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Gene: Ino80c (INO80 complex subunit C) Rattus norvegicus

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Symbol:

Ino80c

Name:

INO80 complex subunit C

RGD ID:

1310199

Description:

Predicted to be involved in several processes, including regulation of embryonic development; regulation of nucleobase-containing compound metabolic process; and telomere maintenance. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of Ino80 complex and MLL1 complex. Orthologous to human INO80C (INO80 complex subunit C); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; INTERACTS WITH bisphenol A; caffeine; flutamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC291737; MGC109171; RGD1310199; similar to RIKEN cDNA D030070L09

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	INO80C (INO80 complex subunit C)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ino80c (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ino80c (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	INO80C (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	INO80C (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ino80c (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	INO80C (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	INO80C (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ino80c (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TSC22D1 (TSC22 domain family member 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	INO80C (INO80 complex subunit C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ino80c (INO80 complex subunit C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ino80c (INO80 complex subunit C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12659	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IES6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ino80c	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	15,653,508 - 15,752,455 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	15,653,511 - 15,668,144 (-)	Ensembl				GRCr8
mRatBN7.2	18	15,378,764 - 15,398,574 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	15,378,770 - 15,393,403 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	15,565,979 - 15,580,823 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	16,348,684 - 16,363,528 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	15,638,515 - 15,653,207 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	15,995,005 - 16,009,639 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	15,995,000 - 16,009,710 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	15,757,172 - 15,771,806 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	15,863,573 - 15,878,207 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	15,326,724 - 15,341,400 (-)	NCBI		Celera
RGSC_v3.1	18	15,890,219 - 15,904,853 (-)	NCBI
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 18q deletion syndrome (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

caffeine (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

ethanol (ISO)

flutamide (EXP)

FR900359 (ISO)

fulvestrant (ISO)

genistein (EXP)

gentamycin (EXP)

indometacin (ISO)

isobutanol (ISO)

ketamine (EXP)

leflunomide (EXP)

methidathion (ISO)

methoxyacetic acid (EXP)

methylmercury chloride (EXP)

Monobutylphthalate (EXP)

nitrates (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

quercitrin (ISO)

rac-lactic acid (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin remodeling (IBA,IEA,ISO)

DNA damage response (IEA)

DNA recombination (IEA)

DNA repair (IEA)

positive regulation of DNA repair (IEA,ISO)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of telomere maintenance in response to DNA damage (IEA,ISO)

regulation of cell cycle (IEA,ISO)

regulation of chromosome organization (IEA,ISO)

regulation of DNA repair (IEA,ISO)

regulation of DNA replication (IEA,ISO)

regulation of DNA strand elongation (IEA,ISO)

regulation of embryonic development (IEA,ISO)

telomere maintenance (IEA,ISO)

Cellular Component

cytosol (IEA,ISO)

fibrillar center (IEA,ISO)

Ino80 complex (IBA,IEA,ISO)

MLL1 complex (IEA,ISO,ISS)

nucleoplasm (IEA,ISO)

nucleus (IEA)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

INO80 family mediated chromatin remodeling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	Comprehensive gene review and curation	RGD comprehensive gene curation
4.	The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics.	Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:15960975	PMID:21303910

Genomics

Comparative Map Data

Ino80c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	15,653,508 - 15,752,455 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	15,653,511 - 15,668,144 (-)	Ensembl				GRCr8
mRatBN7.2	18	15,378,764 - 15,398,574 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	15,378,770 - 15,393,403 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	15,565,979 - 15,580,823 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	16,348,684 - 16,363,528 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	15,638,515 - 15,653,207 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	15,995,005 - 16,009,639 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	15,995,000 - 16,009,710 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	15,757,172 - 15,771,806 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	15,863,573 - 15,878,207 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	15,326,724 - 15,341,400 (-)	NCBI		Celera
RGSC_v3.1	18	15,890,219 - 15,904,853 (-)	NCBI
Cytogenetic Map	18	p12	NCBI

INO80C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	35,468,333 - 35,497,960 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	35,452,230 - 35,497,979 (-)	Ensembl			hg38	GRCh38
GRCh37	18	33,048,297 - 33,077,924 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	31,302,289 - 31,331,953 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	18	31,302,295 - 31,331,953	NCBI
Celera	18	29,856,143 - 29,885,819 (-)	NCBI		Celera
Cytogenetic Map	18	q12.2	NCBI
HuRef	18	29,908,353 - 29,937,720 (-)	NCBI		HuRef
CHM1_1	18	32,975,385 - 33,005,073 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	35,659,720 - 35,689,378 (-)	NCBI		T2T-CHM13v2.0

Ino80c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	24,237,818 - 24,254,876 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	24,237,814 - 24,255,010 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	24,104,761 - 24,121,819 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	24,104,757 - 24,121,953 (-)	Ensembl			mm10	GRCm38
MGSCv37	18	24,263,262 - 24,280,320 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	24,247,771 - 24,264,829 (-)	NCBI		MGSCv36	mm8
Celera	18	24,594,754 - 24,611,292 (-)	NCBI		Celera
Cytogenetic Map	18	A2	NCBI
cM Map	18	12.74	NCBI

Ino80c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	22,189,943 - 22,210,658 (-)	Ensembl
ChiLan1.0	NW_004955402	22,189,943 - 22,210,315 (-)	NCBI	ChiLan1.0	ChiLan1.0

INO80C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	52,856,561 - 52,886,393 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	38,549,152 - 38,578,976 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	28,686,112 - 28,715,946 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	32,274,331 - 32,319,177 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	32,260,924 - 32,304,152 (-)	Ensembl			panPan2	panpan1.1

INO80C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	54,569,954 - 54,586,902 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	54,569,972 - 54,586,782 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	53,994,976 - 54,012,142 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	54,540,829 - 54,558,010 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	54,540,845 - 54,557,893 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	54,223,695 - 54,240,872 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	54,246,861 - 54,264,015 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	54,540,279 - 54,557,460 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ino80c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	50,305,491 - 50,322,123 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936517	9,632,870 - 9,649,527 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936517	9,632,870 - 9,649,525 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

INO80C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	119,262,227 - 119,285,779 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	119,262,488 - 119,285,852 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	111,721,259 - 111,744,557 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

INO80C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	45,282,846 - 45,311,885 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	45,282,812 - 45,311,870 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	19,780,493 - 19,809,933 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ino80c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624779	9,843,065 - 9,862,137 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624779	9,843,068 - 9,861,959 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Ino80c
744 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	257
Count of miRNA genes:	168
Interacting mature miRNAs:	208
Transcripts:	ENSRNOT00000022169
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301410	Bp317	Blood pressure QTL 317		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	12219237	26822399	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	7065728	52065728	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	15642280	31610627	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	12216684	31644508	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	7065728	52065728	Rat
8552968	Pigfal19	Plasma insulin-like growth factor 1 level QTL 19	11.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	18	1	26032889	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	7065728	52065728	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	7065728	52065728	Rat
1331781	Scl28	Serum cholesterol level QTL 28	3.995		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	1	25071266	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	15226101	42690662	Rat
6903347	Bp350	Blood pressure QTL 350	4.4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5460455	42690191	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	12216684	31644508	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	31610627	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	44930869	Rat
12904680	Bw189	Body weight QTL 189		0.019	body mass (VT:0001259)	body weight (CMO:0000012)	18	12219237	26822399	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	12066482	57066482	Rat
1641910	Colcr3	Colorectal carcinoma resistance QTL 3	5.02	0.000007	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	1	25022372	Rat
12904693	Am20	Aortic mass QTL 20		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	12219237	26822399	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
12904695	Kidm73	Kidney mass QTL 73		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	12219237	26822399	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	3811902	30809809	Rat
12904689	Cm128	Cardiac mass QTL 128		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	12219237	26822399	Rat
12904690	Cm129	Cardiac mass QTL 129		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	12219237	26822399	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34566578	Rat
12904691	Cm130	Cardiac mass QTL 130		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	12219237	26822399	Rat
9590248	Scort10	Serum corticosterone level QTL 10	19.71	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	1	26032889	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4482648	49482648	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	7065728	52065728	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34566578	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	4307354	49307354	Rat

