Crb1 (crumbs cell polarity complex component 1) - Rat Genome Database

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Gene: Crb1 (crumbs cell polarity complex component 1) Rattus norvegicus
Analyze
Symbol: Crb1
Name: crumbs cell polarity complex component 1
RGD ID: 1309947
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in establishment or maintenance of epithelial cell apical/basal polarity and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to act upstream of with a negative effect on protein localization. Predicted to act upstream of or within several processes, including detection of light stimulus involved in visual perception; eye morphogenesis; and neurogenesis. Located in microvillus and photoreceptor inner segment. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cannabidiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: crumbs 1, cell polarity complex component; crumbs family member 1, photoreceptor morphogenesis associated; crumbs homolog 1; crumbs homolog 1 (Drosophila); LOC304825
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Crb1m1  
Genetic Models: BN-Crb1m1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21350,801,484 - 50,989,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1350,800,959 - 50,989,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1353,408,027 - 53,587,968 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01354,695,960 - 54,875,896 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01351,963,725 - 52,151,483 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,270,519 - 56,462,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,270,781 - 56,462,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,413,282 - 61,480,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01361,292,273 - 61,369,526 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41352,558,317 - 52,725,099 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11352,572,656 - 52,715,591 (-)NCBI
Celera1351,073,846 - 51,253,703 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12). den Hollander AI, etal., Nat Genet. 1999 Oct;23(2):217-21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Phenotypic variability in patients with retinal dystrophies due to mutations in CRB1. Henderson RH, etal., Br J Ophthalmol. 2011 Jun;95(6):811-7. doi: 10.1136/bjo.2010.186882. Epub 2010 Oct 17.
5. Childhood cone-rod dystrophy with macular cystic degeneration from recessive CRB1 mutation. Khan AO, etal., Ophthalmic Genet. 2014 Sep;35(3):130-7. doi: 10.3109/13816810.2013.804097. Epub 2013 Jun 14.
6. Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. Low BE, etal., Invest Ophthalmol Vis Sci. 2014 Jan 20;55(1):387-95. doi: 10.1167/iovs.13-13278.
7. Pigmented paravenous chorioretinal atrophy is associated with a mutation within the crumbs homolog 1 (CRB1) gene. McKay GJ, etal., Invest Ophthalmol Vis Sci. 2005 Jan;46(1):322-8.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis. Pellissier LP, etal., PLoS Genet. 2013 Dec;9(12):e1003976. doi: 10.1371/journal.pgen.1003976. Epub 2013 Dec 5.
11. Evaluating Potential Therapies in a Mouse Model of Focal Retinal Degeneration with Age-related Macular Degeneration (AMD)-Like Lesions. Popp N, etal., J Clin Exp Ophthalmol. 2013 Oct 1;4(5):1000296.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1. van de Pavert SA, etal., J Neurosci. 2007 Jan 17;27(3):564-73.
17. Novel mutations of CRB1 in Chinese families presenting with retinal dystrophies. Yang L, etal., Mol Vis. 2014 Mar 26;20:359-67. eCollection 2014.
18. A new CRB1 rat mutation links Müller glial cells to retinal telangiectasia. Zhao M, etal., J Neurosci. 2015 Apr 15;35(15):6093-106. doi: 10.1523/JNEUROSCI.3412-14.2015.
Additional References at PubMed
PMID:12915475   PMID:15316081   PMID:15914641   PMID:16885194   PMID:21052544   PMID:22447858   PMID:25147295   PMID:25636444   PMID:33808129  


