Hook2 (hook microtubule-tethering protein 2) - Rat Genome Database

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Gene: Hook2 (hook microtubule-tethering protein 2) Rattus norvegicus
Analyze
Symbol: Hook2
Name: hook microtubule-tethering protein 2
RGD ID: 1310171
Description: Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and microtubule binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to be located in cytosol and trans-Golgi network. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human HOOK2 (hook microtubule tethering protein 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hook homolog 2; hook homolog 2 (Drosophila); LOC304669
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,056,732 - 40,075,027 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1940,056,732 - 40,081,270 (-)EnsemblGRCr8
mRatBN7.21923,151,869 - 23,170,139 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,151,870 - 23,164,181 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1929,974,439 - 29,987,015 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,628,797 - 30,641,376 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01932,851,475 - 32,864,052 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01926,106,713 - 26,119,353 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,106,838 - 26,119,352 (+)Ensemblrn6Rnor6.0
Rnor_5.01937,082,361 - 37,094,976 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41924,808,204 - 24,819,397 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1922,709,747 - 22,721,741 (-)NCBICelera
RGSC_v3.11924,813,376 - 24,824,426 (-)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clofibrate  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
folpet  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
indometacin  (ISO)
inulin  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
Nivalenol  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
quercetin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IBA,ISO)
cytoplasm  (IBA,IEA)
cytoskeleton  (IEA)
cytosol  (ISO)
FHF complex  (ISO)
HOPS complex  (ISO)
microtubule  (IEA)
trans-Golgi network  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:17140400   PMID:18799622  


Genomics

Comparative Map Data
Hook2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,056,732 - 40,075,027 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1940,056,732 - 40,081,270 (-)EnsemblGRCr8
mRatBN7.21923,151,869 - 23,170,139 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,151,870 - 23,164,181 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1929,974,439 - 29,987,015 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,628,797 - 30,641,376 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01932,851,475 - 32,864,052 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01926,106,713 - 26,119,353 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,106,838 - 26,119,352 (+)Ensemblrn6Rnor6.0
Rnor_5.01937,082,361 - 37,094,976 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41924,808,204 - 24,819,397 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1922,709,747 - 22,721,741 (-)NCBICelera
RGSC_v3.11924,813,376 - 24,824,426 (-)NCBI
Cytogenetic Map19q11NCBI
HOOK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,763,003 - 12,792,350 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,763,003 - 12,872,740 (-)Ensemblhg38GRCh38
GRCh371912,873,817 - 12,903,164 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,734,817 - 12,747,434 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341912,734,816 - 12,747,337NCBI
Celera1912,763,527 - 12,776,144 (-)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,446,753 - 12,459,369 (-)NCBIHuRef
CHM1_11912,874,278 - 12,886,908 (-)NCBICHM1_1
T2T-CHM13v2.01912,887,497 - 12,916,842 (-)NCBIT2T-CHM13v2.0
Hook2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,715,402 - 85,729,981 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,717,232 - 85,729,978 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38884,988,776 - 85,003,352 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,990,603 - 85,003,349 (+)Ensemblmm10GRCm38
MGSCv37887,514,494 - 87,527,263 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36887,880,724 - 87,893,366 (+)NCBIMGSCv36mm8
Celera889,285,271 - 89,297,949 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.44NCBI
Hook2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,853,091 - 31,865,450 (-)Ensembl
ChiLan1.0NW_00495541531,855,183 - 31,865,413 (-)NCBIChiLan1.0ChiLan1.0
HOOK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,692,666 - 17,707,853 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,693,212 - 16,708,411 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,325,578 - 12,340,754 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,070,289 - 13,084,690 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,070,289 - 13,082,612 (-)EnsemblpanPan2panpan1.1
HOOK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,367,450 - 49,383,109 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,367,876 - 49,382,813 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2049,241,088 - 49,256,725 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02049,885,871 - 49,901,539 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,890,074 - 49,901,286 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,096,996 - 49,112,621 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,523,273 - 49,538,952 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,765,953 - 49,781,619 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hook2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,475,529 - 208,485,084 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,869,622 - 1,879,213 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,869,622 - 1,879,213 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOOK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,227,601 - 66,244,828 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1266,227,562 - 66,239,671 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,476,422 - 66,493,546 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HOOK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,452,154 - 11,464,718 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,449,026 - 11,464,622 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660748,331,646 - 8,344,488 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hook2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901378,967 - 392,027 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624901379,952 - 391,727 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Hook2
47 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:58
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000035987
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat

Markers in Region
RH137868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,152,021 - 23,152,146 (-)MAPPERmRatBN7.2
Rnor_6.01926,119,076 - 26,119,200NCBIRnor6.0
Rnor_5.01937,094,699 - 37,094,823UniSTSRnor5.0
RGSC_v3.41924,808,351 - 24,808,475UniSTSRGSC3.4
Celera1922,709,900 - 22,710,024UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010059990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010059991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC099235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ203898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB548211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB696289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB785578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000035987   ⟹   ENSRNOP00000033999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1940,056,732 - 40,069,045 (-)Ensembl
mRatBN7.2 Ensembl1923,151,870 - 23,164,181 (-)Ensembl
Rnor_6.0 Ensembl1926,106,838 - 26,119,352 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128519   ⟹   ENSRNOP00000108421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1940,056,732 - 40,074,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133566   ⟹   ENSRNOP00000103421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1940,059,204 - 40,069,045 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135861   ⟹   ENSRNOP00000105635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1940,056,732 - 40,069,045 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160725   ⟹   ENSRNOP00000109072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1940,056,732 - 40,081,270 (-)Ensembl
RefSeq Acc Id: NM_001100562   ⟹   NP_001094032
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,056,732 - 40,069,043 (-)NCBI
mRatBN7.21923,151,869 - 23,164,181 (-)NCBI
Rnor_6.01926,106,838 - 26,119,353 (+)NCBI
Rnor_5.01937,082,361 - 37,094,976 (+)NCBI
Celera1922,709,747 - 22,721,741 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001415053   ⟹   NP_001401982
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,056,732 - 40,069,045 (-)NCBI
mRatBN7.21923,151,869 - 23,164,183 (-)NCBI
RefSeq Acc Id: XM_006255258   ⟹   XP_006255320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,056,827 - 40,069,101 (-)NCBI
mRatBN7.21923,151,875 - 23,164,247 (-)NCBI
Rnor_6.01926,106,713 - 26,119,347 (+)NCBI
Rnor_5.01937,082,361 - 37,094,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097683   ⟹   XP_038953611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,056,827 - 40,069,103 (-)NCBI
mRatBN7.21923,151,875 - 23,164,250 (-)NCBI
RefSeq Acc Id: XM_039097684   ⟹   XP_038953612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,056,827 - 40,074,999 (-)NCBI
mRatBN7.21923,151,875 - 23,170,135 (-)NCBI
RefSeq Acc Id: XM_039097685   ⟹   XP_038953613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,056,827 - 40,075,003 (-)NCBI
mRatBN7.21923,151,875 - 23,170,139 (-)NCBI
RefSeq Acc Id: XM_039097686   ⟹   XP_038953614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,056,827 - 40,068,937 (-)NCBI
mRatBN7.21923,151,875 - 23,164,075 (-)NCBI
RefSeq Acc Id: XM_063277969   ⟹   XP_063134039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,056,827 - 40,069,099 (-)NCBI
RefSeq Acc Id: XM_063277970   ⟹   XP_063134040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,058,666 - 40,075,014 (-)NCBI
RefSeq Acc Id: XM_063277971   ⟹   XP_063134041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,056,827 - 40,074,225 (-)NCBI
RefSeq Acc Id: XM_063277972   ⟹   XP_063134042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,056,827 - 40,068,283 (-)NCBI
RefSeq Acc Id: XR_010059990
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,061,522 - 40,075,027 (-)NCBI
RefSeq Acc Id: XR_010059991
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,061,522 - 40,069,123 (-)NCBI
RefSeq Acc Id: NP_001094032   ⟸   NM_001100562
- Peptide Label: isoform 2
- UniProtKB: E9PTX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255320   ⟸   XM_006255258
- Peptide Label: isoform X4
- UniProtKB: E9PTX3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033999   ⟸   ENSRNOT00000035987
RefSeq Acc Id: XP_038953613   ⟸   XM_039097685
- Peptide Label: isoform X3
- UniProtKB: E9PTX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953612   ⟸   XM_039097684
- Peptide Label: isoform X2
- UniProtKB: E9PTX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953611   ⟸   XM_039097683
- Peptide Label: isoform X1
- UniProtKB: E9PTX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953614   ⟸   XM_039097686
- Peptide Label: isoform X8
- UniProtKB: Q4FZR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001401982   ⟸   NM_001415053
- Peptide Label: isoform 1
- UniProtKB: A6IY41 (UniProtKB/TrEMBL),   E9PTX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134041   ⟸   XM_063277971
- Peptide Label: isoform X7
- UniProtKB: Q4FZR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134039   ⟸   XM_063277969
- Peptide Label: isoform X5
- UniProtKB: E9PTX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134042   ⟸   XM_063277972
- Peptide Label: isoform X7
- UniProtKB: Q4FZR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134040   ⟸   XM_063277970
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000105635   ⟸   ENSRNOT00000135861
Ensembl Acc Id: ENSRNOP00000109072   ⟸   ENSRNOT00000160725
Ensembl Acc Id: ENSRNOP00000103421   ⟸   ENSRNOT00000133566
Ensembl Acc Id: ENSRNOP00000108421   ⟸   ENSRNOT00000128519
Protein Domains
Calponin-homology (CH)   Hook C-terminal   HOOK N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTX3-F1-model_v2 AlphaFold E9PTX3 1-719 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701034
Promoter ID:EPDNEW_R11558
Type:multiple initiation site
Name:Hook2_1
Description:hook microtubule-tethering protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01926,106,836 - 26,106,896EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310171 AgrOrtholog
BioCyc Gene G2FUF-6137 BioCyc
Ensembl Genes ENSRNOG00000003682 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035987 ENTREZGENE
  ENSRNOT00000035987.5 UniProtKB/TrEMBL
  ENSRNOT00000128519 ENTREZGENE
  ENSRNOT00000133566 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7444932 IMAGE-MGC_LOAD
InterPro CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  HOOK UniProtKB/TrEMBL
  HOOK_N UniProtKB/TrEMBL
KEGG Report rno:304669 UniProtKB/TrEMBL
MGC_CLONE MGC:116416 IMAGE-MGC_LOAD
NCBI Gene 304669 ENTREZGENE
PANTHER HOOK PROTEINS UniProtKB/TrEMBL
  PROTEIN HOOK HOMOLOG 2 UniProtKB/TrEMBL
Pfam HOOK UniProtKB/TrEMBL
  HOOK_N UniProtKB/TrEMBL
PhenoGen Hook2 PhenoGen
PROSITE PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003682 RatGTEx
Superfamily-SCOP Hook domain UniProtKB/TrEMBL
UniProt A6IY41 ENTREZGENE, UniProtKB/TrEMBL
  E9PTX3 ENTREZGENE, UniProtKB/TrEMBL
  Q4FZR1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-16 Hook2  hook microtubule-tethering protein 2  Hook2  hook homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Hook2  hook homolog 2 (Drosophila)  Hook2_predicted  hook homolog 2 (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hook2_predicted  hook homolog 2 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED