Mccc2 (methylcrotonyl-CoA carboxylase subunit 2)

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Gene: Mccc2 (methylcrotonyl-CoA carboxylase subunit 2) Rattus norvegicus

Analyze

Symbol:

Mccc2

Name:

methylcrotonyl-CoA carboxylase subunit 2 (Ensembl:methylcrotonoyl-CoA carboxylase 2)

RGD ID:

1310279

Description:

Contributes to methylcrotonoyl-CoA carboxylase activity. Involved in coenzyme A metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be part of 3-methylcrotonyl-CoA carboxylase complex, mitochondrial. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Orthologous to human MCCC2 (methylcrotonyl-CoA carboxylase subunit 2); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; LOC361884; MCCase subunit beta; methylcrotonoyl-CoA carboxylase 2; methylcrotonoyl-CoA carboxylase 2 (beta); methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; methylcrotonoyl-Coenzyme A carboxylase 2 (beta)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	31,304,927 - 31,375,978 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	31,304,932 - 31,375,972 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	38,383,154 - 38,454,061 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	36,477,507 - 36,548,413 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	31,270,308 - 31,341,430 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	30,175,017 - 30,246,028 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	30,175,018 - 30,246,010 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	49,333,901 - 49,404,647 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	30,961,607 - 31,032,883 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	30,881,976 - 30,953,252 (-)	NCBI
Celera	2	27,327,945 - 27,397,754 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Methylcrotonyl-CoA carboxylase 2 deficiency (ISO)

3-Methylcrotonyl-CoA carboxylase deficiency (ISO)

mitochondrial metabolism disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

(+)-schisandrin B (EXP)

(-)-demecolcine (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrabromodibenzodioxine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

5-fluorouracil (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

carbon nanotube (ISO)

choline (ISO)

chromium(6+) (ISO)

clopidogrel (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP,ISO)

dicrotophos (ISO)

diuron (EXP)

doxorubicin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

folic acid (ISO)

formaldehyde (ISO)

genistein (EXP)

glafenine (EXP)

irinotecan (ISO)

isoprenaline (ISO)

isotretinoin (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

lead(2+) (ISO)

lipopolysaccharide (ISO)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

methylparaben (ISO)

methylseleninic acid (ISO)

N-nitrosomorpholine (EXP)

nimesulide (EXP)

paracetamol (ISO)

paraquat (EXP)

phlorizin (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

resveratrol (ISO)

rotenone (EXP)

sodium arsenite (EXP)

sodium dichromate (EXP)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

troglitazone (ISO)

tungsten (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vancomycin (ISO)

vinclozolin (EXP)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

coenzyme A metabolic process (IDA)

leucine catabolic process (IBA,IEA)

Cellular Component

3-methylcrotonyl-CoA carboxylase complex, mitochondrial (ISO)

methylcrotonoyl-CoA carboxylase complex (IBA,ISO,ISS)

mitochondrial matrix (ISO)

mitochondrion (IBA,ISO)

Molecular Function

ATP binding (IEA)

ligase activity (IEA)

methylcrotonoyl-CoA carboxylase activity (IBA,IDA,ISO,ISS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway (ISO)

3-hydroxyisobutyric aciduria pathway (ISO)

3-methylcrotonyl CoA carboxylase 1 deficiency pathway (ISO)

3-methylglutaconic aciduria type 1 pathway (ISO)

3-methylglutaconic aciduria type 3 pathway (ISO)

isobutyryl-CoA dehydrogenase deficiency pathway (ISO)

isovaleric acidemia pathway (ISO)

maple syrup urine disease pathway (ISO)

methylmalonate semialdehyde dehydrogenase deficiency pathway (ISO)

methylmalonic acidemia pathway (ISO)

propionic acidemia pathway (ISO)

valine, leucine and isoleucine degradation pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The molecular basis of 3-methylcrotonylglycinuria, a disorder of leucine catabolism.	Gallardo ME, etal., Am J Hum Genet. 2001 Feb;68(2):334-46. Epub 2001 Jan 17.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Simultaneous preparation of the three biotin-containing mitochondrial carboxylases from rat liver.	Oei J and Robinson BH, Biochim Biophys Acta. 1985 May 29;840(1):1-5.
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14651853	PMID:16023992	PMID:17360195	PMID:18614015	PMID:26316108	PMID:31505169

