Gmps (guanine monophosphate synthase) - Rat Genome Database

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Gene: Gmps (guanine monophosphate synthase) Rattus norvegicus
Analyze
Symbol: Gmps
Name: guanine monophosphate synthase
RGD ID: 1310063
Description: Enables GMP synthase activity and enzyme binding activity. Involved in GMP salvage; response to L-cysteine; and response to xenobiotic stimulus. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human GMPS (guanine monophosphate synthase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutamine amidotransferase; GMP synthase; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; guanine monophosphate synthetase; LOC295088
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82150,587,824 - 150,641,564 (+)NCBIGRCr8
mRatBN7.22148,441,369 - 148,491,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2148,435,643 - 148,485,875 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2155,179,955 - 155,214,681 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02153,229,417 - 153,264,155 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02147,862,091 - 147,896,832 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02154,555,967 - 154,590,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2154,555,871 - 154,590,662 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02173,939,844 - 173,974,539 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42153,804,512 - 153,840,009 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12153,754,474 - 153,789,970 (+)NCBI
Celera2142,726,833 - 142,761,299 (+)NCBICelera
Cytogenetic Map2q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
ivermectin  (ISO)
lovastatin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
oxaliplatin  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
poly(propylene imine) macromolecule  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
tetrachloromethane  (EXP,ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Pediatric neurological syndromes and inborn errors of purine metabolism. Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Purification and characterization of GMP synthetase from Yoshida sarcoma ascites cells. Hirai K, etal., J Biochem (Tokyo). 1987 Oct;102(4):893-902.
5. Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride. Jayaram HN, etal., Cancer Chemother Pharmacol. 1990;26(2):88-92.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene. Pegram LD, etal., Blood. 2000 Dec 15;96(13):4360-2.
8. Insulin regulatory effects on purine- and pyrimidine metabolism in alloxan diabetic rat liver. Pillwein K, etal., Padiatr Padol. 1988;23(2):135-44.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Enzymic programs of rat bone marrow and the impact of acivicin and tiazofurin. Prajda N, etal., Biochem Pharmacol. 1988 Mar 1;37(5):875-80.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Enzymes of purine metabolism in cancer. Weber G Clin Biochem. 1983 Feb;16(1):57-63.
15. Characterization of purine nucleotide metabolism in primary rat muscle cultures. Zoref-Shani E, etal., Biochim Biophys Acta. 1982 Jun 16;716(3):324-30. doi: 10.1016/0304-4165(82)90023-x.
Additional References at PubMed
PMID:7706277   PMID:8081953   PMID:8089153   PMID:12477932   PMID:31505169  


Genomics

Comparative Map Data
Gmps
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82150,587,824 - 150,641,564 (+)NCBIGRCr8
mRatBN7.22148,441,369 - 148,491,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2148,435,643 - 148,485,875 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2155,179,955 - 155,214,681 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02153,229,417 - 153,264,155 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02147,862,091 - 147,896,832 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02154,555,967 - 154,590,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2154,555,871 - 154,590,662 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02173,939,844 - 173,974,539 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42153,804,512 - 153,840,009 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12153,754,474 - 153,789,970 (+)NCBI
Celera2142,726,833 - 142,761,299 (+)NCBICelera
Cytogenetic Map2q31NCBI
GMPS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383155,869,430 - 155,944,020 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3155,870,650 - 155,944,020 (+)EnsemblGRCh38hg38GRCh38
GRCh373155,588,439 - 155,661,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363157,071,019 - 157,138,215 (+)NCBINCBI36Build 36hg18NCBI36
Build 343157,071,026 - 157,138,223NCBI
Celera3154,009,947 - 154,077,188 (+)NCBICelera
Cytogenetic Map3q25.31NCBI
HuRef3152,982,759 - 153,049,917 (+)NCBIHuRef
CHM1_13155,551,614 - 155,618,831 (+)NCBICHM1_1
T2T-CHM13v2.03158,644,070 - 158,718,668 (+)NCBIT2T-CHM13v2.0
Gmps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39363,871,054 - 63,928,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl363,883,527 - 63,930,000 (+)EnsemblGRCm39 Ensembl
GRCm38363,963,633 - 64,021,554 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl363,976,106 - 64,022,579 (+)EnsemblGRCm38mm10GRCm38
MGSCv37363,780,065 - 63,823,000 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36364,064,072 - 64,107,007 (+)NCBIMGSCv36mm8
Celera363,647,946 - 63,691,053 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map330.08NCBI
Gmps
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554486,932,926 - 6,984,662 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554486,931,891 - 6,984,662 (+)NCBIChiLan1.0ChiLan1.0
GMPS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22153,783,747 - 153,852,239 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13153,788,477 - 153,862,949 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03152,925,905 - 152,999,180 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13160,977,222 - 161,045,214 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3160,977,222 - 161,045,214 (+)Ensemblpanpan1.1panPan2
GMPS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12349,569,571 - 49,645,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2349,569,531 - 49,699,199 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2349,445,713 - 49,522,068 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02350,203,908 - 50,286,767 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2350,203,868 - 50,333,624 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12349,789,609 - 49,866,167 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02349,838,479 - 49,915,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02350,126,162 - 50,202,992 (+)NCBIUU_Cfam_GSD_1.0
Gmps
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560286,587,606 - 86,639,212 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365193,104,701 - 3,141,549 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365193,094,763 - 3,143,322 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GMPS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1395,738,659 - 95,819,759 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11395,742,342 - 95,820,903 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213103,766,547 - 103,819,693 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GMPS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11534,817,603 - 34,885,363 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1534,815,066 - 34,885,228 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660417,450,006 - 7,520,263 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gmps
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473033,460,566 - 33,535,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473033,459,059 - 33,535,593 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gmps
136 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat

Markers in Region
D2Rat181  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22148,478,176 - 148,478,373 (+)MAPPERmRatBN7.2
Rnor_6.02154,582,964 - 154,583,160NCBIRnor6.0
Rnor_5.02173,966,841 - 173,967,037UniSTSRnor5.0
RGSC_v3.42153,832,310 - 153,832,507RGDRGSC3.4
RGSC_v3.42153,832,311 - 153,832,507UniSTSRGSC3.4
RGSC_v3.12153,782,274 - 153,782,470RGD
Celera2142,753,601 - 142,753,797UniSTS
RH 3.4 Map2941.0RGD
RH 3.4 Map2941.0UniSTS
RH 2.0 Map2696.8RGD
SHRSP x BN Map260.5598RGD
Cytogenetic Map2q31UniSTS
BE108044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22148,479,491 - 148,479,656 (+)MAPPERmRatBN7.2
Rnor_6.02154,584,279 - 154,584,443NCBIRnor6.0
Rnor_5.02173,968,156 - 173,968,320UniSTSRnor5.0
RGSC_v3.42153,833,626 - 153,833,790UniSTSRGSC3.4
Celera2142,754,916 - 142,755,080UniSTS
RH 3.4 Map2947.4UniSTS
Cytogenetic Map2q31UniSTS
RH135286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22148,478,935 - 148,479,122 (+)MAPPERmRatBN7.2
Rnor_6.02154,583,723 - 154,583,909NCBIRnor6.0
Rnor_5.02173,967,600 - 173,967,786UniSTSRnor5.0
RGSC_v3.42153,833,070 - 153,833,256UniSTSRGSC3.4
Celera2142,754,360 - 142,754,546UniSTS
RH 3.4 Map2936.0UniSTS
Cytogenetic Map2q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000076292   ⟹   ENSRNOP00000068021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2148,450,915 - 148,485,873 (+)Ensembl
Rnor_6.0 Ensembl2154,555,871 - 154,576,770 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076880   ⟹   ENSRNOP00000068212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2148,435,643 - 148,485,875 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076976   ⟹   ENSRNOP00000068164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2154,580,558 - 154,590,662 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084238   ⟹   ENSRNOP00000072183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2148,454,384 - 148,485,875 (+)Ensembl
