Adamts16 (ADAM metallopeptidase with thrombospondin type 1 motif, 16) - Rat Genome Database

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Gene: Adamts16 (ADAM metallopeptidase with thrombospondin type 1 motif, 16) Rattus norvegicus
Analyze
Symbol: Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 16
RGD ID: 1310046
Description: Predicted to enable metalloendopeptidase activity. Involved in male gamete generation; regulation of cilium assembly; and regulation of systemic arterial blood pressure. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Used to study cryptorchidism; hypertension; and male infertility. Orthologous to human ADAMTS16 (ADAM metallopeptidase with thrombospondin type 1 motif 16); INTERACTS WITH paracetamol; 17beta-estradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 16; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16; LOC306664
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Adamts16em1Bj  
Genetic Models: SS-Adamts16em1Bj
Candidate Gene For: Bp344
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8134,258,899 - 34,388,952 (+)NCBIGRCr8
mRatBN7.2132,430,436 - 32,562,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl132,430,436 - 32,560,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx132,257,859 - 32,387,809 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0138,256,498 - 38,386,444 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0132,462,410 - 32,586,379 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0135,067,268 - 35,200,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl135,067,490 - 35,198,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0136,468,949 - 36,599,799 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4172,559,771 - 2,690,663 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1172,390,909 - 2,689,575 (+)NCBI
Celera131,055,382 - 31,178,973 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cryptorchidism and infertility in rats with targeted disruption of the Adamts16 locus. Abdul-Majeed S, etal., PLoS One. 2014 Jul 1;9(7):e100967. doi: 10.1371/journal.pone.0100967. eCollection 2014.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Targeted disruption of Adamts16 gene in a rat genetic model of hypertension. Gopalakrishnan K, etal., Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20555-9. doi: 10.1073/pnas.1211290109. Epub 2012 Nov 26.
4. Positional identification of variants of Adamts16 linked to inherited hypertension. Joe B, etal., Hum Mol Genet. 2009 Aug 1;18(15):2825-38. Epub 2009 May 7.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Interplay between collagenase and undescended testes in Adamts16 knockout rats. Sarila G, etal., J Pediatr Surg. 2020 Jan 7. pii: S0022-3468(19)30929-7. doi: 10.1016/j.jpedsurg.2019.12.019.
Additional References at PubMed
PMID:23661704  