Genomics

Comparative Map Data

Mccc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	31,304,927 - 31,375,978 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	31,304,932 - 31,375,972 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	38,383,154 - 38,454,061 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	36,477,507 - 36,548,413 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	31,270,308 - 31,341,430 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	30,175,017 - 30,246,028 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	30,175,018 - 30,246,010 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	49,333,901 - 49,404,647 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	30,961,607 - 31,032,883 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	30,881,976 - 30,953,252 (-)	NCBI
Celera	2	27,327,945 - 27,397,754 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

MCCC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	71,587,340 - 71,658,706 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	71,579,531 - 71,658,706 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	70,883,167 - 70,954,533 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	70,918,910 - 70,988,981 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	70,918,909 - 70,988,981	NCBI
Celera	5	66,778,848 - 66,850,229 (+)	NCBI		Celera
Cytogenetic Map	5	q13.2	NCBI
HuRef	5	66,088,903 - 66,160,527 (+)	NCBI		HuRef
CHM1_1	5	70,315,816 - 70,387,189 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	72,068,680 - 72,140,018 (+)	NCBI		T2T-CHM13v2.0

Mccc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	100,085,040 - 100,152,147 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	100,085,038 - 100,152,147 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	99,948,532 - 100,015,639 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	99,948,530 - 100,015,639 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	100,718,487 - 100,785,594 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	101,048,783 - 101,115,886 (-)	NCBI		MGSCv36	mm8
Celera	13	103,601,615 - 103,669,283 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI

Mccc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955575	445,619 - 505,040 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955575	445,627 - 503,891 (+)	NCBI	ChiLan1.0	ChiLan1.0

MCCC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	5	44,298,650 - 44,369,106 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	44,298,650 - 44,369,106 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	5	43,650,993 - 43,724,877 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

MCCC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	54,751,703 - 54,825,133 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	54,751,698 - 54,823,273 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	51,718,218 - 51,791,623 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	55,265,241 - 55,340,500 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	55,265,213 - 55,340,215 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	52,327,887 - 52,401,292 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	53,094,755 - 53,168,219 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	53,986,123 - 54,059,570 (+)	NCBI		UU_Cfam_GSD_1.0

Mccc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	186,028,772 - 186,100,599 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936549	4,755,546 - 4,830,242 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936549	4,760,073 - 4,830,190 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MCCC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	47,917,291 - 47,996,534 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	47,917,308 - 47,996,540 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	51,863,689 - 51,939,708 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MCCC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	65,944,742 - 66,013,663 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	65,944,840 - 66,013,663 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	14,689,886 - 14,759,320 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mccc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624905	645,715 - 712,364 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624905	645,782 - 709,611 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mccc2
643 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	178
Count of miRNA genes:	137
Interacting mature miRNAs:	149
Transcripts:	ENSRNOT00000023900
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631682	Bp115	Blood pressure QTL 115	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	1	37410502	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	41244106	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	7887772	42804738	Rat
738012	Anxrr3	Anxiety related response QTL 3	3.8		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	2	9023519	54023519	Rat
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	11591100	56591100	Rat
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	11852062	49003364	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	16491740	61491740	Rat
1357990	Ael1	Aortic elastin QTL 1	3.1	0.00091	aorta elastin amount (VT:0003905)	aortic elastin	2	19076825	64076825	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	20304672	65304672	Rat
2300168	Bmd47	Bone mineral density QTL 47	6.6	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	2	20662448	65662448	Rat
10402051	Gdil2	Gastrointestinal dilation QTL 2			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	24903853	74786777	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	26917817	81754745	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	26917817	81754745	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	81754745	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	26999571	43154682	Rat
1643006	Pain1	Pain QTL 1	3.63	0.005	mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	2	26999571	48268661	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	27157160	72157160	Rat
1300160	Hrtrt3	Heart rate QTL 3	3.62		heart pumping trait (VT:2000009)	absolute change in heart rate (CMO:0000534)	2	29971593	51729300	Rat
10755434	Coatc7	Coat color QTL 7		0.04794	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	30648065	75648065	Rat

Markers in Region

RH131089

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	31,305,061 - 31,305,249 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	30,175,148 - 30,175,335	NCBI	Rnor6.0
Rnor_5.0	2	49,334,031 - 49,334,218	UniSTS	Rnor5.0
RGSC_v3.4	2	30,961,737 - 30,961,924	UniSTS	RGSC3.4
Celera	2	27,328,075 - 27,328,262	UniSTS
RH 3.4 Map	2	63.2	UniSTS
Cytogenetic Map	2	q12	UniSTS

AU049737

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	31,350,338 - 31,350,565 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	30,220,271 - 30,220,497	NCBI	Rnor6.0
Rnor_5.0	2	49,379,001 - 49,379,227	UniSTS	Rnor5.0
RGSC_v3.4	2	31,007,101 - 31,007,327	UniSTS	RGSC3.4
Celera	2	27,372,891 - 27,373,117	UniSTS
Cytogenetic Map	2	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000023900 ⟹ ENSRNOP00000023900

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	31,304,933 - 31,375,957 (-)	Ensembl
Rnor_6.0 Ensembl	2	30,175,018 - 30,246,010 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000076389

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	31,304,932 - 31,375,972 (-)	Ensembl
Rnor_6.0 Ensembl	2	30,175,213 - 30,187,700 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000096471 ⟹ ENSRNOP00000077574

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	31,305,117 - 31,375,972 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108332 ⟹ ENSRNOP00000081925

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	31,304,933 - 31,375,957 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109895 ⟹ ENSRNOP00000083912

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	31,304,933 - 31,375,957 (-)	Ensembl

RefSeq Acc Id:

NM_001012177 ⟹ NP_001012177

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	31,304,932 - 31,375,957 (-)	NCBI
Rnor_6.0	2	30,175,018 - 30,246,010 (-)	NCBI
Rnor_5.0	2	49,333,901 - 49,404,647 (-)	NCBI
RGSC_v3.4	2	30,961,607 - 31,032,883 (-)	RGD
Celera	2	27,327,945 - 27,397,754 (-)	RGD

Sequence:

