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Gene: Rab6b (RAB6B, member RAS oncogene family) Rattus norvegicus

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Symbol:

Rab6b

Name:

RAB6B, member RAS oncogene family

RGD ID:

1309958

Description:

Predicted to enable GTPase activity and myosin V binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; protein localization to Golgi membrane; and retrograde transport, endosome to Golgi. Is active in presynapse. Orthologous to human RAB6B (RAB6B, member RAS oncogene family); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bis(2-ethylhexyl) phthalate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC363123; ras-related protein Rab-6B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RAB6B (RAB6B, member RAS oncogene family)	HGNC	Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Rab6b (RAB6B, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rab6b (RAB6B, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RAB6B (RAB6B, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RAB6B (RAB6B, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rab6b (RAB6B, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RAB6B (RAB6B, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RAB6B (RAB6B, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rab6b (RAB6B, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RAB6A (RAB6A, member RAS oncogene family)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	RAB6B (RAB6B, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rab6b (RAB6B, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rab6bb (RAB6B, member RAS oncogene family b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	rab6ba (RAB6B, member RAS oncogene family a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rab6	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YPT6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rab-6.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rab6b	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	112,574,223 - 112,642,911 (+)	NCBI		GRCr8
mRatBN7.2	8	103,695,328 - 103,764,023 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	103,695,631 - 103,805,732 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	109,354,470 - 109,423,481 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	107,553,634 - 107,622,649 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	105,396,318 - 105,465,325 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	111,600,375 - 111,668,817 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	111,600,532 - 111,668,808 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	110,991,008 - 111,059,794 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	108,151,061 - 108,192,013 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	108,124,726 - 108,209,832 (+)	NCBI
Celera	8	103,101,314 - 103,142,215 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Primary Lymphedema with Myelodysplasia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxyphenyl retinamide (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

Cuprizon (EXP,ISO)

cyclosporin A (ISO)

DDE (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

fenvalerate (EXP)

fipronil (EXP)

folic acid (ISO)

furan (EXP)

gamma-tocopherol (ISO)

genistein (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

hydroquinone O-beta-D-glucopyranoside (ISO)

kojic acid (ISO)

lead(0) (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methoxychlor (EXP)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

nitrates (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

thioacetamide (EXP)

titanium dioxide (EXP,ISO)

tocopherol (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Golgi organization (ISO)

intra-Golgi vesicle-mediated transport (IBA)

intracellular protein transport (IBA)

protein localization to Golgi membrane (IBA,ISO)

retrograde transport, endosome to Golgi (IBA)

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (IBA)

Cellular Component

ciliary basal body (ISO)

cytosol (IEA)

endomembrane system (IBA)

Golgi apparatus (IBA,ISO)

Golgi membrane (ISO)

nucleoplasm (ISO)

presynapse (EXP,IDA,IEP)

Molecular Function

GTP binding (IEA)

GTPase activity (IBA,IEA)

myosin V binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis.	Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:24006491

Genomics

Comparative Map Data

Rab6b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	112,574,223 - 112,642,911 (+)	NCBI		GRCr8
mRatBN7.2	8	103,695,328 - 103,764,023 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	103,695,631 - 103,805,732 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	109,354,470 - 109,423,481 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	107,553,634 - 107,622,649 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	105,396,318 - 105,465,325 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	111,600,375 - 111,668,817 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	111,600,532 - 111,668,808 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	110,991,008 - 111,059,794 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	108,151,061 - 108,192,013 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	108,124,726 - 108,209,832 (+)	NCBI
Celera	8	103,101,314 - 103,142,215 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

RAB6B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	133,824,235 - 133,895,882 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	133,824,235 - 133,895,882 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	133,543,079 - 133,614,726 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	135,025,769 - 135,097,381 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	135,025,784 - 135,097,137	NCBI
Celera	3	131,968,881 - 132,040,477 (-)	NCBI		Celera
Cytogenetic Map	3	q22.1	NCBI
HuRef	3	130,921,268 - 130,992,822 (-)	NCBI		HuRef
CHM1_1	3	133,507,024 - 133,578,520 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	136,569,430 - 136,641,051 (-)	NCBI		T2T-CHM13v2.0

Rab6b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	102,988,866 - 103,062,475 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	102,988,986 - 103,062,475 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	103,111,667 - 103,185,276 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	103,111,787 - 103,185,276 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	103,014,404 - 103,087,600 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	102,970,224 - 103,043,420 (+)	NCBI		MGSCv36	mm8
Celera	9	102,662,484 - 102,735,933 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	54.88	NCBI