Genomics

Comparative Map Data
Adamts16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8134,258,899 - 34,388,952 (+)NCBIGRCr8
mRatBN7.2132,430,436 - 32,562,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl132,430,436 - 32,560,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx132,257,859 - 32,387,809 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0138,256,498 - 38,386,444 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0132,462,410 - 32,586,379 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0135,067,268 - 35,200,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl135,067,490 - 35,198,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0136,468,949 - 36,599,799 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4172,559,771 - 2,690,663 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1172,390,909 - 2,689,575 (+)NCBI
Celera131,055,382 - 31,178,973 (+)NCBICelera
Cytogenetic Map1p11NCBI
ADAMTS16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3855,140,330 - 5,320,304 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl55,140,330 - 5,320,304 (+)EnsemblGRCh38hg38GRCh38
GRCh3755,140,443 - 5,320,417 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3655,193,443 - 5,373,412 (+)NCBINCBI36Build 36hg18NCBI36
Build 3455,193,580 - 5,356,920NCBI
Celera55,166,758 - 5,346,634 (+)NCBICelera
Cytogenetic Map5p15.32NCBI
HuRef55,113,571 - 5,293,984 (+)NCBIHuRef
CHM1_155,140,474 - 5,320,433 (+)NCBICHM1_1
T2T-CHM13v2.055,067,964 - 5,247,892 (+)NCBIT2T-CHM13v2.0
Adamts16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391370,875,917 - 70,989,956 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1370,875,921 - 70,989,930 (-)EnsemblGRCm39 Ensembl
GRCm381370,727,798 - 70,841,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1370,727,802 - 70,841,811 (-)EnsemblGRCm38mm10GRCm38
MGSCv371370,866,686 - 70,980,688 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361371,195,180 - 71,309,182 (-)NCBIMGSCv36mm8
Celera1373,073,259 - 73,187,558 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1335.97NCBI
Adamts16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555043,168,985 - 3,320,949 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555043,167,142 - 3,320,632 (+)NCBIChiLan1.0ChiLan1.0
ADAMTS16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v245,397,878 - 5,578,428 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan153,551,485 - 3,732,035 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v055,470,841 - 5,651,360 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.155,147,570 - 5,330,721 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl55,150,365 - 5,329,556 (+)Ensemblpanpan1.1panPan2
ADAMTS16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1348,196,733 - 8,346,215 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl348,196,716 - 8,346,309 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3412,704,204 - 12,853,653 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0348,097,652 - 8,247,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl348,097,641 - 8,247,536 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1348,145,035 - 8,294,582 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0348,124,702 - 8,274,519 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0348,337,900 - 8,487,709 (-)NCBIUU_Cfam_GSD_1.0
Adamts16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213241,239,025 - 241,367,996 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366341,830,593 - 1,958,640 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366341,830,252 - 1,925,622 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1676,326,721 - 76,491,003 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11676,326,718 - 76,491,050 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21682,629,433 - 82,792,715 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.144,866,300 - 5,040,338 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606423,756,118 - 23,938,354 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247513,116,256 - 3,247,679 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247513,112,602 - 3,248,643 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts16
758 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:113
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000022707, ENSRNOT00000022790
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
731169Bp153Blood pressure QTL 1530.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13105084033492143Rat
2316649Bp344Blood pressure QTL 344arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13224973533038814Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat

Markers in Region
D17Got215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2132,485,349 - 32,485,498 (+)MAPPERmRatBN7.2
Rnor_6.0135,121,779 - 35,121,927NCBIRnor6.0
Rnor_5.0136,523,494 - 36,523,642UniSTSRnor5.0
RGSC_v3.4172,615,631 - 2,615,779UniSTSRGSC3.4
Celera131,110,074 - 31,110,222UniSTS
Cytogenetic Map17p14UniSTS
D1Mco109  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2132,477,786 - 32,477,938 (+)MAPPERmRatBN7.2
mRatBN7.2132,477,786 - 32,477,982 (+)MAPPERmRatBN7.2
Rnor_6.0135,114,420 - 35,114,615NCBIRnor6.0
Rnor_6.0135,114,420 - 35,114,571NCBIRnor6.0
Rnor_5.0136,516,101 - 36,516,296UniSTSRnor5.0
Rnor_5.0136,516,101 - 36,516,252UniSTSRnor5.0
RGSC_v3.4172,606,953 - 2,607,104UniSTSRGSC3.4
RGSC_v3.4172,606,953 - 2,607,148UniSTSRGSC3.4
Celera131,102,542 - 31,102,737UniSTS
Celera131,102,542 - 31,102,693UniSTS
Cytogenetic Map17p14UniSTS
D1Mco110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2132,504,385 - 32,504,551 (+)MAPPERmRatBN7.2
Rnor_6.0135,140,815 - 35,140,980NCBIRnor6.0
Rnor_5.0136,542,530 - 36,542,695UniSTSRnor5.0
RGSC_v3.4172,634,667 - 2,634,832UniSTSRGSC3.4
Celera131,128,909 - 31,129,074UniSTS
Cytogenetic Map17p14UniSTS
D1Mco108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2132,442,655 - 32,442,841 (+)MAPPERmRatBN7.2
Rnor_6.0135,079,487 - 35,079,672NCBIRnor6.0
Rnor_5.0136,481,168 - 36,481,353UniSTSRnor5.0
RGSC_v3.4172,572,019 - 2,572,204UniSTSRGSC3.4
Celera131,067,601 - 31,067,786UniSTS
Cytogenetic Map17p14UniSTS
D1Mco111  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0135,190,165 - 35,190,354NCBIRnor6.0
Rnor_5.0136,589,937 - 36,590,126UniSTSRnor5.0
RGSC_v3.4172,680,797 - 2,680,986UniSTSRGSC3.4
Celera131,168,608 - 31,168,797UniSTS
Cytogenetic Map17p14UniSTS
D1Mco106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2132,429,140 - 32,429,288 (+)MAPPERmRatBN7.2
Rnor_6.0135,065,971 - 35,066,120NCBIRnor6.0
Rnor_5.0136,467,652 - 36,467,801UniSTSRnor5.0
RGSC_v3.4172,558,503 - 2,558,652UniSTSRGSC3.4
Celera131,054,085 - 31,054,234UniSTS
Cytogenetic Map17p14UniSTS
D1Mco107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2132,433,225 - 32,433,375 (+)MAPPERmRatBN7.2
Rnor_6.0135,070,058 - 35,070,207NCBIRnor6.0
Rnor_5.0136,471,739 - 36,471,888UniSTSRnor5.0
RGSC_v3.4172,562,590 - 2,562,739UniSTSRGSC3.4
Celera131,058,172 - 31,058,321UniSTS
Cytogenetic Map17p14UniSTS


Genetic Models
This gene Adamts16 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 15
Low 5 16 12 12 6 8 57 19 22 6
Below cutoff 2 31 36 24 17 24 2 3 13 3 8 2

Sequence


RefSeq Acc Id: ENSRNOT00000022790   ⟹   ENSRNOP00000022790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl132,430,436 - 32,560,494 (+)Ensembl
Rnor_6.0 Ensembl135,067,490 - 35,198,939 (+)Ensembl
RefSeq Acc Id: NM_001372015   ⟹   NP_001358944
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8134,258,899 - 34,388,952 (+)NCBI
mRatBN7.2132,430,436 - 32,560,494 (+)NCBI
RefSeq Acc Id: XM_039110071   ⟹   XP_038965999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8134,303,399 - 34,388,036 (+)NCBI
mRatBN7.2132,474,942 - 32,562,481 (+)NCBI
RefSeq Acc Id: XM_039110074   ⟹   XP_038966002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8134,258,935 - 34,369,493 (+)NCBI
mRatBN7.2132,430,448 - 32,541,035 (+)NCBI
RefSeq Acc Id: XM_063288087   ⟹   XP_063144157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8134,308,601 - 34,388,036 (+)NCBI
RefSeq Acc Id: XR_005504458
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8134,258,935 - 34,339,480 (+)NCBI
mRatBN7.2132,430,449 - 32,511,019 (+)NCBI
RefSeq Acc Id: ENSRNOP00000022790   ⟸   ENSRNOT00000022790
RefSeq Acc Id: NP_001358944   ⟸   NM_001372015
- Peptide Label: precursor
- UniProtKB: D3ZLL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966002   ⟸   XM_039110074
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965999   ⟸   XM_039110071
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063144157   ⟸   XM_063288087
- Peptide Label: isoform X3
Protein Domains
Peptidase M12B   PLAC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLL7-F1-model_v2 AlphaFold D3ZLL7 1-1221 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310046 AgrOrtholog
BioCyc Gene G2FUF-61894 BioCyc
Ensembl Genes ENSRNOG00000016812 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022790 ENTREZGENE
  ENSRNOT00000022790.9 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
NCBI Gene 306664 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 16 UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen Adamts16 PhenoGen
PRINTS ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016812 RatGTEx
SMART TSP1 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
UniProt D3ZLL7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adamts16  ADAM metallopeptidase with thrombospondin type 1 motif, 16  Adamts16  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Adamts16  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16   Adamts16_predicted  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Adamts16_predicted  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16 (predicted)    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Adamts16_predicted  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16 (predicted)      Symbol and Name status set to approved 70820 APPROVED