Markers in Region

RH133170

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	15,380,454 - 15,380,641 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	15,996,691 - 15,996,877	NCBI	Rnor6.0
Rnor_5.0	18	15,758,858 - 15,759,044	UniSTS	Rnor5.0
RGSC_v3.4	18	15,865,259 - 15,865,445	UniSTS	RGSC3.4
Celera	18	15,328,410 - 15,328,596	UniSTS
RH 3.4 Map	18	192.4	UniSTS
Cytogenetic Map	18	p12	UniSTS

RH130469

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	15,378,874 - 15,379,055 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	15,995,111 - 15,995,291	NCBI	Rnor6.0
Rnor_5.0	18	15,757,278 - 15,757,458	UniSTS	Rnor5.0
RGSC_v3.4	18	15,863,679 - 15,863,859	UniSTS	RGSC3.4
Celera	18	15,326,830 - 15,327,010	UniSTS
RH 3.4 Map	18	181.4	UniSTS
Cytogenetic Map	18	p12	UniSTS

RH138450

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	15,383,934 - 15,384,175 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	16,000,171 - 16,000,411	NCBI	Rnor6.0
Rnor_5.0	18	15,762,338 - 15,762,578	UniSTS	Rnor5.0
RGSC_v3.4	18	15,868,739 - 15,868,979	UniSTS	RGSC3.4
Celera	18	15,331,888 - 15,332,128	UniSTS
RH 3.4 Map	18	182.4	UniSTS
Cytogenetic Map	18	p12	UniSTS

MARC_13470-13471:1002300368:2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	15,385,059 - 15,386,080 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	16,001,296 - 16,002,316	NCBI	Rnor6.0
Rnor_5.0	18	15,763,463 - 15,764,483	UniSTS	Rnor5.0
RGSC_v3.4	18	15,869,864 - 15,870,884	UniSTS	RGSC3.4
Celera	18	15,333,013 - 15,334,033	UniSTS
Cytogenetic Map	18	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001017446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001428709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022169 ⟹ ENSRNOP00000022169

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	15,653,511 - 15,668,144 (-)	Ensembl
mRatBN7.2 Ensembl	18	15,378,770 - 15,393,403 (-)	Ensembl
Rnor_6.0 Ensembl	18	15,995,000 - 16,009,710 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118512 ⟹ ENSRNOP00000093588

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	15,653,511 - 15,668,052 (-)	Ensembl
mRatBN7.2 Ensembl	18	15,378,770 - 15,393,311 (-)	Ensembl

RefSeq Acc Id:

NM_001017446 ⟹ NP_001017446

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	15,653,510 - 15,668,144 (-)	NCBI
mRatBN7.2	18	15,378,769 - 15,393,403 (-)	NCBI
Rnor_6.0	18	15,995,005 - 16,009,639 (-)	NCBI
Rnor_5.0	18	15,757,172 - 15,771,806 (-)	NCBI
RGSC_v3.4	18	15,863,573 - 15,878,207 (-)	RGD
Celera	18	15,326,724 - 15,341,400 (-)	RGD

Sequence:

show sequence

GGAGTTTCCTGGCATCAACACGGAAGTAACATCTAGCCGGAAGTTTTAGGGCTCGCCTTGGGAG
GGGTGGGGGCGGGGAGCCGCAGGCCGACTGCGGGCAGAATGGCGGCTCAAATTCCAATCGTGGC
TGCTACCTCTACTCCCACCGTAGCTAGGAACAGCAAGAAGAGGCCGGCTAGCCCTTCTCACAAC
AGCAGCGGAGGGGGATATGGTGCTAGTAAGAAGAAAAAACTGTCGGCCTCCGGCTTTGCTCAGG
GTGTCAGCATTGAAGCCATGAGTGAGAGTAAAATGGCATCCTCTGAGTTAAGCTCAGGGCCTGT
GGAGAAAGCTGCCAAGCCTTTGCCATTTAAAGATCCCAACTTTGTGCACTCTGGCCATGGCGGT
GCAGTAGCTGGCAAGAAGAATAGAACCTGGAAGAACCTCAAACAGATCCTCGCTGCTGAAAGGG
CGTTGCCATGGCAACTGAACGATCCTAACTACTTTAGTATTGATGCTCCTCCATCCTTTAAGCC
AGCTAAGAAGTATTCTGATGTTTCTGGCCTTCTTGCCAACTACACAGACCCTCAGAGCAAGTTG
CGGTTCAGCACTGTTGAGGAATTCTCCTACATTCGCAGGCTGCCATCAGATGTGGTCACAGGTT
ACCTGACACTGAGGAAAGCCACAAGCATCGTCCCCTGAGTCTCGAAAATGGCGATGGGATGGGA
ACAGCCTCGAAAGCGGACTGCACTTGTGACTTTGTTTCATGGAAACAAACATTTCTACTGAAAG
TCTGAAAATGTCAACTCTGGGCTTTGGGAAGAACGCCTGGCTTTCCTGTGAGGAGTTTTTCGTT
TGTTTTCTTCCTCTCCAAGTGCGACCTTCCTAGTTGAATGAAATCATACTTCAGTTGTTGCCTT
ATGTAAAAATTGTTTGATAAGAACATGTAGTAAAATTATGCATTTAAATTAACCCAAGCAAGTC
CCTGAATTTTGTTTGCAAGTTGTGAACTCTCCTCTAACGTTTTCAAAGAATGTGCAGTGAAGAC
ACACAGGCCTGGGTTGTTCTGGAGCCTAACAAGCATGCTGGTCTTTCCGTGGGTCAGAAGCTTC
TGTGTGTTTTCTGCTGTGCAGTTGAATGACTTTACCCATCATGGCCTGCCTGCTGGTGACTTAT
TTGTCTCTGCTGTATGGTGAATTGTGACATTGGCTTCCAGGGGCCAAAGGAGAGATTCAGCTCT
CAAAAGGAAAAGTATTTAGCTAGGTTGAAGAAAACAGATTTTTGGAGACTTAGCCTTTAAGACC
ACTCATTGCTTTTGCAGGGGACCCAGGCTTGGTTCCCAGCACTCACATGGTGACCCACAGCTAT
CTCTAACACCAGTTCCAAGGCATCCAATACCCCCTTCTGACTTCACCAGGCGAGTACATAAATA
CACACAGGCAAACTCTCATATATACAAAAATAATATAATTTTTAAAAATTGTATTTTTTTCTTA
CGAGCACACTGATATCAAGACTGCTCTGAGGTGAGTCCTTCTGATACCTGCTGCATGTCTTCCC
CATAAGAGAGAAGCTTCGAGGTGTACCTTAAAGTGACCAGAATGTTAGAGATTCCTCACCTTGC
AGAGCTGGGGTGAGGAAGAGTTTCTTGCCACTGTGGTTACTTTTCATGCAGTGACCAAATGCCC
ATCAAAAAGGAATACATGCCCATCTCTGTGGGGACTCATGACGGCAGGAGTGGGAGGCAGCTGG
CTGAACTGTATCCACCGCTATGACACAGAACAGACAAGTAAGACTGGACGGTAACACCTCGAGG
CCTCCCTCCAGTGACCCACTCCCTCCAGAAAGGGTCTACCATTGCAACAACCTTCCAACCTGCC
ACCCACACCGGGCACCAATTGTTCCAACATATTTTACATTCAGATCACTACACCATGTCTCCCG
AGTTAAAGCACGTATCCACCCAGACTTCAAATGTGCTTTGTAACTGTTGATGGCACCTTACAAA
GGGCCAAAGTGTTTCCCATCAGATAGCACTTTTCTGAACCCACGCCTCTTGGGAAGAGATCACA
GGGCTTGACCCATCATCAGATAGGCTCAGGTGGCCTATGGAGAGGTCACAATGATGGCTTCCTA
CATGAAACAGTCAAGTCAATTTCCCATAATGCTCTCATCTGAGAGAATGCATGAACCTTATTTG
AATCCTGGTTCAAACAGAAAGCTTACAGTATGTATGAGACAGTTATGAACCTGACAGACTTTGC
TGTGTGAAGATATTTATGAACATTTTCAGTCAGAATGCTGGTATCATCCTGTTAAGGGAAGGGG
TCATATATTAGAGACAAAGGCTGAAACATTTGTGCACAGAGCGATATGATATCTGGGATTTGTT
TTAGGATGATGTGGGAGGGAGGAAATGGATGGAAGTGGTGTTGAGACAATATTGGCCATGAGTC
AGCTATTGTGTGCTAAGAAGTTCCTCACACCAGTCTACTCTGTATGTGTTTGAATTTCTCCACA
ATAAACTTAACAAGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039096736 ⟹ XP_038952664

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	15,653,508 - 15,752,455 (-)	NCBI
mRatBN7.2	18	15,378,764 - 15,398,574 (-)	NCBI

RefSeq Acc Id:

XM_063277257 ⟹ XP_063133327

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	15,653,508 - 15,752,455 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001017446	(Get FASTA)	NCBI Sequence Viewer
	NP_001415638	(Get FASTA)	NCBI Sequence Viewer
	XP_038952664	(Get FASTA)	NCBI Sequence Viewer
	XP_063133327	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91281	(Get FASTA)	NCBI Sequence Viewer
	EDL76130	(Get FASTA)	NCBI Sequence Viewer
	EDL76131	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022169
	ENSRNOP00000022169.5
GenBank Protein	Q5BJY3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001017446 ⟸ NM_001017446
- UniProtKB:	Q5BJY3 (UniProtKB/Swiss-Prot), A6J2J9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAQIPIVAATSTPTVARNSKKRPASPSHNSSGGGYGASKKKKLSASGFAQGVSIEAMSESKMA SSELSSGPVEKAAKPLPFKDPNFVHSGHGGAVAGKKNRTWKNLKQILAAERALPWQLNDPNYFS IDAPPSFKPAKKYSDVSGLLANYTDPQSKLRFSTVEEFSYIRRLPSDVVTGYLTLRKATSIVP hide sequence

Ensembl Acc Id:

ENSRNOP00000022169 ⟸ ENSRNOT00000022169

RefSeq Acc Id:	XP_038952664 ⟸ XM_039096736
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000093588 ⟸ ENSRNOT00000118512

RefSeq Acc Id:	XP_063133327 ⟸ XM_063277257
- Peptide Label:	isoform X2

Protein Domains

Vps72/YL1 C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5BJY3-F1-model_v2	AlphaFold	Q5BJY3	1-191	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310199	AgrOrtholog
BioCyc Gene	G2FUF-8163	BioCyc
Ensembl Genes	ENSRNOG00000016532	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000022169	ENTREZGENE
	ENSRNOT00000022169.7	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7097077	IMAGE-MGC_LOAD
	IMAGE:7192011	IMAGE-MGC_LOAD
InterPro	INO80C/Ies6	UniProtKB/Swiss-Prot
	Vps72/YL1_C	UniProtKB/Swiss-Prot
KEGG Report	rno:291737	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109171	IMAGE-MGC_LOAD
	MGC:94762	IMAGE-MGC_LOAD
NCBI Gene	291737	ENTREZGENE
PANTHER	INO80 COMPLEX SUBUNIT C	UniProtKB/Swiss-Prot
	PTHR31200	UniProtKB/Swiss-Prot
Pfam	YL1_C	UniProtKB/Swiss-Prot
PhenoGen	Ino80c	PhenoGen
RatGTEx	ENSRNOG00000016532	RatGTEx
SMART	YL1_C	UniProtKB/Swiss-Prot
UniProt	A0A8I6AX91_RAT	UniProtKB/TrEMBL
	A6J2J9	ENTREZGENE, UniProtKB/TrEMBL
	IN80C_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-09	Ino80c	INO80 complex subunit C	RGD1310199	similar to RIKEN cDNA D030070L09	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1310199	similar to RIKEN cDNA D030070L09	RGD1310199_predicted	similar to RIKEN cDNA D030070L09 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1310199_predicted	similar to RIKEN cDNA D030070L09 (predicted)	LOC291737_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC291737_predicted	similar to RIKEN cDNA D030070L09 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations