
TTTTATAGAATACTACAGGATGATATTGAAAGTCTGATGCCAATTGTGTACACACCAACAGTTG
GTCTTGCCTGTTGTCAATACGGACATATCTTTAGGAGACCTAAGGGATTGTTTATTTCAATCTC
AGACAGAGGTCATGTTAGATCAATTGTGGATAACTGGCCAGAAAATCATGTTAAGGCTGTTGTG
GTGACTGATGGAGAGAGAATCCTGGGACTTGGAGATTTGGGTGTCTATGGAATGGGGATTCCAG
TCGGGAAGCTTTGCTTGTATACAGCATGCGCAGGAATCCAGCCTGAGAAATGCCTGCCTGTGTG
CATCGATGTAGGGACTGATAACATGGCTCTACTGAAAGACCCGTTTTATATGGGCTTGTATCAG
AAGCGAGACCGCTCCCAGCTCTATGACGATCTGATGGATGAGTTTATGAAGGCGATCACTGACA
GATATGGCCGGAACACACTTATTCAGTTTGAAGACTTTGGAAATCATAATGCATTCAGATTCTT
AAAAAAATACCAGGAAAAATACTGTACCTTCAATGACGACATTCAAGGGACTGCTGCAGTTGCC
TTGTCTGGTCTCCTTGCGGCCCAAAGAGTGATTAATAAACCAATCTCAGAACACAGAATCTTAT
TCCTCGGGGCAGGAGAGGCTGCACTTGGAATTGCGAAGCTTATAGTCATATCAATGATGGAAAG
TGGTCTCTCAGAAGAGGAGGCACAGAGAAAGATCTGGATGTTCGACAAGAACGGCTTGCTAGTT
AAGGGCCGGACTGCTAGAATAGATAGTAACCAGGAACCATATGCTCATGCTGCCTCAGAGAACA
TACCTGCAACCTTTGAAGATGCAGTAAATAAACTTAAGCCTTCAGTTATAATTGGAGTGGCAGG
TGCTGGCCCGCTTTTTACTCCTGGCGTAATTAAAGCCATGGCCGCTATCAACGAGAGGCCCATA
ATATTTGCTTTAAGCAATCCTACAGCACAGGCCGAGTGCACTGCCGAAGACGCTTACACACTTA
CAGAGGGCAGGTGCTTGTTTGCCAGTGGCAGCCCATTTGAGCCGGTGAGACTCCAGGATGGGCG
TGTCTTCACCCCGGGCCAAGGGAACAATGCATACATCTTCCCAGGTGTGGCTTTAGCTGTTATT
CTCTGTGAAGCCCGACACATCAGTGACACCGTTTTCTTAGAAGCTGCAAAGGCACTGACATCCC
AATTGACAGATGAAGAGTTAGCCCAAGGGAGGCTTTACCCATCACTTGCTAATATTCAGGAAGT
TTCTGCTAACATAGCTATTAAAATTGCAGAGTACCTGTACGCTAATAAAATGGCTTTCCGATAC
CCAGAGCCCGAGGACAAGGCCAAATATGTGAAGGAAAGGATATGGCGGAGTAATTATGTTTCCC
TGCTGCCAGATGTGTATGATTGGCCAGAGTCGTCATTGAAGCCTCCGCAGATACCAGAATAGAA
GCTTTCCCTTTAAGACATTCCGTGCTGCAGGGACAAAAAGATAATATTCTCTGAGTTACTGTGT
CCTCTGGTTTATTCCTCCGTACTACTTTGCTTGGCATTTTTCCTGTGAATCTAGCTTTGGTTGG
GGACAGACATGCTGACTATGCTGTGGTGCCCACAGTCCAGTACTGGGAATGCTTCATTCAGTTC
AGTGGGTCTCCTCGTGTGCTCTGCTTTGAGCTCGCCACGGTATTGTTGCTGTTACGTGAATGTC
TCTCTTCTTCCACTCAGTCCTCTAGCACTGTGCATATGAGTACAACGTGTTGAGAAGAAGCTAA
GTGTTCACCAAATCCCAAAGAAAAAGTTGTTAGCACTTAAAGCTGTTCTTTTTCTTTTCTTTCT
TTTTTTTTTTTTTTTTTTTTTTTGGAGCTGGGGACCGAACCCAGGGCCTTGCGCTTGCTAGGCA
AACGCTCTACCACTGAGCTAAATCCCCCACCCCAAGCTGTTCTTTTCTATATACTTCATTTCAC
TTTCTGCTCTGAAATTCCTTTGTAGTAGACAGGTTTGGGGAAATAGGAAAACAAAAAAAAAGAT
CCCAGTTTCCTAGAACTAAATCAGTGCTAACTGTAACATTCTAGAAGAATGGGAGGAGCCACTG
CTGCCTTTAGACAGACTGAACAGCCATCTGCAACAGTGTACAAACAAGTTTTACTAATAAAACC
AATTCCTTACGTTTAATTGCTTCAGTTACATTATCTTATTGACCACACAGAAACTTAGGTTTGT
TGGTTATGACAAGAGTTTCATCATCTTCACTCAGTTAAGGGAGTATCATCTATCTACCACGCAT
GACTAATGTCATGTGATTCGGAGATGGTGCCTAAGGGGTTAACTACAGCCTAGGTCTTCCCCCT
GTCAGTCACGTCCTTTACTGTGCAGTAATTAGAGGATCTCCTCACATACATTCCTTTGAATATT
AGCAGTGATGGCTTTCTCTGCTGAGAATGCAAAATAGATTCCAAGATTACTGGAGATAAATAAA
GTAGAATCAGACCAGGAAA

hide sequence

RefSeq Acc Id:

XM_006254923 ⟹ XP_006254985

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	69,627,842 - 69,673,554 (-)	NCBI
mRatBN7.2	18	67,352,604 - 67,397,659 (-)	NCBI
Rnor_6.0	18	69,737,515 - 69,782,567 (-)	NCBI
Rnor_5.0	18	68,882,367 - 68,927,780 (-)	NCBI

Sequence:

show sequence

TTGATTGGTTTTTTAGACAGGGTCTGACATCACCCAAGTTGGCCTTGCATTGACTTGCAATTGC
GTTGCCAGGATTCCCAAGTGCTCGAACACCTGGGCGTCCTCCATGCCCGCTCGTTTAGCAGGCT
TTGTCATTGTTTAAGTTAAAAGCTTCTTGATTCTGTTTGTGCCTAATTTGTATTTAACTCCCAT
TTTTTAAGTTTGCATCTGTATTTTTTATATTATGTTAAATTAAAATGATAACTCATAGATCATG
AAACAAACTAGTTGTATTTGAGACACAAGTATAATATAATATACAATACACAAATATAATATTT
GAGACTATAAAGATAACTGTTAACATTAGGGAACGAAATCTAGGCTCAGAGTTAATTTGGTTTA
ATTACTTTATTGAAAGGTAACTAGTTTATTTAAAGGTAAATGCTTATGGCTGAAACATGCTCGT
GTGTCTGAGACTGACCAATGTTTATGAATTTCCAAGTGAAGAACATGTTATTTCTATAGGTACT
GTTCAGTATTTTCATTTATCTGGATCTCTGTACTGTTCATGTTCTTCTTGACCCAGATAGAGAA
TGAAGTATGTTGTGTTAATCTTGATTGTCCTCATAACCTCTTAATTTAATCATCAAAAAAATGT
TGATGCAGAAACTCCCAGGCATTTAGAGCGTAACTCCTGTCCAGGTTAGCCAGTAGCAGTGGTA
ATACTTAATAAGGAACATTTATACAGCAGCGCAATAAGCATTTGGGATCTAATTTAAATTTAAA
CTATCTTAATTTTAACCTTCAGGGAGTGGAGGAAGCCCTTTGAGTAGTTCCTGTTGTAAGCTTG
AGGGAGAACTGAAACTCAGAGAGGGCGAGTGAGACTTTACCACCAGATAGAGGATACAGACAGT
GGCAAACCAAGGGTGTAAGACCGGGCAGTCTGACTGTGGAGCTTGCAGAACGACCTTTCTTTTT
ATTGGAAAAACCTTCAAGTCAGGCAGTGAGGCTTGTGATGAGGTCCCAGTACTCTATGTGGATG
TACTCTGTCACTCTGTGAGTTTGACAGCTAGGTTTCCCTTTCCTTTCCCTTTGTGTGTTATACC
TGTGTTCACTGAGTGTGGAGGCCACAGCTGCTGTCCTCAGTTACTTCATCTTATTTCCAGAGAT
ACAGTCTTTCACTTGTTCCTCTGTCTAGACTGGCTCGAACAAGATCTGCTGTTGCAACCCTCCT
GCCGCTGTCACGGGGGTTACGTGCACCTATATATCTGCCTTTCATATGAGCTTGTTAGGGATTT
GAATTCGGGTCCTCGTGATTGTGAAGGGAGCACTTTACTTACTGAGCCAGACAGACGAGCGTTC
TGATGGCGTGGTTGGTTCCTAGATTAAACTTCAATAACAGGGTTTTTTTAATTGTTGTTGTTAA
GTATATATGTAGAGATGTGTTGTGATATTTGTAGATATTTGGGACCAGACATGAGGTTGCCAGT
GTTTCTTTATGTTTAGACCCTTCCTAAAGATTCAGTAAATTCTACTGATTGGGACACGGGAGGG
CTACTGTGATTTTGAGACCTGTCTGTTCTAATTAGTGACTTTGAGACCCAAACATAGCCCAACA
GTGTCTTTAAGACGATAACACAACCCCTTGAAAAGTCCACTGTCCCTATCCTGTCCTAAAAGAT
AGGATTTAACCACCAGAAAGGGAAGGTCATAATAACATAAAAACAGAGGATACATTTAGTATTA
TGAACAATGCTATTATATTGTCCTAGTTTCTCCTTAGGTTGTCACAGGCCAGTGAAACCGTGAC
TAACCCCAGTGCCAAATCAAAGACCATTTTGGATCTCCAGAGTGACTGCTCATGCTAAACTGGA
GAGAGAAGATGTTTTCCCGGTTAAGAGCTGTTACCACTCCTTGCACTTTGACCTGCCGCAGAGT
GCACCTGAAGGAGAAGGGCAAGCCACTCATGTTGAATCCAAGAACAAACAAGGGGATGGCGTTT
ACATTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTTTACCTCCTAAAATAGAGACACAGG
ATATTCAAGCCTTACGATTCCATAGAAACTTGAAAAAAATGACTAGCCCTTTGGAAAAATACAT
CTATATAATGGGCATACAAGAAAGAAACGAGAAACTGTTTTATAGAATACTACAGGATGATATT
GAAAGTCTGATGCCAATTGTGTACACACCAACAGTTGGTCTTGCCTGTTGTCAATACGGACATA
TCTTTAGGAGACCTAAGGGATTGTTTATTTCAATCTCAGACAGAGGTCATGTTAGATCAATTGT
GGATAACTGGCCAGAAAATCATGTTAAGGCTGTTGTGGTGACTGATGGAGAGAGAATCCTGGGA
CTTGGAGATTTGGGTGTCTATGGAATGGGGATTCCAGTCGGGAAGCTTTGCTTGTATACAGCAT
GCGCAGGAATCCAGCCTGAGAAATGCCTGCCTGTGTGCATCGATGTAGGGACTGATAACATGGC
TCTACTGAAAGACCCGTTTTATATGGGCTTGTATCAGAAGCGAGACCGCTCCCAGCTCTATGAC
GATCTGATGGATGAGTTTATGAAGGCGATCACTGACAGATATGGCCGGAACACACTTATTCAGT
TTGAAGACTTTGGAAATCATAATGCATTCAGATTCTTAAAAAAATACCAGGAAAAATACTGTAC
CTTCAATGACGACATTCAAGGGACTGCTGCAGTTGCCTTGTCTGGTCTCCTTGCGGCCCAAAGA
GTGATTAATAAACCAATCTCAGAACACAGAATCTTATTCCTCGGGGCAGGAGAGGCTGCACTTG
GAATTGCGAAGCTTATAGTCATATCAATGATGGAAAGTGGTCTCTCAGAAGAGGAGGCACAGAG
AAAGATCTGGATGTTCGACAAGAACGGCTTGCTAGTTAAGGGCCGGACTGCTAGAATAGATAGT
AACCAGGAACCATATGCTCATGCTGCCTCAGAGAACATACCTGCAACCTTTGAAGATGCAGTAA
ATAAACTTAAGCCTTCAGTTATAATTGGAGTGGCAGGTGCTGGCCCGCTTTTTACTCCTGGCGT
AATTAAAGCCATGGCCGCTATCAACGAGAGGCCCATAATATTTGCTTTAAGCAATCCTACAGCA
CAGGCCGAGTGCACTGCCGAAGACGCTTACACACTTACAGAGGGCAGGTGCTTGTTTGCCAGTG
GCAGCCCATTTGAGCCGGTGAGACTCCAGGATGGGCGTGTCTTCACCCCGGGCCAAGGGAACAA
TGCATACATCTTCCCAGGTGTGGCTTTAGCTGTTATTCTCTGTGAAGCCCGACACATCAGTGAC
ACCGTTTTCTTAGAAGCTGCAAAGGCACTGACATCCCAATTGACAGATGAAGAGTTAGCCCAAG
GGAGGCTTTACCCATCACTTGCTAATATTCAGGAAGTTTCTGCTAACATAGCTATTAAAATTGC
AGAGTACCTGTACGCTAATAAAATGGCTTTCCGATACCCAGAGCCCGAGGACAAGGCCAAATAT
GTGAAGGAAAGGATATGGCGGAGTAATTATGTTTCCCTGCTGCCAGATGTGTATGATTGGCCAG
AGTCGTCATTGAAGCCTCCGCAGATACCAGAATAGAAGCTTTCCCTTTAAGACATTCCGTGCTG
CAGGGACAAAAAGATAATATTCTCTGAGTTACTGTGTCCTCTGGTTTATTCCTCCGTACTACTT
TGCTTGGCATTTTTCCTGTGAATCTAGCTTTGGTTGGGGACAGACATGCTGACTATGCTGTGGT
GCCCACAGTCCAGTACTGGGAATGCTTCATTCAGTTCAGTGGGTCTCCTCGTGTGCTCTGCTTT
GAGCTCGCCACGGTATTGTTGCTGTTACGTGAATGTCTCTCTTCTTCCACTCAGTCCTCTAGCA
CTGTGCATATGAGTACAACGTGTTGAGAAGAAGCTAAGTGTTCACCAAATCCCAAAGAAAAAGT
TGTTAGCACTTAAAGCTGTTCTTTTTCTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTTGGAG
CTGGGGACCGAACCCAGGGCCTTGCGCTTGCTAGGCAAACGCTCTACCACTGAGCTAAATCCCC
CACCCCAAGCTGTTCTTTTCTATATACTTCATTTCACTTTCTGCTCTGAAATTCCTTTGTAGTA
GACAGGTTTGGGGAAATAGGAAAACAAAAAAAAAGATCCCAGTTTCCTAGAACTAAATCAGTGC
TAACTGTAACATTCTAGAAGAATGGGAGGAGCCACTGCTGCCTTTAGACAGACTGAACAGCCAT
CTGCAACAGTGTACAAACAAGTTTTACTAATAAAACCAATTCCTTACGTTTAATTGCTTCAGTT
ACATTATCTTATTGACCACACAGAAACTTAGGTTTGTTGGTTATGACAAGAGTTTCATCATCTT
CACTCAGTTAAGGGAGTATCATCTATCTACCACGCATGACTAATGTCATGTGATTCGGAGATGG
TGCCTAAGGGGTTAACTACAGCCTAGGTCTTCCCCCTGTCAGTCACGTCCTTTACTGTGCAGTA
ATTAGAGGATCTCCTCACATACATTCCTTTGAATATTAGCAGTGATGGCTTTCTCTGCTGAGAA
TGCAAAATAGATTCCAAGATTACTGGAGATAAATAAAGTAGAATCAGACCAGGAAATGCTTTTT
GTATTTTCAAGATAGGATCTTACTATGTAGGCCTGGCTGTCCTGAAACTCACCCTGTAGACCAG
AGTGGCCCAAAACTCACCGAGATCTACCTGCCTCCAGAGTGCTGGGATTGGGGACGTACACTAC
TACACCTGGCAGGAAATTCCTTTTTTTTTTTTTTTAAAGATTTATTTATTTCATTTCTATGAGT
ACATTGTTATTCTCTTCAGATACACCAGAAGAGGGCATCGGATCCCATTACAGATGGTTGTGAG
CCACCATGTGGTTGCTGGGAATTGAACTCAAGAGCAGTCAGTGCTCTTAACCTCTGAGCCATCT
CTCCAGCCCAGCCGAGGAATTGCCATCTTTAATCCCAGGGCAAGCGCTGTAGAAAGACATCAGT
GTTCATGAGTCACGTTCTCAAGAACTCTGAAGTATTTGGAGAAAATGGCAATGGCTGTGGTATT
CACCTGTCTAGATGCTTTGAGAGACAAAGTTTGTTTTTATTTTGAGACTGTAGCAAGCTGGCCT
GGAACTCACTACGTGTCTCTGGCTTGCTTCCACATGCTGAGACCGTAGCTATGAACTACCATGT
GCAGGGACAAGACTTAAACATGCTTACCCTGGAACGATGGCAGTACAAAGCAATTCCAGGTCCA
TACCACAGTGCATGTTTTACACTCTGTAGGCAGAGGGGACCTTTTATCCATCTCCCTGCTTAAG
AAGATTGATTCGAAATTCTGAAGATGTGTTCAGACTACTTAGTATGCGCAGACCTTGGATTCAG
TGCACAGGGCCACCCCAAAAAGAGGCAGACTTGAAATGGCATTTCAATTTTAAATATGGGTAAG
CACGATGGCTAATTTAGCATCAATAGCCGTCTGCTTAGTAAAACAATGACGCAAATCGTAGTTT
GATTGAAAGGTGAATATGTACACATGGTCTAGCACCAAGGCAGGAAAATCTCAAGTTCAAAGCC
AGACTGCCTACTAAAGAACTCACAAAAGGAATGCAAGATGGTTCAGTGGTTAAGGCCCTTGTCC
TCAAGCCTTGACATTTAATCCCAGGACCTAGATGGCGGACAGAAAACCAATTTCCATAAGTTAT
TCTCTGACCGTCCCCACCCTCCACTTGCCACACACACACATCATAAATAAAAGAACGAAAATTA
TGAGAAACGTT

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RefSeq Acc Id:

XM_039096780 ⟹ XP_038952708

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	69,626,073 - 69,673,639 (-)	NCBI
mRatBN7.2	18	67,350,833 - 67,397,675 (-)	NCBI

RefSeq Acc Id:

XM_063277298 ⟹ XP_063133368

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	69,627,842 - 69,675,998 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100846	(Get FASTA)	NCBI Sequence Viewer
	XP_006254985	(Get FASTA)	NCBI Sequence Viewer
	XP_038952708	(Get FASTA)	NCBI Sequence Viewer
	XP_063133368	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL82919	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000041737
	ENSRNOP00000041737.3
	ENSRNOP00000073241.1
	ENSRNOP00000100974
	ENSRNOP00000103470

RefSeq Acc Id:

NP_001100846 ⟸ NM_001107376

- UniProtKB:

D3ZJH9 (UniProtKB/TrEMBL), A6KRC6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFSRLRAVTTPCTLTCRRVHLKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQ
ALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACCQYGHIFR
RPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAG
IQPEKCLPVCIDVGTDNMALLKDPFYMGLYQKRDRSQLYDDLMDEFMKAITDRYGRNTLIQFED
FGNHNAFRFLKKYQEKYCTFNDDIQGTAAVALSGLLAAQRVINKPISEHRILFLGAGEAALGIA
KLIVISMMESGLSEEEAQRKIWMFDKNGLLVKGRTARIDSNQEPYAHAASENIPATFEDAVNKL
KPSVIIGVAGAGPLFTPGVIKAMAAINERPIIFALSNPTAQAECTAEDAYTLTEGRCLFASGSP
FEPVRLQDGRVFTPGQGNNAYIFPGVALAVILCEARHISDTVFLEAAKALTSQLTDEELAQGRL
YPSLANIQEVSANIAIKIAEYLYANKMAFRYPEPEDKAKYVKERIWRSNYVSLLPDVYDWPESS
LKPPQIPE

hide sequence

RefSeq Acc Id:	XP_006254985 ⟸ XM_006254923
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K502 (UniProtKB/TrEMBL), A6KRC6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLNWREKMFSRLRAVTTPCTLTCRRVHLKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPK IETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACC QYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLC LYTACAGIQPEKCLPVCIDVGTDNMALLKDPFYMGLYQKRDRSQLYDDLMDEFMKAITDRYGRN TLIQFEDFGNHNAFRFLKKYQEKYCTFNDDIQGTAAVALSGLLAAQRVINKPISEHRILFLGAG EAALGIAKLIVISMMESGLSEEEAQRKIWMFDKNGLLVKGRTARIDSNQEPYAHAASENIPATF EDAVNKLKPSVIIGVAGAGPLFTPGVIKAMAAINERPIIFALSNPTAQAECTAEDAYTLTEGRC LFASGSPFEPVRLQDGRVFTPGQGNNAYIFPGVALAVILCEARHISDTVFLEAAKALTSQLTDE ELAQGRLYPSLANIQEVSANIAIKIAEYLYANKMAFRYPEPEDKAKYVKERIWRSNYVSLLPDV YDWPESSLKPPQIPE hide sequence

Ensembl Acc Id:

ENSRNOP00000073241 ⟸ ENSRNOT00000079093

Ensembl Acc Id:

ENSRNOP00000041737 ⟸ ENSRNOT00000049759

RefSeq Acc Id:	XP_038952708 ⟸ XM_039096780
- Peptide Label:	isoform X2
- UniProtKB:	A6KRC6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133368 ⟸ XM_063277298
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K502 (UniProtKB/TrEMBL), A6KRC6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000103470 ⟸ ENSRNOT00000173790

Ensembl Acc Id:

ENSRNOP00000100974 ⟸ ENSRNOT00000163051

Protein Domains

Malic enzyme N-terminal Malic enzyme NAD-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K502-F1-model_v2	AlphaFold	A0A0G2K502	1-591	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700860

Promoter ID:

EPDNEW_R11384

Type:

initiation region

Name:

Me2_1

Description:

malic enzyme 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	69,784,145 - 69,784,205	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310321	AgrOrtholog
BioCyc Gene	G2FUF-7051	BioCyc
Ensembl Genes	ENSRNOG00000015582	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000049759	ENTREZGENE
	ENSRNOT00000049759.5	UniProtKB/TrEMBL
	ENSRNOT00000079093.2	UniProtKB/TrEMBL
	ENSRNOT00000163051	ENTREZGENE
	ENSRNOT00000173790	ENTREZGENE
Gene3D-CATH	3.40.50.10380	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	Aminiacid_DH-like_N_sf	UniProtKB/TrEMBL
	Malic_enzyme_CS	UniProtKB/TrEMBL
	Malic_N	UniProtKB/TrEMBL
	Malic_N_dom_sf	UniProtKB/TrEMBL
	Malic_NAD-bd	UniProtKB/TrEMBL
	Malic_OxRdtase	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:307270	UniProtKB/TrEMBL
NCBI Gene	307270	ENTREZGENE
PANTHER	MALIC ENZYME-RELATED	UniProtKB/TrEMBL
	NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	malic	UniProtKB/TrEMBL
	Malic_M	UniProtKB/TrEMBL
PhenoGen	Me2	PhenoGen
PIRSF	PIRSF000106	UniProtKB/TrEMBL
PRINTS	MALOXRDTASE	UniProtKB/TrEMBL
PROSITE	MALIC_ENZYMES	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015582	RatGTEx
SMART	malic	UniProtKB/TrEMBL
	Malic_M	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
	SSF53223	UniProtKB/TrEMBL
UniProt	A0A0G2K502	ENTREZGENE, UniProtKB/TrEMBL
	A6KRC6	ENTREZGENE, UniProtKB/TrEMBL
	D3ZJH9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-14	Me2	malic enzyme 2	Me2	malic enzyme 2, NAD(+)-dependent, mitochondrial	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Me2	malic enzyme 2, NAD(+)-dependent, mitochondrial	Me2_predicted	malic enzyme 2, NAD(+)-dependent, mitochondrial (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Me2_predicted	malic enzyme 2, NAD(+)-dependent, mitochondrial (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)