Rnor_6.0 Ensembl2154,556,029 - 154,590,643 (+)Ensembl
RefSeq Acc Id: NM_001024754   ⟹   NP_001019925
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82150,600,829 - 150,635,531 (+)NCBI
mRatBN7.22148,451,173 - 148,485,875 (+)NCBI
Rnor_6.02154,555,967 - 154,590,662 (+)NCBI
Rnor_5.02173,939,844 - 173,974,539 (+)NCBI
RGSC_v3.42153,804,512 - 153,840,009 (+)RGD
Celera2142,726,833 - 142,761,299 (+)RGD
Sequence:
RefSeq Acc Id: XM_039102016   ⟹   XP_038957944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82150,587,824 - 150,641,564 (+)NCBI
mRatBN7.22148,441,369 - 148,491,908 (+)NCBI
RefSeq Acc Id: XM_039102017   ⟹   XP_038957945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82150,600,684 - 150,629,330 (+)NCBI
mRatBN7.22148,451,056 - 148,479,656 (+)NCBI
RefSeq Acc Id: XM_063281587   ⟹   XP_063137657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82150,589,703 - 150,641,564 (+)NCBI
RefSeq Acc Id: NP_001019925   ⟸   NM_001024754
- UniProtKB: Q4V7C6 (UniProtKB/Swiss-Prot),   A0A0G2K2C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068164   ⟸   ENSRNOT00000076976
RefSeq Acc Id: ENSRNOP00000072183   ⟸   ENSRNOT00000084238
RefSeq Acc Id: ENSRNOP00000068021   ⟸   ENSRNOT00000076292
RefSeq Acc Id: XP_038957944   ⟸   XM_039102016
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R0S7 (UniProtKB/TrEMBL),   A0A0G2K2C2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957945   ⟸   XM_039102017
- Peptide Label: isoform X2
- UniProtKB: A6JVP6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000068212   ⟸   ENSRNOT00000076880
RefSeq Acc Id: XP_063137657   ⟸   XM_063281587
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2C2 (UniProtKB/TrEMBL),   A0A8L2R0S7 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V7C6-F1-model_v2 AlphaFold Q4V7C6 1-693 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691360
Promoter ID:EPDNEW_R1882
Type:initiation region
Name:Gmps_1
Description:guanine monophosphate synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02154,555,894 - 154,555,954EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310063 AgrOrtholog
BioCyc Gene G2FUF-52923 BioCyc
BioCyc Pathway CITRULBIO-PWY [L-citrulline biosynthesis] BioCyc
  GLUTAMINDEG-PWY [L-glutamine degradation I] BioCyc
  PWY-5921 [glutaminyl-tRNAgln biosynthesis via transamidation] BioCyc
  PWY-7221 [guanosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image CITRULBIO-PWY BioCyc
  GLUTAMINDEG-PWY BioCyc
  PWY-5921 BioCyc
  PWY-7221 BioCyc
Ensembl Genes ENSRNOG00000051151 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076292 ENTREZGENE
  ENSRNOT00000076292.3 UniProtKB/TrEMBL
  ENSRNOT00000076880.3 UniProtKB/TrEMBL
  ENSRNOT00000084238.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7454908 IMAGE-MGC_LOAD
InterPro Class_I_gatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GMP_synth_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GMP_synth_GATase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GMPS_ATP_PPase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD/GMP_synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:295088 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116167 IMAGE-MGC_LOAD
NCBI Gene 295088 ENTREZGENE
PANTHER GMP SYNTHASE [GLUTAMINE-HYDROLYZING] UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GMP SYNTHASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GATase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GMP_synt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gmps PhenoGen
PRINTS ANTSNTHASEII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GATASE_TYPE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GMPS_ATP_PPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051151 RatGTEx
Superfamily-SCOP Adenine nucleotide alpha hydrolases-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GMP synthetase C-terminal dimerisation domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MJ75_RAT UniProtKB/TrEMBL
  A0A0G2K2C2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R0S7 ENTREZGENE, UniProtKB/TrEMBL
  A6JVP6 ENTREZGENE, UniProtKB/TrEMBL
  A6JVP7_RAT UniProtKB/TrEMBL
  GUAA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-09-04 Gmps  guanine monophosphate synthase  Gmps  guanine monphosphate synthase  Name changed 629549 APPROVED
2013-07-09 Gmps  guanine monphosphate synthase  Gmps  guanine monphosphate synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Gmps  guanine monphosphate synthetase  Gmps_predicted  guanine monphosphate synthetase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gmps_predicted  guanine monphosphate synthetase (predicted)      Symbol and Name status set to approved 70820 APPROVED