1. |
Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. |
Adinolfi LE, etal., Hepatology. 2005 May;41(5):995-1003.
|
2. |
Frequency of the MTHFR C677T polymorphism in Yemeni children with sickle cell disease. |
Al-Saqladi AW, etal., Hemoglobin. 2010;34(1):67-77. doi: 10.3109/09687630903554111.
|
3. |
Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation. |
Alroy S, etal., Isr Med Assoc J. 2007 Apr;9(4):321-5.
|
4. |
Analysis of polymorphism in renin angiotensin system and other related genes in South Indian chronic kidney disease patients. |
Anbazhagan K, etal., Clin Chim Acta. 2009 Aug;406(1-2):108-12. Epub 2009 Jun 9.
|
5. |
The effect of riboflavin deficiency on methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.20) and folate metabolism in the rat. |
Bates CJ and Fuller NJ, Br J Nutr. 1986 Mar;55(2):455-64.
|
6. |
Analysis of inherited thrombophilic mutations and natural anticoagulant deficiency in patients with idiopathic portal hypertension. |
Bayan K, etal., J Thromb Thrombolysis. 2009 Jul;28(1):57-62. doi: 10.1007/s11239-008-0244-8. Epub 2008 Aug 7.
|
7. |
Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis. |
Biagini MR, etal., World J Gastroenterol. 2006 Mar 14;12(10):1607-12.
|
8. |
Mild neonatal hypoxia exacerbates the effects of vitamin-deficient diet on homocysteine metabolism in rats. |
Blaise S, etal., Pediatr Res 2005 Jun;57(6):777-82. Epub 2005 Apr 21.
|
9. |
Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. |
Blom HJ and Smulders Y, J Inherit Metab Dis. 2011 Feb;34(1):75-81. doi: 10.1007/s10545-010-9177-4. Epub 2010 Sep 4.
|
10. |
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and promoter methylation in cervical oncogenic lesions and cancer. |
Botezatu A, etal., J Cell Mol Med. 2013 Apr;17(4):543-9. doi: 10.1111/jcmm.12032. Epub 2013 Feb 28.
|
11. |
5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. |
Botto LD and Yang Q, Am J Epidemiol. 2000 May 1;151(9):862-77.
|
12. |
Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa. |
Bronowicki JP, etal., J Hepatol. 2008 Apr;48(4):532-9. doi: 10.1016/j.jhep.2007.11.017. Epub 2008 Jan 2.
|
13. |
Methylenetetrahydrofolate reductase in the rat central nervous system: intracellular and regional distribution. |
Burton EG and Sallach HJ, Arch Biochem Biophys. 1975 Feb;166(2):483-94.
|
14. |
Lack of association between inherited thrombophilic risk factors and idiopathic sudden sensorineural hearing loss in Italian patients. |
Cadoni G, etal., Ann Otol Rhinol Laryngol. 2006 Mar;115(3):195-200.
|
15. |
Genetic polymorphisms of MTHFR and aberrant promoter hypermethylation of the RASSF1A gene in bladder cancer risk in a Chinese population. |
Cai DW, etal., J Int Med Res. 2009 Nov-Dec;37(6):1882-9.
|
16. |
Sudden hearing loss and MTHFR 677C>T/1298A>C gene polymorphisms. |
Capaccio P, etal., Genet Med. 2005 Mar;7(3):206-8.
|
17. |
Effect of chronic phenobarbital treatment on folates and one-carbon enzymes in the rat. |
Carl GF and Smith DB, Biochem Pharmacol. 1984 Nov 1;33(21):3457-63.
|
18. |
The effect of chronic phenytoin treatment on tissue folate concentrations and on the activities of the methyl synthetic enzymes in the rat. |
Carl GF and Smith DB, J Nutr. 1983 Nov;113(11):2368-74.
|
19. |
Effect of chronic valproate treatment on folate-dependent methyl biosynthesis in the rat. |
Carl GF Neurochem Res. 1986 May;11(5):671-85.
|
20. |
Effect of chronic primidone treatment on folate-dependent one-carbon metabolism in the rat. |
Carl GF, etal., Biochem Pharmacol. 1987 Jul 1;36(13):2139-44.
|
21. |
Effect of methionine-loading on methyl group synthesis and activation in rat brain and liver. |
Carl GF, etal., Biol Psychiatry. 1978 Dec;13(6):661-9.
|
22. |
The MTHFR C677T polymorphism is associated with mitral valve rheumatic heart disease. |
Carlus SJ, etal., Eur Rev Med Pharmacol Sci. 2016;20(1):109-14.
|
23. |
Homocysteine and stroke: evidence on a causal link from mendelian randomisation. |
Casas JP, etal., Lancet. 2005 Jan 15-21;365(9455):224-32.
|
24. |
Non-alcoholic fatty liver disease (NAFLD) and MTHFR 1298A > C gene polymorphism. |
Catalano D, etal., Eur Rev Med Pharmacol Sci. 2014;18(2):151-9.
|
25. |
Cloning and expression of 5, 10-Methylenetetrahydrofolate reductase (MTHFR) gene. |
Chen G, etal., Sci China C Life Sci. 1998 Dec;41(6):636-43.
|
26. |
Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site. |
Chen J, etal., Genet Mol Res. 2014 Jan 24;13(4):9718-26. doi: 10.4238/2014.January.24.2.
|
27. |
The anti-folate effect of methionine on bone marrow of normal and vitamin B12 deficient rats. |
Cheng FW, etal., Br J Haematol. 1975 Nov;31(3):323-36.
|
28. |
The role of MTHFR and RFC1 polymorphisms on toxicity and outcome of adult patients with hematological malignancies treated with high-dose methotrexate followed by leucovorin rescue. |
Chiusolo P, etal., Cancer Chemother Pharmacol. 2012 Mar;69(3):691-6. doi: 10.1007/s00280-011-1751-4. Epub 2011 Oct 9.
|
29. |
MTHFR Gene variants C677T, A1298C and association with Down syndrome: A Case-control study from South India. |
Cyril C, etal., Indian J Hum Genet. 2009 May;15(2):60-4. doi: 10.4103/0971-6866.55217.
|
30. |
Thrombophilic genetic factors PAI-1 4G-4G and MTHFR 677TT as risk factors of alcohol, cryptogenic liver cirrhosis and portal vein thrombosis, in a Caucasian population. |
D'Amico M, etal., Gene. 2015 Aug 15;568(1):85-8. doi: 10.1016/j.gene.2015.05.034. Epub 2015 May 16.
|
31. |
The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. |
D'Angelo A, etal., Thromb Haemost. 2000 Apr;83(4):563-70.
|
32. |
Cigarette smoke increases intimal hyperplasia and homocysteine in a rat carotid endarterectomy. |
Davis JA, etal., J Surg Res. 2004 Sep;121(1):69-75.
|
33. |
MTHFR C677T/A1298C genotype: a possible risk factor for liver sinusoidal obstruction syndrome. |
Efrati E, etal., Bone Marrow Transplant. 2014 May;49(5):726-7. doi: 10.1038/bmt.2014.16. Epub 2014 Mar 3.
|
34. |
Association of factor V Leiden, Janus kinase 2, prothrombin, and MTHFR mutations with primary Budd-Chiari syndrome in Egyptian patients. |
El Sebay HM, etal., J Gastroenterol Hepatol. 2016 Jan;31(1):235-40. doi: 10.1111/jgh.13066.
|
35. |
MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients. |
El-Baz R, etal., J Renin Angiotensin Aldosterone Syst. 2012 May 3.
|
36. |
Study of the pharmacokinetic and pharmacogenetic contribution to the toxicity of high-dose methotrexate in children with acute lymphoblastic leukemia. |
El-Khodary NM, etal., Med Oncol. 2012 Sep;29(3):2053-62. doi: 10.1007/s12032-011-9997-6. Epub 2011 Jun 5.
|
37. |
Methylenetetrahydrofolate reductase gene polymorphisms in Turkish children with attention-deficit/hyperactivity disorder. |
Ergul E, etal., Genet Test Mol Biomarkers. 2012 Jan;16(1):67-9. doi: 10.1089/gtmb.2011.0062. Epub 2011 Aug 5.
|
38. |
Neural tube defects, vitamins and homocysteine. |
Eskes TK Eur J Pediatr 1998 Apr;157 Suppl 2:S139-41.
|
39. |
Thrombophilic risk factors in the pathogenesis of non-arteritic anterior ischemic optic neuropathy patients. |
Felekis T, etal., Graefes Arch Clin Exp Ophthalmol. 2010 Jun;248(6):877-84. doi: 10.1007/s00417-010-1308-y. Epub 2010 Feb 17.
|
40. |
Impact of the MTHFR C677T polymorphism on risk of Wilms tumor: case-control study. |
Ferrara M, etal., J Pediatr Hematol Oncol. 2009 Apr;31(4):256-8.
|
41. |
Identifying multiple causative genes at a single GWAS locus. |
Flister MJ, etal., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4.
|
42. |
Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection. |
Fodil-Cornu N, etal., Genes Immun. 2009 Oct;10(7):662-6. doi: 10.1038/gene.2009.50. Epub 2009 Jul 16.
|
43. |
Comprehensive analysis of Methylenetetrahydrofolate reductase C677T in younger acute lymphoblastic leukemia patients: A single-center experience. |
Frikha R, etal., J Oncol Pharm Pract. 2019 Jul;25(5):1182-1186. doi: 10.1177/1078155218818244. Epub 2018 Dec 14.
|
44. |
Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC). |
Fung MM, etal., Nephrol Dial Transplant. 2012 Jan;27(1):197-205. Epub 2011 May 25.
|
45. |
Role of genetic and acquired prothrombotic risk factors in genesis of sudden sensorineural hearing loss. |
Fusconi M, etal., Audiol Neurootol. 2011;16(3):185-90. doi: 10.1159/000319310. Epub 2010 Aug 25.
|
46. |
The G1691 --> A mutation of factor V, but not the G20210 --> A mutation of factor II or the C677 --> T mutation of methylenetetrahydrofolate reductase genes, is associated with venous thrombosis in patients with lupus anticoagulants. |
Galli M, etal., Br J Haematol. 2000 Mar;108(4):865-70.
|
47. |
MTHFR C677T mutation in central retinal vein occlusion: a case-control study in Chinese population. |
Gao W, etal., Thromb Res. 2008;121(5):699-703. Epub 2007 Aug 23.
|
48. |
Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer. |
Garcia-Aguilar J, etal., Ann Surg. 2011 Sep;254(3):486-92; discussion 492-3.
|
49. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
|
50. |
C677T substitution in the methylenetetrahydrofolate reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients. |
Gemmati D, etal., Haematologica. 1999 Sep;84(9):824-8.
|
51. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
|
52. |
Renal vascular sclerosis is associated with inherited thrombophilias. |
Goforth RL, etal., Kidney Int. 2006 Aug;70(4):743-50. Epub 2006 Jun 7.
|
53. |
Analysis of thrombophilic genetic mutations in patients with Sheehan's syndrome: is thrombophilia responsible for the pathogenesis of Sheehan's syndrome? |
Gokalp D, etal., Pituitary. 2011 Jun;14(2):168-73. doi: 10.1007/s11102-010-0276-x.
|
54. |
Methylenetetrahydrofolate reductase gene polymorphisms in children with attention deficit hyperactivity disorder. |
Gokcen C, etal., Int J Med Sci. 2011;8(7):523-8. Epub 2011 Aug 30.
|
55. |
Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects. |
Gong D, etal., Clin Chem Lab Med. 2012 Feb 4;50(8):1455-61. doi: 10.1515/cclm-2011-0759.
|
56. |
MTHFR polymorphic variant C677T is associated to vascular complications in sickle-cell disease. |
Hatzlhofer BL, etal., Genet Test Mol Biomarkers. 2012 Sep;16(9):1038-43. doi: 10.1089/gtmb.2011.0361. Epub 2012 Aug 27.
|
57. |
The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients. |
Haviv YS, etal., Nephron. 2002 Sep;92(1):120-6.
|
58. |
MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study. |
Hishida A, etal., Int Urol Nephrol. 2013 Apr 18.
|
59. |
The importance of homozygous polymorphisms of methylenetetrahydrofolate reductase gene in romanian patients with idiopathic venous thromboembolism. |
Hotoleanu C, etal., Balkan Med J. 2013 Jun;30(2):197-203. doi: 10.5152/balkanmedj.2013.7159. Epub 2013 Jun 1.
|
60. |
Assays of methylenetetrahydrofolate reductase and methionine synthase activities by monitoring 5-methyltetrahydrofolate and tetrahydrofolate using high-performance liquid chromatography with fluorescence detection. |
Huang L, etal., Anal Biochem. 2001 Dec 15;299(2):253-9.
|
61. |
Association between polymorphisms in genes encoding methylenetetrahydrofolate reductase and the risk of Meniere's disease. |
Huang Y, etal., J Neurogenet. 2013 Jun;27(1-2):5-10. doi: 10.3109/01677063.2013.770510. Epub 2013 Mar 13.
|
62. |
Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene mutations in iranian women with polycystic ovary syndrome. |
Idali F, etal., Am J Reprod Immunol. 2012 Nov;68(5):400-7. doi: 10.1111/aji.12002. Epub 2012 Aug 6.
|
63. |
IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects. |
Inanir A, etal., Immunol Lett. 2013 May;152(2):104-8. doi: 10.1016/j.imlet.2013.05.004. Epub 2013 May 15.
|
64. |
Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males. |
Inbal A, etal., Blood. 1999 Apr 1;93(7):2186-90.
|
65. |
MTHFR gene polymorphisms in bladder cancer in the Turkish population. |
Izmirli M, etal., Asian Pac J Cancer Prev. 2011;12(7):1833-5.
|
66. |
Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat. |
Jacobs RL, etal., Diabetes. 1998 Dec;47(12):1967-70.
|
67. |
Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESRD: a prospective study. |
Jamison RL, etal., Am J Kidney Dis. 2009 May;53(5):779-89. Epub 2009 Mar 9.
|
68. |
The relationship between methylenetetrahydrofolate reductase polymorphism and hematological malignancy. |
Jiang N, etal., Clin Lab. 2014;60(5):767-74.
|
69. |
C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma. |
Junemann AG, etal., Am J Ophthalmol. 2005 Apr;139(4):721-3.
|
70. |
Genetic risk factors for thrombosis in systemic lupus erythematosus. |
Kaiser R, etal., J Rheumatol. 2012 Aug;39(8):1603-10. Epub 2012 Jun 15.
|
71. |
Association of MTHFR gene C677T mutation with recurrent aphthous stomatitis and number of oral ulcers. |
Kalkan G, etal., Clin Oral Investig. 2014;18(2):437-41. doi: 10.1007/s00784-013-0997-0. Epub 2013 May 11.
|
72. |
Possible Association Between the Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Preexisting Portal Vein Thrombosis in Liver Transplant Recipients. |
Kamei H, etal., Exp Clin Transplant. 2016 Jun;14(3):313-6.
|
73. |
Methylenetetrahydrofolate Reductase gene polymorphism in patients receiving hemodialysis. |
Kiseljakovic E, etal., Bosn J Basic Med Sci. 2010 Apr;10 Suppl 1:S91-5.
|
74. |
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. |
Klerk M, etal., JAMA. 2002 Oct 23-30;288(16):2023-31.
|
75. |
Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population. |
Ko KH, etal., Anticancer Res. 2006 Nov-Dec;26(6B):4229-33.
|
76. |
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene. |
Koturbash I, etal., Mol Carcinog. 2011 Dec 27. doi: 10.1002/mc.21861.
|
77. |
The C677T methylenetetrahydrofolate reductase gene mutation and nephropathy in type 2 diabetes mellitus. |
Ksiazek P, etal., Med Sci Monit. 2004 Feb;10(2):BR47-51.
|
78. |
Association of congenital cardiovascular malformations with 33 single nucleotide polymorphisms of selected cardiovascular disease-related genes. |
Kuehl K, etal., Birth Defects Res A Clin Mol Teratol. 2010 Feb;88(2):101-10.
|
79. |
The thermolabile variant of 5,10-methylenetetrahydrofolate reductase is a possible risk factor for amyotrophic lateral sclerosis. |
Kuhnlein P, etal., Amyotroph Lateral Scler. 2011 Mar;12(2):136-9. doi: 10.3109/17482968.2010.536985. Epub 2010 Dec 6.
|
80. |
Interrelationships among genetic C677T polymorphism of 5,10-methylenetetrahydrofolate reductase, biochemical folate status, and lymphocytic p53 oxidative damage in association with tumor malignancy and survivals of patients with hepatocellular carcinoma. |
Kuo CS, etal., Mol Nutr Food Res. 2014 Feb;58(2):329-42. doi: 10.1002/mnfr.201200479. Epub 2013 Aug 29.
|
81. |
Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms as risk factors for hepatocellular carcinoma in a Korean population. |
Kwak SY, etal., Anticancer Res. 2008 Sep-Oct;28(5A):2807-11.
|
82. |
Association of methylenetetrahydrofolate reductase polymorphism and the risk of squamous cell carcinoma in renal transplant patients. |
Laing ME, etal., Transplantation. 2007 Jul 15;84(1):113-6.
|
83. |
Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes. |
Lawrance AK, etal., J Inherit Metab Dis. 2011 Feb;34(1):147-57. doi: 10.1007/s10545-010-9127-1. Epub 2010 Jun 8.
|
84. |
MTHFR C677T polymorphism as a risk factor for vascular calcification in chronic hemodialysis patients. |
Lee SY, etal., J Korean Med Sci. 2011 Mar;26(3):461-5. Epub 2011 Feb 25.
|
85. |
Hyperhomocysteinemia and the MTHFR C677T mutation in Budd-Chiari syndrome. |
Li XM, etal., Am J Hematol. 2002 Sep;71(1):11-4.
|
86. |
A common haplotype for the 677T thermolabile variant of the 5,10-methylenetetrahydrofolate reductase gene in thrombophilic patients and controls. |
Linnebank M, etal., Hum Mutat. 2002 Dec;20(6):478.
|
87. |
Retinal vein occlusion associated with methylenetetrahydrofolate reductase mutation. |
Loewenstein A, etal., Ophthalmology. 1999 Sep;106(9):1817-20.
|
88. |
MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients. |
Maeda M, etal., J Diabetes Complications. 2008 Mar-Apr;22(2):119-25.
|
89. |
Association study between methylenetetrahydrofolate reductase gene polymorphisms and Graves' disease. |
Mao R, etal., Cell Biochem Funct. 2010 Oct;28(7):585-90. doi: 10.1002/cbf.1694.
|
90. |
Thrombophilic risk factors in patients with severe carotid atherosclerosis. |
Marcucci R, etal., J Thromb Haemost. 2005 Mar;3(3):502-7.
|
91. |
Prognostic significance of folate metabolism polymorphisms for lung cancer. |
Matakidou A, etal., Br J Cancer. 2007 Jul 16;97(2):247-52. Epub 2007 May 29.
|
92. |
Methylenetetrahydrofolate reductase: a common human polymorphism and its biochemical implications. |
Matthews RG Chem Rec 2002;2(1):4-12.
|
93. |
Rat ISS GO annotations from MGI mouse gene data--August 2006 |
MGD data from the GO Consortium
|
94. |
MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma. |
Micheal S, etal., Mol Vis. 2009 Nov 9;15:2268-78.
|
95. |
MTHFR 677CC/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea. |
Moon HW, etal., Leuk Res. 2007 Sep;31(9):1213-7. Epub 2006 Dec 6.
|
96. |
Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer. |
Moore LE, etal., Int J Cancer. 2007 Jun 1;120(11):2452-8.
|
97. |
Folate metabolism genes, vegetable intake and renal cancer risk in central Europe. |
Moore LE, etal., Int J Cancer. 2008 Apr 15;122(8):1710-5.
|
98. |
Association of methylene tetrahydrofolate reductase C677T genotype with type 2 diabetes mellitus patients with and without renal complications. |
Movva S, etal., Genet Test Mol Biomarkers. 2011 Apr;15(4):257-61. Epub 2010 Dec 27.
|
99. |
MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients. |
Mtiraoui N, etal., Diabetes Res Clin Pract. 2007 Jan;75(1):99-106. Epub 2006 Jul 7.
|
100. |
Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population. |
Mu LN, etal., Cancer Causes Control. 2007 Aug;18(6):665-75. doi: 10.1007/s10552-007-9012-x. Epub 2007 May 15.
|
101. |
Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. |
Muntjewerff JW, etal., Mol Psychiatry. 2006 Feb;11(2):143-9.
|
102. |
Folate-mediated incorporation of ring-2-carbon of histidine into nucleic acids: influence of thyroid hormone. |
Nair CP, etal., Metabolism. 1994 Dec;43(12):1575-8.
|
103. |
Defective homocysteine metabolism as a risk factor for diabetic retinopathy. |
Neugebauer S, etal., Lancet. 1997 Feb 15;349(9050):473-4.
|
104. |
MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection. |
Neves Filho EH, etal., Virchows Arch. 2010 Dec;457(6):627-33. doi: 10.1007/s00428-010-0996-3. Epub 2010 Oct 19.
|
105. |
Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain. |
Ngai YF, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R613-22. doi: 10.1152/ajpregu.00075.2015. Epub 2015 Jul 15.
|
106. |
[Frequency of C677T polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR) in Chilean mothers of spina bifida cases and controls ]. |
Nitsche F, etal., Rev Med Chil. 2003 Dec;131(12):1399-404.
|
107. |
MTHFR gene C677T and A1298C variants are associated with FMF risk in a Turkish cohort. |
Nursal AF, etal., J Clin Lab Anal. 2018 Feb;32(2). doi: 10.1002/jcla.22259. Epub 2017 May 22.
|
108. |
OMIM Disease Annotation Pipeline |
OMIM Disease Annotation Pipeline
|
109. |
5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects. |
Ou CY, etal., Am J Med Genet. 1996 Jun 28;63(4):610-4.
|
110. |
Recurrent pregnancy loss and its relation to combined parental thrombophilic gene mutations. |
Ozdemir O, etal., Genet Test Mol Biomarkers. 2012 Apr;16(4):279-86. doi: 10.1089/gtmb.2011.0191. Epub 2011 Nov 2.
|
111. |
5,10-Methylenetetrahydrofolate reductase C677T gene polymorphism in Behcet's patients with or without ocular involvement. |
Ozkul Y, etal., Br J Ophthalmol. 2005 Dec;89(12):1634-7.
|
112. |
MTHFR C677T polymorphism associates with unexplained infertile male factors. |
Park JH, etal., J Assist Reprod Genet. 2005 Oct;22(9-10):361-8.
|
113. |
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. |
Patino-Garcia A, etal., J Pediatr. 2009 May;154(5):688-93. Epub 2009 Jan 21.
|
114. |
Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control study. |
Peeters AC, etal., J Vasc Surg. 2007 Apr;45(4):701-5.
|
115. |
KEGG Annotation Import Pipeline |
Pipeline to import KEGG annotations from KEGG into RGD
|
116. |
SMPDB Annotation Import Pipeline |
Pipeline to import SMPDB annotations from SMPDB into RGD
|
117. |
MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage renal disease in North Indians. |
Poduri A, etal., Mol Cell Biochem. 2008 Jan;308(1-2):43-50. Epub 2007 Sep 25.
|
118. |
Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes. |
Pollex RL, etal., Cardiovasc Diabetol. 2005 Nov 7;4:17.
|
119. |
MTHFR C677T and A1298C polymorphisms are risk factors for Down's syndrome in Indian mothers. |
Rai AK, etal., J Hum Genet. 2006;51(4):278-83. Epub 2006 Feb 18.
|
120. |
MTHFR c.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile. |
Ramirez-Chau C, etal., Oral Dis. 2016 Oct;22(7):703-8. doi: 10.1111/odi.12533. Epub 2016 Aug 1.
|
121. |
Genetic basis for adverse events after smallpox vaccination. |
Reif DM, etal., J Infect Dis. 2008 Jul 1;198(1):16-22. doi: 10.1086/588670.
|
122. |
Can MTHFR C677T and A1298C Polymorphisms Alter the Risk and Severity of Sporadic Breast Cancer in Brazilian Women? |
Rezende LM, etal., Clin Breast Cancer. 2017 Jul;17(4):e199-e208. doi: 10.1016/j.clbc.2017.02.004. Epub 2017 Feb 16.
|
123. |
GOA pipeline |
RGD automated data pipeline
|
124. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
|
125. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
|
126. |
No association of MTHFR c.677C>T variant with sporadic ALS in an Italian population. |
Ricci C, etal., Neurobiol Aging. 2012 Jan;33(1):208.e7-8. doi: 10.1016/j.neurobiolaging.2011.07.010. Epub 2011 Aug 25.
|
127. |
Association of drug metabolism gene polymorphisms with toxicities, graft-versus-host disease and survival after HLA-identical sibling hematopoietic stem cell transplantation for patients with leukemia. |
Rocha V, etal., Leukemia. 2009 Mar;23(3):545-56. Epub 2008 Nov 13.
|
128. |
Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population. |
Rouissi K, etal., Cancer Genet Cytogenet. 2009 Nov;195(1):43-53.
|
129. |
Impact of methylenetetrahydrofolate reductase C677T polymorphism on the risk of gastric cancer and its interaction with Helicobacter pylori infection. |
Saberi S, etal., Iran Biomed J. 2012;16(4):179-84. doi: 10.6091/ibj.1102.2012.
|
130. |
Methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C and G1793A polymorphisms: association with risk for clear cell renal cell carcinoma and tumour behaviour in men. |
Safarinejad MR, etal., Clin Oncol (R Coll Radiol). 2012 May;24(4):269-81. doi: 10.1016/j.clon.2011.03.005. Epub 2011 Apr 13.
|
131. |
Genetic susceptibility of methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C, and G1793A polymorphisms with risk for bladder transitional cell carcinoma in men. |
Safarinejad MR, etal., Med Oncol. 2011 Dec;28 Suppl 1:S398-412. Epub 2010 Oct 29.
|
132. |
Gender-specific association of methylenetetrahydrofolate reductase genotype and haplotype with the aggressiveness and prognosis of clear cell renal cell carcinoma in Japanese patients. |
Sakano S, etal., BJU Int. 2010 Aug;106(3):424-30. Epub 2009 Dec 22.
|
133. |
Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis. |
Samaan Z, etal., BMC Neurol. 2011 Jun 2;11:66. doi: 10.1186/1471-2377-11-66.
|
134. |
Methylenetetrahydrofolate reductase gene polymorphisms in patients with nonalcoholic steatohepatitis (NASH). |
Sazci A, etal., Cell Biochem Funct. 2008 Apr;26(3):291-6. doi: 10.1002/cbf.1424.
|
135. |
Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria. |
Sibani S, etal., Hum Mutat. 2000;15(3):280-7.
|
136. |
Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East. |
Siraj AK, etal., Ann Hematol. 2007 Dec;86(12):887-95. Epub 2007 Aug 22.
|
137. |
Plasma total homocysteine levels and methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes mellitus. |
Soares AL, etal., Pathophysiol Haemost Thromb. 2008;36(5):275-81. Epub 2009 Dec 9.
|
138. |
Methylenetetrahydrofolate reductase C677T mutation and risk of retinal vein thrombosis. |
Soltanpour MS, etal., J Res Med Sci. 2013 Jun;18(6):487-91.
|
139. |
Association between 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and conotruncal heart defects. |
Storti S, etal., Clin Chem Lab Med. 2003 Mar;41(3):276-80.
|
140. |
Trafficking of intracellular folates. |
Stover PJ and Field MS, Adv Nutr. 2011 Jul;2(4):325-31. doi: 10.3945/¿an.111.000596. Epub 2011 Jun 28.
|
141. |
Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies. |
Stover PJ J Nutrigenet Nutrigenomics. 2011;4(5):293-305. doi: 10.1159/000334586. Epub 2012 Feb 22.
|
142. |
The TT genotype of the C677T polymorphism in the methylentetrahydrofolate reductase as a risk factor in thrombotic microangiopathies: results from a pilot study. |
Sucker C, etal., Clin Appl Thromb Hemost. 2009 May-Jun;15(3):283-8.
|
143. |
Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk. |
Suzuki T, etal., Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2742-7.
|
144. |
Analysis of candidate genes for age-related macular degeneration subtypes in the Japanese population. |
Tanaka K, etal., Mol Vis. 2011;17:2751-8. Epub 2011 Oct 22.
|
145. |
Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia. |
Tantawy AA, etal., Blood Coagul Fibrinolysis. 2010 Jan;21(1):28-34. doi: 10.1097/MBC.0b013e32833135e9.
|
146. |
Atopy, asthma, and lung function in relation to folate and vitamin B in adults. |
Thuesen BH, etal., Allergy. 2010 Nov;65(11):1446-54. doi: 10.1111/j.1398-9995.2010.02378.x.
|
147. |
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients. |
Toffoli G, etal., Int J Cancer. 2003 Jan 20;103(3):294-9.
|
148. |
Analysis of the MTHFR (methylenetetrahydrofolate reductase) 677 C>T and 1298 A>C polymorphisms in BCR-ABL-negative myeloproliferative neoplasms. |
Trifa AP, etal., Int J Lab Hematol. 2013 Feb;35(1):e9-12. doi: 10.1111/ijlh.12017. Epub 2012 Oct 29.
|
149. |
Role of thrombotic risk factors in end-stage renal disease. |
Tripathi G, etal., Clin Appl Thromb Hemost. 2010 Apr;16(2):132-40. Epub 2009 Jun 10.
|
150. |
Relationship of MTHFR gene polymorphisms with renal and cardiac disease. |
Trovato FM, etal., World J Nephrol. 2015 Feb 6;4(1):127-37. doi: 10.5527/wjn.v4.i1.127.
|
151. |
Effect of prothrombotic mutations on factor consumption in children with hemophilia. |
Tuten H, etal., Clin Appl Thromb Hemost. 2013 Jul-Aug;19(4):445-8. doi: 10.1177/1076029612438610. Epub 2012 Mar 12.
|
152. |
Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia. |
Tyagi N, etal., J Mol Neurosci. 2012 May;47(1):128-38. doi: 10.1007/s12031-011-9695-z. Epub 2012 Jan 3.
|
153. |
Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study. |
Uchida Y, etal., BMC Med Genet. 2011 Mar 7;12:35. doi: 10.1186/1471-2350-12-35.
|
154. |
Methylenetetrahydrofolate reductase polymorphism and minor increase of risk for oral cancer. |
Vairaktaris E, etal., J Cancer Res Clin Oncol. 2006 Apr;132(4):219-22. Epub 2005 Dec 20.
|
155. |
Evaluation of infant methylenetetrahydrofolate reductase genotype, maternal vitamin use, and risk of high versus low level spina bifida defects. |
Volcik KA, etal., Birth Defects Res A Clin Mol Teratol. 2003 Mar;67(3):154-7.
|
156. |
Major determinants of hyperhomocysteinemia in peritoneal dialysis patients. |
Vychytil A, etal., Kidney Int. 1998 Jun;53(6):1775-82. doi: 10.1046/j.1523-1755.1998.00918.x.
|
157. |
[Study on the relations between genetic polymorphisms in methylenetetrahydrofolate reductase, methionine synthase and the risk of pancreatic cancer] |
Wang L, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2006 Jan;27(1):50-4.
|
158. |
Update and new concepts in vitamin responsive disorders of folate transport and metabolism. |
Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
|
159. |
Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes. |
Wiltshire EJ, etal., Pediatr Diabetes. 2008 Aug;9(4 Pt 2):348-53.
|
160. |
A prospective case-control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss. |
Yenicesu GI, etal., Am J Reprod Immunol. 2010 Feb;63(2):126-36. doi: 10.1111/j.1600-0897.2009.00770.x. Epub 2009 Nov 10.
|
161. |
The effect of IL-4 and MTHFR gene variants in ankylosing spondylitis. |
Yigit S, etal., Z Rheumatol. 2015 Feb;74(1):60-6. doi: 10.1007/s00393-014-1403-2.
|
162. |
C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease. |
Yilmaz H, etal., Cell Biochem Funct. 2006 Jan-Feb;24(1):87-90.
|
163. |
A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: data from Turkey. |
Yilmaz S, etal., J Thromb Thrombolysis. 2006 Dec;22(3):205-12.
|
164. |
Genetic polymorphisms associated with retinal vein occlusion: a Greek case-control study and meta-analysis. |
Yioti GG, etal., Ophthalmic Genet. 2013 Sep;34(3):130-9. doi: 10.3109/13816810.2012.746376. Epub 2013 Jan 4.
|
165. |
Synergistic association of DNA repair relevant gene polymorphisms with the risk of coronary artery disease in northeastern Han Chinese. |
Yu X, etal., Thromb Res. 2014 Feb;133(2):229-34. doi: 10.1016/j.thromres.2013.11.017. Epub 2013 Nov 25.
|
166. |
Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. |
Yuan JM, etal., Hepatology. 2007 Sep;46(3):749-58. doi: 10.1002/hep.21735.
|
167. |
Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract. |
Zetterberg M, etal., Am J Ophthalmol. 2005 Nov;140(5):932-4.
|
168. |
Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma. |
Zetterberg M, etal., Ophthalmic Genet. 2007 Jun;28(2):47-50.
|
169. |
Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. |
Zgheib NK, etal., Pharmacogenet Genomics. 2014 Aug;24(8):387-96. doi: 10.1097/FPC.0000000000000069.
|
170. |
[Relationship between the methylenetetrahydrofolate reductase gene polymorphism and adverse reactions of high-dose methotrexate in children with acute lymphocytic leukemia]. |
Zheng MM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2013 Mar;15(3):201-6.
|
171. |
Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population. |
Zheng YZ, etal., Br J Haematol. 2000 Jun;109(4):870-4.
|
172. |
Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease. |
Zimmerman SA and Ware RE, Am J Hematol. 1998 Dec;59(4):267-72.
|
173. |
Genetic polymorphisms and the risk of progressive renal failure in elderly Hungarian patients. |
Zsom M, etal., Hemodial Int. 2011 Oct;15(4):501-8. doi: 10.1111/j.1542-4758.2011.00593.x. Epub 2011 Sep 13.
|