Rab6b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955501	4,732,616 - 4,781,094 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955501	4,751,647 - 4,781,094 (+)	NCBI	ChiLan1.0	ChiLan1.0

RAB6B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	131,748,402 - 131,820,183 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	131,753,131 - 131,824,912 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	130,869,494 - 130,941,280 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	138,344,807 - 138,416,358 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	138,344,815 - 138,416,358 (-)	Ensembl	panpan1.1		panPan2

RAB6B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	30,714,723 - 30,754,765 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	30,717,062 - 30,749,188 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	30,693,860 - 30,754,169 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	31,235,166 - 31,295,933 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	31,235,171 - 31,295,965 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	30,931,304 - 30,989,279 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	30,986,735 - 31,047,041 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	31,234,354 - 31,294,724 (-)	NCBI		UU_Cfam_GSD_1.0

Rab6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	70,209,010 - 70,271,228 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	6,969,284 - 7,031,918 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	6,969,507 - 7,031,733 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAB6B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	75,012,268 - 75,075,239 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	75,012,267 - 75,075,324 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	82,510,690 - 82,573,714 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAB6B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	56,472,615 - 56,541,083 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	56,472,634 - 56,541,434 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	29,455,217 - 29,523,670 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rab6b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	10,133,949 - 10,197,551 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	10,134,215 - 10,197,534 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rab6b
288 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	602
Count of miRNA genes:	265
Interacting mature miRNAs:	363
Transcripts:	ENSRNOT00000012219
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
8693654	Alc32	Alcohol consumption QTL 32	2	0.755	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	8	88612425	107550209	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	51351728	107062046	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30848259	105647037	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
631217	Activ1	Activity QTL 1	15.9		voluntary movement trait (VT:0003491)	number of photobeam interruptions in an experimental apparatus (CMO:0001517)	8	102370617	108923645	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat

Markers in Region

D8Rat175

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	112,566,432 - 112,566,555 (+)	Marker Load Pipeline
mRatBN7.2	8	103,687,536 - 103,687,659 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	111,592,312 - 111,592,434	NCBI	Rnor6.0
Rnor_5.0	8	110,982,909 - 110,983,031	UniSTS	Rnor5.0
RGSC_v3.4	8	108,114,913 - 108,115,036	RGD	RGSC3.4
RGSC_v3.4	8	108,114,914 - 108,115,036	UniSTS	RGSC3.4
RGSC_v3.1	8	108,134,368 - 108,134,491	RGD
Celera	8	103,066,183 - 103,066,305	UniSTS
SHRSP x BN Map	8	66.2399	UniSTS
SHRSP x BN Map	8	66.2399	RGD
Cytogenetic Map	8	q32	UniSTS

RH134267

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	103,763,734 - 103,763,916 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	111,668,529 - 111,668,710	NCBI	Rnor6.0
Rnor_5.0	8	111,059,512 - 111,059,693	UniSTS	Rnor5.0
RGSC_v3.4	8	108,191,734 - 108,191,915	UniSTS	RGSC3.4
Celera	8	103,141,936 - 103,142,117	UniSTS
RH 3.4 Map	8	1158.0	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH141805

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	103,761,457 - 103,761,638 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	111,666,252 - 111,666,432	NCBI	Rnor6.0
Rnor_5.0	8	111,057,235 - 111,057,415	UniSTS	Rnor5.0
RGSC_v3.4	8	108,189,457 - 108,189,637	UniSTS	RGSC3.4
Celera	8	103,139,659 - 103,139,839	UniSTS
RH 3.4 Map	8	1163.8	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH125121

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	103,763,855 - 103,763,998 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	111,668,650 - 111,668,792	NCBI	Rnor6.0
Rnor_5.0	8	111,059,633 - 111,059,775	UniSTS	Rnor5.0
RGSC_v3.4	8	108,191,855 - 108,191,997	UniSTS	RGSC3.4
Celera	8	103,142,057 - 103,142,199	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	90	89	58	25	58	6	217	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012219 ⟹ ENSRNOP00000012219

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	111,627,856 - 111,668,808 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081952 ⟹ ENSRNOP00000068600

