Lipi (lipase I) - Rat Genome Database

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Gene: Lipi (lipase I) Rattus norvegicus
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Symbol: Lipi
Name: lipase I
RGD ID: 1310162
Description: Predicted to enable heparin binding activity and phospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Orthologous to human LIPI (lipase I); INTERACTS WITH bisphenol A; glyphosate; indole-3-methanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: lipase member I; lipase, member H; lipase, member I; Liph; LOC288322
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81127,676,354 - 27,716,025 (-)NCBIGRCr8
mRatBN7.21114,189,323 - 14,228,992 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1114,189,323 - 14,228,985 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1122,814,757 - 22,854,069 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01115,541,131 - 15,580,448 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01114,709,001 - 14,748,311 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01113,960,246 - 13,999,869 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1113,960,246 - 13,999,862 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01117,618,917 - 17,658,537 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41114,336,377 - 14,376,050 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11114,347,383 - 14,369,651 (-)NCBI
Celera1114,202,968 - 14,242,626 (-)NCBICelera
Cytogenetic Map11p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. Wen XY, etal., Hum Mol Genet. 2003 May 15;12(10):1131-43.
Additional References at PubMed
PMID:12963729  


Genomics

Comparative Map Data
Lipi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81127,676,354 - 27,716,025 (-)NCBIGRCr8
mRatBN7.21114,189,323 - 14,228,992 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1114,189,323 - 14,228,985 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1122,814,757 - 22,854,069 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01115,541,131 - 15,580,448 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01114,709,001 - 14,748,311 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01113,960,246 - 13,999,869 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1113,960,246 - 13,999,862 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01117,618,917 - 17,658,537 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41114,336,377 - 14,376,050 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11114,347,383 - 14,369,651 (-)NCBI
Celera1114,202,968 - 14,242,626 (-)NCBICelera
Cytogenetic Map11p11NCBI
LIPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382114,108,812 - 14,210,955 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2114,108,813 - 14,210,955 (-)EnsemblGRCh38hg38GRCh38
GRCh372115,481,133 - 15,583,276 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362114,403,005 - 14,501,125 (-)NCBINCBI36Build 36hg18NCBI36
Celera21638,370 - 736,505 (-)NCBICelera
Cytogenetic Map21q11.2NCBI
HuRef21851,595 - 949,613 (-)NCBIHuRef
CHM1_12115,041,616 - 15,139,768 (-)NCBICHM1_1
T2T-CHM13v2.02112,451,516 - 12,553,663 (-)NCBIT2T-CHM13v2.0
Lipi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391675,337,431 - 75,382,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1675,337,402 - 75,382,949 (-)EnsemblGRCm39 Ensembl
GRCm381675,540,514 - 75,586,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1675,540,514 - 75,586,061 (-)EnsemblGRCm38mm10GRCm38
MGSCv371675,540,789 - 75,730,778 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361675,423,224 - 75,450,362 (-)NCBIMGSCv36mm8
Celera1675,777,640 - 75,819,822 (-)NCBICelera
Cytogenetic Map16C3.1NCBI
cM Map1643.22NCBI
Lipi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540716,012,264 - 16,056,796 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540716,013,285 - 16,071,187 (-)NCBIChiLan1.0ChiLan1.0
LIPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22210,580,859 - 10,693,126 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1215,411,435 - 5,526,865 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v021832,890 - 937,342 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12114,203,425 - 14,304,676 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2114,203,425 - 14,304,852 (-)Ensemblpanpan1.1panPan2
LIPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13111,139,134 - 11,196,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3111,139,110 - 11,230,181 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3111,149,515 - 11,190,700 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03111,162,558 - 11,203,526 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13111,136,267 - 11,176,855 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03111,174,044 - 11,214,900 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03111,569,879 - 11,610,726 (-)NCBIUU_Cfam_GSD_1.0
Lipi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497112,265,731 - 12,327,079 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365057,185,660 - 7,226,228 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365057,185,885 - 7,226,653 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13179,128,660 - 179,180,626 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113179,128,549 - 179,180,612 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213189,317,871 - 189,369,597 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIPI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1278,278,754 - 78,352,973 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl278,275,913 - 78,352,855 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605075,499,469 - 75,601,547 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lipi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247452,631,598 - 2,681,098 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247452,612,605 - 2,681,179 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lipi
130 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:318
Count of miRNA genes:208
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000045835
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)11121836709Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111283104625121472Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

reproductive system respiratory system
High
Medium
Low 1
Below cutoff 12 1

Sequence


RefSeq Acc Id: ENSRNOT00000045835   ⟹   ENSRNOP00000041652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1114,189,323 - 14,228,985 (-)Ensembl
Rnor_6.0 Ensembl1113,960,246 - 13,999,862 (-)Ensembl
RefSeq Acc Id: NM_001105899   ⟹   NP_001099369
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81127,676,354 - 27,716,025 (-)NCBI
mRatBN7.21114,189,323 - 14,228,992 (-)NCBI
Rnor_6.01113,960,246 - 13,999,869 (-)NCBI
Rnor_5.01117,618,917 - 17,658,537 (-)NCBI
RGSC_v3.41114,336,377 - 14,376,050 (-)RGD
Celera1114,202,968 - 14,242,626 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099369 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10577 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041652
  ENSRNOP00000041652.3
RefSeq Acc Id: NP_001099369   ⟸   NM_001105899
- Peptide Label: precursor
- UniProtKB: D3ZMG4 (UniProtKB/TrEMBL),   A6JL12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041652   ⟸   ENSRNOT00000045835
Protein Domains
Lipase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMG4-F1-model_v2 AlphaFold D3ZMG4 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310162 AgrOrtholog
BioCyc Gene G2FUF-22237 BioCyc
Ensembl Genes ENSRNOG00000033441 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045835 ENTREZGENE
  ENSRNOT00000045835.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Lipase UniProtKB/TrEMBL
  Lipase_N UniProtKB/TrEMBL
  Lipase_N UniProtKB/TrEMBL
  Lipoprotein_lipase_LIPH UniProtKB/TrEMBL
KEGG Report rno:288322 UniProtKB/TrEMBL
NCBI Gene 288322 ENTREZGENE
PANTHER Lipase UniProtKB/TrEMBL
  LIPASE MEMBER I UniProtKB/TrEMBL
Pfam Lipase UniProtKB/TrEMBL
PhenoGen Lipi PhenoGen
PIRSF Lipoprotein_lipase_LIPH UniProtKB/TrEMBL
PRINTS TAGLIPASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033441 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A6JL12 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMG4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Lipi  lipase I  Lipi  lipase, member I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Lipi  lipase, member I   Lipi_predicted  lipase, member I (predicted)  'predicted' is removed 2292626 APPROVED
2007-09-21 Lipi_predicted  lipase, member I (predicted)  Liph_predicted  lipase, member H (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Liph_predicted  lipase, member H (predicted)      Symbol and Name status set to approved 70820 APPROVED