show sequence

CTGGCCTGGGAGCTTGGTGGACCAAGGCTGGTGGTGCAAGAATTCTGGAGGAACAGCGGCCCGG
AGCTGCAAAACTCAGCTGCAGGGCCGCTCTCTCTCTTTCTCTCTCTCTCTTTCTCTTGGGTGCT
TGCTATCGCCATGTGGGGCGCGCTGAGGTCAGTTCTGCGGCCCTGCAGTCGGGCCTCCGTACCC
CGGCAGCGCGCCTATCACGGGGACGCGGTGGCCCGACTGGGCACCCAGCCTGACTCGGGCTCCT
CCACCTACCAGGAGAACTATGAGCAGATGAAAGCTTTAGTGAATCAACTTCATGAACGAGCCCA
GTATGTAAGACTGGGAGGGAGTGAGAAAGCCCGGGCGCGACACACATCAAGAGGAAAACTGTTA
CCCAGAGACCGAATCGACAACCTCATAGACCCAGGGTCTCCCTTTCTGGAATTCTCCCAGTTCG
CAGGTTACAAGTTATATGGCGAGGAGGAAGTCCCTGCAGGTGGCATCATCACAGGCATTGGGCG
AGTGTCTGGAGTAGAATGCATGATTGTGGCTAACGATGCCACCGTCAAAGGAGGCACCTACTAC
CCAGTGACGGTGAAAAAGCACGTTCGGGCACAAGAGATCGCACTGCAGAACAGGCTCCCATGCA
TCTATCTGGTTGACTCAGGAGGGGCCAACTTACCTCGGCAAGCAGACACCTTTCCAGACCGGGA
CCACTTTGGCCGCATATTCTATAATCAAGCTATTATGTCTTCTAAAAATATCACACAGATAGCT
GTGGTCATGGGCTCCTGTACGGCAGGAGGTGCATATGTGCCGGCCATGGCTGATGAAAACATCA
TTGTACAAAGACAGGGTACTATCTTCTTGGCTGGACCACCCTTGGTGAAGGCAGCTACCGGCGA
AGAGGTGTCCGCTGAGGATCTCGGAGGTGCTGACTTGCACTGCAGAAGGTCTGGGGTCACTGAC
CACTATGCTTTGGATGACCACCACGCCCTTCACTTGACAAGGAAGGTTGTGAGGAGTCTCAATT
ATCAGAAGAAACTGGATGTTACCGTTGAACCTTCTGAAGAGCCCTTGTTCCCCGCAGATGAATT
GTATGGGATAGTCGGTGCGAACCTTAAGAGGAGCTTTGATGTCCGAGAGGTCATTGCTAGAATC
GTCGATGGAAGCAGATTCAATGAGTTCAAGGCCTTGTATGGAGACACGCTCGTCACAGGATTCG
CTCGAATATTTGGGTACCCAGTAGGCATCATTGGAAACAATGGAGTTTTGTTTTCTGAATCTGC
CAAAAAGGGCGCTCACTTCGTCCAGCTGTGCTGCCAAAGAAATATCCCCCTGCTGTTTCTCCAG
AACATCACTGGATTCATGGTTGGTAAAGACTATGAAGCCGAAGGGATTGCCAAGGATGGCGCCA
AGATGGTAGCCGCAGTATCCTGTGCCAAAGTGCCTAAGATAACTGTCATAATCGGGGGATCATA
TGGGGCTGGAAACTACGGAATGTGTGGCAGAGCATATAGTCCAAGATTTCTCTACATGTGGCCA
AATGCTCGCATCTCAGTGATGGGAGGAGAGCAGGCAGCCACCGTGTTAGCCACGGTGGCGAGAG
ACCAGAGAGCCCGTGAGGGGAAGCAGTTCTCCAGTGCAGAGGAGGCAGCTTTGAAAGAGCCCAT
CATCAAGAGGTTCGAAGAGGAAGGGAACCCTTACTATTCCAGTGCAAGGCTGTGGGATGATGGG
ATTATCGACCCCGTGGACACCAGGCTGGTTCTGGGACTCAGCATCAGTGCAGCCCTCAATGCGC
CCATCCAGAGGACAGACTTTGGCATCTTCAGGATGTAACCCAGATACGGAACGTGTTGCCACAG
CTGTAATAAAAATTAACACGTGTGACTAGCCTTAAAACTTGAGATCCACTGGGCATTTGCTGGC
ACAGGAATTCTTTTCTTAACAGTATGATGTATGGGTTTTTTTTTTTTTAATTGTAAAAATCAGT
GAGTATTCTGCTTGATGAGCTTTGATTTGTCAAAAATTTTTCTTACAGACACTTCTCATGGCTC
ATTTTTTACCACCCATAAAATGAAGTGACCGATTTTGCAATTATCCTTTTGAGAACCACAAACA
GTTTGAAAAATAAATCTCTCTAATCTATGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039102544 ⟹ XP_038958472

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	31,304,927 - 31,375,978 (-)	NCBI

RefSeq Acc Id:

XM_039102546 ⟹ XP_038958474

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	31,310,396 - 31,375,978 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012177	(Get FASTA)	NCBI Sequence Viewer
	XP_038958472	(Get FASTA)	NCBI Sequence Viewer
	XP_038958474	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83581	(Get FASTA)	NCBI Sequence Viewer
	Q5XIT9	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001012177 ⟸ NM_001012177

- UniProtKB:

Q5XIT9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MWGALRSVLRPCSRASVPRQRAYHGDAVARLGTQPDSGSSTYQENYEQMKALVNQLHERAQYVR
LGGSEKARARHTSRGKLLPRDRIDNLIDPGSPFLEFSQFAGYKLYGEEEVPAGGIITGIGRVSG
VECMIVANDATVKGGTYYPVTVKKHVRAQEIALQNRLPCIYLVDSGGANLPRQADTFPDRDHFG
RIFYNQAIMSSKNITQIAVVMGSCTAGGAYVPAMADENIIVQRQGTIFLAGPPLVKAATGEEVS
AEDLGGADLHCRRSGVTDHYALDDHHALHLTRKVVRSLNYQKKLDVTVEPSEEPLFPADELYGI
VGANLKRSFDVREVIARIVDGSRFNEFKALYGDTLVTGFARIFGYPVGIIGNNGVLFSESAKKG
AHFVQLCCQRNIPLLFLQNITGFMVGKDYEAEGIAKDGAKMVAAVSCAKVPKITVIIGGSYGAG
NYGMCGRAYSPRFLYMWPNARISVMGGEQAATVLATVARDQRAREGKQFSSAEEAALKEPIIKR
FEEEGNPYYSSARLWDDGIIDPVDTRLVLGLSISAALNAPIQRTDFGIFRM

hide sequence

RefSeq Acc Id:

ENSRNOP00000023900 ⟸ ENSRNOT00000023900

RefSeq Acc Id:	XP_038958472 ⟸ XM_039102544
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A3M2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958474 ⟸ XM_039102546
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000081925 ⟸ ENSRNOT00000108332

RefSeq Acc Id:

ENSRNOP00000077574 ⟸ ENSRNOT00000096471

RefSeq Acc Id:

ENSRNOP00000083912 ⟸ ENSRNOT00000109895

Protein Domains

CoA carboxyltransferase C-terminal CoA carboxyltransferase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XIT9-F1-model_v2	AlphaFold	Q5XIT9	1-563	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691100

Promoter ID:

EPDNEW_R1625

Type:

initiation region

Name:

Mccc2_1

Description:

methylcrotonoyl-CoA carboxylase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	30,245,994 - 30,246,054	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310279	AgrOrtholog
BioCyc Gene	G2FUF-54680	BioCyc
BioCyc Pathway	LEU-DEG2-PWY [L-leucine degradation I]	BioCyc
Ensembl Genes	ENSRNOG00000017752	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000023900	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000077574.1	UniProtKB/TrEMBL
	ENSRNOP00000081925.1	UniProtKB/TrEMBL
	ENSRNOP00000083912.1	UniProtKB/TrEMBL
	ENSRNOP00000085238	ENTREZGENE
	ENSRNOP00000085238.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023900	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000076389	ENTREZGENE
	ENSRNOT00000076389.2	UniProtKB/TrEMBL
	ENSRNOT00000096471.1	UniProtKB/TrEMBL
	ENSRNOT00000108332.1	UniProtKB/TrEMBL
	ENSRNOT00000109895.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7129446	IMAGE-MGC_LOAD
InterPro	AcCoA_carboxyl	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ClpP/crotonase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	COA_CT_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	COA_CT_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MCCB/AccD1-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:361884	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94191	IMAGE-MGC_LOAD
NCBI Gene	361884	ENTREZGENE
PANTHER	PTHR22855	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Carboxyl_trans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	MCCC2	RGD
PhenoGen	Mccc2	PhenoGen
PROSITE	COA_CT_CTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	COA_CT_NTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52096	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5Y1R2_RAT	UniProtKB/TrEMBL
	A0A8I5ZSP4_RAT	UniProtKB/TrEMBL
	A0A8I6A3M2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G9M3_RAT	UniProtKB/TrEMBL
	MCCB_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-26	Mccc2	methylcrotonyl-CoA carboxylase subunit 2	Mccc2	methylcrotonoyl-CoA carboxylase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-12-10	Mccc2	methylcrotonoyl-CoA carboxylase 2	Mccc2	methylcrotonoyl-CoA carboxylase 2 (beta)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Mccc2	methylcrotonoyl-CoA carboxylase 2 (beta)	Mccc2	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Mccc2	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	Mccc2_predicted	methylcrotonoyl-Coenzyme A carboxylase 2 (beta) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Mccc2_predicted	methylcrotonoyl-Coenzyme A carboxylase 2 (beta) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)