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	103,695,631 - 103,805,732 (+)	Ensembl
Rnor_6.0 Ensembl	8	111,600,532 - 111,664,987 (+)	Ensembl

RefSeq Acc Id:

NM_001108775 ⟹ NP_001102245

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	112,574,223 - 112,642,911 (+)	NCBI
mRatBN7.2	8	103,695,328 - 103,764,023 (+)	NCBI
Rnor_6.0	8	111,627,856 - 111,668,808 (+)	NCBI
Rnor_5.0	8	110,991,008 - 111,059,794 (+)	NCBI
RGSC_v3.4	8	108,151,061 - 108,192,013 (+)	RGD
Celera	8	103,101,314 - 103,142,215 (+)	RGD

Sequence:

show sequence

GTCGGGAAGACGTCTCTCATCACGAGGTTCATGTACGACAGCTTCGACAACACCTACCAGGCAA
CCATCGGGATTGACTTCTTGTCAAAAACCATGTACTTGGAAGACCGTACGGTTCGACTGCAGCT
CTGGGACACCGCTGGGCAAGAGAGGTTCCGCAGCCTGATTCCCAGCTACATCCGGGACTCCACG
GTGGCTGTGGTGGTGTACGACATCACTAATCTCAACTCCTTCCAGCAGACTTCTAAATGGATTG
ATGACGTCAGGACAGAGAGGGGCAGTGACGTGATCATCATGCTTGTGGGCAACAAGACGGATCT
GGCTGACAAGAGGCAGATAACCATCGAGGAAGGGGAACAGCGGGCCAAAGAACTGAGTGTCATG
TTCATCGAGACCAGCGCGAAGACCGGCTACAACGTGAAGCAGCTCTTTCGACGTGTGGCATCAG
CTCTGCCCGGCATGGAGAACGTCCAGGAGAAGAGCAAAGAAGGGATGATTGACATCAAGCTGGA
CAAACCTCAGGAGCCCCCGGCCAGCGAGGGCGGCTGTTCCTGCTAATGCACAGCCCACTCGGCT
TCCTCAACACCACTCACTTGTTTTGCCTCCTATCGGTTAGCTTCCTAACGGGGTGGGAACTGAG
TTTATCAAGACGGGGAGGATCTTTCTTTTCTCTCTCTCTCTAGGAGTAGGGTGGGACATGGGGA
GGGAGGCTGGGCGTCAGGGACCACGTCACTCTTAAACAGCTGTTACCTAAACGACTATTTTTTG
GTTTGGTTGTAATATATTGTACTTTATTAAGATTGCCAAAAACTGTTAAAATTTAAAAAAAAAT
TTAAATCATGTGTATACAACTTTTTGCCAGATAAGAAAAGTAGTCATTTTTATTTGAAAGAAGT
GCTTTTTTTGTTTGTTTGTTTTTGTATATTTGTAAACTTACAGAGAACCTCTCTACACACCCCT
TCCTTCCTGTTCTCTTGGAACTGTGTGTCACCTCTATTATCCTCCTACCCCCAGCCCAGAAAAT
TAAAGCAATTAACTGAACAGTAGTAATTACGTTCTAGTTCTGGGTCACATGACCCAAGCCAACC
AAGCCCAGGACCCCACAGTCAAATCAGACTTTAATCTAACAAAACGGCCCCAGCAGGGCCATTA
TTGAGCCCTTCCTTGGCAGAGTGGGGCACATTAGCAGGTCCCTGAGTGGAAATGAAGGCCCTTG
GACCATAGCTTCAGCAGCAAACCCCTCGGCTGCTTCTGCCTCTTCTCCTTCCCTGAAAAGCAAA
CATGGAGTCAGAGAGCACAGGCAACAGTGTGTTCTCTGGGCTGACCCAGTGACGAGCAGAACAA
GAAGTTACCGGAAGGATGGGGTGCTCTTGGCAGCTGTGGGCTGAGGCAGTGTGTGGTCTCAAAG
GTTGTAATCTACTGGCCCCACAGCTGACACATGTGGTTAGGCTGACTTGCCAACTCGTTATGTG
ATGCTGGGTGGCTCAGGGATGCTGACGCCTAGGGCACATGCTATCACTGCAGCTGTGATTGAGG
AAGAGAGGGGTGTCCGCCGTGACTCTGAACGCTCCATGTTCTCAGACCCTTGGTTACCAATCTT
GCCGAACGCTGTCCTGGAAAAGTTGATTCCTCAGTGTGTTCTCACCCCTGGCATGGTACGTTTG
CAGTCTTTGTATGAATACCTTTGGTTGGGAGTGCTGCGGCTGCACTTCGAGCATCTTGGAGTCA
CTGTGGGGTTTCCAGAAGGCTGCCCAGGGCACTGCCACCTGCCCCCCCCCCCCAGCAGGCTGTC
CTTGCCGTCTCCACTCATTCCCCAGACCGTTTCTGTCCTGAAGACCTTCAGAGTCTCTAACAGA
GAGTGCTCTTCTCAAAGCAAAATAACTCACATTCTAACTCACTACCCATCTGTCTGCCTTTGGG
CAGGCCTAGGGCAGTGACTCTAATCAGAACATCCCAGCCCCAGTAGCAGTGGTTCTTCTTCCAG
ACTGCTGGTGGGCAAAGTGAATTGTCTCCACAGGGCAGAACTACAGCAAGGAAGTTGGCATGAA
TGATGGAATCTCTCAAAAATGAGTTCAAAATGGCAGGCTGATTCTGTGAGTGGGCCTGTCATGC
CCCTCCATCATGGGAGACAGTGTCAGAGCCGGTTCTGGTGAAGGAGAGGAAGCAGGATCCCCCT
GGGTACCTCTTCCAGAAGGCAAGGACCAATGTATGAGCATACTGAAGTGTCACGTGTTTAGTTT
TTATATGTGTGTACATAACTATACTTAGAGATAGACTTGTGTATACACCCTCCACACATCCTCA
CATACACATGTGCTCACTGTATATCCACGTCTCTCCTGCTCACCACTTGGAACTTGCATTGTGA
TTCCGGTTTTTGGAAAAAAGTATGCAGTGTACTGAAATAAGAAATAATTCAATATTGTCAAATA
ACTTGTGGTTGTCTTGCCTTCAATAAAAATAGTGCATAGATGTGTTAAACTACAAGCAAAAATA
GTCCACAGAATTACCTTCACACTGCTTTATGTACCTGTGTGCACAGGTGTGCATGCCGTCGTGG
GCCAGTGTCCCCCCCAGTGTGGACACCCCACCTATGTGGTGCTTGTTGGAAGAAAGCATACTTA
CCCCGTGGTGACAGCAGCCTGGTTGGCAGTGAGGGGCTTTGCTGGTGGCCTCTGGCAGAGCCCC
ACTGTCAGAACTCTCTACTGGCTCTCACTGAATGAATGTAGGGTGAATTTTAACCTTCTTGACC
CTGAATAACCTTTCTTGTATTCCTGTAACTCGGATTAGAAGCTCCATTCTCTCGCTTGTACACA
CAATCTAAGGCGTCATGGTCTGCTGTTAGAAACAGCAGGTGCCATGTCAGACACTATTTCTGGT
TGATCCAGCCTAAGGAACCCTGCCTTCCTAACCTGTGTACAAAATTCCTTCTTGAGTTTAGGCT
CTCCCAGCCCTGCGGCCCCTGAAAATGAGGGTTCTGCCCCATCACTCTCCCATCCCAGAGGTAC
CCTGGCCTTCTTTTCCTCAGCCAAGCTACCCATTTCCTTCCCTAAAGGCAGTTAAAGCAGCCAG
GCCTTAACACAGAACAGTATTGGACCTGGGCTCTCCCCTTGACCATCACCACCATCATCCTACT
TGTAGGTAGGATCCAGTCAGGTTCTCTTAAAGACGTCCTGAAATTATTTGTCCCTGTTTTTACT
AAATTCAGATCAGTCAGAGGACAAAGTGGAGGATTCCTCGTAGGGCATGATCTCTGGACACCGT
GTCTGGCCTGGCAGATGGGCATGGCCCTCTTCCTTTTCTTTAGGAGCCTTGAAGGACAATTGTC
AGTAAAACTTCTGTGAGCAGTGCAGAAATAGTCTGAGATTGAAAAGGCAGGTAGCATAGCTGTA
CACACCTGCAGACCAAAACAAAGGTGTGACGTCAGTGTCCTGAGTGCTGGTATTGCTGTGGGGT
CAGAGGCTACAGTGCTTGGTGGTGAGAGCCTTGCTGTTATATCAGTCACCGCTCCCTGTCGACA
TCTTTACACATTTCCCAGTATCTCAAGATCCAGGAAGCCATGGCCACATCAGTTCAATGTCTCA
GGAAACAAAAATAAGAATTTCGAAGGGGTAGCTAGGAGTGTAGTTGCCTGGGCCTAGTCTCTAT
CCCAGTGGCTAACCAATGTCAGATCTAAGCACTGCTGGCTTCAGCATCCTGTGGGCAGAGCAGT
TTATTCCTCCTCCATATGGATGGGGGAGAGGCTGTCAGCAAAGACTGGGTAGCTGAGGATGGGG
AGTTAGCGACACAAGAACCAGCTAGCAAGAGTCTGTCTGAGTGTCAAAGGCTCAGGGCTCAATG
CCCACTAGTTTCTAAACTACCTCTCCCCCAAGAATGGGAGGCACCGTGACCTTGCCACAGCACT
GGGAGCCAAACCCTTCCTGTTGCACAGGTGGGAGAACCGGAAAAGACAAGGTCACCCCCAAGCC
AGAGATGATCAGAACTAGTGTTGGCATTCTTGATGAGGACTGCTGTGCTCATGCCCCTAAGCCA
TCTCTACTGCGTGGCTTACATAAGGATATTCCCAGCCCGACTAGCTAGAGAGAAGATAGGTGCA
TTTCAGGCTCTCACTGTAAGGAAGGGTGGTCCCCAAATCTACTTGCATTGTCTGTGTACACACA
CACACACACACACTCACACACATGGAGCAGTAGTCAGGGTACCCTTTTCATTTTTGTTTGAAAT
CAACTTCTTCGCTACTCCGAAAACTTGCAGTTTCAATGTGCAGACCCCTTGGACTCCAGACCCC
GTCTGATTGACACTCTGCAGTGCGGTATGATTATCAGGAAAACCTTGCAGCGGGAGTTTGGATG
GGCCCTTCAGGAGGCAGGAAGCTTCCATAGCAACGAAGGCCAGCCTGCCTGTTGTAATGTGTTG
ACTTCTCACCTCACCTGTCCTTCAAAGTGAGGAGCAGAGGGCAGCATCTCCATCTGTACTGGGC
TCAGAAGGCACAGTGGCCATATTGACTTTACATTCAACTGTGTAATATGTGGAAAAGACTCAGC
ATGTTGGTCAAACAATAAACTGTCCTAATTCTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102245	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL77393	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068600
	ENSRNOP00000068600.1

RefSeq Acc Id:	NP_001102245 ⟸ NM_001108775
- UniProtKB:	A0A0G2JT78 (UniProtKB/TrEMBL)
- Sequence:	show sequence MYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITN LNSFQQTSKWIDDVRTERGSDVIIMLVGNKTDLADKRQITIEEGEQRAKELSVMFIETSAKTGY NVKQLFRRVASALPGMENVQEKSKEGMIDIKLDKPQEPPASEGGCSC hide sequence

Ensembl Acc Id:

ENSRNOP00000012219 ⟸ ENSRNOT00000012219

Ensembl Acc Id:

ENSRNOP00000068600 ⟸ ENSRNOT00000081952

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JT78-F1-model_v2	AlphaFold	A0A0G2JT78	1-208	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696230

Promoter ID:

EPDNEW_R6752

Type:

multiple initiation site

Name:

Rab6b_1

Description:

RAB6B, member RAS oncogene family

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	111,600,552 - 111,600,612	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309958	AgrOrtholog
BioCyc Gene	G2FUF-29334	BioCyc
Ensembl Genes	ENSRNOG00000009198	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000081952	ENTREZGENE
	ENSRNOT00000081952.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Rab	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/TrEMBL
KEGG Report	rno:363123	UniProtKB/TrEMBL
NCBI Gene	363123	ENTREZGENE
PANTHER	RAS-RELATED PROTEIN RAB	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PhenoGen	Rab6b	PhenoGen
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009198	RatGTEx
SMART	RAB	UniProtKB/TrEMBL
	RAN	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0G2JT78	ENTREZGENE, UniProtKB/TrEMBL
	A6I2I4_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Rab6b	RAB6B, member RAS oncogene family	Rab6b_predicted	RAB6B, member RAS oncogene family (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Rab6b_predicted	RAB6B, member RAS oncogene family (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar