Mccc2 (methylcrotonyl-CoA carboxylase subunit 2) - Rat Genome Database

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Gene: Mccc2 (methylcrotonyl-CoA carboxylase subunit 2) Rattus norvegicus
Analyze
Symbol: Mccc2
Name: methylcrotonyl-CoA carboxylase subunit 2 (Ensembl:methylcrotonoyl-CoA carboxylase 2)
RGD ID: 1310279
Description: Contributes to methylcrotonoyl-CoA carboxylase activity. Involved in coenzyme A metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be part of 3-methylcrotonyl-CoA carboxylase complex, mitochondrial. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Orthologous to human MCCC2 (methylcrotonyl-CoA carboxylase subunit 2); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; LOC361884; MCCase subunit beta; methylcrotonoyl-CoA carboxylase 2; methylcrotonoyl-CoA carboxylase 2 (beta); methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2231,304,927 - 31,375,978 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,304,932 - 31,375,972 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,383,154 - 38,454,061 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0236,477,507 - 36,548,413 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0231,270,308 - 31,341,430 (-)NCBIRnor_WKY
Rnor_6.0230,175,017 - 30,246,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,175,018 - 30,246,010 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,333,901 - 49,404,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,961,607 - 31,032,883 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,881,976 - 30,953,252 (-)NCBI
Celera227,327,945 - 27,397,754 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clopidogrel  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
glafenine  (EXP)
irinotecan  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
N-nitrosomorpholine  (EXP)
nimesulide  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
phlorizin  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The molecular basis of 3-methylcrotonylglycinuria, a disorder of leucine catabolism. Gallardo ME, etal., Am J Hum Genet. 2001 Feb;68(2):334-46. Epub 2001 Jan 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Simultaneous preparation of the three biotin-containing mitochondrial carboxylases from rat liver. Oei J and Robinson BH, Biochim Biophys Acta. 1985 May 29;840(1):1-5.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14651853   PMID:16023992   PMID:17360195   PMID:18614015   PMID:26316108   PMID:31505169  


Genomics

Comparative Map Data
Mccc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2231,304,927 - 31,375,978 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,304,932 - 31,375,972 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,383,154 - 38,454,061 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0236,477,507 - 36,548,413 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0231,270,308 - 31,341,430 (-)NCBIRnor_WKY
Rnor_6.0230,175,017 - 30,246,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,175,018 - 30,246,010 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,333,901 - 49,404,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,961,607 - 31,032,883 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,881,976 - 30,953,252 (-)NCBI
Celera227,327,945 - 27,397,754 (-)NCBICelera
Cytogenetic Map2q12NCBI
MCCC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38571,587,340 - 71,658,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl571,579,531 - 71,658,706 (+)EnsemblGRCh38hg38GRCh38
GRCh37570,883,167 - 70,954,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36570,918,910 - 70,988,981 (+)NCBINCBI36Build 36hg18NCBI36
Build 34570,918,909 - 70,988,981NCBI
Celera566,778,848 - 66,850,229 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef566,088,903 - 66,160,527 (+)NCBIHuRef
CHM1_1570,315,816 - 70,387,189 (+)NCBICHM1_1
T2T-CHM13v2.0572,068,680 - 72,140,018 (+)NCBIT2T-CHM13v2.0
Mccc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,085,040 - 100,152,147 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,085,038 - 100,152,147 (-)EnsemblGRCm39 Ensembl
GRCm381399,948,532 - 100,015,639 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1399,948,530 - 100,015,639 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713100,718,487 - 100,785,594 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,048,783 - 101,115,886 (-)NCBIMGSCv36mm8
Celera13103,601,615 - 103,669,283 (-)NCBICelera
Cytogenetic Map13D1NCBI
Mccc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955575445,619 - 505,040 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955575445,627 - 503,891 (+)NCBIChiLan1.0ChiLan1.0
MCCC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1544,298,650 - 44,369,106 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl544,298,650 - 44,369,106 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0543,650,993 - 43,724,877 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MCCC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,751,703 - 54,825,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,751,698 - 54,823,273 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,718,218 - 51,791,623 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0255,265,241 - 55,340,500 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,265,213 - 55,340,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,327,887 - 52,401,292 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,094,755 - 53,168,219 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,986,123 - 54,059,570 (+)NCBIUU_Cfam_GSD_1.0
Mccc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213186,028,772 - 186,100,599 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365494,755,546 - 4,830,242 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365494,760,073 - 4,830,190 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCCC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,917,291 - 47,996,534 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,917,308 - 47,996,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,863,689 - 51,939,708 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCCC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,944,742 - 66,013,663 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,944,840 - 66,013,663 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604914,689,886 - 14,759,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mccc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905645,715 - 712,364 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624905645,782 - 709,611 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mccc2
643 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:137
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000023900
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat

Markers in Region
RH131089  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2231,305,061 - 31,305,249 (+)MAPPERmRatBN7.2
Rnor_6.0230,175,148 - 30,175,335NCBIRnor6.0
Rnor_5.0249,334,031 - 49,334,218UniSTSRnor5.0
RGSC_v3.4230,961,737 - 30,961,924UniSTSRGSC3.4
Celera227,328,075 - 27,328,262UniSTS
RH 3.4 Map263.2UniSTS
Cytogenetic Map2q12UniSTS
AU049737  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2231,350,338 - 31,350,565 (+)MAPPERmRatBN7.2
Rnor_6.0230,220,271 - 30,220,497NCBIRnor6.0
Rnor_5.0249,379,001 - 49,379,227UniSTSRnor5.0
RGSC_v3.4231,007,101 - 31,007,327UniSTSRGSC3.4
Celera227,372,891 - 27,373,117UniSTS
Cytogenetic Map2q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023900   ⟹   ENSRNOP00000023900
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,304,933 - 31,375,957 (-)Ensembl
Rnor_6.0 Ensembl230,175,018 - 30,246,010 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076389
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,304,932 - 31,375,972 (-)Ensembl
Rnor_6.0 Ensembl230,175,213 - 30,187,700 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096471   ⟹   ENSRNOP00000077574
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,305,117 - 31,375,972 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108332   ⟹   ENSRNOP00000081925
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,304,933 - 31,375,957 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109895   ⟹   ENSRNOP00000083912
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,304,933 - 31,375,957 (-)Ensembl
RefSeq Acc Id: NM_001012177   ⟹   NP_001012177
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2231,304,932 - 31,375,957 (-)NCBI
Rnor_6.0230,175,018 - 30,246,010 (-)NCBI
Rnor_5.0249,333,901 - 49,404,647 (-)NCBI
RGSC_v3.4230,961,607 - 31,032,883 (-)RGD
Celera227,327,945 - 27,397,754 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102544   ⟹   XP_038958472
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2231,304,927 - 31,375,978 (-)NCBI
RefSeq Acc Id: XM_039102546   ⟹   XP_038958474
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2231,310,396 - 31,375,978 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001012177 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958472 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958474 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83581 (Get FASTA)   NCBI Sequence Viewer  
  Q5XIT9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001012177   ⟸   NM_001012177
- UniProtKB: Q5XIT9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023900   ⟸   ENSRNOT00000023900
RefSeq Acc Id: XP_038958472   ⟸   XM_039102544
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3M2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958474   ⟸   XM_039102546
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000081925   ⟸   ENSRNOT00000108332
RefSeq Acc Id: ENSRNOP00000077574   ⟸   ENSRNOT00000096471
RefSeq Acc Id: ENSRNOP00000083912   ⟸   ENSRNOT00000109895
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIT9-F1-model_v2 AlphaFold Q5XIT9 1-563 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691100
Promoter ID:EPDNEW_R1625
Type:initiation region
Name:Mccc2_1
Description:methylcrotonoyl-CoA carboxylase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0230,245,994 - 30,246,054EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310279 AgrOrtholog
BioCyc Gene G2FUF-54680 BioCyc
BioCyc Pathway LEU-DEG2-PWY [L-leucine degradation I] BioCyc
Ensembl Genes ENSRNOG00000017752 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023900 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000077574.1 UniProtKB/TrEMBL
  ENSRNOP00000081925.1 UniProtKB/TrEMBL
  ENSRNOP00000083912.1 UniProtKB/TrEMBL
  ENSRNOP00000085238 ENTREZGENE
  ENSRNOP00000085238.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023900 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000076389 ENTREZGENE
  ENSRNOT00000076389.2 UniProtKB/TrEMBL
  ENSRNOT00000096471.1 UniProtKB/TrEMBL
  ENSRNOT00000108332.1 UniProtKB/TrEMBL
  ENSRNOT00000109895.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7129446 IMAGE-MGC_LOAD
InterPro AcCoA_carboxyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COA_CT_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COA_CT_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCCB/AccD1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361884 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94191 IMAGE-MGC_LOAD
NCBI Gene 361884 ENTREZGENE
PANTHER PTHR22855 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carboxyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MCCC2 RGD
PhenoGen Mccc2 PhenoGen
PROSITE COA_CT_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COA_CT_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y1R2_RAT UniProtKB/TrEMBL
  A0A8I5ZSP4_RAT UniProtKB/TrEMBL
  A0A8I6A3M2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G9M3_RAT UniProtKB/TrEMBL
  MCCB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Mccc2  methylcrotonyl-CoA carboxylase subunit 2  Mccc2  methylcrotonoyl-CoA carboxylase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-10 Mccc2  methylcrotonoyl-CoA carboxylase 2  Mccc2  methylcrotonoyl-CoA carboxylase 2 (beta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Mccc2  methylcrotonoyl-CoA carboxylase 2 (beta)  Mccc2  methylcrotonoyl-Coenzyme A carboxylase 2 (beta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Mccc2  methylcrotonoyl-Coenzyme A carboxylase 2 (beta)  Mccc2_predicted  methylcrotonoyl-Coenzyme A carboxylase 2 (beta) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mccc2_predicted  methylcrotonoyl-Coenzyme A carboxylase 2 (beta) (predicted)      Symbol and Name status set to approved 70820 APPROVED