Genomics

Comparative Map Data
Crb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21350,801,484 - 50,989,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1350,800,959 - 50,989,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1353,408,027 - 53,587,968 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01354,695,960 - 54,875,896 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01351,963,725 - 52,151,483 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,270,519 - 56,462,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,270,781 - 56,462,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,413,282 - 61,480,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01361,292,273 - 61,369,526 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41352,558,317 - 52,725,099 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11352,572,656 - 52,715,591 (-)NCBI
Celera1351,073,846 - 51,253,703 (-)NCBICelera
Cytogenetic Map13q13NCBI
CRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381197,201,504 - 197,478,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1197,268,204 - 197,478,455 (+)EnsemblGRCh38hg38GRCh38
GRCh371197,170,634 - 197,447,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361195,504,031 - 195,714,208 (+)NCBINCBI36Build 36hg18NCBI36
Build 341193,969,064 - 194,179,241NCBI
Celera1170,362,823 - 170,573,037 (+)NCBICelera
Cytogenetic Map1q31.3NCBI
HuRef1168,328,124 - 168,606,472 (+)NCBIHuRef
CHM1_11198,593,055 - 198,870,040 (+)NCBICHM1_1
T2T-CHM13v2.01196,463,303 - 196,740,260 (+)NCBIT2T-CHM13v2.0
Crb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391139,101,288 - 139,307,262 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1139,124,794 - 139,304,838 (-)EnsemblGRCm39 Ensembl
GRCm381139,176,649 - 139,379,316 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1139,197,056 - 139,377,100 (-)EnsemblGRCm38mm10GRCm38
MGSCv371141,094,831 - 141,273,653 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361141,014,754 - 141,193,452 (-)NCBIMGSCv36mm8
Celera1141,833,551 - 142,013,612 (-)NCBICelera
Cytogenetic Map1E4- FNCBI
cM Map160.87NCBI
Crb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540633,817,605 - 34,005,943 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540633,817,754 - 34,005,937 (+)NCBIChiLan1.0ChiLan1.0
CRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1151,867,477 - 52,146,450 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,794,523 - 173,076,045 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11177,174,431 - 177,389,289 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1177,174,431 - 177,422,867 (+)Ensemblpanpan1.1panPan2
CRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.175,277,394 - 5,490,542 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl75,277,394 - 5,490,470 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha74,896,806 - 5,113,389 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.074,967,450 - 5,180,345 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl74,967,446 - 5,180,191 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.174,909,374 - 5,120,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,009,956 - 5,223,118 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,042,374 - 5,255,595 (-)NCBIUU_Cfam_GSD_1.0
Crb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934477,112,995 - 77,325,150 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365676,366,489 - 6,559,766 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365676,347,661 - 6,559,731 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1020,137,451 - 20,332,414 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11020,137,246 - 20,332,539 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21024,720,738 - 24,900,728 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12531,710,712 - 32,143,121 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2531,906,803 - 32,088,995 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605532,840,856 - 33,051,363 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247982,861,520 - 2,999,697 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247982,861,481 - 2,999,387 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crb1
1764 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:163
Interacting mature miRNAs:182
Transcripts:ENSRNOT00000032122
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat

Markers in Region
D13Got230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21350,880,586 - 50,880,742 (+)MAPPERmRatBN7.2
Rnor_6.01356,349,844 - 56,349,999NCBIRnor6.0
Rnor_5.01361,371,158 - 61,371,313UniSTSRnor5.0
RGSC_v3.41352,637,499 - 52,637,654UniSTSRGSC3.4
Celera1351,152,836 - 51,152,983UniSTS
Cytogenetic Map13q13UniSTS
AB072758  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21350,935,075 - 50,935,204 (+)MAPPERmRatBN7.2
Rnor_6.01356,408,146 - 56,408,274NCBIRnor6.0
Rnor_5.01361,426,184 - 61,426,312UniSTSRnor5.0
Celera1351,201,544 - 51,201,672UniSTS
Cytogenetic Map13q13UniSTS
RH133772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21350,836,641 - 50,836,840 (+)MAPPERmRatBN7.2
Rnor_6.01356,305,855 - 56,306,053NCBIRnor6.0
Rnor_5.01361,327,347 - 61,327,545UniSTSRnor5.0
RGSC_v3.41352,593,564 - 52,593,762UniSTSRGSC3.4
Celera1351,108,919 - 51,109,117UniSTS
Cytogenetic Map13q13UniSTS


Genetic Models
This gene Crb1 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 4 4 65 13 20 4
Below cutoff 1 20 17 4 13 4 4 7 9 22 20 7 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032122   ⟹   ENSRNOP00000037018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1350,801,484 - 50,989,261 (-)Ensembl
Rnor_6.0 Ensembl1356,270,781 - 56,462,834 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097209   ⟹   ENSRNOP00000078309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1350,800,959 - 50,989,261 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110674   ⟹   ENSRNOP00000096962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1350,855,374 - 50,989,261 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114575   ⟹   ENSRNOP00000086071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1350,838,338 - 50,989,261 (-)Ensembl
RefSeq Acc Id: NM_001107182   ⟹   NP_001100652
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21350,801,484 - 50,989,261 (-)NCBI
Rnor_6.01356,270,781 - 56,462,834 (-)NCBI
Rnor_5.01361,292,273 - 61,369,526 (-)NCBI
Rnor_5.01361,413,282 - 61,480,872 (-)NCBI
RGSC_v3.41352,558,317 - 52,725,099 (-)RGD
Celera1351,073,846 - 51,253,703 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100652 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09625 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001100652   ⟸   NM_001107182
- Peptide Label: precursor
- UniProtKB: D3ZZL8 (UniProtKB/TrEMBL),   A6ICM2 (UniProtKB/TrEMBL),   A0A8I5ZKN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000037018   ⟸   ENSRNOT00000032122
RefSeq Acc Id: ENSRNOP00000078309   ⟸   ENSRNOT00000097209
RefSeq Acc Id: ENSRNOP00000096962   ⟸   ENSRNOT00000110674
RefSeq Acc Id: ENSRNOP00000086071   ⟸   ENSRNOT00000114575
Protein Domains
EGF-like   Laminin G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZL8-F1-model_v2 AlphaFold D3ZZL8 1-1407 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309947 AgrOrtholog
BioCyc Gene G2FUF-18077 BioCyc
Ensembl Genes ENSRNOG00000010903 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000037018 ENTREZGENE
  ENSRNOP00000037018.5 UniProtKB/TrEMBL
  ENSRNOP00000078309.1 UniProtKB/TrEMBL
  ENSRNOP00000086071.1 UniProtKB/TrEMBL
  ENSRNOP00000096962.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032122 ENTREZGENE
  ENSRNOT00000032122.6 UniProtKB/TrEMBL
  ENSRNOT00000097209.1 UniProtKB/TrEMBL
  ENSRNOT00000110674.1 UniProtKB/TrEMBL
  ENSRNOT00000114575.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
KEGG Report rno:304825 UniProtKB/TrEMBL
NCBI Gene 304825 ENTREZGENE
PANTHER CRUMBS FAMILY MEMBER UniProtKB/TrEMBL
  CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 UniProtKB/TrEMBL
  DROSOPHILA CRUMBS HOMOLOG UniProtKB/TrEMBL
  NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 UniProtKB/TrEMBL
  PROTEIN CRUMBS HOMOLOG 1 UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
PhenoGen Crb1 PhenoGen
PRINTS EGFBLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A8I5ZKN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4M0_RAT UniProtKB/TrEMBL
  A0A8I6AQJ2_RAT UniProtKB/TrEMBL
  A6ICM2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZL8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Crb1  crumbs 1, cell polarity complex component  Crb1  crumbs family member 1, photoreceptor morphogenesis associated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-02-13 Crb1  crumbs family member 1, photoreceptor morphogenesis associated  Crb1  crumbs homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Crb1  crumbs homolog 1 (Drosophila)   Crb1_predicted  crumbs homolog 1 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Crb1_predicted  crumbs homolog 1 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED